Skip to main content

Rajesh Chandra Dash

Professor of Pathology
Pathology
Rm 3426 Duke Hospital South, Duke Box 3712, Durham, NC 27710
Rm 3426 Duke Hospital South, Box 3712 Med Ctr, Durham, NC 27710

Selected Publications


Pathologist-performed ultrasound-guided fine needle aspiration biopsies of extrathyroidal sites: An observational study.

Journal Article Diagn Cytopathol · April 2023 BACKGROUND: Pathologist-performed ultrasound-guided fine needle aspiration (USFNA) biopsies have become an increasingly important component of the interventional cytopathologist's toolbox. However, its application varies between institutions, and there is ... Full text Link to item Cite

Pathologist-performed ultrasound-guided fine-needle aspirations of the thyroid: A single institution observational study.

Journal Article Cancer Cytopathol · September 2022 BACKGROUND: Ultrasound-guided fine-needle aspiration biopsies (USFNAs) are increasingly performed by pathologists. This study was designed to assess the diagnostic yield and characterization of thyroid nodules biopsied at a teaching hospital setting in whi ... Full text Link to item Cite

Performance of repeat cytology with reflex ThyroSeq genomic classifier for indeterminant thyroid cytology.

Journal Article Cancer Cytopathol · June 2022 BACKGROUND: The American Thyroid Association recommends either repeat fine-needle aspiration biopsy (FNAB) or molecular testing (eg, ThyroSeq) of Bethesda category III (atypia of undetermined significance/follicular lesion of undetermined significance [AUS ... Full text Link to item Cite

Pleural effusions associated with squamous cell lung carcinoma have a low diagnostic yield and a poor prognosis.

Journal Article Transl Lung Cancer Res · June 2021 BACKGROUND: Malignant pleural effusion (MPE) portends a poor prognosis in non-small cell lung cancer (NSCLC). However, the yield of pleural fluid cytology as well as survival of patients with MPE associated with squamous cell carcinoma versus adenocarcinom ... Full text Link to item Cite

Integrating the Health-care Enterprise Pathology and Laboratory Medicine Guideline for Digital Pathology Interoperability.

Journal Article J Pathol Inform · 2021 Integrating the health-care enterprise (IHE) is an international initiative to promote the use of standards to achieve interoperability among health information technology systems. The Pathology and Laboratory Medicine domain within IHE has brought togethe ... Full text Link to item Cite

Pathologist Opinions about EPIC Beaker AP: a Multi-Institutional Survey of Early Adopters.

Conference J Med Syst · May 6, 2020 EPIC Systems Corporation provides a widely used electronic medical record. Beaker Anatomic Pathology is a newly developed laboratory information system (LIS) that has been implemented at a small number of academic pathology departments. Pathologist opinion ... Full text Link to item Cite

A Model Information Management Plan for Molecular Pathology Sequence Data Using Standards: From Sequencer to Electronic Health Record.

Journal Article J Mol Diagn · May 2019 Incorporating genetic variant data into the electronic health record (EHR) in discrete computable fashion has vexed the informatics community for years. Genetic sequence test results are typically communicated by the molecular laboratory and stored in the ... Full text Link to item Cite

Yield of Malignant Pleural Effusion for Detection of Oncogenic Driver Mutations in Lung Adenocarcinoma.

Journal Article J Bronchology Interv Pulmonol · April 2019 BACKGROUND: Pleural fluid can be used to assess targetable mutations in patients with lung adenocarcinoma. The primary objective of this study was to assess the yield of pleural fluid cytology for targetable oncogenic mutations (EGFR, KRAS, BRAF, ALK, and ... Full text Link to item Cite

Flow cytometry immunophenotyping of vitreous specimens does not contribute to diagnosis of lymphoma without supporting morphologic features.

Journal Article Diagn Cytopathol · April 2019 BACKGROUND: Diagnostic vitrectomy with flow cytometry immunophenotyping (FCI) is being increasingly used as part of screening for diagnostically challenging cases. We aim to evaluate the utility of combined cytopathology and FCI in diagnostic pars plana vi ... Full text Link to item Cite

The College of American Pathologists Biorepository Accreditation Program: Results from the First 5 Years.

