Journal ArticleEur Heart J Digit Health · October 2023
AIMS: Artificial intelligence (AI) techniques have been proposed for automating analysis of short-axis (SAX) cine cardiac magnetic resonance (CMR), but no CMR analysis tool exists to automatically analyse large (unstructured) clinical CMR datasets. We deve ...
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Journal ArticleCirc Cardiovasc Imaging · August 2023
BACKGROUND: Patients with a working diagnosis of myocardial infarction with unobstructed coronary arteries (MINOCA) represent a heterogeneous cohort. The prognosis could vary substantially depending on the underlying cause. Although cardiac magnetic resona ...
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Journal ArticleJ Am Coll Cardiol · May 16, 2023
BACKGROUND: Quantitative cardiac magnetic resonance (CMR) outcome studies in aortic regurgitation (AR) are few. It is unclear if volume measurements are beneficial over diameters. OBJECTIVES: This study sought to evaluate the association of CMR quantitativ ...
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Journal ArticleJ Cardiovasc Magn Reson · December 5, 2022
The Society for Cardiovascular Magnetic Resonance (SCMR) recommendations for training and competency of cardiovascular magnetic resonance (CMR) technologists document will define the knowledge, experiences and skills required for a technologist to be compe ...
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Journal ArticleAm Heart J · December 2022
BACKGROUND: Despite successful primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI), myocardial salvage is often suboptimal, resulting in large infarct size and increased rates of heart failure and mortality. Unloa ...
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Journal ArticleJACC Cardiovasc Imaging · December 2022
BACKGROUND: Myocardial fibrosis is a fundamental process in cardiac injury. Cardiac magnetic resonance native T1 mapping has been proposed for diagnosing myocardial fibrosis without the need for gadolinium contrast. However, recent studies suggest that T1 ...
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Journal ArticleRadiology · November 2022
Background The relationship between papillary muscle infarction (papMI) and the culprit coronary lesion has not been fully investigated. Delayed enhancement cardiac MRI may detect papMI, yet its accuracy is unknown. Flow-independent dark-blood delayed enha ...
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Journal ArticleNMR Biomed · October 2022
Myocardial lipomatous metaplasia, which can serve as substrate for ventricular arrhythmias, is usually composed of regions in which there is an admixture of fat and nonfat tissue. Although dedicated sequences for the detection of fat are available, it woul ...
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Journal ArticleJ Invasive Cardiol · August 2022
OBJECTIVES: To determine the predictive value of cardiac magnetic resonance (CMR) and echocardiographic parameters on left ventricular (LV) remodeling in ST-segment elevation myocardial infarction (STEMI) patients without cardiogenic shock and treated with ...
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Journal ArticleJACC Cardiovasc Imaging · July 2022
BACKGROUND: Left ventricular (LV) ischemia has been variably associated with functional mitral regurgitation (FMR). Determinants of FMR in patients with ischemia are poorly understood. OBJECTIVES: This study sought to test whether contractile mechanics in ...
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ConferenceLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2022
Flow analysis carried out using phase contrast cardiac magnetic resonance imaging (PC-CMR) enables the quantification of important parameters that are used in the assessment of cardiovascular function. An essential part of this analysis is the identificati ...
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Journal ArticleEur Heart J · December 28, 2021
AIMS: Cardiovascular magnetic resonance (CMR) imaging is a key diagnostic tool for the evaluation of patients with suspected cardiac tumours. Patient management is guided by the CMR diagnosis, including no further testing if a mass is excluded or if only a ...
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Journal ArticleJAMA Cardiol · October 1, 2021
IMPORTANCE: Vaccine-associated myocarditis is an unusual entity that has been described for the smallpox vaccine, but only anecdotal case reports have been described for other vaccines. Whether COVID-19 vaccination may be linked to the occurrence of myocar ...
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Journal ArticleNMR Biomed · October 2021
Despite clinical use of late gadolinium enhancement (LGE) for two decades, an efficient, robust fat suppression (FS) technique still does not exist for this CMR mainstay. In ischemic and non-ischemic heart disease, differentiating fibrotic tissue from infi ...
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Journal ArticleRadiology · October 2021
Cardiac MRI is a noninvasive diagnostic tool using nonionizing radiation that is widely used in patients with ST-segment elevation myocardial infarction (STEMI). Cardiac MRI depicts different prognosticating components of myocardial damage such as edema, i ...
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Journal ArticleJACC Cardiovasc Imaging · August 2021
OBJECTIVES: This study sought to evaluate the prognostic value of cardiac magnetic resonance (CMR) feature-tracking-derived right ventricular (RV) free wall longitudinal strain (RVFWLS) in a large multicenter population of patients with severe functional t ...
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Journal ArticleEur Radiol · July 2021
OBJECTIVE: Cardiac motion and aortic pulsatility can affect the image quality of 3D contrast-enhanced MR angiography (CE-MRA). The addition of ECG gating improves image quality; however, no studies have directly linked image quality improvements to clinica ...
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Journal ArticleCirc Cardiovasc Imaging · July 2021
BACKGROUND: Patients with a class I recommendation for cardiac resynchronization therapy (CRT) are likely to benefit, but the effect of CRT in class II patients is more heterogeneous and additional selection parameters are needed in this group. The recentl ...
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Journal ArticleCirculation · April 6, 2021
BACKGROUND: Nonischemic cardiomyopathy is a leading cause of reduced left ventricular ejection fraction (LVEF) and is associated with high mortality risk from progressive heart failure and arrhythmias. Myocardial scar on cardiovascular magnetic resonance i ...
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Journal ArticleEur Heart J Digit Health · October 2023
AIMS: Artificial intelligence (AI) techniques have been proposed for automating analysis of short-axis (SAX) cine cardiac magnetic resonance (CMR), but no CMR analysis tool exists to automatically analyse large (unstructured) clinical CMR datasets. We deve ...
Full textLink to itemCite
Journal ArticleCirc Cardiovasc Imaging · August 2023
BACKGROUND: Patients with a working diagnosis of myocardial infarction with unobstructed coronary arteries (MINOCA) represent a heterogeneous cohort. The prognosis could vary substantially depending on the underlying cause. Although cardiac magnetic resona ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · May 16, 2023
BACKGROUND: Quantitative cardiac magnetic resonance (CMR) outcome studies in aortic regurgitation (AR) are few. It is unclear if volume measurements are beneficial over diameters. OBJECTIVES: This study sought to evaluate the association of CMR quantitativ ...
Full textLink to itemCite
Journal ArticleJ Cardiovasc Magn Reson · December 5, 2022
The Society for Cardiovascular Magnetic Resonance (SCMR) recommendations for training and competency of cardiovascular magnetic resonance (CMR) technologists document will define the knowledge, experiences and skills required for a technologist to be compe ...
Full textLink to itemCite
Journal ArticleAm Heart J · December 2022
BACKGROUND: Despite successful primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI), myocardial salvage is often suboptimal, resulting in large infarct size and increased rates of heart failure and mortality. Unloa ...
Full textLink to itemCite
Journal ArticleJACC Cardiovasc Imaging · December 2022
BACKGROUND: Myocardial fibrosis is a fundamental process in cardiac injury. Cardiac magnetic resonance native T1 mapping has been proposed for diagnosing myocardial fibrosis without the need for gadolinium contrast. However, recent studies suggest that T1 ...
