Scholars@Duke
Ranee Chatterjee

Ranee Chatterjee

Associate Professor of Medicine
Medicine, General Internal Medicine
Duke Box 2720, Durham, NC 27708
710 W. Main Street, 1st Floor, Durham, NC 27701

Selected Publications

A Pragmatic Trial Evaluating the Impact of the Anumana Clinical Decision Support Tool for Guideline-Directed Management of Heart Failure (ACT-HF): Clinical trial design and methods.

Conference Am Heart J Plus · January 2026 BACKGROUND: Heart failure with reduced ejection fraction (HFrEF) is progressive and pervasive. Guidelines provide evidence-based recommendations to manage HFrEF, yet adherence to Guideline Directed Medical Therapy (GDMT) is low. An opportunity exists to im ... Full text Link to item Cite

Effectiveness of motivational interviewing plus cognitive behavioral therapy vs shared decision making for voluntary opioid tapering in patients with chronic pain: the INSPIRE randomized pragmatic trial.

Journal Article Pain Med · August 1, 2025 OBJECTIVE: To compare the effectiveness of motivational interviewing plus cognitive behavioral therapy vs shared decision making on change in daily dosage of prescribed opioids for individuals with chronic non-cancer pain. DESIGN: Pragmatic randomized tria ... Full text Open Access Link to item Cite

Designing a Patient-Centered Interdisciplinary Intervention to Promote Equitable Access to Kidney Transplantation across Health Systems: The STEPS Study.

Journal Article Health Soc Work · August 1, 2025 In the United States, health inequities persist in the management of chronic kidney disease and end-stage kidney disease, including unequal access to kidney transplantation. These disparities are deeply rooted in complex social and structural determinants ... Full text Link to item Cite

Multi-modal analyses of proteomic measurements associated with type 2 diabetes from the Project Baseline Health Study.

Journal Article Commun Med (Lond) · July 3, 2025 BACKGROUND: Understanding diabetes at the molecular level can help refine diagnostic approaches and personalized treatment efforts. METHODS: We generated proteomic data from plasma collected from participants enrolled in the longitudinal observational coho ... Full text Link to item Cite

A multicenter pragmatic implementation study of AI-ECG-based clinical decision support software to identify low LVEF: Clinical trial design and methods.

Conference Am Heart J Plus · June 2025 BACKGROUND: Artificial intelligence (AI) enabled algorithms can detect or predict cardiovascular conditions using electrocardiogram (ECG) data. Clinical studies have evaluated ECG-AI algorithms, including a recent single-center study which evaluated outcom ... Full text Link to item Cite

Associations between potassium, arterial stiffness, and risk of cardiovascular disease in the Jackson Heart Study: Potassium, arterial stiffness, and CVD risk.

Journal Article Am J Prev Cardiol · June 2025 BACKGROUND: Potassium (K) measures are associated with cardiovascular disease (CVD) risk factors, particularly blood pressure (BP). Arterial stiffness is a pre-clinical marker of CVD risk. We sought to study associations of K measures with arterial stiffne ... Full text Link to item Cite

Returning Individual-Level Urgent or Emergent Research Results to Participants: The Project Baseline Health Study Experience.

Journal Article Am J Med Open · June 2025 BACKGROUND: Returning results to research participants is increasingly recognized as an ethical mandate, yet little is known about best practices to optimally communicate urgent or emergent results. METHODS: We describe the development of and experience wi ... Full text Link to item Cite

Complexities and approaches for deriving longitudinal daily morphine milligram equivalents using electronic health record prescription data.

Journal Article JAMIA Open · June 2025 OBJECTIVE: To describe challenges and solutions for calculating longitudinal daily opioid dose in morphine milligram equivalents from electronic health record prescriptions for a clinical trial of voluntary opioid reduction in patients with chronic non-can ... Full text Open Access Link to item Cite

Standards and infrastructure for multisite deployment of the research participant perception survey.

Journal Article JAMIA Open · April 2025 OBJECTIVES: To develop and disseminate a technical framework for administering the Research Participant Perception Survey (RPPS) and aggregating data across institutions using REDCap. MATERIALS AND METHODS: Six RPPS Steering Committee (RSC) member institut ... Full text Link to item Cite

Atrial Fibrillation Burden on a 14-Day ECG Monitor: Findings From the GUARD-AF Trial Screening Arm.