Journal Article Biopreserv Biobank · February 2018 The College of American Pathologists (CAP) developed the Biorepository Accreditation Program (BAP) in 2012. This program integrates best practices from the International Society for Biological and Environmental Biorepositories, the National Cancer Institut ... Full text Link to item Cite

Anticipatory Positive Urine Tests for Bladder Cancer.

Journal Article Ann Surg Oncol · June 2017 PURPOSE: The aim of this study was to establish the criteria defining an anticipatory positive test for bladder cancer. METHODS: We reviewed all patients at our institution who underwent urine cytology or UroVysion fluorescence in situ hybridization (FISH) ... Full text Link to item Cite

The diagnostic accuracy of urine-based tests for bladder cancer varies greatly by patient.

Journal Article BMC Urol · June 13, 2016 BACKGROUND: Spectrum effects refer to the phenomenon that test performance varies across subgroups of a population. When spectrum effects occur during diagnostic testing for cancer, difficult patient misdiagnoses can occur. Our objective was to evaluate th ... Full text Link to item Cite

A call to standardize preanalytic data elements for biospecimens.

Journal Article Arch Pathol Lab Med · April 2014 CONTEXT: Biospecimens must have appropriate clinical annotation (data) to ensure optimal quality for both patient care and research. Clinical preanalytic variables are the focus of this study. OBJECTIVE: To define the essential preanalytic variables (data ... Full text Link to item Cite

Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy.

Journal Article Cancer Prev Res (Phila) · September 2013 Aerobic exercise training (AET) is an effective adjunct therapy to attenuate the adverse side-effects of adjuvant chemotherapy in women with early breast cancer. Whether AET interacts with the antitumor efficacy of chemotherapy has received scant attention ... Full text Link to item Cite

Risk of invasive breast cancer and ductal carcinoma in situ in women with atypical papillary lesions of the breast.

Journal Article Breast J · September 2012 Benign papillary lesions of the breast include papilloma and papillomatosis. A retrospective analysis of patients with a papillary breast lesion diagnosed between October 1992 and December 2009 was performed. Patients were excluded if they had a previous o ... Full text Link to item Cite

Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer.

Journal Article J Appl Physiol (1985) · July 2012 The purpose of this study is to investigate the effects of exercise on cancer progression, metastasis, and underlying mechanisms in an orthotopic model of murine prostate cancer. C57BL/6 male mice (6-8 wk of age) were orthotopically injected with transgeni ... Full text Link to item Cite

Biospecimens and biorepositories for the community pathologist.

Journal Article Arch Pathol Lab Med · June 2012 Pathologists have long served as custodians of human biospecimens collected for diagnostic purposes. Rapid advancements in diagnostic technologies require that pathologists change their practices to optimize patient care. The proper handling of biospecimen ... Full text Link to item Cite

Recurrence risk and margin status in granular cell tumors of the breast: a clinicopathologic study of 13 patients.

Journal Article Arch Pathol Lab Med · July 2011 CONTEXT: Granular cell tumors (GCTs) of the breast are rare neoplasms that mimic epithelial malignancy clinically and rarely occur in association with it. Granular cell tumors of the breast are not infrequently excised with positive margins. Reports descri ... Full text Link to item Cite

The cancer translational research informatics platform.

Journal Article BMC Med Inform Decis Mak · December 24, 2008 Featured Publication BACKGROUND: Despite the pressing need for the creation of applications that facilitate the aggregation of clinical and molecular data, most current applications are proprietary and lack the necessary compliance with standards that would allow for cross-ins ... Full text Link to item Cite

Designing the "next generation" of medical information systems

Journal Article Proceedings - 9th International Conference on Information Technology, ICIT 2006 · November 16, 2007 A new breed of medical information systems is required to more effectively address unresolved and newly emerging needs in the healthcare environment. This paper attempts to define those needs and describe the design and implementation of a solution. In ord ... Full text Cite

Pathologist-performed ultrasound-guided fine needle aspiration biopsies of extrathyroidal sites: An observational study.

Journal Article Diagn Cytopathol · April 2023 BACKGROUND: Pathologist-performed ultrasound-guided fine needle aspiration (USFNA) biopsies have become an increasingly important component of the interventional cytopathologist's toolbox. However, its application varies between institutions, and there is ... Full text Link to item Cite

Pathologist-performed ultrasound-guided fine-needle aspirations of the thyroid: A single institution observational study.