Full textLink to itemCite
Journal ArticleRadiology · November 2022
Background The relationship between papillary muscle infarction (papMI) and the culprit coronary lesion has not been fully investigated. Delayed enhancement cardiac MRI may detect papMI, yet its accuracy is unknown. Flow-independent dark-blood delayed enha ...
Full textLink to itemCite
Journal ArticleNMR Biomed · October 2022
Myocardial lipomatous metaplasia, which can serve as substrate for ventricular arrhythmias, is usually composed of regions in which there is an admixture of fat and nonfat tissue. Although dedicated sequences for the detection of fat are available, it woul ...
Full textLink to itemCite
Journal ArticleJ Invasive Cardiol · August 2022
OBJECTIVES: To determine the predictive value of cardiac magnetic resonance (CMR) and echocardiographic parameters on left ventricular (LV) remodeling in ST-segment elevation myocardial infarction (STEMI) patients without cardiogenic shock and treated with ...
Full textLink to itemCite
Journal ArticleJACC Cardiovasc Imaging · July 2022
BACKGROUND: Left ventricular (LV) ischemia has been variably associated with functional mitral regurgitation (FMR). Determinants of FMR in patients with ischemia are poorly understood. OBJECTIVES: This study sought to test whether contractile mechanics in ...
Full textLink to itemCite
ConferenceLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2022
Flow analysis carried out using phase contrast cardiac magnetic resonance imaging (PC-CMR) enables the quantification of important parameters that are used in the assessment of cardiovascular function. An essential part of this analysis is the identificati ...
Full textCite
Journal ArticleEur Heart J · December 28, 2021
AIMS: Cardiovascular magnetic resonance (CMR) imaging is a key diagnostic tool for the evaluation of patients with suspected cardiac tumours. Patient management is guided by the CMR diagnosis, including no further testing if a mass is excluded or if only a ...
Full textLink to itemCite
Journal ArticleJAMA Cardiol · October 1, 2021
IMPORTANCE: Vaccine-associated myocarditis is an unusual entity that has been described for the smallpox vaccine, but only anecdotal case reports have been described for other vaccines. Whether COVID-19 vaccination may be linked to the occurrence of myocar ...
Full textLink to itemCite
Journal ArticleNMR Biomed · October 2021
Despite clinical use of late gadolinium enhancement (LGE) for two decades, an efficient, robust fat suppression (FS) technique still does not exist for this CMR mainstay. In ischemic and non-ischemic heart disease, differentiating fibrotic tissue from infi ...
Full textLink to itemCite
Journal ArticleRadiology · October 2021
Cardiac MRI is a noninvasive diagnostic tool using nonionizing radiation that is widely used in patients with ST-segment elevation myocardial infarction (STEMI). Cardiac MRI depicts different prognosticating components of myocardial damage such as edema, i ...
Full textLink to itemCite
Journal ArticleJACC Cardiovasc Imaging · August 2021
OBJECTIVES: This study sought to evaluate the prognostic value of cardiac magnetic resonance (CMR) feature-tracking-derived right ventricular (RV) free wall longitudinal strain (RVFWLS) in a large multicenter population of patients with severe functional t ...
Full textLink to itemCite
Journal ArticleEur Radiol · July 2021
OBJECTIVE: Cardiac motion and aortic pulsatility can affect the image quality of 3D contrast-enhanced MR angiography (CE-MRA). The addition of ECG gating improves image quality; however, no studies have directly linked image quality improvements to clinica ...
Full textLink to itemCite
Journal ArticleCirc Cardiovasc Imaging · July 2021
BACKGROUND: Patients with a class I recommendation for cardiac resynchronization therapy (CRT) are likely to benefit, but the effect of CRT in class II patients is more heterogeneous and additional selection parameters are needed in this group. The recentl ...
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Journal ArticleCirculation · April 6, 2021
BACKGROUND: Nonischemic cardiomyopathy is a leading cause of reduced left ventricular ejection fraction (LVEF) and is associated with high mortality risk from progressive heart failure and arrhythmias. Myocardial scar on cardiovascular magnetic resonance i ...
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Journal ArticleJ Cardiovasc Magn Reson · April 5, 2021
BACKGROUND: Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) is widely used to identify cardiac neoplasms, for which diagnosis is predicated on enhancement stemming from lesion vascularity: Impact of contrast-enhancement pattern on ...
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Journal ArticleJACC Cardiovasc Imaging · April 2021
OBJECTIVES: The goal of this study was to test whether ischemia-mediated contractile dysfunction underlying the mitral valve affects functional mitral regurgitation (FMR) and the prognostic impact of FMR. BACKGROUND: FMR results from left ventricular (LV) ...
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Journal ArticleJ Cardiovasc Magn Reson · March 22, 2021
BACKGROUND: Invasive coronary angiography (ICA) is still the reference test in suspected non-ST elevation myocardial infarction (NSTEMI), although a substantial number of patients do not have obstructive coronary artery disease (CAD). Early cardiovascular ...
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Journal ArticleCirc Cardiovasc Imaging · February 2021
BACKGROUND: Microvascular obstruction (MO) is a pathophysiologic complication of acute myocardial infarction that portends poor prognosis; however, it is transient and disappears with infarct healing. Much remains unknown regarding its pathophysiology and ...
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Journal ArticleBMJ Open · January 15, 2021
INTRODUCTION: Recent randomised clinical trials showed benefit of non-culprit lesion revascularisation in ST-elevation myocardial infarction (STEMI) patients. However, it remains unclear whether revascularisation should be performed at the index procedure ...
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Journal ArticleNMR Biomed · November 2020
Recently developed dark-blood techniques such as Flow-Independent Dark-blood DeLayed Enhancement (FIDDLE) allow simultaneous visualization of tissue contrast-enhancement and blood-pool suppression. Critical to FIDDLE is the magnetization preparation, which ...
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Journal ArticleJ Am Coll Cardiol · September 29, 2020
BACKGROUND: Gadolinium-based contrast agents were not approved in the United States for detecting coronary artery disease (CAD) prior to the current studies. OBJECTIVES: The purpose of this study was to determine the sensitivity and specificity of gadobutr ...
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Journal ArticleAm Heart J · June 2020
BACKGROUND: Adverse cardiac remodeling is a major risk factor for the development of post myocardial infarction (MI) heart failure (HF). This study investigates the effects of the chymase inhibitor fulacimstat on adverse cardiac remodeling after acute ST-s ...
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Journal ArticleJ Card Fail · May 2020
BACKGROUND: Diastolic dysfunction (DD) is common and occurs at an earlier age among human immunodeficiency virus-infected (HIV+) individuals, but the mechanisms and consequences of DD among HIV+ individuals are unclear. METHODS AND RESULTS: The Characteriz ...
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Journal ArticleJ Card Fail · May 2020
BACKGROUND: Elamipretide, a novel mitochondrial modulating agent, improves myocardial energetics; however, it is unknown whether this mechanistic benefit translates into improved cardiac structure and function in heart failure (HF) with reduced ejection fr ...
