Scholars@Duke
Raymond J. Kim

Raymond J. Kim

Professor of Medicine
Medicine, Cardiology
raymond.kim@duke.edu
Duke Box 3934, Durham, NC 27710
Duke Medical Pavilion, 10 Medicine Circle, Rm IE-58, Durham, NC 27710

Selected Publications

Tissue-Based Predictors of Impaired Right Ventricular Strain in Coronary Artery Disease: A Multicenter Stress Perfusion Study.

Journal Article Circ Cardiovasc Imaging · August 2024 BACKGROUND: Right ventricular (RV) dysfunction is known to impact prognosis, but its determinants in coronary artery disease are poorly understood. Stress cardiac magnetic resonance (CMR) has been used to assess ischemia and infarction in relation to the l ... Full text Link to item Cite

An artificial intelligence tool for automated analysis of large-scale unstructured clinical cine cardiac magnetic resonance databases.

Journal Article Eur Heart J Digit Health · October 2023 AIMS: Artificial intelligence (AI) techniques have been proposed for automating analysis of short-axis (SAX) cine cardiac magnetic resonance (CMR), but no CMR analysis tool exists to automatically analyse large (unstructured) clinical CMR datasets. We deve ... Full text Link to item Cite

Prognostic Value of Cardiac Magnetic Resonance Imaging in Patients With a Working Diagnosis of MINOCA-An Outcome Study With up to 10 Years of Follow-Up.

Journal Article Circ Cardiovasc Imaging · August 2023 BACKGROUND: Patients with a working diagnosis of myocardial infarction with unobstructed coronary arteries (MINOCA) represent a heterogeneous cohort. The prognosis could vary substantially depending on the underlying cause. Although cardiac magnetic resona ... Full text Link to item Cite

Influence of Cardiac Remodeling on Clinical Outcomes in Patients With Aortic Regurgitation.

Journal Article J Am Coll Cardiol · May 16, 2023 BACKGROUND: Quantitative cardiac magnetic resonance (CMR) outcome studies in aortic regurgitation (AR) are few. It is unclear if volume measurements are beneficial over diameters. OBJECTIVES: This study sought to evaluate the association of CMR quantitativ ... Full text Link to item Cite

Society for cardiovascular magnetic resonance recommendations for training and competency of CMR technologists.

Journal Article J Cardiovasc Magn Reson · December 5, 2022 The Society for Cardiovascular Magnetic Resonance (SCMR) recommendations for training and competency of cardiovascular magnetic resonance (CMR) technologists document will define the knowledge, experiences and skills required for a technologist to be compe ... Full text Link to item Cite

Primary left ventricular unloading with delayed reperfusion in patients with anterior ST-elevation myocardial infarction: Rationale and design of the STEMI-DTU randomized pivotal trial.

Journal Article Am Heart J · December 2022 BACKGROUND: Despite successful primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI), myocardial salvage is often suboptimal, resulting in large infarct size and increased rates of heart failure and mortality. Unloa ... Full text Link to item Cite

Native T1 Mapping for the Diagnosis of Myocardial Fibrosis in Patients With Chronic Myocardial Infarction.

Journal Article JACC Cardiovasc Imaging · December 2022 BACKGROUND: Myocardial fibrosis is a fundamental process in cardiac injury. Cardiac magnetic resonance native T1 mapping has been proposed for diagnosing myocardial fibrosis without the need for gadolinium contrast. However, recent studies suggest that T1 ... Full text Link to item Cite

Assessment of Papillary Muscle Infarction with Dark-Blood Delayed Enhancement Cardiac MRI in Canines and Humans.

Journal Article Radiology · November 2022 Background The relationship between papillary muscle infarction (papMI) and the culprit coronary lesion has not been fully investigated. Delayed enhancement cardiac MRI may detect papMI, yet its accuracy is unknown. Flow-independent dark-blood delayed enha ... Full text Link to item Cite

Assessment of myocardial lipomatous metaplasia using an optimized out-of-phase cine steady-state free-precession sequence: Validation and clinical implementation.

Journal Article NMR Biomed · October 2022 Myocardial lipomatous metaplasia, which can serve as substrate for ventricular arrhythmias, is usually composed of regions in which there is an admixture of fat and nonfat tissue. Although dedicated sequences for the detection of fat are available, it woul ... Full text Link to item Cite

Left Ventricular Remodeling After Anterior-STEMI PCI: Imaging Observations in the Door-to-Unload (DTU) Pilot Trial.

Journal Article J Invasive Cardiol · August 2022 OBJECTIVES: To determine the predictive value of cardiac magnetic resonance (CMR) and echocardiographic parameters on left ventricular (LV) remodeling in ST-segment elevation myocardial infarction (STEMI) patients without cardiogenic shock and treated with ... Full text Link to item Cite

Myocardial Contractile Mechanics in Ischemic Mitral Regurgitation: Multicenter Data Using Stress Perfusion Cardiovascular Magnetic Resonance.

Journal Article JACC Cardiovasc Imaging · July 2022 BACKGROUND: Left ventricular (LV) ischemia has been variably associated with functional mitral regurgitation (FMR). Determinants of FMR in patients with ischemia are poorly understood. OBJECTIVES: This study sought to test whether contractile mechanics in ... Full text Link to item Cite

Automated Quality Controlled Analysis of 2D Phase Contrast Cardiovascular Magnetic Resonance Imaging

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2022 Flow analysis carried out using phase contrast cardiac magnetic resonance imaging (PC-CMR) enables the quantification of important parameters that are used in the assessment of cardiovascular function. An essential part of this analysis is the identificati ... Full text Cite

Cardiovascular magnetic resonance imaging in suspected cardiac tumour: a multicentre outcomes study.

Journal Article Eur Heart J · December 28, 2021 AIMS: Cardiovascular magnetic resonance (CMR) imaging is a key diagnostic tool for the evaluation of patients with suspected cardiac tumours. Patient management is guided by the CMR diagnosis, including no further testing if a mass is excluded or if only a ... Full text Link to item Cite

Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination.

Journal Article JAMA Cardiol · October 1, 2021 IMPORTANCE: Vaccine-associated myocarditis is an unusual entity that has been described for the smallpox vaccine, but only anecdotal case reports have been described for other vaccines. Whether COVID-19 vaccination may be linked to the occurrence of myocar ... Full text Link to item Cite

Double spectral attenuated inversion recovery (DSPAIR)-an efficient fat suppression technique for late gadolinium enhancement at 3 tesla.

Journal Article NMR Biomed · October 2021 Despite clinical use of late gadolinium enhancement (LGE) for two decades, an efficient, robust fat suppression (FS) technique still does not exist for this CMR mainstay. In ischemic and non-ischemic heart disease, differentiating fibrotic tissue from infi ... Full text Link to item Cite

Cardiac MRI to Visualize Myocardial Damage after ST-Segment Elevation Myocardial Infarction: A Review of Its Histologic Validation.

Journal Article Radiology · October 2021 Cardiac MRI is a noninvasive diagnostic tool using nonionizing radiation that is widely used in patients with ST-segment elevation myocardial infarction (STEMI). Cardiac MRI depicts different prognosticating components of myocardial damage such as edema, i ... Full text Link to item Cite

Prognostic Value of Feature-Tracking Right Ventricular Longitudinal Strain in Severe Functional Tricuspid Regurgitation: A Multicenter Study.

Journal Article JACC Cardiovasc Imaging · August 2021 OBJECTIVES: This study sought to evaluate the prognostic value of cardiac magnetic resonance (CMR) feature-tracking-derived right ventricular (RV) free wall longitudinal strain (RVFWLS) in a large multicenter population of patients with severe functional t ... Full text Link to item Cite

ECG-gated MR angiography provides better reproducibility for standard aortic measurements.

Journal Article Eur Radiol · July 2021 OBJECTIVE: Cardiac motion and aortic pulsatility can affect the image quality of 3D contrast-enhanced MR angiography (CE-MRA). The addition of ECG gating improves image quality; however, no studies have directly linked image quality improvements to clinica ... Full text Link to item Cite

Segment Length in Cine Strain Analysis Predicts Cardiac Resynchronization Therapy Outcome Beyond Current Guidelines.

Journal Article Circ Cardiovasc Imaging · July 2021 BACKGROUND: Patients with a class I recommendation for cardiac resynchronization therapy (CRT) are likely to benefit, but the effect of CRT in class II patients is more heterogeneous and additional selection parameters are needed in this group. The recentl ... Full text Link to item Cite

Relationship of LVEF and Myocardial Scar to Long-Term Mortality Risk and Mode of Death in Patients With Nonischemic Cardiomyopathy.

Journal Article Circulation · April 6, 2021 BACKGROUND: Nonischemic cardiomyopathy is a leading cause of reduced left ventricular ejection fraction (LVEF) and is associated with high mortality risk from progressive heart failure and arrhythmias. Myocardial scar on cardiovascular magnetic resonance i ... Full text Link to item Cite

Risk stratification of cardiac metastases using late gadolinium enhancement cardiovascular magnetic resonance: prognostic impact of hypo-enhancement evidenced tumor avascularity.