Journal Article Cancer Cytopathol · September 2022 BACKGROUND: Ultrasound-guided fine-needle aspiration biopsies (USFNAs) are increasingly performed by pathologists. This study was designed to assess the diagnostic yield and characterization of thyroid nodules biopsied at a teaching hospital setting in whi ... Full text Link to item Cite

Performance of repeat cytology with reflex ThyroSeq genomic classifier for indeterminant thyroid cytology.

Journal Article Cancer Cytopathol · June 2022 BACKGROUND: The American Thyroid Association recommends either repeat fine-needle aspiration biopsy (FNAB) or molecular testing (eg, ThyroSeq) of Bethesda category III (atypia of undetermined significance/follicular lesion of undetermined significance [AUS ... Full text Link to item Cite

Pleural effusions associated with squamous cell lung carcinoma have a low diagnostic yield and a poor prognosis.

Journal Article Transl Lung Cancer Res · June 2021 BACKGROUND: Malignant pleural effusion (MPE) portends a poor prognosis in non-small cell lung cancer (NSCLC). However, the yield of pleural fluid cytology as well as survival of patients with MPE associated with squamous cell carcinoma versus adenocarcinom ... Full text Link to item Cite

Integrating the Health-care Enterprise Pathology and Laboratory Medicine Guideline for Digital Pathology Interoperability.

Journal Article J Pathol Inform · 2021 Integrating the health-care enterprise (IHE) is an international initiative to promote the use of standards to achieve interoperability among health information technology systems. The Pathology and Laboratory Medicine domain within IHE has brought togethe ... Full text Link to item Cite

Pathologist Opinions about EPIC Beaker AP: a Multi-Institutional Survey of Early Adopters.

Conference J Med Syst · May 6, 2020 EPIC Systems Corporation provides a widely used electronic medical record. Beaker Anatomic Pathology is a newly developed laboratory information system (LIS) that has been implemented at a small number of academic pathology departments. Pathologist opinion ... Full text Link to item Cite

A Model Information Management Plan for Molecular Pathology Sequence Data Using Standards: From Sequencer to Electronic Health Record.

Journal Article J Mol Diagn · May 2019 Incorporating genetic variant data into the electronic health record (EHR) in discrete computable fashion has vexed the informatics community for years. Genetic sequence test results are typically communicated by the molecular laboratory and stored in the ... Full text Link to item Cite

Yield of Malignant Pleural Effusion for Detection of Oncogenic Driver Mutations in Lung Adenocarcinoma.

Journal Article J Bronchology Interv Pulmonol · April 2019 BACKGROUND: Pleural fluid can be used to assess targetable mutations in patients with lung adenocarcinoma. The primary objective of this study was to assess the yield of pleural fluid cytology for targetable oncogenic mutations (EGFR, KRAS, BRAF, ALK, and ... Full text Link to item Cite

Flow cytometry immunophenotyping of vitreous specimens does not contribute to diagnosis of lymphoma without supporting morphologic features.

Journal Article Diagn Cytopathol · April 2019 BACKGROUND: Diagnostic vitrectomy with flow cytometry immunophenotyping (FCI) is being increasingly used as part of screening for diagnostically challenging cases. We aim to evaluate the utility of combined cytopathology and FCI in diagnostic pars plana vi ... Full text Link to item Cite

The College of American Pathologists Biorepository Accreditation Program: Results from the First 5 Years.

Journal Article Biopreserv Biobank · February 2018 The College of American Pathologists (CAP) developed the Biorepository Accreditation Program (BAP) in 2012. This program integrates best practices from the International Society for Biological and Environmental Biorepositories, the National Cancer Institut ... Full text Link to item Cite

Anticipatory Positive Urine Tests for Bladder Cancer.

Journal Article Ann Surg Oncol · June 2017 PURPOSE: The aim of this study was to establish the criteria defining an anticipatory positive test for bladder cancer. METHODS: We reviewed all patients at our institution who underwent urine cytology or UroVysion fluorescence in situ hybridization (FISH) ... Full text Link to item Cite

The diagnostic accuracy of urine-based tests for bladder cancer varies greatly by patient.