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Journal ArticleJACC Cardiovasc Imaging · April 2020
OBJECTIVES: The goal of this study was to evaluate the prognostic value of global longitudinal strain (GLS) derived from cardiac magnetic resonance (CMR) feature-tracking in a large multicenter population of patients with preserved ejection fraction. BACKG ...
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Journal ArticleJ Cardiovasc Magn Reson · March 12, 2020
With mounting data on its accuracy and prognostic value, cardiovascular magnetic resonance (CMR) is becoming an increasingly important diagnostic tool with growing utility in clinical routine. Given its versatility and wide range of quantitative parameters ...
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Journal ArticleJ Cardiovasc Magn Reson · February 24, 2020
This document is an update to the 2013 publication of the Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Protocols. Concurrent with this publication, 3 additional task forces will publish documents that sh ...
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Journal ArticleJ Am Coll Cardiol · November 19, 2019
BACKGROUND: Patients with non-ST-segment elevation myocardial infarction and elevated high-sensitivity cardiac troponin levels often routinely undergo invasive coronary angiography (ICA), but many do not have obstructive coronary artery disease. OBJECTIVES ...
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Journal ArticleJACC Cardiovasc Imaging · September 2019
OBJECTIVES: This study sought to evaluate the prognostic value of cardiac magnetic resonance (CMR)-derived mitral annular plane systolic excursion (MAPSE) in a large multicenter population of patients with hypertension. BACKGROUND: In patients with hyperte ...
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Journal ArticleJ Am Coll Cardiol · July 16, 2019
After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema, inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and ultimately replacement by fibrosis). The extension and magnitude of these changes contribut ...
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Journal ArticleDiabetes Care · July 2019
OBJECTIVE: To determine the prevalence and prognostic significance of unrecognized myocardial infarction (MI) by delayed-enhancement MRI (DE-MRI) in asymptomatic patients with diabetes. RESEARCH DESIGN AND METHODS: In this prospective, two-center study of ...
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Journal ArticleJ Am Heart Assoc · May 21, 2019
Background Cardiac magnetic resonance ( CMR) differentiates neoplasm from thrombus via contrast enhancement; positron emission tomography ( PET) assesses metabolism. The relationship between CMR contrast enhancement and metabolism on PET is unknown. Method ...
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Journal ArticleCirc Cardiovasc Interv · May 2019
BACKGROUND: Determining the infarct-related artery (IRA) in non-ST-segment-elevation myocardial infarction (MI) can be challenging. Delayed-enhancement cardiac magnetic resonance (DE-CMR) can accurately identify small MIs. The purpose of this study was to ...
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Journal ArticleJAMA Cardiol · March 1, 2019
IMPORTANCE: Stress cardiac magnetic resonance imaging (CMR) is not widely used in current clinical practice, and its ability to predict patient mortality is unknown. OBJECTIVE: To determine whether stress CMR is associated with patient mortality. DESIGN, S ...
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Journal ArticleJ Cardiovasc Magn Reson · January 7, 2019
BACKGROUND: Routine cine cardiovascular magnetic resonance (CMR) allows for the measurement of left atrial (LA) volumes. Normal reference values for LA volumes have been published based on a group of European individuals without known cardiovascular diseas ...
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Journal ArticleJ Cardiovasc Magn Reson · January 7, 2019
BACKGROUND: Phase contrast (PC) cardiovascular magnetic resonance (CMR) is widely employed for flow quantification, but analysis typically requires time consuming manual segmentation which can require human correction. Advances in machine learning have mar ...
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Journal ArticleJACC Cardiovasc Imaging · December 2018
OBJECTIVES: This study introduced and validated a novel flow-independent delayed enhancement technique that shows hyperenhanced myocardium while simultaneously suppressing blood-pool signal. BACKGROUND: The diagnosis and assessment of myocardial infarction ...
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Journal ArticleJACC Cardiovasc Imaging · December 2018
OBJECTIVES: This study investigated the prevalence of silent myocardial infarction (MI) in patients presenting with first acute myocardial infarction (AMI), and its relation with mortality and major adverse cardiovascular events (MACE) at long-term follow- ...
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Journal ArticleCirc Arrhythm Electrophysiol · December 2018
BACKGROUND: In patients with left bundle branch block (LBBB), QRS duration (QRSd) depends on left ventricular (LV) dimension. Previously, we demonstrated that normalizing QRSd to LV dimension, to adjust for variations in LV size, improved prediction of hem ...
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Journal ArticleJACC Cardiovasc Imaging · October 2018
OBJECTIVES: The aim of this study was to evaluate the prognostic value of cardiac magnetic resonance (CMR) feature-tracking-derived global longitudinal strain (GLS) in a large multicenter population of patients with ischemic and nonischemic dilated cardiom ...
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Journal ArticleCrit Pathw Cardiol · September 2018
BACKGROUND: Stress cardiac magnetic resonance imaging (CMR) has become increasingly used in patients presenting to the emergency department (ED) with symptoms concerning for acute coronary syndrome (ACS). We hypothesized that CMR detects a number of altern ...
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Journal ArticleJ Am Coll Cardiol · August 21, 2018
BACKGROUND: Recent studies reported left ventricular (LV) fibrosis in patients with primary mitral regurgitation (MR) thought to be principally due to mitral valve prolapse (MVP). OBJECTIVES: This study sought to evaluate the prevalence, characteristics, a ...
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Journal ArticleJ Cardiovasc Magn Reson · August 16, 2018
These "Guidelines for training in Cardiovascular Magnetic Resonance" were developed by the Certification Committee of the Society for Cardiovascular Magnetic Resonance (SCMR) and approved by the SCMR Board of Trustees. ...
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Journal ArticleJ Card Fail · April 2018
Antiretroviral therapy (ART) has been associated with a shift in the epidemiology of human immunodeficiency virus (HIV)-associated cardiomyopathy from a phenotype of primarily left ventricular (LV) systolic dysfunction to LV diastolic dysfunction (DD). Pat ...
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Journal ArticleRadiology · February 2018
Purpose To evaluate the prognostic value of a simple index of left ventricular (LV) long-axis function-lateral mitral annular plane systolic excursion (MAPSE)-in a large multicenter population of patients with reduced ejection fraction (EF) who were underg ...
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Chapter · January 1, 2018
Since the first dedicated cardiovascular magnetic resonance (CMR) clinical services opened in the mid-1990s, CMR imaging has become routine at most medical centers. In recent years, cross-institutional CMR protocols have become more consistent. This chapte ...
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Journal ArticleMagn Reson Med · October 2017
PURPOSE: We demonstrate an improved segmented inversion-recovery sequence that suppresses ghost artifacts arising from tissues with long T1 ( > 1.5 s). THEORY AND METHODS: Long T1 species such as pericardial fluid can create bright ghost artifacts in segme ...
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Journal ArticleJACC Cardiovasc Imaging · October 2017
OBJECTIVES: This study sought to determine the prevalence, correlates, and impact on cardiac mortality of right ventricular (RV) dysfunction in nonischemic cardiomyopathy. BACKGROUND: Current heart failure guidelines place little emphasis on RV assessment ...