Journal Article J Cardiovasc Magn Reson · April 5, 2021 BACKGROUND: Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) is widely used to identify cardiac neoplasms, for which diagnosis is predicated on enhancement stemming from lesion vascularity: Impact of contrast-enhancement pattern on ... Full text Link to item Cite

Ischemia-Mediated Dysfunction in Subpapillary Myocardium as a Marker of Functional Mitral Regurgitation.

Journal Article JACC Cardiovasc Imaging · April 2021 OBJECTIVES: The goal of this study was to test whether ischemia-mediated contractile dysfunction underlying the mitral valve affects functional mitral regurgitation (FMR) and the prognostic impact of FMR. BACKGROUND: FMR results from left ventricular (LV) ... Full text Link to item Cite

Cardiovascular magnetic resonance accurately detects obstructive coronary artery disease in suspected non-ST elevation myocardial infarction: a sub-analysis of the CARMENTA Trial.

Journal Article J Cardiovasc Magn Reson · March 22, 2021 BACKGROUND: Invasive coronary angiography (ICA) is still the reference test in suspected non-ST elevation myocardial infarction (NSTEMI), although a substantial number of patients do not have obstructive coronary artery disease (CAD). Early cardiovascular ... Full text Link to item Cite

Epicardial Surface Area of Infarction: A Stable Surrogate of Microvascular Obstruction in Acute Myocardial Infarction.

Journal Article Circ Cardiovasc Imaging · February 2021 BACKGROUND: Microvascular obstruction (MO) is a pathophysiologic complication of acute myocardial infarction that portends poor prognosis; however, it is transient and disappears with infarct healing. Much remains unknown regarding its pathophysiology and ... Full text Link to item Cite

Instantaneous wave-free ratio guided multivessel revascularisation during percutaneous coronary intervention for acute myocardial infarction: study protocol of the randomised controlled iMODERN trial.

Journal Article BMJ Open · January 15, 2021 INTRODUCTION: Recent randomised clinical trials showed benefit of non-culprit lesion revascularisation in ST-elevation myocardial infarction (STEMI) patients. However, it remains unclear whether revascularisation should be performed at the index procedure ... Full text Link to item Cite

Comparison of magnetization transfer-preparation and T2-preparation for dark-blood delayed-enhancement imaging.

Journal Article NMR Biomed · November 2020 Recently developed dark-blood techniques such as Flow-Independent Dark-blood DeLayed Enhancement (FIDDLE) allow simultaneous visualization of tissue contrast-enhancement and blood-pool suppression. Critical to FIDDLE is the magnetization preparation, which ... Full text Link to item Cite

Gadobutrol-Enhanced Cardiac Magnetic Resonance Imaging for Detection of Coronary Artery Disease.

Journal Article J Am Coll Cardiol · September 29, 2020 BACKGROUND: Gadolinium-based contrast agents were not approved in the United States for detecting coronary artery disease (CAD) prior to the current studies. OBJECTIVES: The purpose of this study was to determine the sensitivity and specificity of gadobutr ... Full text Link to item Cite

Effects of the chymase inhibitor fulacimstat on adverse cardiac remodeling after acute myocardial infarction-Results of the Chymase Inhibitor in Adverse Remodeling after Myocardial Infarction (CHIARA MIA) 2 trial.

Journal Article Am Heart J · June 2020 BACKGROUND: Adverse cardiac remodeling is a major risk factor for the development of post myocardial infarction (MI) heart failure (HF). This study investigates the effects of the chymase inhibitor fulacimstat on adverse cardiac remodeling after acute ST-s ... Full text Link to item Cite

Diastolic Dysfunction in Patients With Human Immunodeficiency Virus Receiving Antiretroviral Therapy: Results From the CHART Study.

Journal Article J Card Fail · May 2020 BACKGROUND: Diastolic dysfunction (DD) is common and occurs at an earlier age among human immunodeficiency virus-infected (HIV+) individuals, but the mechanisms and consequences of DD among HIV+ individuals are unclear. METHODS AND RESULTS: The Characteriz ... Full text Link to item Cite

Effects of Elamipretide on Left Ventricular Function in Patients With Heart Failure With Reduced Ejection Fraction: The PROGRESS-HF Phase 2 Trial.

Journal Article J Card Fail · May 2020 BACKGROUND: Elamipretide, a novel mitochondrial modulating agent, improves myocardial energetics; however, it is unknown whether this mechanistic benefit translates into improved cardiac structure and function in heart failure (HF) with reduced ejection fr ... Full text Link to item Cite

Feature-Tracking Global Longitudinal Strain Predicts Mortality in Patients With Preserved Ejection Fraction: A Multicenter Study.

Journal Article JACC Cardiovasc Imaging · April 2020 OBJECTIVES: The goal of this study was to evaluate the prognostic value of global longitudinal strain (GLS) derived from cardiac magnetic resonance (CMR) feature-tracking in a large multicenter population of patients with preserved ejection fraction. BACKG ... Full text Link to item Cite

Standardized image interpretation and post-processing in cardiovascular magnetic resonance - 2020 update : Society for Cardiovascular Magnetic Resonance (SCMR): Board of Trustees Task Force on Standardized Post-Processing.

Journal Article J Cardiovasc Magn Reson · March 12, 2020 With mounting data on its accuracy and prognostic value, cardiovascular magnetic resonance (CMR) is becoming an increasingly important diagnostic tool with growing utility in clinical routine. Given its versatility and wide range of quantitative parameters ... Full text Link to item Cite

Standardized cardiovascular magnetic resonance imaging (CMR) protocols: 2020 update.

Journal Article J Cardiovasc Magn Reson · February 24, 2020 This document is an update to the 2013 publication of the Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Protocols. Concurrent with this publication, 3 additional task forces will publish documents that sh ... Full text Link to item Cite

Initial Imaging-Guided Strategy Versus Routine Care in Patients With Non-ST-Segment Elevation Myocardial Infarction.

Journal Article J Am Coll Cardiol · November 19, 2019 BACKGROUND: Patients with non-ST-segment elevation myocardial infarction and elevated high-sensitivity cardiac troponin levels often routinely undergo invasive coronary angiography (ICA), but many do not have obstructive coronary artery disease. OBJECTIVES ... Full text Link to item Cite

Prognostic Implications of Mitral Annular Plane Systolic Excursion in Patients with Hypertension and a Clinical Indication for Cardiac Magnetic Resonance Imaging: A Multicenter Study.

Journal Article JACC Cardiovasc Imaging · September 2019 OBJECTIVES: This study sought to evaluate the prognostic value of cardiac magnetic resonance (CMR)-derived mitral annular plane systolic excursion (MAPSE) in a large multicenter population of patients with hypertension. BACKGROUND: In patients with hyperte ... Full text Link to item Cite

Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel.

Journal Article J Am Coll Cardiol · July 16, 2019 After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema, inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and ultimately replacement by fibrosis). The extension and magnitude of these changes contribut ... Full text Link to item Cite

Prevalence and Prognosis of Unrecognized Myocardial Infarction in Asymptomatic Patients With Diabetes: A Two-Center Study With Up to 5 Years of Follow-up.

Journal Article Diabetes Care · July 2019 OBJECTIVE: To determine the prevalence and prognostic significance of unrecognized myocardial infarction (MI) by delayed-enhancement MRI (DE-MRI) in asymptomatic patients with diabetes. RESEARCH DESIGN AND METHODS: In this prospective, two-center study of ... Full text Link to item Cite

Late Gadolinium Enhancement Cardiac Magnetic Resonance Tissue Characterization for Cancer-Associated Cardiac Masses: Metabolic and Prognostic Manifestations in Relation to Whole-Body Positron Emission Tomography.

Journal Article J Am Heart Assoc · May 21, 2019 Background Cardiac magnetic resonance ( CMR) differentiates neoplasm from thrombus via contrast enhancement; positron emission tomography ( PET) assesses metabolism. The relationship between CMR contrast enhancement and metabolism on PET is unknown. Method ... Full text Link to item Cite

Identifying the Infarct-Related Artery in Patients With Non-ST-Segment-Elevation Myocardial Infarction.

Journal Article Circ Cardiovasc Interv · May 2019 BACKGROUND: Determining the infarct-related artery (IRA) in non-ST-segment-elevation myocardial infarction (MI) can be challenging. Delayed-enhancement cardiac magnetic resonance (DE-CMR) can accurately identify small MIs. The purpose of this study was to ... Full text Link to item Cite

Prognostic Value of Vasodilator Stress Cardiac Magnetic Resonance Imaging: A Multicenter Study With 48 000 Patient-Years of Follow-up.

Journal Article JAMA Cardiol · March 1, 2019 IMPORTANCE: Stress cardiac magnetic resonance imaging (CMR) is not widely used in current clinical practice, and its ability to predict patient mortality is unknown. OBJECTIVE: To determine whether stress CMR is associated with patient mortality. DESIGN, S ... Full text Link to item Cite

Association of left atrial volume index and all-cause mortality in patients referred for routine cardiovascular magnetic resonance: a multicenter study.