Journal Article JACC Clin Electrophysiol · January 2025 BACKGROUND: The "burden" of atrial fibrillation (AF) detected by screening likely influences stroke risk, but the distribution of burden is not well described. OBJECTIVES: This study aims to determine the frequency of AF and the distribution of AF burden f ... Full text Link to item Cite

What research participants say about their research experiences in Empowering the Participant Voice: Outcomes and actionable data.

Journal Article J Clin Transl Sci · 2025 BACKGROUND: Research participants" feedback about their participation experiences offers critical insights for improving programs. A shared Empowering the Participant Voice (EPV) infrastructure enabled a multiorganization collaborative to collect, analyze, ... Full text Link to item Cite

Description and toolkit for a research participant referral service.

Journal Article J Clin Transl Sci · 2025 The success of clinical research studies depends on effective recruitment and retention of study participants, yet only a small fraction of patients engage in research studies, even in academic health systems. Increasing awareness of research opportunities ... Full text Link to item Cite

Effect of Screening for Undiagnosed Atrial Fibrillation on Stroke Prevention.

Journal Article J Am Coll Cardiol · November 19, 2024 BACKGROUND: Atrial fibrillation (AF) often remains undiagnosed, and it independently raises the risk of ischemic stroke, which is largely reversible by oral anticoagulation. Although randomized trials using longer term screening approaches increase identif ... Full text Link to item Cite

Sex-Specific Cardiovascular Risk Factors and Treatment in Females With T2DM and CVD: Developments and Knowledge Gaps.

Journal Article J Clin Endocrinol Metab · November 18, 2024 PURPOSE: There are large disparities in the impact of diabetes on cardiovascular disease (CVD) risk and outcomes by sex and gender. Achieving health equity requires understanding risks and medication efficacy in female patients, especially now, as novel ph ... Full text Link to item Cite

EXpanding Technology-Enabled, Nurse-Delivered Chronic Disease Care (EXTEND): Protocol and Baseline Data for a Randomized Trial.

Journal Article Contemp Clin Trials · November 2024 BACKGROUND: Approximately 10-15 % of individuals with type 2 diabetes have persistently poorly-controlled diabetes mellitus (PPDM) despite receiving available care, and frequently have comorbid hypertension. Mobile monitoring-enabled telehealth has the pot ... Full text Open Access Link to item Cite

Cardiovascular Outcomes in GRADE (Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness Study).

Journal Article Circulation · March 26, 2024 BACKGROUND: Cardiovascular disease is a major cause of morbidity and mortality in patients with type 2 diabetes. The effects of glucose-lowering medications on cardiovascular outcomes in individuals with type 2 diabetes and low cardiovascular risk are uncl ... Full text Link to item Cite

Feasibility of tracking invasive Escherichia coli disease among older adults in a community setting: A prospective observational study.

Journal Article Eur J Clin Microbiol Infect Dis · March 2024 PURPOSE: Invasive Escherichia coli disease (IED) encompasses a diverse range of sterile site infections. This study evaluated the feasibility of capturing IED among community-dwelling older adults to inform the implementation of a phase 3 efficacy trial of ... Full text Link to item Cite

Racial differences in measures of glycemia in the Vitamin D and Type 2 Diabetes (D2d) Study: a secondary analysis of a randomized trial.

Journal Article BMJ Open Diabetes Res Care · February 12, 2024 INTRODUCTION: Understanding how race may influence the association between A1c and glycemia can improve diabetes screening. We sought to determine whether, for a given A1c level, glucose levels during an oral glucose tolerance test (OGTT) differed by race. ... Full text Link to item Cite

Empowering the Participant Voice (EPV): Design and implementation of collaborative infrastructure to collect research participant experience feedback at scale.

Journal Article J Clin Transl Sci · 2024 Empowering the Participant Voice (EPV) is an NCATS-funded six-CTSA collaboration to develop, demonstrate, and disseminate a low-cost infrastructure for collecting timely feedback from research participants, fostering trust, and providing data for improving ... Full text Link to item Cite

Fielding the research participant perception survey to evaluate a culturally tailored Latinx cohort study.