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Journal ArticleJ Cardiovasc Magn Reson · August 11, 2017
BACKGROUND: Acute myocardial infarct (AMI) size depicted by late gadolinium enhancement cardiovascular magnetic resonance (CMR) is increasingly used as an efficacy endpoint in randomized trials comparing AMI therapies. Infarct size is quantified using manu ...
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Journal ArticleHeart Fail Rev · May 2017
Heart failure is a growing cardiovascular disease with significant epidemiological, clinical, and societal implications and represents a high unmet need. Strong efforts are currently underway by academic and industrial researchers to develop novel treatmen ...
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Journal ArticleJ Cardiovasc Med (Hagerstown) · April 2017
AIMS: This article describes an ongoing study investigating the safety and efficacy of ischemia-tolerant mesenchymal stem cell (MSC) therapy in patients with nonischemic heart failure and dysfunctional viable myocardium without scarring. This study will fo ...
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Journal ArticleJ Clin Pharmacol · April 2017
We studied safety and tolerability of neladenoson bialanate, a novel oral selective partial adenosine A1 receptor agonist that maintains the cardioprotective effects of adenosine without the undesired side effects of a full agonist, in 2 pilot studies in p ...
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Journal ArticleCirc Res · January 20, 2017
RATIONALE: Potential benefits of mesenchymal stem cell (MSC) therapy in heart failure may be related to paracrine properties and systemic effects, including anti-inflammatory activities. If this hypothesis is valid, intravenous administration of MSCs shoul ...
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Journal ArticleJACC Cardiovasc Imaging · November 2016
Cardiovascular magnetic resonance (CMR) has evolved from a pioneering research tool to an established noninvasive imaging method for detecting inducible myocardial perfusion deficits. In this consensus document, experts of different imaging techniques summ ...
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Journal ArticleJ Cardiovasc Ultrasound · June 2016
Cardiac magnetic resonance imaging (CMR) is a useful diagnostic imaging modality in patients with known or suspected coronary artery disease (CAD). It provides unique information not available from other modalities, however, it is complex. CMR is not a sin ...
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Journal ArticleJACC Cardiovasc Imaging · May 2016
OBJECTIVES: The goal of this study was to determine the prevalence of post-myocardial infarction (MI) left ventricular (LV) thrombus in the current era and to develop an effective algorithm (predicated on echocardiography [echo]) to discern patients warran ...
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Journal ArticleCirc Heart Fail · May 2016
Compared with heart failure (HF) care 20 to 30 years ago, there has been tremendous advancement in therapy for ambulatory HF with reduced ejection fraction with the use of agents that block maladaptive neurohormonal pathways. However, during the past decad ...
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Journal ArticleJ Nucl Cardiol · April 2016
OBJECTIVES: To assess the diagnostic performance of stress cardiac magnetic resonance (stress CMR) vs stress single-photon emission computed tomography (SPECT) in patients presenting to the emergency department (ED) with chest pain. BACKGROUND: SPECT imagi ...
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Journal ArticlePLoS One · 2016
Given the emerging recognition of left atrial structure and function as an important marker of disease in heart failure with preserved ejection fraction (HF-pEF), we investigated the association between left atrial volume and function with markers of disea ...
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Journal ArticleAnn Noninvasive Electrocardiol · November 2015
AIMS: It is necessary to clarify if the presence of a prominent R wave in V1, in post-myocardial infarction (MI) patients, is due to the involvement of the posterior wall (currently inferobasal segment) or the lateral wall (as has been demonstrated recentl ...
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Journal ArticleJACC Heart Fail · September 2015
Myocardial recovery in heart failure (HF) is possible, but its determinants are not fully defined. At least partial functional improvement is possible with current evidence-based therapies. However, once significant HF symptoms develop, patients have varie ...
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Journal ArticleCirc Res · July 17, 2015
RATIONALE: After acute myocardial infarction (MI), delineating the area-at-risk (AAR) is crucial for measuring how much, if any, ischemic myocardium has been salvaged. T2-weighted MRI is promoted as an excellent method to delineate the AAR. However, the ev ...
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Journal ArticleJACC Cardiovasc Imaging · June 2015
OBJECTIVES: The purpose of this study was to assess the performance of cardiac magnetic resonance (CMR) methods for discriminating acute from chronic myocardial infarction (MI). BACKGROUND: Although T2-weighted CMR is thought to be accurate in differentiat ...
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Journal ArticleLancet · September 27, 2014
BACKGROUND: p38 MAPK inhibition has potential myocardial protective effects. We assessed losmapimod, a potent oral p38 MAPK inhibitor, in patients with non-ST-segment elevation myocardial infarction (NSTEMI) in a double-blind, randomised, placebo-controlle ...
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Journal ArticleJ Heart Valve Dis · September 2014
BACKGROUND AND AIM OF THE STUDY: Mitral regurgitation (MR) is an important complication after prosthetic mitral valve (PMV) implantation. Transthoracic echocardiography is widely used to screen for native MR, but can be limited with PMV. Cine-cardiac magne ...
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Journal ArticleRadiology · April 2014
PURPOSE: To compare the utility and efficacy of stress cardiac magnetic resonance (MR) imaging and stress echocardiography in an emergency setting in patients with acute chest pain (CP) and intermediate risk of coronary artery disease (CAD). MATERIALS AND ...
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Journal ArticleJACC Cardiovasc Imaging · February 2014
OBJECTIVES: This study tested the diagnostic and prognostic utility of a rapid, visual T1 assessment method for identification of cardiac amyloidosis (CA) in a "real-life" referral population undergoing cardiac magnetic resonance for suspected CA. BACKGROU ...
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Journal ArticleMagn Reson Med · November 2013
A versatile method for generating T2 -weighting is a T2 -preparation module, which has been used successfully for cardiac imaging at 1.5T. Although it has been applied at 3T, higher fields (B0 ≥ 3T) can degrade B0 and B1 homogeneity and result in nonunifor ...
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Journal ArticleJ Thromb Thrombolysis · November 2013
Erythropoietin (EPO) was hypothesized to mitigate reperfusion injury, in part via mobilization of endothelial progenitor cells (EPCs). The REVEAL trial found no reduction in infarct size with a single dose of EPO (60,000 U) in patients with ST-segment elev ...
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Journal ArticleJ Cardiovasc Magn Reson · October 8, 2013
This document is an update to the 2008 publication of the Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Protocols. Since the time of the original publication, 3 additional task forces (Reporting, Post-Pro ...
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Journal ArticleJ Cardiovasc Magn Reson · May 1, 2013
With mounting data on its accuracy and prognostic value, cardiovascular magnetic resonance (CMR) is becoming an increasingly important diagnostic tool with growing utility in clinical routine. Given its versatility and wide range of quantitative parameters ...
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Journal ArticleJAMA · March 27, 2013
IMPORTANCE: Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved ejection fraction (HFPEF). OBJECTIVE: To determine the ef ...
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Journal ArticleJAMA · March 6, 2013
IMPORTANCE: Regional left ventricular (LV) wall thinning is believed to represent chronic transmural myocardial infarction and scar tissue. However, recent case reports using delayed-enhancement cardiovascular magnetic resonance (CMR) imaging raise the pos ...
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Journal ArticleAm Heart J · February 2013
BACKGROUND: Aborted myocardial infarction (AbMI) in patients with ST-elevation MI defined by ST resolution with less than 2-fold elevation in biomarkers has been previously reported. We examined the association among AbMI, other metrics of infarct size, an ...