Journal Article J Cardiovasc Magn Reson · January 7, 2019 BACKGROUND: Routine cine cardiovascular magnetic resonance (CMR) allows for the measurement of left atrial (LA) volumes. Normal reference values for LA volumes have been published based on a group of European individuals without known cardiovascular diseas ... Full text Link to item Cite

Machine learning derived segmentation of phase velocity encoded cardiovascular magnetic resonance for fully automated aortic flow quantification.

Journal Article J Cardiovasc Magn Reson · January 7, 2019 BACKGROUND: Phase contrast (PC) cardiovascular magnetic resonance (CMR) is widely employed for flow quantification, but analysis typically requires time consuming manual segmentation which can require human correction. Advances in machine learning have mar ... Full text Link to item Cite

Dark-Blood Delayed Enhancement Cardiac Magnetic Resonance of Myocardial Infarction.

Journal Article JACC Cardiovasc Imaging · December 2018 OBJECTIVES: This study introduced and validated a novel flow-independent delayed enhancement technique that shows hyperenhanced myocardium while simultaneously suppressing blood-pool signal. BACKGROUND: The diagnosis and assessment of myocardial infarction ... Full text Open Access Link to item Cite

Long-Term Prognostic Implications of Previous Silent Myocardial Infarction in Patients Presenting With Acute Myocardial Infarction.

Journal Article JACC Cardiovasc Imaging · December 2018 OBJECTIVES: This study investigated the prevalence of silent myocardial infarction (MI) in patients presenting with first acute myocardial infarction (AMI), and its relation with mortality and major adverse cardiovascular events (MACE) at long-term follow- ... Full text Link to item Cite

Size Matters: Normalization of QRS Duration to Left Ventricular Dimension Improves Prediction of Long-Term Cardiac Resynchronization Therapy Outcome.

Journal Article Circ Arrhythm Electrophysiol · December 2018 BACKGROUND: In patients with left bundle branch block (LBBB), QRS duration (QRSd) depends on left ventricular (LV) dimension. Previously, we demonstrated that normalizing QRSd to LV dimension, to adjust for variations in LV size, improved prediction of hem ... Full text Link to item Cite

Feature-Tracking Global Longitudinal Strain Predicts Death in a Multicenter Population of Patients With Ischemic and Nonischemic Dilated Cardiomyopathy Incremental to Ejection Fraction and Late Gadolinium Enhancement.

Journal Article JACC Cardiovasc Imaging · October 2018 OBJECTIVES: The aim of this study was to evaluate the prognostic value of cardiac magnetic resonance (CMR) feature-tracking-derived global longitudinal strain (GLS) in a large multicenter population of patients with ischemic and nonischemic dilated cardiom ... Full text Link to item Cite

Unexpected Cardiac MRI Findings in Patients Presenting to the Emergency Department for Possible Acute Coronary Syndrome.

Journal Article Crit Pathw Cardiol · September 2018 BACKGROUND: Stress cardiac magnetic resonance imaging (CMR) has become increasingly used in patients presenting to the emergency department (ED) with symptoms concerning for acute coronary syndrome (ACS). We hypothesized that CMR detects a number of altern ... Full text Open Access Link to item Cite

Myocardial Fibrosis in Patients With Primary Mitral Regurgitation With and Without Prolapse.

Journal Article J Am Coll Cardiol · August 21, 2018 BACKGROUND: Recent studies reported left ventricular (LV) fibrosis in patients with primary mitral regurgitation (MR) thought to be principally due to mitral valve prolapse (MVP). OBJECTIVES: This study sought to evaluate the prevalence, characteristics, a ... Full text Link to item Cite

Guidelines for training in cardiovascular magnetic resonance (CMR).

Journal Article J Cardiovasc Magn Reson · August 16, 2018 These "Guidelines for training in Cardiovascular Magnetic Resonance" were developed by the Certification Committee of the Society for Cardiovascular Magnetic Resonance (SCMR) and approved by the SCMR Board of Trustees. ... Full text Link to item Cite

Diastolic Dysfunction in Individuals With Human Immunodeficiency Virus Infection: Literature Review, Rationale and Design of the Characterizing Heart Function on Antiretroviral Therapy (CHART) Study.

Journal Article J Card Fail · April 2018 Antiretroviral therapy (ART) has been associated with a shift in the epidemiology of human immunodeficiency virus (HIV)-associated cardiomyopathy from a phenotype of primarily left ventricular (LV) systolic dysfunction to LV diastolic dysfunction (DD). Pat ... Full text Link to item Cite

Left Ventricular Long-Axis Function Assessed with Cardiac Cine MR Imaging Is an Independent Predictor of All-Cause Mortality in Patients with Reduced Ejection Fraction: A Multicenter Study.

Journal Article Radiology · February 2018 Purpose To evaluate the prognostic value of a simple index of left ventricular (LV) long-axis function-lateral mitral annular plane systolic excursion (MAPSE)-in a large multicenter population of patients with reduced ejection fraction (EF) who were underg ... Full text Link to item Cite

Clinical Cardiovascular Magnetic Resonance Imaging Techniques

Chapter · January 1, 2018 Since the first dedicated cardiovascular magnetic resonance (CMR) clinical services opened in the mid-1990s, CMR imaging has become routine at most medical centers. In recent years, cross-institutional CMR protocols have become more consistent. This chapte ... Full text Cite

Suppression of ghost artifacts arising from long T1 species in segmented inversion-recovery imaging.

Journal Article Magn Reson Med · October 2017 PURPOSE: We demonstrate an improved segmented inversion-recovery sequence that suppresses ghost artifacts arising from tissues with long T1 ( > 1.5 s). THEORY AND METHODS: Long T1 species such as pericardial fluid can create bright ghost artifacts in segme ... Full text Link to item Cite

The Prevalence, Correlates, and Impact on Cardiac Mortality of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy.

Journal Article JACC. Cardiovascular imaging · October 2017 ObjectivesThis study sought to determine the prevalence, correlates, and impact on cardiac mortality of right ventricular (RV) dysfunction in nonischemic cardiomyopathy.BackgroundCurrent heart failure guidelines place little emphasis on R ... Full text Cite

Sources of variability in quantification of cardiovascular magnetic resonance infarct size - reproducibility among three core laboratories.

Journal Article J Cardiovasc Magn Reson · August 11, 2017 BACKGROUND: Acute myocardial infarct (AMI) size depicted by late gadolinium enhancement cardiovascular magnetic resonance (CMR) is increasingly used as an efficacy endpoint in randomized trials comparing AMI therapies. Infarct size is quantified using manu ... Full text Open Access Link to item Cite

Redefining the role of biomarkers in heart failure trials: expert consensus document.

Journal Article Heart Fail Rev · May 2017 Heart failure is a growing cardiovascular disease with significant epidemiological, clinical, and societal implications and represents a high unmet need. Strong efforts are currently underway by academic and industrial researchers to develop novel treatmen ... Full text Link to item Cite

Rationale and design of a randomized controlled trial of allogeneic mesenchymal stem cells in patients with nonischemic cardiomyopathy.

Journal Article J Cardiovasc Med (Hagerstown) · April 2017 AIMS: This article describes an ongoing study investigating the safety and efficacy of ischemia-tolerant mesenchymal stem cell (MSC) therapy in patients with nonischemic heart failure and dysfunctional viable myocardium without scarring. This study will fo ... Full text Link to item Cite

Safety and Tolerability of Neladenoson Bialanate, a Novel Oral Partial Adenosine A1 Receptor Agonist, in Patients With Chronic Heart Failure.

Journal Article J Clin Pharmacol · April 2017 We studied safety and tolerability of neladenoson bialanate, a novel oral selective partial adenosine A1 receptor agonist that maintains the cardioprotective effects of adenosine without the undesired side effects of a full agonist, in 2 pilot studies in p ... Full text Link to item Cite

Intravenous Allogeneic Mesenchymal Stem Cells for Nonischemic Cardiomyopathy: Safety and Efficacy Results of a Phase II-A Randomized Trial.

Journal Article Circ Res · January 20, 2017 RATIONALE: Potential benefits of mesenchymal stem cell (MSC) therapy in heart failure may be related to paracrine properties and systemic effects, including anti-inflammatory activities. If this hypothesis is valid, intravenous administration of MSCs shoul ... Full text Link to item Cite

CMR First-Pass Perfusion for Suspected Inducible Myocardial Ischemia.

Journal Article JACC Cardiovasc Imaging · November 2016 Cardiovascular magnetic resonance (CMR) has evolved from a pioneering research tool to an established noninvasive imaging method for detecting inducible myocardial perfusion deficits. In this consensus document, experts of different imaging techniques summ ... Full text Link to item Cite

The Use of Cardiac Magnetic Resonance in Patients with Suspected Coronary Artery Disease: A Clinical Practice Perspective.