Journal Article J Clin Transl Sci · 2024 INTRODUCTION: Latinx populations are underrepresented in clinical research. Asking Latinx research participants about their research experiences, barriers, and facilitators could help to improve research participation for these populations. METHODS: The Sa ... Full text Link to item Cite

Clinical and Echocardiographic Diversity Associated With Physical Fitness in the Project Baseline Health Study: Implications for Heart Failure Staging.

Journal Article J Card Fail · November 2023 BACKGROUND: Clinical and echocardiographic features may carry diverse information about the development of heart failure (HF). Therefore, we determined heterogeneity in clinical and echocardiographic phenotypes and its association with exercise capacity. M ... Full text Link to item Cite

Effect of intratrial mean 25(OH)D concentration on diabetes risk, by race and weight: an ancillary analysis in the D2d study.

Journal Article Am J Clin Nutr · July 2023 BACKGROUND: Higher serum 25-hydroxyvitamin D [25(OH)D] is associated with lower type 2 diabetes risk. 25(OH)D varies due to skin pigmentation and weight. OBJECTIVES: This analysis aims to determine whether the effect of vitamin D differs among people of co ... Full text Link to item Cite

Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy.

Journal Article Circ Genom Precis Med · June 2023 BACKGROUND: Epigenetic clocks estimate chronologic age using methylation levels at specific loci. We tested the hypothesis that accelerated epigenetic aging is associated with abnormal values in a range of clinical, imaging, and laboratory characteristics. ... Full text Link to item Cite

Pragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale.

Journal Article J Am Geriatr Soc · June 2023 Whether initiation of statins could increase survival free of dementia and disability in adults aged ≥75 years is unknown. PREVENTABLE, a double-blind, placebo-controlled randomized pragmatic clinical trial, will compare high-intensity statin therapy (ator ... Full text Link to item Cite

Describing current use, barriers, and facilitators of patient portal messaging for research recruitment: Perspectives from study teams and patients at one institution.

Journal Article J Clin Transl Sci · 2023 INTRODUCTION: The electronic health record (EHR) and patient portal are used increasingly for clinical research, including patient portal recruitment messaging (PPRM). Use of PPRM has grown rapidly; however, best practices are still developing. In this stu ... Full text Link to item Cite

Safety and tolerability of high-dose daily vitamin D3 supplementation in the vitamin D and type 2 diabetes (D2d) study-a randomized trial in persons with prediabetes.

Journal Article Eur J Clin Nutr · August 2022 BACKGROUND/OBJECTIVES: Routine use of vitamin D supplements has increased substantially in the United States. However, the safety and tolerability of long-term use of high-dose vitamin D are not known. We assessed the safety and tolerability of high-dose, ... Full text Link to item Cite

The effect of vitamin D supplementation on cardiovascular risk in patients with prediabetes: A secondary analysis of the D2d study.

Journal Article J Diabetes Complications · August 2022 AIMS: Low blood 25(OH)D level is associated with increased cardiovascular disease (CVD) risk. Additionally, individuals with prediabetes are at higher risk for CVD than individuals with normoglycemia. We investigated the effects of vitamin D supplementatio ... Full text Link to item Cite

Multi-dimensional characterization of prediabetes in the Project Baseline Health Study.

Journal Article Cardiovasc Diabetol · July 18, 2022 BACKGROUND: We examined multi-dimensional clinical and laboratory data in participants with normoglycemia, prediabetes, and diabetes to identify characteristics of prediabetes and predictors of progression from prediabetes to diabetes or reversion to no di ... Full text Link to item Cite

Practice Patterns of Fundoscopic Examination for Diabetic Retinopathy Screening in Primary Care.

Journal Article JAMA Netw Open · June 1, 2022 IMPORTANCE: Primary care professionals (PCPs) have a central role in screening for diabetic retinopathy (DR), especially in settings where access to specialty eye care is limited. Data on current DR screening practice patterns in primary care are needed to ... Full text Link to item Cite

Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes.