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Journal ArticleMethodist Debakey Cardiovasc J · 2013
This article focuses on delayed contrast enhanced MRI (DE-MRI) to assess myocardial viability. We start by discussing previous literature that evaluated the potential importance of myocardial viability testing and follow up with the more recent Surgical Tr ...
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Journal ArticleRadiology · October 2012
The use of T2-weighted MR imaging to delineate the area at risk and subsequently quantify myocardial salvage is problematic on many levels. The validation studies available thus far are inadequate. Unlike the data validating DE MR imaging, in which patholo ...
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Journal ArticleJ Am Coll Cardiol · July 31, 2012
OBJECTIVES: We tested whether an assessment of myocardial scarring by cardiac magnetic resonance imaging (MRI) would improve risk stratification in patients evaluated for implantable cardioverter-defibrillator (ICD) implantation. BACKGROUND: Current sudden ...
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Journal ArticlePLoS One · 2012
BACKGROUND: Detecting and quantifying the severity of mitral regurgitation is essential for risk stratification and clinical decision-making regarding timing of surgery. Our objective was to assess specific visual parameters by cine-magnetic resonance imag ...
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Journal ArticleHeart · January 2012
Objective Validation of methods to assess the area at risk (AAR) in patients with ST elevation myocardial infarction is limited. A study was undertaken to test different AAR methods using established physiological concepts to provide a reference standard. ...
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Journal ArticleCirc Cardiovasc Imaging · November 2011
BACKGROUND: Cardiac magnetic resonance (CMR) is considered the reference standard for assessment of left ventricular ejection fraction (LVEF) and myocardial damage. However, few studies have evaluated the relationship between CMR findings and patient outco ...
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Journal ArticleJACC Cardiovasc Imaging · July 2011
OBJECTIVES: This study sought to evaluate performance characteristics of routine echo for left ventricular thrombus (LVT). BACKGROUND: Although the utility of dedicated echocardiography (echo) for LVT is established, echo is widely used as a general test f ...
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Journal ArticleCurr Cardiol Rep · June 2011
In patients with heart failure, cardiovascular magnetic resonance imaging (CMR) allows a multifaceted approach to cardiac evaluation by enabling an assessment of morphology, function, perfusion, viability, tissue characterization, and blood flow during a s ...
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Journal ArticleJAMA · May 11, 2011
CONTEXT: Acute ST-segment elevation myocardial infarction (STEMI) is a leading cause of morbidity and mortality. In experimental models of MI, erythropoietin reduces infarct size and improves left ventricular (LV) function. OBJECTIVE: To evaluate the safet ...
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Journal ArticleCirc Cardiovasc Imaging · May 2011
BACKGROUND: Endocardial fibrous tissue (FT) deposition is a hallmark of endomyocardial fibrosis (EMF). Echocardiography is a first-line and the standard technique for the diagnosis of this disease. Although late gadolinium enhancement (LGE) cardiovascular ...
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Journal ArticleEur J Echocardiogr · February 2011
UNLABELLED: Aim The presence of septal hypertrophy in hypertrophic cardiomyopathy (HCM) is common. To date, there has been no accepted classification of septal morphology in HCM. Furthermore, the possible relationship between septal morphology and clinical ...
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Journal ArticleMol Genet Metab · December 2010
BACKGROUND: Pompe disease (acid α-glucosidase deficiency) is one of several lysosomal storage diseases amenable to treatment with enzyme replacement therapy (ERT). While echocardiography (echo) has been the standard method to evaluate the cardiac response ...
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Journal ArticleAm Heart J · November 2010
BACKGROUND: Acute myocardial infarction (MI) remains a leading cause of death despite advances in pharmacologic and percutaneous therapies. Animal models of ischemia/reperfusion have demonstrated that single-dose erythropoietin may reduce infarct size, dec ...
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Journal ArticleAtherosclerosis · September 2010
BACKGROUND: Inflammation has been shown to be a major component in the pathophysiology of acute coronary syndrome (ACS). In patients presenting with acute myocardial infarction (AMI), a critical component of the ACS spectrum, multiple coronary arteries are ...
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Journal ArticleAm Heart J · August 2010
OBJECTIVES: The purpose of this study was to determine predictors of 90-day left ventricular function following acute ST-segment elevation myocardial infarction (STEMI) using variables from clinical presentation, biomarker testing, and cardiovascular magne ...
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Journal ArticlePLoS One · January 5, 2010
BACKGROUND: Image contrast in clinical MRI is often determined by differences in tissue water proton relaxation behavior. However, many aspects of water proton relaxation in complex biological media, such as protein solutions and tissue are not well unders ...
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Journal ArticleJACC Cardiovasc Imaging · January 2010
OBJECTIVES: The purpose of the study was to understand determinants of infarct size in a primary percutaneous intervention (PCI) population treated with pexelizumab compared with placebo. BACKGROUND: In the multicenter APEX-AMI (Pexelizumab in Conjunction ...
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Journal ArticleJ Am Coll Cardiol · December 29, 2009
In patients with known or suspected myocardial infarction (MI), cardiovascular magnetic resonance (CMR) provides a comprehensive, multifaceted view of the heart. The data, including that from a recent multicenter clinical trial, indicate that delayed-enhan ...
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Journal ArticleEur Radiol · December 2009
Several cardiovascular magnetic resonance imaging (CMR) techniques are used to detect microvascular obstruction (MVO) after acute myocardial infarction (AMI). To determine the prevalence of MVO and gain more insight into the dynamic changes in appearance o ...
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Journal ArticleCirculation · November 17, 2009
BACKGROUND: In patients with sarcoidosis, sudden death is a leading cause of mortality, which may represent unrecognized cardiac involvement. Delayed-enhancement cardiovascular magnetic resonance (DE-CMR) can detect minute amounts of myocardial damage. We ...
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Journal ArticleJACC Cardiovasc Imaging · August 2009
OBJECTIVES: This study sought to compare contrast-enhanced anatomic imaging and contrast-enhanced tissue characterization (delayed-enhancement cardiac magnetic resonance [DE-CMR]) for left ventricular (LV) thrombus detection. BACKGROUND: Contrast echocardi ...
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Journal ArticleHeart Fail Clin · July 2009
Approximately two thirds of patients with heart failure have underlying coronary artery disease. In the setting of ischemic heart disease, cardiovascular magnetic resonance has demonstrated usefulness in two ways: for the detection of coronary artery disea ...
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Journal ArticleHeart Fail Clin · July 2009
In patients who have heart failure, treatment and survival are directly related to the cause. Clinically, as a practical first step, patients are classified as having either ischemic or non-ischemic cardiomyopathy, a delineation usually based on the presen ...
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Journal ArticlePLoS Med · April 21, 2009
BACKGROUND: Unrecognized myocardial infarction (UMI) is known to constitute a substantial portion of potentially lethal coronary heart disease. However, the diagnosis of UMI is based on the appearance of incidental Q-waves on 12-lead electrocardiography. T ...