Journal Article J Cardiovasc Ultrasound · June 2016 Cardiac magnetic resonance imaging (CMR) is a useful diagnostic imaging modality in patients with known or suspected coronary artery disease (CAD). It provides unique information not available from other modalities, however, it is complex. CMR is not a sin ... Full text Link to item Cite

Echocardiographic Algorithm for Post-Myocardial Infarction LV Thrombus: A Gatekeeper for Thrombus Evaluation by Delayed Enhancement CMR.

Journal Article JACC Cardiovasc Imaging · May 2016 OBJECTIVES: The goal of this study was to determine the prevalence of post-myocardial infarction (MI) left ventricular (LV) thrombus in the current era and to develop an effective algorithm (predicated on echocardiography [echo]) to discern patients warran ... Full text Link to item Cite

Developing New Treatments for Heart Failure: Focus on the Heart.

Journal Article Circ Heart Fail · May 2016 Compared with heart failure (HF) care 20 to 30 years ago, there has been tremendous advancement in therapy for ambulatory HF with reduced ejection fraction with the use of agents that block maladaptive neurohormonal pathways. However, during the past decad ... Full text Link to item Cite

Comparison of stress cardiovascular magnetic resonance imaging (CMR) with stress nuclear perfusion for the diagnosis of coronary artery disease.

Journal Article J Nucl Cardiol · April 2016 OBJECTIVES: To assess the diagnostic performance of stress cardiac magnetic resonance (stress CMR) vs stress single-photon emission computed tomography (SPECT) in patients presenting to the emergency department (ED) with chest pain. BACKGROUND: SPECT imagi ... Full text Link to item Cite

Left Atrial Structure and Function in Heart Failure with Preserved Ejection Fraction: A RELAX Substudy.

Journal Article PLoS One · 2016 Given the emerging recognition of left atrial structure and function as an important marker of disease in heart failure with preserved ejection fraction (HF-pEF), we investigated the association between left atrial volume and function with markers of disea ... Full text Link to item Cite

Validation of a novel dark-blood delayed enhancement technique for the detection of papillary muscle SCAR

Journal Article Journal of Cardiovascular Magnetic Resonance · January 1, 2016 Full text Cite

Lateral MI Explains the Presence of Prominent R Wave (R ≥ S) in V1.

Journal Article Ann Noninvasive Electrocardiol · November 2015 AIMS: It is necessary to clarify if the presence of a prominent R wave in V1, in post-myocardial infarction (MI) patients, is due to the involvement of the posterior wall (currently inferobasal segment) or the lateral wall (as has been demonstrated recentl ... Full text Link to item Cite

"Targeting the Heart" in Heart Failure: Myocardial Recovery in Heart Failure With Reduced Ejection Fraction.

Journal Article JACC Heart Fail · September 2015 Myocardial recovery in heart failure (HF) is possible, but its determinants are not fully defined. At least partial functional improvement is possible with current evidence-based therapies. However, once significant HF symptoms develop, patients have varie ... Full text Link to item Cite

Relationship of T2-Weighted MRI Myocardial Hyperintensity and the Ischemic Area-At-Risk.

Journal Article Circ Res · July 17, 2015 RATIONALE: After acute myocardial infarction (MI), delineating the area-at-risk (AAR) is crucial for measuring how much, if any, ischemic myocardium has been salvaged. T2-weighted MRI is promoted as an excellent method to delineate the AAR. However, the ev ... Full text Open Access Link to item Cite

Performance of CMR Methods for Differentiating Acute From Chronic MI.

Journal Article JACC Cardiovasc Imaging · June 2015 OBJECTIVES: The purpose of this study was to assess the performance of cardiac magnetic resonance (CMR) methods for discriminating acute from chronic myocardial infarction (MI). BACKGROUND: Although T2-weighted CMR is thought to be accurate in differentiat ... Full text Link to item Cite

Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.

Journal Article Lancet · September 27, 2014 BACKGROUND: p38 MAPK inhibition has potential myocardial protective effects. We assessed losmapimod, a potent oral p38 MAPK inhibitor, in patients with non-ST-segment elevation myocardial infarction (NSTEMI) in a double-blind, randomised, placebo-controlle ... Full text Link to item Cite

Routine cine-CMR for prosthesis-associated mitral regurgitation: a multicenter comparison to echocardiography.

Journal Article J Heart Valve Dis · September 2014 BACKGROUND AND AIM OF THE STUDY: Mitral regurgitation (MR) is an important complication after prosthetic mitral valve (PMV) implantation. Transthoracic echocardiography is widely used to screen for native MR, but can be limited with PMV. Cine-cardiac magne ... Link to item Cite

Stress cardiac MR imaging compared with stress echocardiography in the early evaluation of patients who present to the emergency department with intermediate-risk chest pain.

Journal Article Radiology · April 2014 PURPOSE: To compare the utility and efficacy of stress cardiac magnetic resonance (MR) imaging and stress echocardiography in an emergency setting in patients with acute chest pain (CP) and intermediate risk of coronary artery disease (CAD). MATERIALS AND ... Full text Link to item Cite

CMR imaging with rapid visual T1 assessment predicts mortality in patients suspected of cardiac amyloidosis.

Journal Article JACC Cardiovasc Imaging · February 2014 OBJECTIVES: This study tested the diagnostic and prognostic utility of a rapid, visual T1 assessment method for identification of cardiac amyloidosis (CA) in a "real-life" referral population undergoing cardiac magnetic resonance for suspected CA. BACKGROU ... Full text Link to item Cite

Motion and flow insensitive adiabatic T2 -preparation module for cardiac MR imaging at 3 Tesla.

Journal Article Magn Reson Med · November 2013 A versatile method for generating T2 -weighting is a T2 -preparation module, which has been used successfully for cardiac imaging at 1.5T. Although it has been applied at 3T, higher fields (B0 ≥ 3T) can degrade B0 and B1 homogeneity and result in nonunifor ... Full text Link to item Cite

EPC mobilization after erythropoietin treatment in acute ST-elevation myocardial infarction: the REVEAL EPC substudy.

Journal Article J Thromb Thrombolysis · November 2013 Erythropoietin (EPO) was hypothesized to mitigate reperfusion injury, in part via mobilization of endothelial progenitor cells (EPCs). The REVEAL trial found no reduction in infarct size with a single dose of EPO (60,000 U) in patients with ST-segment elev ... Full text Link to item Cite

Standardized cardiovascular magnetic resonance (CMR) protocols 2013 update.

Journal Article J Cardiovasc Magn Reson · October 8, 2013 This document is an update to the 2008 publication of the Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Protocols. Since the time of the original publication, 3 additional task forces (Reporting, Post-Pro ... Full text Link to item Cite

Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) board of trustees task force on standardized post processing.

Journal Article J Cardiovasc Magn Reson · May 1, 2013 With mounting data on its accuracy and prognostic value, cardiovascular magnetic resonance (CMR) is becoming an increasingly important diagnostic tool with growing utility in clinical routine. Given its versatility and wide range of quantitative parameters ... Full text Link to item Cite

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.

Journal Article JAMA · March 27, 2013 IMPORTANCE: Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved ejection fraction (HFPEF). OBJECTIVE: To determine the ef ... Full text Link to item Cite

Prevalence of regional myocardial thinning and relationship with myocardial scarring in patients with coronary artery disease.

Journal Article JAMA · March 6, 2013 IMPORTANCE: Regional left ventricular (LV) wall thinning is believed to represent chronic transmural myocardial infarction and scar tissue. However, recent case reports using delayed-enhancement cardiovascular magnetic resonance (CMR) imaging raise the pos ... Full text Link to item Cite

Aborted myocardial infarction after primary percutaneous coronary intervention: magnetic resonance imaging insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial.

Journal Article Am Heart J · February 2013 BACKGROUND: Aborted myocardial infarction (AbMI) in patients with ST-elevation MI defined by ST resolution with less than 2-fold elevation in biomarkers has been previously reported. We examined the association among AbMI, other metrics of infarct size, an ... Full text Link to item Cite

Cardiac MR for the assessment of myocardial viability.

Journal Article Methodist Debakey Cardiovasc J · 2013 This article focuses on delayed contrast enhanced MRI (DE-MRI) to assess myocardial viability. We start by discussing previous literature that evaluated the potential importance of myocardial viability testing and follow up with the more recent Surgical Tr ... Full text Link to item Cite

Controversies in cardiovascular MR imaging: T2-weighted imaging should not be used to delineate the area at risk in ischemic myocardial injury.

Journal Article Radiology · October 2012 The use of T2-weighted MR imaging to delineate the area at risk and subsequently quantify myocardial salvage is problematic on many levels. The validation studies available thus far are inadequate. Unlike the data validating DE MR imaging, in which patholo ... Full text Link to item Cite

Extracellular space measurements with CMR imaging.