Journal Article J Clin Endocrinol Metab · January 1, 2022 CONTEXT: Vitamin D regulates glucose homeostasis pathways, but effects of vitamin D supplementation on β-cell function remain unclear. OBJECTIVE: To investigate the effects of vitamin D3 supplementation on insulin sensitivity and β-cell function. METHODS: ... Full text Link to item Cite

Vitamin D Supplementation for Prevention of Cancer: The D2d Cancer Outcomes (D2dCA) Ancillary Study.

Journal Article J Clin Endocrinol Metab · August 18, 2021 CONTEXT: Observational studies suggest that low vitamin D status may be a risk factor for cancer. OBJECTIVE: In a population with prediabetes and overweight/obesity that is at higher risk of cancer than the general population, we sought to determine if vit ... Full text Link to item Cite

Effect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes: A Secondary Analysis of a Randomized Trial.

Journal Article Clin J Am Soc Nephrol · August 2021 BACKGROUND AND OBJECTIVES: Low serum 25-hydroxyvitamin D (25[OH]D) concentration has been associated with higher levels of proteinuria and lower levels of eGFR in observational studies. In the Vitamin D and Type 2 Diabetes (D2d) study, we investigated the ... Full text Link to item Cite

Preliminary evidence of effects of potassium chloride on a metabolomic path to diabetes and cardiovascular disease.

Journal Article Metabolomics · June 18, 2020 INTRODUCTION: Low potassium intake can affect cardiovascular disease (CVD) risk and cardiometabolic risk factors. OBJECTIVE: We hypothesize that potassium chloride (KCl) supplementation can improve cardiovascular risk metabolomic profile. METHODS: In this ... Full text Open Access Link to item Cite

Reproducibility of a prediabetes classification in a contemporary population.

Journal Article Metabol Open · June 2020 AIMS: To assess whether meeting both fasting plasma glucose (FPG) and HbA1c criteria for prediabetes in people at high risk indicates with near certainty the presence of dysglycemia on repeat testing. METHODS: Observational study using data from Vitamin D ... Full text Link to item Cite

Implications of the Hemoglobin Glycation Index on the Diagnosis of Prediabetes and Diabetes.

Journal Article J Clin Endocrinol Metab · March 1, 2020 OBJECTIVE: Fasting plasma glucose (FPG), 2-hour plasma glucose (2hPG) from a 75-g oral glucose tolerance test (OGTT) and glycated hemoglobin (HbA1c) can lead to different results when diagnosing prediabetes and diabetes. The Hemoglobin Glycation Index (HGI ... Full text Link to item Cite

Vitamin D Supplementation and Prevention of Type 2 Diabetes.

Journal Article N Engl J Med · August 8, 2019 BACKGROUND: Observational studies support an association between a low blood 25-hydroxyvitamin D level and the risk of type 2 diabetes. However, whether vitamin D supplementation lowers the risk of diabetes is unknown. METHODS: We randomly assigned adults ... Full text Link to item Cite

Establishing an electronic health record-supported approach for outreach to and recruitment of persons at high risk of type 2 diabetes in clinical trials: The vitamin D and type 2 diabetes (D2d) study experience.

Journal Article Clin Trials · June 2019 AIMS: To establish recruitment approaches that leverage electronic health records in multicenter prediabetes/diabetes clinical trials and compare recruitment outcomes between electronic health record-supported and conventional recruitment methods. METHODS: ... Full text Link to item Cite

Vitamin D supplementation for prevention of cancer: The D2d cancer outcomes (D2dCA) study.

Journal Article Contemp Clin Trials · June 2019 Evidence on biological plausibility from mechanistic studies and data from observational studies suggest that vitamin D may be linked to risk of several types of cancer. However, evidence from clinical trials evaluating the effect of vitamin D supplementat ... Full text Link to item Cite

Interventions for Preventing Thromboembolic Events in Patients With Atrial Fibrillation: A Systematic Review.

Journal Article Ann Intern Med · December 4, 2018 BACKGROUND: The comparative safety and effectiveness of treatments to prevent thromboembolic complications in atrial fibrillation (AF) remain uncertain. PURPOSE: To compare the effectiveness of medical and procedural therapies in preventing thromboembolic ... Full text Link to item Cite

Predicting Thromboembolic and Bleeding Event Risk in Patients with Non-Valvular Atrial Fibrillation: A Systematic Review.