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Journal ArticleCardiovascular MRI In Practice: A Teaching File Approach · December 1, 2008
In the early 20th century, plain film radiography probably evoked the same sense of wonder that we now associate with cardiac magnetic resonance (CMR). Extensive technical developments and a growth of studies in the literature have increased demand for CMR ...
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Journal ArticleJ Magn Reson Imaging · December 2008
PURPOSE: To assess the safety data from two large, multicenter, phase 2 trials on the use of gadoversetamide (OptiMARK, Tyco Healthcare/Mallinckrodt, St. Louis, MO) as a contrast agent in delayed hyperenhancement magnetic resonance imaging (DE-MRI) in pati ...
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Journal ArticleNat Clin Pract Cardiovasc Med · December 2008
Microvascular obstruction after acute myocardial infarction has been associated with adverse ventricular remodeling, arrhythmias, and poor clinical outcome. Hirsch et al. demonstrate a moderate concordance between abnormal intracoronary Doppler flow charac ...
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Journal ArticleJ Am Coll Cardiol · July 8, 2008
OBJECTIVES: This study sought to assess the prevalence and markers of left ventricular (LV) thrombus among patients with systolic dysfunction. BACKGROUND: Prior studies have yielded discordant findings regarding prevalence and markers of LV thrombus. Delay ...
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Journal ArticleJ Cardiovasc Magn Reson · July 7, 2008
1. General techniques 1.1. Stress and safety equipment 1.2. Left ventricular (LV) structure and function module 1.3. Right ventricular (RV) structure and function module 1.4. Gadolinium dosing module. 1.5. First pass perfusion 1.6. Late gadolinium enhancem ...
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Journal ArticleJACC Cardiovasc Imaging · July 2008
OBJECTIVES: We wanted to assess the value of cardiovascular magnetic resonance (CMR) stress testing for evaluation of women with suspected coronary artery disease (CAD). BACKGROUND: A combined perfusion and infarction CMR examination can accurately diagnos ...
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Journal ArticleCirc Cardiovasc Imaging · July 2008
BACKGROUND: Atrial septal defect (ASD) flow can be measured indirectly by velocity-encoded cardiovascular magnetic resonance (veCMR) of the pulmonary artery and aorta. Imaging the secundum ASD en face could potentially enable direct flow measurement and pr ...
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Journal ArticleRadiology · April 2008
PURPOSE: To prospectively compare in canines the diagnostic accuracy for myocardial infarction (MI) of standard delayed-enhancement (DE) magnetic resonance (MR) imaging versus that of subsecond DE MR imaging with and without breath holding and/or cardiac a ...
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Journal ArticleCirculation · February 5, 2008
BACKGROUND: The identification and assessment of myocardial infarction (MI) are important for therapeutic and prognostic purposes, yet current recommended diagnostic strategies have significant limitations. We prospectively tested the performance of delaye ...
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Journal ArticleRadiographics · 2008
With ongoing technical advances in magnetic resonance (MR) imaging, the clinical demand for cardiac MR evaluations has been increasing. Cardiac MR imaging techniques have evolved from traditional spin-echo sequences to breath-hold spoiled gradient-echo and ...
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Journal ArticleAm Heart J · November 2007
BACKGROUND: Training cardiovascular (CV) imaging specialists is becoming increasingly complex owing to rapidly emerging technological advances and the growing recognition that single modality training is inefficient and results in suboptimal education and ...
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Journal ArticleMagn Reson Imaging Clin N Am · November 2007
Cardiovascular magnetic resonance (CMR) is now considered the "gold standard" for the assessment of regional and global systolic function, myocardial infarction and viability, and congenital heart disease. At specialized centers, CMR has become a clinical ...
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Journal ArticleMagn Reson Imaging Clin N Am · November 2007
With recent technical and clinical advances, adenosine stress perfusion MRI has evolved from a promising research tool to an everyday clinical test. This article reviews the current state of stress perfusion MRI. Specifically, it addresses the following to ...
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Journal ArticleMagnetic Resonance Imaging Clinics of North America · November 1, 2007
This article provides the reader with a clinically relevant practical approach to obtaining high-quality magnetic resonance angiograms of the lower extremities. The physics underlying this imaging are discussed as they relate to practical matters such as c ...
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Journal ArticleMagn Reson Med · July 2007
To extend the signal longevity of magnetically excited spins in flowing fluids while in a state of global coherent free precession (GCFP), a refocusing radiofrequency (RF) pulse and bipolar gradient waveforms were combined with the GCFP sequence. The data ...
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Journal ArticleAm Heart J · June 2007
Accurate and timely prediction of sudden cardiac death (SCD) is a necessary prerequisite for effective prevention and therapy. Although the largest number of SCD events occurs in patients without overt heart disease, there are currently no tests that are o ...
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Journal ArticleExpert Rev Cardiovasc Ther · March 2007
Cardiovascular magnetic resonance (CMR) imaging is a comprehensive clinical tool for assessing a large variety of cardiovascular diseases. Using the clinical service of the Duke Cardiovascular Magnetic Resonance Center as an example, we describe how to per ...
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Journal ArticleCardiol Clin · February 2007
Cardiovascular magnetic resonance (CMR) is now considered the "gold standard" for the assessment of regional and global systolic function, myocardial infarction and viability, and congenital heart disease. At specialized centers, CMR has become a clinical ...
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Journal ArticleCardiol Clin · February 2007
With recent technical and clinical advances, adenosine stress perfusion MRI has evolved from a promising research tool to an everyday clinical test. This article reviews the current state of stress perfusion MRI. Specifically, it addresses the following to ...
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Journal ArticleCardiol Clin · February 2007
This article provides the reader with a clinically relevant practical approach to obtaining high-quality magnetic resonance angiograms of the lower extremities. The physics underlying this imaging are discussed as they relate to practical matters such as c ...
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Journal ArticleCirculation · January 16, 2007
BACKGROUND: An ultrafast, delayed contrast-enhancement cardiovascular magnetic resonance technique that can acquire subsecond, "snapshot" images during free breathing (subsecond) is becoming widely available. This technique provides myocardial infarction ( ...
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Chapter · January 1, 2007
Magnetic resonance imaging (MRI) plays a pivotal role in the diagnostic work-up of a broad spectrum of aortic diseases. In this chapter we will describe the MRI pulse sequences commonly used in the comprehensive assessment of the thoracic aorta, including ...
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Chapter · January 1, 2007
Peripheral arterial disease (PAD) is a common problem worldwide, with an estimated 20 million patients in the US alone. Although most patients with PAD are asymptomatic, it is common to present with lower extremity symptoms such as claudication and sometim ...
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Journal ArticleJ Cardiovasc Magn Reson · 2007
These "Guidelines for Training in Cardiovascular Magnetic Resonance" were developed by the Clinical Practice Committee of the Society for Cardiovascular Magnetic Resonance (SCMR) and approved by the SCMR Board of Trustees. ...
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Journal ArticleRadiology · September 2006
PURPOSE: To retrospectively determine the safety of cardiac magnetic resonance (MR) imaging performed early (<14 days) after coronary stent implantation in patients with acute myocardial infarction (AMI). MATERIALS AND METHODS: This HIPPA-compliant study w ...