Journal Article JACC Cardiovasc Imaging · September 2012 Full text Link to item Cite

The authors' reply

Journal Article Heart · August 1, 2012 Full text Cite

Assessment of myocardial scarring improves risk stratification in patients evaluated for cardiac defibrillator implantation.

Journal Article J Am Coll Cardiol · July 31, 2012 OBJECTIVES: We tested whether an assessment of myocardial scarring by cardiac magnetic resonance imaging (MRI) would improve risk stratification in patients evaluated for implantable cardioverter-defibrillator (ICD) implantation. BACKGROUND: Current sudden ... Full text Link to item Cite

Assessment and improvement of image homogeneity in black-blood T2-weighted turbo spin-echo CMR

Journal Article Journal of Cardiovascular Magnetic Resonance · February 1, 2012 Full text Cite

Quantifying the area at risk using the infarct lateral border: importance of infarct transmurality

Journal Article Journal of Cardiovascular Magnetic Resonance · February 1, 2012 Full text Cite

Prognostic value of delayed enhancement cardiovascular magnetic resonance in patients with sarcoidosis

Journal Article Journal of Cardiovascular Magnetic Resonance · February 1, 2012 Full text Cite

Reply

Journal Article JACC: Cardiovascular Imaging · February 1, 2012 Full text Cite

Clinical application of cine-MRI in the visual assessment of mitral regurgitation compared to echocardiography and cardiac catheterization.

Journal Article PLoS One · 2012 BACKGROUND: Detecting and quantifying the severity of mitral regurgitation is essential for risk stratification and clinical decision-making regarding timing of surgery. Our objective was to assess specific visual parameters by cine-magnetic resonance imag ... Full text Link to item Cite

Performance of angiographic, electrocardiographic and MRI methods to assess the area at risk in acute myocardial infarction.

Journal Article Heart · January 2012 Objective Validation of methods to assess the area at risk (AAR) in patients with ST elevation myocardial infarction is limited. A study was undertaken to test different AAR methods using established physiological concepts to provide a reference standard. ... Full text Link to item Cite

Direct in vivo myocardial infarct visualization using 3D ultrasound and passive strain contrast

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2011 An approach for myocardial elastography is presented for infarct visualization. Infarcts are visualized using passive strain in the ventricles induced by atrial contraction. Results are compared against ARFI and delay-enhanced contrast MR. © 2011 IEEE. ... Full text Cite

Prognostic value of routine cardiac magnetic resonance assessment of left ventricular ejection fraction and myocardial damage: an international, multicenter study.

Journal Article Circ Cardiovasc Imaging · November 2011 BACKGROUND: Cardiac magnetic resonance (CMR) is considered the reference standard for assessment of left ventricular ejection fraction (LVEF) and myocardial damage. However, few studies have evaluated the relationship between CMR findings and patient outco ... Full text Link to item Cite

T2-weighted imaging to assess post-infarct myocardium at risk.

Journal Article JACC Cardiovasc Imaging · September 2011 Full text Link to item Cite

LV thrombus detection by routine echocardiography: insights into performance characteristics using delayed enhancement CMR.

Journal Article JACC Cardiovasc Imaging · July 2011 OBJECTIVES: This study sought to evaluate performance characteristics of routine echo for left ventricular thrombus (LVT). BACKGROUND: Although the utility of dedicated echocardiography (echo) for LVT is established, echo is widely used as a general test f ... Full text Link to item Cite

The role of cardiac MR in new-onset heart failure.

Journal Article Curr Cardiol Rep · June 2011 In patients with heart failure, cardiovascular magnetic resonance imaging (CMR) allows a multifaceted approach to cardiac evaluation by enabling an assessment of morphology, function, perfusion, viability, tissue characterization, and blood flow during a s ... Full text Link to item Cite

Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial.

Journal Article JAMA · May 11, 2011 CONTEXT: Acute ST-segment elevation myocardial infarction (STEMI) is a leading cause of morbidity and mortality. In experimental models of MI, erythropoietin reduces infarct size and improves left ventricular (LV) function. OBJECTIVE: To evaluate the safet ... Full text Link to item Cite

Late gadolinium enhancement magnetic resonance imaging in the diagnosis and prognosis of endomyocardial fibrosis patients.

Journal Article Circ Cardiovasc Imaging · May 2011 BACKGROUND: Endocardial fibrous tissue (FT) deposition is a hallmark of endomyocardial fibrosis (EMF). Echocardiography is a first-line and the standard technique for the diagnosis of this disease. Although late gadolinium enhancement (LGE) cardiovascular ... Full text Link to item Cite

Anatomic and clinical correlates of septal morphology in hypertrophic cardiomyopathy.

Journal Article Eur J Echocardiogr · February 2011 UNLABELLED: Aim The presence of septal hypertrophy in hypertrophic cardiomyopathy (HCM) is common. To date, there has been no accepted classification of septal morphology in HCM. Furthermore, the possible relationship between septal morphology and clinical ... Full text Link to item Cite

Use of cardiac magnetic resonance imaging to evaluate cardiac structure, function and fibrosis in children with infantile Pompe disease on enzyme replacement therapy.

Journal Article Mol Genet Metab · December 2010 BACKGROUND: Pompe disease (acid α-glucosidase deficiency) is one of several lysosomal storage diseases amenable to treatment with enzyme replacement therapy (ERT). While echocardiography (echo) has been the standard method to evaluate the cardiac response ... Full text Link to item Cite

Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial.

Journal Article Am Heart J · November 2010 BACKGROUND: Acute myocardial infarction (MI) remains a leading cause of death despite advances in pharmacologic and percutaneous therapies. Animal models of ischemia/reperfusion have demonstrated that single-dose erythropoietin may reduce infarct size, dec ... Full text Link to item Cite

The aorta wall of patients presenting to the emergency department with acute myocardial infarction by cardiac magnetic resonance.

Journal Article Atherosclerosis · September 2010 BACKGROUND: Inflammation has been shown to be a major component in the pathophysiology of acute coronary syndrome (ACS). In patients presenting with acute myocardial infarction (AMI), a critical component of the ACS spectrum, multiple coronary arteries are ... Full text Link to item Cite

Predicting chronic left ventricular dysfunction 90 days after ST-segment elevation myocardial infarction: An Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) Substudy.

Journal Article Am Heart J · August 2010 OBJECTIVES: The purpose of this study was to determine predictors of 90-day left ventricular function following acute ST-segment elevation myocardial infarction (STEMI) using variables from clinical presentation, biomarker testing, and cardiovascular magne ... Full text Link to item Cite

Magnetic resonance water proton relaxation in protein solutions and tissue: T(1rho) dispersion characterization.

Journal Article PLoS One · January 5, 2010 BACKGROUND: Image contrast in clinical MRI is often determined by differences in tissue water proton relaxation behavior. However, many aspects of water proton relaxation in complex biological media, such as protein solutions and tissue are not well unders ... Full text Open Access Link to item Cite

Pexelizumab and infarct size in patients with acute myocardial infarction undergoing primary percutaneous coronary Intervention: a delayed enhancement cardiac magnetic resonance substudy from the APEX-AMI trial.

Journal Article JACC Cardiovasc Imaging · January 2010 OBJECTIVES: The purpose of the study was to understand determinants of infarct size in a primary percutaneous intervention (PCI) population treated with pexelizumab compared with placebo. BACKGROUND: In the multicenter APEX-AMI (Pexelizumab in Conjunction ... Full text Link to item Cite

Cardiovascular magnetic resonance in patients with myocardial infarction: current and emerging applications.

Journal Article J Am Coll Cardiol · December 29, 2009 In patients with known or suspected myocardial infarction (MI), cardiovascular magnetic resonance (CMR) provides a comprehensive, multifaceted view of the heart. The data, including that from a recent multicenter clinical trial, indicate that delayed-enhan ... Full text Link to item Cite

Detection and characteristics of microvascular obstruction in reperfused acute myocardial infarction using an optimized protocol for contrast-enhanced cardiovascular magnetic resonance imaging.

Journal Article Eur Radiol · December 2009 Several cardiovascular magnetic resonance imaging (CMR) techniques are used to detect microvascular obstruction (MVO) after acute myocardial infarction (AMI). To determine the prevalence of MVO and gain more insight into the dynamic changes in appearance o ... Full text Link to item Cite

Detection of myocardial damage in patients with sarcoidosis.

Journal Article Circulation · November 17, 2009 BACKGROUND: In patients with sarcoidosis, sudden death is a leading cause of mortality, which may represent unrecognized cardiac involvement. Delayed-enhancement cardiovascular magnetic resonance (DE-CMR) can detect minute amounts of myocardial damage. We ... Full text Link to item Cite

Contrast-enhanced anatomic imaging as compared to contrast-enhanced tissue characterization for detection of left ventricular thrombus.

Journal Article JACC Cardiovasc Imaging · August 2009 OBJECTIVES: This study sought to compare contrast-enhanced anatomic imaging and contrast-enhanced tissue characterization (delayed-enhancement cardiac magnetic resonance [DE-CMR]) for left ventricular (LV) thrombus detection. BACKGROUND: Contrast echocardi ... Full text Link to item Cite

Evaluation of ischemic heart disease.