Journal Article BMC Urol · June 13, 2016 BACKGROUND: Spectrum effects refer to the phenomenon that test performance varies across subgroups of a population. When spectrum effects occur during diagnostic testing for cancer, difficult patient misdiagnoses can occur. Our objective was to evaluate th ... Full text Link to item Cite

A call to standardize preanalytic data elements for biospecimens.

Journal Article Arch Pathol Lab Med · April 2014 CONTEXT: Biospecimens must have appropriate clinical annotation (data) to ensure optimal quality for both patient care and research. Clinical preanalytic variables are the focus of this study. OBJECTIVE: To define the essential preanalytic variables (data ... Full text Link to item Cite

Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy.

Journal Article Cancer Prev Res (Phila) · September 2013 Aerobic exercise training (AET) is an effective adjunct therapy to attenuate the adverse side-effects of adjuvant chemotherapy in women with early breast cancer. Whether AET interacts with the antitumor efficacy of chemotherapy has received scant attention ... Full text Link to item Cite

Risk of invasive breast cancer and ductal carcinoma in situ in women with atypical papillary lesions of the breast.

Journal Article Breast J · September 2012 Benign papillary lesions of the breast include papilloma and papillomatosis. A retrospective analysis of patients with a papillary breast lesion diagnosed between October 1992 and December 2009 was performed. Patients were excluded if they had a previous o ... Full text Link to item Cite

Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer.

Journal Article J Appl Physiol (1985) · July 2012 The purpose of this study is to investigate the effects of exercise on cancer progression, metastasis, and underlying mechanisms in an orthotopic model of murine prostate cancer. C57BL/6 male mice (6-8 wk of age) were orthotopically injected with transgeni ... Full text Link to item Cite

Biospecimens and biorepositories for the community pathologist.

Journal Article Arch Pathol Lab Med · June 2012 Pathologists have long served as custodians of human biospecimens collected for diagnostic purposes. Rapid advancements in diagnostic technologies require that pathologists change their practices to optimize patient care. The proper handling of biospecimen ... Full text Link to item Cite

Recurrence risk and margin status in granular cell tumors of the breast: a clinicopathologic study of 13 patients.

Journal Article Arch Pathol Lab Med · July 2011 CONTEXT: Granular cell tumors (GCTs) of the breast are rare neoplasms that mimic epithelial malignancy clinically and rarely occur in association with it. Granular cell tumors of the breast are not infrequently excised with positive margins. Reports descri ... Full text Link to item Cite

The cancer translational research informatics platform.

Journal Article BMC Med Inform Decis Mak · December 24, 2008 Featured Publication BACKGROUND: Despite the pressing need for the creation of applications that facilitate the aggregation of clinical and molecular data, most current applications are proprietary and lack the necessary compliance with standards that would allow for cross-ins ... Full text Link to item Cite

Designing the "next generation" of medical information systems

Journal Article Proceedings - 9th International Conference on Information Technology, ICIT 2006 · November 16, 2007 A new breed of medical information systems is required to more effectively address unresolved and newly emerging needs in the healthcare environment. This paper attempts to define those needs and describe the design and implementation of a solution. In ord ... Full text Cite

Schistosoma haematobium in urine: morphology with ThinPrep method.

Journal Article Diagn Cytopathol · October 2007 Featured Publication Full text Link to item Cite

Desmoplastic small round cell tumor: using FISH as an ancillary technique to support cytologic diagnosis in an unusual case.

Journal Article Diagn Cytopathol · August 2007 Featured Publication Desmoplastic small round cell tumor is a rare and aggressive neoplasm that predominantly affects young males. In almost all cases, a reciprocal translocation is present resulting in the fusion of the Ewing sarcoma gene with the Wilms' tumor gene. Here we d ... Full text Link to item Cite

NSAIDs and cardiovascular risk - Reply [2]

Journal Article Cell Metabolism · December 1, 2005 Full text Cite

Prostacyclin protects against elevated blood pressure and cardiac fibrosis.

Journal Article Cell Metab · September 2005 Specific inhibitors of COX-2 have been associated with increased risk for cardiovascular complications. These agents reduce prostacyclin (PGI2) without affecting production of thromboxane (Tx) A2. While this abnormal pattern of eicosanoid generation has be ... Full text Link to item Cite

The value of fluorescence in situ hybridization and polymerase chain reaction in the diagnosis of B-cell non-Hodgkin lymphoma by fine-needle aspiration.