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Journal ArticleBasic Res Cardiol · September 2006
Ischemic myocardial injury can be broadly characterized as either reversible or irreversible. Within irreversibly injured (infarcted) regions microvascular perfusion can vary from nearly normal to nearly zero, even in the presence of an open infarct-relate ...
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Journal ArticleJ Am Coll Cardiol · May 16, 2006
OBJECTIVES: This study sought to investigate the influence of time, dose, and inversion time (TI) and their interactions on myocardial infarct size measurements to establish the foundation for a standardized protocol for multicenter trials. BACKGROUND: The ...
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Journal ArticleJ Am Coll Cardiol · April 18, 2006
OBJECTIVES: We tested a pre-defined visual interpretation algorithm that combines cardiovascular magnetic resonance (CMR) data from perfusion and infarction imaging for the diagnosis of coronary artery disease (CAD). BACKGROUND: Cardiovascular magnetic res ...
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Journal ArticleJ Cardiovasc Magn Reson · 2006
We present a case of aortic intramural hematoma (IMH) in an elderly woman who presented with sudden onset of mid-scapular pain. The patient underwent a series of multimodality imaging studies before the diagnosis of IMH was evident by cardiovascular magnet ...
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Journal ArticleNat Clin Pract Cardiovasc Med · November 2005
MRI is emerging as the method of choice for the evaluation of a wide variety of cardiovascular disorders. A major advantage of this technique over the other cardiac imaging modalities is the fact that it allows the operator--via special software programs c ...
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Journal ArticleCoron Artery Dis · September 2005
Delayed-enhancement magnetic resonance imaging is a viability imaging technique that has been demonstrated in both animal and patient studies to accurately identify and characterize the presence and transmural extent of myocardial scarring. The precise inf ...
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Journal ArticleEur Heart J · August 2005
Non-ischaemic cardiomyopathies (NICMs) are chronic, progressive myocardial diseases with distinct patterns of morphological, functional, and electrophysiological changes. In the setting of cardiomyopathy (CM), determining the exact aetiology is important b ...
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Journal ArticleAdvanced Studies in Medicine · July 1, 2005
PURPOSE: To review the uses of cardiac magnetic resonance (CMR) imaging in the management of patients with heart disease. EPIDEMIOLOGY: CMR has applications in the evaluation of congenital heart defects, which are present in more than 1 million adults in t ...
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Journal ArticleJ Am Coll Cardiol · April 5, 2005
OBJECTIVES: We sought to evaluate whether infarct size characterization by cardiac magnetic resonance imaging (MRI) is a better predictor of inducible ventricular tachycardia (VT) than left ventricular ejection fraction (LVEF). BACKGROUND: Inducibility of ...
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Journal ArticleClin Nucl Med · April 2005
The authors report a case of a left-sided silicone breast implant interfering with nuclear imaging of the myocardium. Cardiac SPECT imaging of a woman documented widespread infarct in the anterolateral, inferior, and posterolateral walls, as well as mixed ...
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Journal ArticleMagn Reson Med · April 2005
Although (23)Na MRI has been shown to delineate acute myocardial infarction (MI), the time course of in vivo (23)Na MRI during infarct healing remains unknown. In this study (23)Na MRI was combined with contrast-enhanced (CE) (1)H MRI to noninvasively char ...
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Journal ArticleCirculation · March 1, 2005
BACKGROUND: Magnetic resonance global coherent free precession (GCFP) is a new technique that produces cine projection angiograms directly analogous to those of x-ray angiography noninvasively and without a contrast agent. In this study, we compared GCFP b ...
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Journal ArticleNat Clin Pract Cardiovasc Med · March 2005
Myocardial viability is of established importance to the management of cardiac patients being considered for revascularization. Existing noninvasive imaging tests to examine myocardial viability, such as stress echocardiography and nuclear scintigraphy, ar ...
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Journal ArticleJ Cardiovasc Magn Reson · 2005
We present a case demonstrating the utility of cardiovascular magnetic resonance (CMR) in the diagnosis of a cardiac mass. A 70-year-old female who presented with chest pressure and left sided jaw pain was found to have a cardiac mass on transthoracic and ...
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Journal ArticleCurr Cardiol Rep · January 2005
The accurate differentiation of viable and nonviable myocardium is crucial for therapy planning in patients with coronary artery disease and left ventricular dysfunction. Traditional techniques such as echocardiography, positron emission tomography, single ...
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Journal ArticleJ Am Coll Cardiol · June 2, 2004
OBJECTIVES: We sought to identify advantages of contrast-enhanced magnetic resonance imaging (MRI) in studying postinfarction ventricular remodeling. BACKGROUND: Although sequential measurements of ventricular volumes, internal dimensions, and total ventri ...
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Journal ArticleJ Magn Reson Imaging · June 2004
The identification of myocardial viability in the setting of left ventricular (LV) dysfunction is crucial for the prediction of functional recovery following revascularization. Although echocardiography, positron emission tomography (PET), and nuclear imag ...
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Journal ArticleNat Med · May 2004
Cardiovascular disease is primarily diagnosed using invasive X-ray cineangiography. Here we introduce a new concept in magnetic resonance imaging (MRI) that, for the first time, produces similar images noninvasively and without a contrast agent. Protons in ...
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Journal ArticleCatheter Cardiovasc Interv · April 2004
Contrast-enhanced cardiac MRI (ceMRI) and TIMI myocardial perfusion grade analysis (TMPG) are proven methods for visualization of microinfarction and assessment of microvascular perfusion, respectively. To determine whether microvascular obstruction accoun ...
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Journal ArticleItal Heart J · February 2004
We report the case of a 70-year-old man with a history of myocardial infarction and coronary artery bypass grafting, presenting with signs and symptoms of heart failure. Cardiac magnetic resonance imaging demonstrated a small amount of scarring in the ante ...
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Journal ArticleCardiol Rev · 2004
A case of a 19-year-old man with congenitally acquired HIV infection who was found to have a large intracardiac mass is presented. Presurgical imaging studies and subsequent pathologic findings and histology are discussed. ...
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Journal ArticleCirculation · October 21, 2003
BACKGROUND: In some patients with heart failure, beta-blockers can improve left ventricular (LV) function and reduce morbidity and mortality. We hypothesized that gadolinium-enhanced cardiovascular magnetic resonance imaging (CMR) can predict reversible my ...
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Journal ArticleJ Am Coll Cardiol · August 6, 2003
OBJECTIVES: We sought to determine the relationship of contractile function to the transmural extent of infarction (TEI) in patients with chronic coronary artery disease. BACKGROUND: In the setting of reperfused, chronic myocardial infarction (MI), the rel ...
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Journal ArticleJ Cardiovasc Magn Reson · July 2003
Recently, numerous studies have demonstrated the effectiveness of a segmented inversion recovery fast gradient echo (seg IR-FGE) sequence for differentiating injured from normal myocardium. This technique for delayed enhancement imaging has been shown to b ...
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Journal ArticleLancet · February 1, 2003
BACKGROUND: Myocardial infarcts are routinely detected by nuclear imaging techniques such as single photon emission computed tomography (SPECT) myocardial perfusion imaging. A newly developed technique for infarct detection based on contrast-enhanced cardi ...