Journal Article Heart Fail Clin · July 2009 Approximately two thirds of patients with heart failure have underlying coronary artery disease. In the setting of ischemic heart disease, cardiovascular magnetic resonance has demonstrated usefulness in two ways: for the detection of coronary artery disea ... Full text Link to item Cite

Identifying the etiology: a systematic approach using delayed-enhancement cardiovascular magnetic resonance.

Journal Article Heart Fail Clin · July 2009 In patients who have heart failure, treatment and survival are directly related to the cause. Clinically, as a practical first step, patients are classified as having either ischemic or non-ischemic cardiomyopathy, a delineation usually based on the presen ... Full text Link to item Cite

Unrecognized non-Q-wave myocardial infarction: prevalence and prognostic significance in patients with suspected coronary disease.

Journal Article PLoS Med · April 21, 2009 BACKGROUND: Unrecognized myocardial infarction (UMI) is known to constitute a substantial portion of potentially lethal coronary heart disease. However, the diagnosis of UMI is based on the appearance of incidental Q-waves on 12-lead electrocardiography. T ... Full text Link to item Cite

Cardiovascular MRI in practice a teaching file approach

Journal Article Cardiovascular MRI In Practice: A Teaching File Approach · December 1, 2008 In the early 20th century, plain film radiography probably evoked the same sense of wonder that we now associate with cardiac magnetic resonance (CMR). Extensive technical developments and a growth of studies in the literature have increased demand for CMR ... Full text Cite

Safety of gadoversetamide in patients with acute and chronic myocardial infarction.

Journal Article J Magn Reson Imaging · December 2008 PURPOSE: To assess the safety data from two large, multicenter, phase 2 trials on the use of gadoversetamide (OptiMARK, Tyco Healthcare/Mallinckrodt, St. Louis, MO) as a contrast agent in delayed hyperenhancement magnetic resonance imaging (DE-MRI) in pati ... Full text Link to item Cite

Assessment of microvascular injury after acute myocardial infarction: importance of the area at risk.

Journal Article Nat Clin Pract Cardiovasc Med · December 2008 Microvascular obstruction after acute myocardial infarction has been associated with adverse ventricular remodeling, arrhythmias, and poor clinical outcome. Hirsch et al. demonstrate a moderate concordance between abnormal intracoronary Doppler flow charac ... Full text Link to item Cite

Detection of left ventricular thrombus by delayed-enhancement cardiovascular magnetic resonance prevalence and markers in patients with systolic dysfunction.

Journal Article J Am Coll Cardiol · July 8, 2008 OBJECTIVES: This study sought to assess the prevalence and markers of left ventricular (LV) thrombus among patients with systolic dysfunction. BACKGROUND: Prior studies have yielded discordant findings regarding prevalence and markers of LV thrombus. Delay ... Full text Link to item Cite

Standardized cardiovascular magnetic resonance imaging (CMR) protocols, society for cardiovascular magnetic resonance: board of trustees task force on standardized protocols.

Journal Article J Cardiovasc Magn Reson · July 7, 2008 1. General techniques 1.1. Stress and safety equipment 1.2. Left ventricular (LV) structure and function module 1.3. Right ventricular (RV) structure and function module 1.4. Gadolinium dosing module. 1.5. First pass perfusion 1.6. Late gadolinium enhancem ... Full text Link to item Cite

Value of cardiovascular magnetic resonance stress perfusion testing for the detection of coronary artery disease in women.

Journal Article JACC Cardiovasc Imaging · July 2008 OBJECTIVES: We wanted to assess the value of cardiovascular magnetic resonance (CMR) stress testing for evaluation of women with suspected coronary artery disease (CAD). BACKGROUND: A combined perfusion and infarction CMR examination can accurately diagnos ... Full text Link to item Cite

Direct en face imaging of secundum atrial septal defects by velocity-encoded cardiovascular magnetic resonance in patients evaluated for possible transcatheter closure.

Journal Article Circ Cardiovasc Imaging · July 2008 BACKGROUND: Atrial septal defect (ASD) flow can be measured indirectly by velocity-encoded cardiovascular magnetic resonance (veCMR) of the pulmonary artery and aorta. Imaging the secundum ASD en face could potentially enable direct flow measurement and pr ... Full text Link to item Cite

Respiratory motion and cardiac arrhythmia effects on diagnostic accuracy of myocardial delayed-enhanced MR imaging in canines.

Journal Article Radiology · April 2008 PURPOSE: To prospectively compare in canines the diagnostic accuracy for myocardial infarction (MI) of standard delayed-enhancement (DE) magnetic resonance (MR) imaging versus that of subsecond DE MR imaging with and without breath holding and/or cardiac a ... Full text Link to item Cite

Comparison of stress CMR with stress SPECT for the diagnosis of coronary artery disease

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 11, 2008 Link to item Cite

Performance of delayed-enhancement magnetic resonance imaging with gadoversetamide contrast for the detection and assessment of myocardial infarction: an international, multicenter, double-blinded, randomized trial.

Journal Article Circulation · February 5, 2008 BACKGROUND: The identification and assessment of myocardial infarction (MI) are important for therapeutic and prognostic purposes, yet current recommended diagnostic strategies have significant limitations. We prospectively tested the performance of delaye ... Full text Link to item Cite

Optimizing cardiac MR imaging: practical remedies for artifacts.

Journal Article Radiographics · 2008 With ongoing technical advances in magnetic resonance (MR) imaging, the clinical demand for cardiac MR evaluations has been increasing. Cardiac MR imaging techniques have evolved from traditional spin-echo sequences to breath-hold spoiled gradient-echo and ... Full text Link to item Cite

Training cardiovascular specialists in imaging: a curriculum based on fundamental concepts required for multimodal imaging.

Journal Article Am Heart J · November 2007 BACKGROUND: Training cardiovascular (CV) imaging specialists is becoming increasingly complex owing to rapidly emerging technological advances and the growing recognition that single modality training is inefficient and results in suboptimal education and ... Full text Link to item Cite

A clinical cardiovascular magnetic resonance service: operational considerations and the basic examination.

Journal Article Magn Reson Imaging Clin N Am · November 2007 Cardiovascular magnetic resonance (CMR) is now considered the "gold standard" for the assessment of regional and global systolic function, myocardial infarction and viability, and congenital heart disease. At specialized centers, CMR has become a clinical ... Full text Link to item Cite

Detection of myocardial ischemia by stress perfusion cardiovascular magnetic resonance.

Journal Article Magn Reson Imaging Clin N Am · November 2007 With recent technical and clinical advances, adenosine stress perfusion MRI has evolved from a promising research tool to an everyday clinical test. This article reviews the current state of stress perfusion MRI. Specifically, it addresses the following to ... Full text Link to item Cite

Magnetic Resonance Evaluation of Peripheral Arterial Disease

Journal Article Magnetic Resonance Imaging Clinics of North America · November 1, 2007 This article provides the reader with a clinically relevant practical approach to obtaining high-quality magnetic resonance angiograms of the lower extremities. The physics underlying this imaging are discussed as they relate to practical matters such as c ... Full text Cite

Combining spin echoes with gradient echoes in the context of the global coherent free precession pulse sequence.

Journal Article Magn Reson Med · July 2007 To extend the signal longevity of magnetically excited spins in flowing fluids while in a state of global coherent free precession (GCFP), a refocusing radiofrequency (RF) pulse and bipolar gradient waveforms were combined with the GCFP sequence. The data ... Full text Link to item Cite

Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death.

Journal Article Am Heart J · June 2007 Accurate and timely prediction of sudden cardiac death (SCD) is a necessary prerequisite for effective prevention and therapy. Although the largest number of SCD events occurs in patients without overt heart disease, there are currently no tests that are o ... Full text Link to item Cite

Cardiovascular MRI: its current and future use in clinical practice.

Journal Article Expert Rev Cardiovasc Ther · March 2007 Cardiovascular magnetic resonance (CMR) imaging is a comprehensive clinical tool for assessing a large variety of cardiovascular diseases. Using the clinical service of the Duke Cardiovascular Magnetic Resonance Center as an example, we describe how to per ... Full text Link to item Cite

A clinical cardiovascular magnetic resonance service: operational considerations and the basic examination.

Journal Article Cardiol Clin · February 2007 Cardiovascular magnetic resonance (CMR) is now considered the "gold standard" for the assessment of regional and global systolic function, myocardial infarction and viability, and congenital heart disease. At specialized centers, CMR has become a clinical ... Full text Link to item Cite

Detection of myocardial ischemia by stress perfusion cardiovascular magnetic resonance.

Journal Article Cardiol Clin · February 2007 With recent technical and clinical advances, adenosine stress perfusion MRI has evolved from a promising research tool to an everyday clinical test. This article reviews the current state of stress perfusion MRI. Specifically, it addresses the following to ... Full text Link to item Cite

Magnetic resonance evaluation of peripheral arterial disease.