Journal Article Thromb Haemost · December 2018 BACKGROUND:  Atrial fibrillation (AF) is a common cardiac arrhythmia that increases the risk of stroke. Medical therapy for decreasing stroke risk involves anticoagulation, which may increase bleeding risk for certain patients. In determining the optimal t ... Full text Link to item Cite

Baseline Characteristics of the Vitamin D and Type 2 Diabetes (D2d) Study: A Contemporary Prediabetes Cohort That Will Inform Diabetes Prevention Efforts.

Journal Article Diabetes Care · August 2018 OBJECTIVE: To describe baseline characteristics of the Vitamin D and Type 2 Diabetes (D2d) study, the first large U.S. diabetes prevention clinical trial to apply current American Diabetes Association (ADA) criteria for prediabetes. RESEARCH DESIGN AND MET ... Full text Link to item Cite

A feasibility study to develop and test a Spanish patient and provider intervention for managing osteoarthritis in Hispanic/Latino adults (PRIMO-Latino).

Journal Article Pilot Feasibility Stud · 2018 BACKGROUND: Arthritis affects approximately 50 million adults in the USA. Hispanics/Latinos have a higher prevalence of arthritis-attributed activity limitations primarily related to osteoarthritis (OA). Hispanic/Latinos are less likely to receive hip repl ... Full text Open Access Link to item Cite

KCNJ11 variants and their effect on the association between serum potassium and diabetes risk in the Atherosclerosis Risk in Communities (ARIC) Study and Jackson Heart Study (JHS) cohorts.

Journal Article PLoS One · 2018 BACKGROUND: In the Atherosclerosis Risk in Communities (ARIC) Study and Jackson Heart Study (JHS) cohorts, serum potassium (K) is an independent predictor of diabetes risk, particularly among African-American participants. Experimental studies show that se ... Full text Link to item Cite

Effects of potassium supplements on glucose metabolism in African Americans with prediabetes: a pilot trial.

Journal Article Am J Clin Nutr · December 2017 Background: Low potassium has been identified both as a risk factor for type 2 diabetes and as a mediator of the racial disparity in diabetes risk. Low potassium could be a potentially modifiable risk factor, particularly for African Americans.Objective: W ... Full text Open Access Link to item Cite

Patient, Provider, and Combined Interventions for Managing Osteoarthritis in Primary Care: A Cluster Randomized Trial.

Journal Article Ann Intern Med · March 21, 2017 BACKGROUND: A single-site study showed that a combined patient and provider intervention improved outcomes for patients with knee osteoarthritis, but it did not assess separate effects of the interventions. OBJECTIVE: To examine whether patient-based, prov ... Full text Open Access Link to item Cite

Serum potassium is a predictor of incident diabetes in African Americans with normal aldosterone: the Jackson Heart Study.

Journal Article Am J Clin Nutr · February 2017 BACKGROUND: Low-normal potassium is a risk factor for diabetes and may account for some of the racial disparity in diabetes risk. Aldosterone affects serum potassium and is associated with insulin resistance. OBJECTIVES: We sought to confirm the associatio ... Full text Open Access Link to item Cite

Potassium Measures and Their Associations with Glucose and Diabetes Risk: The Multi-Ethnic Study of Atherosclerosis (MESA).

Journal Article PLoS One · 2016 BACKGROUND: Recent studies have found low-normal potassium (K) to be associated with increased diabetes risk. We sought to verify these associations in a multi-ethnic US cohort; and to determine if these associations extend to US Hispanics and Asian-Americ ... Full text Open Access Link to item Cite

Novel Risk Factors for Type 2 Diabetes in African-Americans.

Journal Article Curr Diab Rep · December 2015 In the USA, compared to whites, African-Americans are disproportionately impacted by the diabetes epidemic. Traditional diabetes risk factors, such as obesity, are more common among African-Americans, but these traditional risk factors do not explain all o ... Full text Link to item Cite

Potassium and glucose measures in older adults: the Cardiovascular Health Study.

Journal Article J Gerontol A Biol Sci Med Sci · February 2015 BACKGROUND: We sought to determine the impacts of serum and dietary potassium measures on glucose metabolism and diabetes risk in older adults. METHODS: Among participants of the Cardiovascular Health Study, a community-based cohort of older American adult ... Full text Link to item Cite

Clinic variation in recruitment metrics, patient characteristics and treatment use in a randomized clinical trial of osteoarthritis management.