Journal Article Arch Pathol Lab Med · December 2004 Featured Publication CONTEXT: Molecular genetic analyses have been predicted to improve the diagnostic accuracy of fine-needle aspiration of B-cell non-Hodgkin lymphoma. OBJECTIVE: To determine the value of routine molecular genetic assays, polymerase chain reaction (PCR) and ... Full text Link to item Cite

A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice.

Journal Article Physiol Genomics · August 11, 2004 Featured Publication To understand the physiological role of angiotensin type 1 (AT(1)) receptors in the proximal tubule of the kidney, we generated a transgenic mouse line in which the major murine AT(1) receptor isoform, AT(1A), was expressed under the control of the P1 port ... Full text Link to item Cite

Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma.

Journal Article Diagn Cytopathol · July 2004 We retrospectively reviewed 74 fine-needle aspiration (FNA) cases of presumptive non-Hodgkin lymphoma (NHL). All the cases had cytology and core-needle biopsy and 53 cases had concurrent flow cytometric analysis. FNA (cytology and flow cytometry) and core- ... Full text Link to item Cite

Cytopathology of mesenchymal chondrosarcomas: a report and comparison of four patients.

Journal Article Cancer · August 25, 2003 BACKGROUND: Mesenchymal chondrosarcoma (MC) is an infrequent neoplasm, representing approximately 1% of all chondrosarcomas. Cytologic descriptions of MCs have been confined to rare case reports. In the current report, the authors describe their experience ... Full text Link to item Cite

Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics.

Journal Article Radiology · July 2002 Featured Publication PURPOSE: To determine if water diffusivity within lymphomas and high-grade astrocytomas correlates with cellularity. MATERIALS AND METHODS: Echo-planar diffusion-weighted magnetic resonance (MR) images obtained in 11 patients with brain lymphomas (19 lesio ... Full text Link to item Cite

Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types.

Journal Article Int J Gynecol Pathol · April 2001 One thousand consecutive cases of surgically proven endometriosis were reviewed to evaluate the frequency and types of pelvic cancers that were associated with ovarian and extraovarian endometriosis. The frequency and types of histologic abnormalities pres ... Full text Link to item Cite

Provocative angiography in obscure gastrointestinal bleeding.

Journal Article South Med J · December 2000 Obscure gastrointestinal (GI) bleeding is relatively common but difficult to manage. By definition, diagnosis of a specific etiology is particularly challenging. We report the diagnostic use of provocative angiography in a patient with recurrent obscure GI ... Link to item Cite

Fine-needle aspiration findings in idiopathic retroperitoneal fibrosis.

Journal Article Diagn Cytopathol · July 1999 Featured Publication Idiopathic retroperitoneal fibrosis (IRF) is an inflammatory and fibrosing process that can be complicated by periureteral encasement, ureteral obstruction, and subsequent renal failure if left untreated. Unfortunately, treatment is often delayed due to th ... Full text Link to item Cite

Fine-needle aspiration cytology of "ancient" schwannoma.

Journal Article Diagn Cytopathol · May 1999 Featured Publication The term "ancient" schwannoma was proposed for a group of neural tumors showing degenerative changes and marked nuclear atypia. Prior to the realization that the observed atypia was a regressive phenomenon, many of these lesions were erroneously diagnosed ... Full text Link to item Cite

Malignant supratentorial ganglioglioma (ganglion cell-giant cell glioblastoma): a case report and review of the literature.

Journal Article Arch Pathol Lab Med · April 1999 Featured Publication BACKGROUND: From both epidemiologic and pathologic viewpoints, gangliogliomas exhibiting components of giant cell glioblastomas are extraordinary neoplasms. We report herein the case of a 6-year-old girl who presented initially with a World Health Organiza ... Full text Link to item Cite

Decay of androgen receptor immunoreactivity in archived tissue by using monoclonal antibody F39.4.1

Journal Article Applied Immunohistochemistry · October 7, 1998 Hormone receptor status in neoplasms such as breast adenocarcinoma has been well established as providing valuable prognostic and therapeutic information. Analogous data regarding the significance of the androgen receptor (AR) in prostatic adenocarcinoma a ... Full text Cite