Journal Article Cardiol Clin · February 2007 This article provides the reader with a clinically relevant practical approach to obtaining high-quality magnetic resonance angiograms of the lower extremities. The physics underlying this imaging are discussed as they relate to practical matters such as c ... Full text Link to item Cite

Rapid detection of myocardial infarction by subsecond, free-breathing delayed contrast-enhancement cardiovascular magnetic resonance.

Journal Article Circulation · January 16, 2007 BACKGROUND: An ultrafast, delayed contrast-enhancement cardiovascular magnetic resonance technique that can acquire subsecond, "snapshot" images during free breathing (subsecond) is becoming widely available. This technique provides myocardial infarction ( ... Full text Link to item Cite

MR angiography of the thoracic aorta with protocols

Chapter · January 1, 2007 Magnetic resonance imaging (MRI) plays a pivotal role in the diagnostic work-up of a broad spectrum of aortic diseases. In this chapter we will describe the MRI pulse sequences commonly used in the comprehensive assessment of the thoracic aorta, including ... Cite

MR angiography of the lower extremity circulation with protocols

Chapter · January 1, 2007 Peripheral arterial disease (PAD) is a common problem worldwide, with an estimated 20 million patients in the US alone. Although most patients with PAD are asymptomatic, it is common to present with lower extremity symptoms such as claudication and sometim ... Cite

Preface

Journal Article Magnetic Resonance Imaging Clinics of North America · January 1, 2007 Full text Cite

Cardiomyopathies: When is CMR necessary?

Journal Article ACC Cardiosource Review Journal · January 1, 2007 Cite

Guidelines for training in Cardiovascular Magnetic Resonance (CMR).

Journal Article J Cardiovasc Magn Reson · 2007 These "Guidelines for Training in Cardiovascular Magnetic Resonance" were developed by the Clinical Practice Committee of the Society for Cardiovascular Magnetic Resonance (SCMR) and approved by the SCMR Board of Trustees. ... Full text Link to item Cite

Acute myocardial infarction: safety of cardiac MR imaging after percutaneous revascularization with stents.

Journal Article Radiology · September 2006 PURPOSE: To retrospectively determine the safety of cardiac magnetic resonance (MR) imaging performed early (<14 days) after coronary stent implantation in patients with acute myocardial infarction (AMI). MATERIALS AND METHODS: This HIPPA-compliant study w ... Full text Link to item Cite

Assessment of no-reflow regions using cardiac MRI.

Journal Article Basic Res Cardiol · September 2006 Ischemic myocardial injury can be broadly characterized as either reversible or irreversible. Within irreversibly injured (infarcted) regions microvascular perfusion can vary from nearly normal to nearly zero, even in the presence of an open infarct-relate ... Full text Link to item Cite

Diagnostic testing.

Journal Article J Am Coll Cardiol · June 6, 2006 Full text Link to item Cite

Effects of time, dose, and inversion time for acute myocardial infarct size measurements based on magnetic resonance imaging-delayed contrast enhancement.

Journal Article J Am Coll Cardiol · May 16, 2006 OBJECTIVES: This study sought to investigate the influence of time, dose, and inversion time (TI) and their interactions on myocardial infarct size measurements to establish the foundation for a standardized protocol for multicenter trials. BACKGROUND: The ... Full text Link to item Cite

Improved detection of coronary artery disease by stress perfusion cardiovascular magnetic resonance with the use of delayed enhancement infarction imaging.

Journal Article J Am Coll Cardiol · April 18, 2006 OBJECTIVES: We tested a pre-defined visual interpretation algorithm that combines cardiovascular magnetic resonance (CMR) data from perfusion and infarction imaging for the diagnosis of coronary artery disease (CAD). BACKGROUND: Cardiovascular magnetic res ... Full text Link to item Cite

Where's the flap?

Journal Article J Cardiovasc Magn Reson · 2006 We present a case of aortic intramural hematoma (IMH) in an elderly woman who presented with sudden onset of mid-scapular pain. The patient underwent a series of multimodality imaging studies before the diagnosis of IMH was evident by cardiovascular magnet ... Full text Link to item Cite

Diagnosis of a solitary cardiac metastasis from ocular melanoma.

Journal Article J Thorac Cardiovasc Surg · December 2005 Full text Link to item Cite

Technology insight: MRI of the myocardium.

Journal Article Nat Clin Pract Cardiovasc Med · November 2005 MRI is emerging as the method of choice for the evaluation of a wide variety of cardiovascular disorders. A major advantage of this technique over the other cardiac imaging modalities is the fact that it allows the operator--via special software programs c ... Full text Link to item Cite

Late gadolinium cardiovascular magnetic resonance in the assessment of myocardial viability.

Journal Article Coron Artery Dis · September 2005 Delayed-enhancement magnetic resonance imaging is a viability imaging technique that has been demonstrated in both animal and patient studies to accurately identify and characterize the presence and transmural extent of myocardial scarring. The precise inf ... Full text Link to item Cite

Delayed enhancement cardiovascular magnetic resonance assessment of non-ischaemic cardiomyopathies.

Journal Article Eur Heart J · August 2005 Non-ischaemic cardiomyopathies (NICMs) are chronic, progressive myocardial diseases with distinct patterns of morphological, functional, and electrophysiological changes. In the setting of cardiomyopathy (CM), determining the exact aetiology is important b ... Full text Link to item Cite

Clinical use of cardiac magnetic resonance imaging

Journal Article Advanced Studies in Medicine · July 1, 2005 PURPOSE: To review the uses of cardiac magnetic resonance (CMR) imaging in the management of patients with heart disease. EPIDEMIOLOGY: CMR has applications in the evaluation of congenital heart defects, which are present in more than 1 million adults in t ... Cite

Infarct morphology identifies patients with substrate for sustained ventricular tachycardia.

Journal Article J Am Coll Cardiol · April 5, 2005 OBJECTIVES: We sought to evaluate whether infarct size characterization by cardiac magnetic resonance imaging (MRI) is a better predictor of inducible ventricular tachycardia (VT) than left ventricular ejection fraction (LVEF). BACKGROUND: Inducibility of ... Full text Link to item Cite

Cardiac imaging impaired by a silicone breast implant.

Journal Article Clin Nucl Med · April 2005 The authors report a case of a left-sided silicone breast implant interfering with nuclear imaging of the myocardium. Cardiac SPECT imaging of a woman documented widespread infarct in the anterolateral, inferior, and posterolateral walls, as well as mixed ... Full text Link to item Cite

23Na MRI combined with contrast-enhanced 1H MRI provides in vivo characterization of infarct healing.

Journal Article Magn Reson Med · April 2005 Although (23)Na MRI has been shown to delineate acute myocardial infarction (MI), the time course of in vivo (23)Na MRI during infarct healing remains unknown. In this study (23)Na MRI was combined with contrast-enhanced (CE) (1)H MRI to noninvasively char ... Full text Link to item Cite

Noninvasive assessment of blood flow based on magnetic resonance global coherent free precession.

Journal Article Circulation · March 1, 2005 BACKGROUND: Magnetic resonance global coherent free precession (GCFP) is a new technique that produces cine projection angiograms directly analogous to those of x-ray angiography noninvasively and without a contrast agent. In this study, we compared GCFP b ... Full text Link to item Cite

Technology insight: assessment of myocardial viability by delayed-enhancement magnetic resonance imaging.

Journal Article Nat Clin Pract Cardiovasc Med · March 2005 Myocardial viability is of established importance to the management of cardiac patients being considered for revascularization. Existing noninvasive imaging tests to examine myocardial viability, such as stress echocardiography and nuclear scintigraphy, ar ... Full text Link to item Cite

The case of the disappearing myxoma.

Journal Article J Cardiovasc Magn Reson · 2005 We present a case demonstrating the utility of cardiovascular magnetic resonance (CMR) in the diagnosis of a cardiac mass. A 70-year-old female who presented with chest pressure and left sided jaw pain was found to have a cardiac mass on transthoracic and ... Full text Link to item Cite

Use of cardiac magnetic resonance to assess viability.

Journal Article Curr Cardiol Rep · January 2005 The accurate differentiation of viable and nonviable myocardium is crucial for therapy planning in patients with coronary artery disease and left ventricular dysfunction. Traditional techniques such as echocardiography, positron emission tomography, single ... Full text Link to item Cite

Infarct resorption, compensatory hypertrophy, and differing patterns of ventricular remodeling following myocardial infarctions of varying size.

Journal Article J Am Coll Cardiol · June 2, 2004 OBJECTIVES: We sought to identify advantages of contrast-enhanced magnetic resonance imaging (MRI) in studying postinfarction ventricular remodeling. BACKGROUND: Although sequential measurements of ventricular volumes, internal dimensions, and total ventri ... Full text Link to item Cite

Magnetic resonance imaging for the assessment of myocardial viability.