Journal Article BMC Musculoskelet Disord · December 6, 2014 BACKGROUND: The Patient and PRovider Interventions for Managing Osteoarthritis (OA) in Primary Care (PRIMO) study is one of the first health services trials targeting OA in a multi-site, primary care network. This multi-site approach is important for asses ... Full text Open Access Link to item Cite

Rationale and design of the Vitamin D and Type 2 Diabetes (D2d) study: a diabetes prevention trial.

Journal Article Diabetes Care · December 2014 OBJECTIVE: Observational studies suggest that vitamin D may lower the risk of type 2 diabetes. However, data from long-term trials are lacking. The Vitamin D and Type 2 Diabetes (D2d) study is a randomized clinical trial designed to examine whether a causa ... Full text Link to item Cite

Prioritization of patient-centered comparative effectiveness research for osteoarthritis.

Journal Article Ann Intern Med · June 17, 2014 Osteoarthritis is a leading cause of disability in the United States. This article describes a prioritized research agenda about osteoarthritis management developed for the Patient-Centered Outcomes Research Institute. Evidence gaps were identified by revi ... Full text Link to item Cite

Rate- and rhythm-control therapies in patients with atrial fibrillation: a systematic review.

Journal Article Ann Intern Med · June 3, 2014 BACKGROUND: The comparative effectiveness of treatments for atrial fibrillation (AF) is uncertain. PURPOSE: To evaluate the comparative effectiveness of rate- and rhythm-control therapies. DATA SOURCES: English-language studies in PubMed, EMBASE, and the C ... Full text Link to item Cite

Prioritization of research addressing management strategies for ductal carcinoma in situ.

Journal Article Ann Intern Med · April 1, 2014 Ductal carcinoma in situ is a common finding in women having mammography screening, and there is considerable uncertainty about the balance of harms and benefits of different management options. This article outlines the process for developing a prioritize ... Full text Link to item Cite

Prioritization of research addressing antipsychotics for adolescents and young adults with bipolar disorder.

Journal Article Ann Intern Med · April 1, 2014 Despite a paucity of high-quality evidence about benefits and harms, antipsychotic medication use among adolescents and young adults with bipolar disorder is increasing. The Patient-Centered Outcomes Research Institute tasked the Duke Evidence Synthesis Gr ... Full text Link to item Cite

Non-traditional risk factors are important contributors to the racial disparity in diabetes risk: the atherosclerosis risk in communities study.

Journal Article J Gen Intern Med · February 2014 BACKGROUND: Traditional risk factors, particularly obesity, do not completely explain the excess risk of diabetes among African Americans compared to whites. OBJECTIVE: We sought to quantify the impact of recently identified, non-traditional risk factors o ... Full text Link to item Cite

Screening for diabetes and prediabetes should be cost-saving in patients at high risk.

Journal Article Diabetes Care · July 2013 OBJECTIVE: Although screening for diabetes and prediabetes is recommended, it is not clear how best or whom to screen. We therefore compared the economics of screening according to baseline risk. RESEARCH DESIGN AND METHODS: Five screening tests were perfo ... Full text Link to item Cite

Effects of changes in potassium with valsartan use on diabetes risk: Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) trial.

Journal Article Am J Hypertens · June 2013 BACKGROUND: Low and low-normal serum potassium is associated with an increased risk of diabetes. We hypothesized that the protective effect of valsartan on diabetes risk could be mediated by its effect of raising serum potassium. METHODS: We analyzed data ... Full text Link to item Cite

The patient centered medical home. A systematic review.

Journal Article Ann Intern Med · February 5, 2013 BACKGROUND: The patient-centered medical home (PCMH) describes mechanisms for organizing primary care to provide high quality care across the full range of individuals' health care needs.It is being widely implemented by provider organizations and third pa ... Full text Link to item Cite

Closing the quality gap: revisiting the state of the science (vol. 2: the patient-centered medical home).