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Journal ArticleMagn Reson Imaging Clin N Am · February 2003
CMR is a rapidly developing new modality with applications in clinical cardiology for detection and assessment of myocardial ischemia and viability. CMR perfusion results for the detection of ischemia in comparison with stress echocardiography and scintigr ...
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Journal ArticleJ Am Coll Cardiol · December 18, 2002
Featured Publication
OBJECTIVES: We sought to ascertain whether myocardial scarring occurs in living unselected patients with hypertrophic cardiomyopathy (HCM). BACKGROUND: Myocardial scarring is known to occur in select HCM patients, who were highly symptomatic prior to death ...
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Journal ArticleCirculation · October 29, 2002
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BACKGROUND: The reproducibility of contrast-enhanced MRI has not been established. We compared MRI reproducibility for infarct size determination with that of (99m)Tc-sestamibi (MIBI) single photon emission computed tomography (SPECT). METHODS AND RESULTS: ...
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Journal ArticleMagn Reson Med · May 2002
A fast imaging method is described that yields an approximately six-fold acquisition time reduction relative to conventional techniques. The method involves: 1) acquisition of every sixth k-space line; 2) shifting of acquired k-space lines between odd and ...
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Journal ArticleCirculation · January 15, 2002
BACKGROUND: Discrepant reports have been published recently regarding the relationship of contrast-enhanced magnetic resonance image intensities to reversible and irreversible ischemic injury. Unlike image intensities, contrast agent concentrations provide ...
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Journal ArticleMagnetic Resonance in Medicine · 2002
Nicorandil is an adenosine triphosphate-sensitive potassium channel opener with a nitrate-like effect. It is approved for clinical use in Europe and Japan as an antianginal drug. The purpose of this investigation was to assess the acute effects of nicorand ...
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Journal ArticleCirculation · November 13, 2001
BACKGROUND: Perfusion imaging techniques intended to identify regional limitations in coronary flow reserve in viable myocardium need to identify 2-fold differences in regional flow during coronary vasodilation consistently. This study evaluated the suitab ...
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Journal ArticleCirculation · September 4, 2001
BACKGROUND: Previous animal studies have demonstrated that the transmural extent of acute myocardial infarction defined by contrast-enhanced MRI (ceMRI) relates to early restoration of flow and future improvements in contractile function. We tested the hyp ...
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Journal ArticleRadiology · August 2001
Selective line acquisition mode (SLAM) reduces magnetic resonance imaging time by a factor n relative to conventional techniques. Seventeen patients with cardiac disease and three volunteers were examined with SLAM and two-frame interpolation (2FI). SLAM i ...
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Journal ArticleCirculation · June 12, 2001
Featured Publication
BACKGROUND: Mild elevations in creatine kinase-MB (CK-MB) are common after successful percutaneous coronary interventions and are associated with future adverse cardiac events. The mechanism for CK-MB release remains unclear. A new contrast-enhanced MRI te ...
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Journal ArticleLancet · January 6, 2001
BACKGROUND: A technical advance in contrast-enhanced magnetic resonance imaging (MRI) has significantly improved image quality. We investigated whether healed myocardial infarction can be visualised as hyperenhanced regions with this new technique, and whe ...
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Journal ArticleRadiology · January 2001
PURPOSE: To design a segmented inversion-recovery turbo fast low-angle shot (turboFLASH) magnetic resonance (MR) imaging pulse sequence for the visualization of myocardial infarction, compare this technique with other MR imaging approaches in a canine mode ...
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Journal ArticleN Engl J Med · November 16, 2000
BACKGROUND: Recent studies indicate that magnetic resonance imaging (MRI) after the administration of contrast material can be used to distinguish between reversible and irreversible myocardial ischemic injury regardless of the extent of wall motion or the ...
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Journal ArticleJ Am Coll Cardiol · November 15, 2000
OBJECTIVES: We sought to determine the relationship of delayed hyperenhancement by contrast magnetic resonance imaging (MRI) to viable and nonviable myocardium within the region at risk throughout infarct healing. BACKGROUND: The relationship of delayed MR ...
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Journal ArticleCirc Res · October 13, 2000
Loss of membrane permeability caused by ischemia leads to cellular sodium accumulation and myocardial edema. This phenomenon has important implications to left ventricular structure and function in the first hours after myocardial infarction. We hypothesiz ...
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Journal ArticleCirculation · October 3, 2000
BACKGROUND: Myocardial salvage after acute myocardial infarction is defined clinically by early restoration of flow and long-term improvement in contractile function. We hypothesized that contrast-enhanced magnetic resonance imaging (MRI), performed early ...
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Journal ArticleHerz · June 2000
Distinguishing between viable and non-viable myocardium is an important clinical issue. Several magnetic resonance (MR) techniques to address this issue have been proposed. Spectroscopy of phosphorus-31 and hydrogen-1 from creatine as well as imaging of so ...
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Journal ArticleCirculation · November 9, 1999
BACKGROUND: Contrast MRI enhancement patterns in several pathophysiologies resulting from ischemic myocardial injury are controversial or have not been investigated. We compared contrast enhancement in acute infarction (AI), after severe but reversible isc ...
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Journal ArticleCirculation · July 13, 1999
BACKGROUND: Elevated 23Na MR image intensity after acute myocardial infarction has previously been shown to correspond to high tissue [Na+] and loss of myocardial viability. In this study, we explored the potential of in vivo 23Na MRI to assess infarct siz ...
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Journal ArticleCirc Res · April 30, 1999
The potassium cation (K+) is fundamentally involved in myocyte metabolism. To explore the potential utility of direct MRI of the most abundant natural isotope of potassium, 39K, we compared 39K magnetic resonance (MR) image intensity with regional myocardi ...
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Journal ArticleJ Am Coll Cardiol · November 15, 1998
OBJECTIVES: We aimed to validate contrast-enhanced echocardiography (CE) in the quantification of microvascular obstruction (MO) against magnetic resonance imaging (MRI) and the histopathologic standards of radioactive microspheres and thioflavin-S stainin ...
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Journal ArticleCirculation · April 1, 1997
BACKGROUND: The ability of the myocyte to maintain an ionic concentration gradient is perhaps the best indication of myocardial viability. We studied the relationship of 23Na MRI intensity to viability and explored the potential of fast-imaging techniques ...
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Journal ArticleCirculation · 1997
Background: The ability of the myocyte to maintain an ionic concentration gradient is perhaps the best indication of myocardial viability. We studied the relationship of 23Na MRI intensity to viability and explored the potential of fast-imaging techniques ...
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Journal ArticleCirculation · December 15, 1996
BACKGROUND: Contrast medium-enhanced magnetic resonance images of acute, reperfused infarcts have shown hypoenhanced and hyperenhanced regions in areas of injured myocardium. The precise mechanisms that lead to these altered enhancement patterns are unknow ...
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Journal ArticleComputers in Cardiology · May 1, 1991
Magnetic resonance images (MRI) are overlapped with positron emission tomography (PET) images to allow a correlation between structure and function of the heart. This is done by using the structural information inherent in PET attenuation images which are ...
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We present a highly effective and robust fat suppression technique for T1-weighted inversion recovery (IR) imaging such as delayed enhancement, that is compatible with phase sensitive IR (PSIR) imaging. It combines a double-SPAIR (Spectral Selection Attenu ...
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