Journal Article Evid Rep Technol Assess (Full Rep) · July 2012 OBJECTIVES: As part of the Closing the Quality Gap: Revisiting the State of the Science series of the Agency for Healthcare Research and Quality (AHRQ), this systematic review sought to identify completed and ongoing evaluations of the comprehensive patien ... Link to item Cite

THE PATIENT-CENTERED MEDICAL HOME, A SYSTEMATIC REVIEW

Journal Article JOURNAL OF GENERAL INTERNAL MEDICINE · July 1, 2012 Link to item Cite

Potassium intake and risk of incident type 2 diabetes mellitus: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Journal Article Diabetologia · May 2012 AIMS/HYPOTHESIS: Serum potassium has been found to be a significant predictor of diabetes risk, but the effect of dietary potassium on diabetes risk is not clear. We sought to determine if dietary potassium is associated with risk of incident type 2 diabet ... Full text Link to item Cite

Patient and provider interventions for managing osteoarthritis in primary care: protocols for two randomized controlled trials.

Journal Article BMC Musculoskelet Disord · April 24, 2012 BACKGROUND: Osteoarthritis (OA) of the hip and knee are among the most common chronic conditions, resulting in substantial pain and functional limitations. Adequate management of OA requires a combination of medical and behavioral strategies. However, some ... Full text Open Access Link to item Cite

Putting evidence for diabetes care into practice.

Journal Article Curr Diabetes Rev · November 2011 The amount of research and technology related to diabetes mellitus has grown dramatically over the past few decades. This knowledge has led to many advances in the detection and treatment of prediabetes and diabetes and the prevention of their related comp ... Full text Link to item Cite

Potassium and risk of Type 2 diabetes.

Journal Article Expert Rev Endocrinol Metab · September 2011 The rising incidence and prevalence of Type 2 diabetes worldwide requires us to try to identify the determinants of this epidemic and to identify improved measures to prevent and treat this condition. While obesity is a major risk factor for diabetes, ther ... Full text Link to item Cite

Comparative effectiveness and safety of medications for type 2 diabetes: an update including new drugs and 2-drug combinations.

Journal Article Ann Intern Med · May 3, 2011 BACKGROUND: Given the increase in medications for type 2 diabetes mellitus, clinicians and patients need information about their effectiveness and safety to make informed choices. PURPOSE: To summarize the benefits and harms of metformin, second-generation ... Full text Link to item Cite

Serum potassium and the racial disparity in diabetes risk: the Atherosclerosis Risk in Communities (ARIC) Study.

Journal Article Am J Clin Nutr · May 2011 BACKGROUND: Low serum potassium appears to be independently associated with incident type 2 diabetes, and low dietary potassium is more common in African Americans than in whites. OBJECTIVE: We hypothesized that low serum potassium contributes to the exces ... Full text Link to item Cite

Serum and dietary potassium and risk of incident type 2 diabetes mellitus: The Atherosclerosis Risk in Communities (ARIC) study.

Journal Article Arch Intern Med · October 25, 2010 BACKGROUND: Serum potassium levels affect insulin secretion by pancreatic β-cells, and hypokalemia associated with diuretic use has been associated with dysglycemia. We hypothesized that adults with lower serum potassium levels and lower dietary potassium ... Full text Link to item Cite

Screening adults for pre-diabetes and diabetes may be cost-saving.

Journal Article Diabetes Care · July 2010 OBJECTIVE: The economic costs of hyperglycemia are substantial. Early detection would allow management to prevent or delay development of diabetes and diabetes-related complications. We investigated the economic justification for screening for pre-diabetes ... Full text Link to item Cite

Glucose challenge test screening for prediabetes and undiagnosed diabetes.

Journal Article Diabetologia · September 2009 AIMS/HYPOTHESIS: Diabetes prevention and care are limited by lack of screening. We hypothesised that screening could be done with a strategy similar to that used near-universally for gestational diabetes, i.e. a 50 g oral glucose challenge test (GCT) perfo ... Full text Link to item Cite

African strains of hepatitis E virus that are distinct from Asian strains.

Journal Article J Med Virol · October 1997 Partial genomic sequences of four hepatitis E virus (HEV) strains from Africa (Morocco and Tunisia) and one from Central Asia (Tashkent, Uzbekistan) were obtained. The reverse transcriptase-polymerase chain reaction was used to amplify 5' and hypervariable ... Link to item Cite