Journal Article J Magn Reson Imaging · June 2004 The identification of myocardial viability in the setting of left ventricular (LV) dysfunction is crucial for the prediction of functional recovery following revascularization. Although echocardiography, positron emission tomography (PET), and nuclear imag ... Full text Link to item Cite

Noninvasive cineangiography by magnetic resonance global coherent free precession.

Journal Article Nat Med · May 2004 Cardiovascular disease is primarily diagnosed using invasive X-ray cineangiography. Here we introduce a new concept in magnetic resonance imaging (MRI) that, for the first time, produces similar images noninvasively and without a contrast agent. Protons in ... Full text Link to item Cite

Myonecrosis following stent placement: association between impaired TIMI myocardial perfusion grade and MRI visualization of microinfarction.

Journal Article Catheter Cardiovasc Interv · April 2004 Contrast-enhanced cardiac MRI (ceMRI) and TIMI myocardial perfusion grade analysis (TMPG) are proven methods for visualization of microinfarction and assessment of microvascular perfusion, respectively. To determine whether microvascular obstruction accoun ... Full text Link to item Cite

Improvement in the function of hibernating myocardium in a patient with heart failure due to coronary artery disease receiving high-dose simvastatin.

Journal Article Ital Heart J · February 2004 We report the case of a 70-year-old man with a history of myocardial infarction and coronary artery bypass grafting, presenting with signs and symptoms of heart failure. Cardiac magnetic resonance imaging demonstrated a small amount of scarring in the ante ... Link to item Cite

An intracardiac mass in a young man with congenitally acquired HIV.

Journal Article Cardiol Rev · 2004 A case of a 19-year-old man with congenitally acquired HIV infection who was found to have a large intracardiac mass is presented. Presurgical imaging studies and subsequent pathologic findings and histology are discussed. ... Full text Link to item Cite

Erratum: How We Perform Delayed Enhancement Imaging (Journal of Cardiovascular Magnetic Resonance (2003) 5:3 (505-514))

Journal Article Journal of Cardiovascular Magnetic Resonance · November 25, 2003 Cite

Gadolinium cardiovascular magnetic resonance predicts reversible myocardial dysfunction and remodeling in patients with heart failure undergoing beta-blocker therapy.

Journal Article Circulation · October 21, 2003 BACKGROUND: In some patients with heart failure, beta-blockers can improve left ventricular (LV) function and reduce morbidity and mortality. We hypothesized that gadolinium-enhanced cardiovascular magnetic resonance imaging (CMR) can predict reversible my ... Full text Link to item Cite

Relationship of contractile function to transmural extent of infarction in patients with chronic coronary artery disease.

Journal Article J Am Coll Cardiol · August 6, 2003 OBJECTIVES: We sought to determine the relationship of contractile function to the transmural extent of infarction (TEI) in patients with chronic coronary artery disease. BACKGROUND: In the setting of reperfused, chronic myocardial infarction (MI), the rel ... Full text Link to item Cite

How we perform delayed enhancement imaging.

Journal Article J Cardiovasc Magn Reson · July 2003 Recently, numerous studies have demonstrated the effectiveness of a segmented inversion recovery fast gradient echo (seg IR-FGE) sequence for differentiating injured from normal myocardium. This technique for delayed enhancement imaging has been shown to b ... Full text Link to item Cite

Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study.

Journal Article Lancet · February 1, 2003 BACKGROUND: Myocardial infarcts are routinely detected by nuclear imaging techniques such as single photon emission computed tomography (SPECT) myocardial perfusion imaging. A newly developed technique for infarct detection based on contrast-enhanced cardi ... Full text Link to item Cite

MR imaging of myocardial perfusion and viability.

Journal Article Magn Reson Imaging Clin N Am · February 2003 CMR is a rapidly developing new modality with applications in clinical cardiology for detection and assessment of myocardial ischemia and viability. CMR perfusion results for the detection of ischemia in comparison with stress echocardiography and scintigr ... Full text Link to item Cite

Myocardial scarring in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy.

Journal Article J Am Coll Cardiol · December 18, 2002 Featured Publication OBJECTIVES: We sought to ascertain whether myocardial scarring occurs in living unselected patients with hypertrophic cardiomyopathy (HCM). BACKGROUND: Myocardial scarring is known to occur in select HCM patients, who were highly symptomatic prior to death ... Full text Link to item Cite

Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging.

Journal Article Circulation · October 29, 2002 Featured Publication BACKGROUND: The reproducibility of contrast-enhanced MRI has not been established. We compared MRI reproducibility for infarct size determination with that of (99m)Tc-sestamibi (MIBI) single photon emission computed tomography (SPECT). METHODS AND RESULTS: ... Full text Link to item Cite

Rapid cine MRI of the human heart using reconstruction by estimation of lines and inhibition of fold-in.

Journal Article Magn Reson Med · May 2002 A fast imaging method is described that yields an approximately six-fold acquisition time reduction relative to conventional techniques. The method involves: 1) acquisition of every sixth k-space line; 2) shifting of acquired k-space lines between odd and ... Full text Link to item Cite

Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury.

Journal Article Circulation · January 15, 2002 BACKGROUND: Discrepant reports have been published recently regarding the relationship of contrast-enhanced magnetic resonance image intensities to reversible and irreversible ischemic injury. Unlike image intensities, contrast agent concentrations provide ... Full text Link to item Cite

Blood pool contrast-enhanced MRI detects suppression of microvascular permeability in early postinfarction reperfusion after nicorandil therapy

Journal Article Magnetic Resonance in Medicine · 2002 Nicorandil is an adenosine triphosphate-sensitive potassium channel opener with a nitrate-like effect. It is approved for clinical use in Europe and Japan as an antianginal drug. The purpose of this investigation was to assess the acute effects of nicorand ... Full text Cite

Limits of detection of regional differences in vasodilated flow in viable myocardium by first-pass magnetic resonance perfusion imaging.

Journal Article Circulation · November 13, 2001 BACKGROUND: Perfusion imaging techniques intended to identify regional limitations in coronary flow reserve in viable myocardium need to identify 2-fold differences in regional flow during coronary vasodilation consistently. This study evaluated the suitab ... Full text Link to item Cite

Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function.

Journal Article Circulation · September 4, 2001 BACKGROUND: Previous animal studies have demonstrated that the transmural extent of acute myocardial infarction defined by contrast-enhanced MRI (ceMRI) relates to early restoration of flow and future improvements in contractile function. We tested the hyp ... Full text Link to item Cite

Theory of high-speed MR imaging of the human heart with the selective line acquisition mode.

Journal Article Radiology · August 2001 Selective line acquisition mode (SLAM) reduces magnetic resonance imaging time by a factor n relative to conventional techniques. Seventeen patients with cardiac disease and three volunteers were examined with SLAM and two-frame interpolation (2FI). SLAM i ... Full text Link to item Cite

Visualization of discrete microinfarction after percutaneous coronary intervention associated with mild creatine kinase-MB elevation.

Journal Article Circulation · June 12, 2001 Featured Publication BACKGROUND: Mild elevations in creatine kinase-MB (CK-MB) are common after successful percutaneous coronary interventions and are associated with future adverse cardiac events. The mechanism for CK-MB release remains unclear. A new contrast-enhanced MRI te ... Full text Link to item Cite

Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction.

Journal Article Lancet · January 6, 2001 BACKGROUND: A technical advance in contrast-enhanced magnetic resonance imaging (MRI) has significantly improved image quality. We investigated whether healed myocardial infarction can be visualised as hyperenhanced regions with this new technique, and whe ... Full text Link to item Cite

An improved MR imaging technique for the visualization of myocardial infarction.

Journal Article Radiology · January 2001 PURPOSE: To design a segmented inversion-recovery turbo fast low-angle shot (turboFLASH) magnetic resonance (MR) imaging pulse sequence for the visualization of myocardial infarction, compare this technique with other MR imaging approaches in a canine mode ... Full text Link to item Cite

The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction.

Journal Article N Engl J Med · November 16, 2000 BACKGROUND: Recent studies indicate that magnetic resonance imaging (MRI) after the administration of contrast material can be used to distinguish between reversible and irreversible myocardial ischemic injury regardless of the extent of wall motion or the ... Full text Link to item Cite

Contrast-enhanced magnetic resonance imaging of myocardium at risk: distinction between reversible and irreversible injury throughout infarct healing.

Journal Article J Am Coll Cardiol · November 15, 2000 OBJECTIVES: We sought to determine the relationship of delayed hyperenhancement by contrast magnetic resonance imaging (MRI) to viable and nonviable myocardium within the region at risk throughout infarct healing. BACKGROUND: The relationship of delayed MR ... Full text Link to item Cite

Microvascular integrity and the time course of myocardial sodium accumulation after acute infarction.

Journal Article Circ Res · October 13, 2000 Loss of membrane permeability caused by ischemia leads to cellular sodium accumulation and myocardial edema. This phenomenon has important implications to left ventricular structure and function in the first hours after myocardial infarction. We hypothesiz ... Full text Link to item Cite

Early assessment of myocardial salvage by contrast-enhanced magnetic resonance imaging.

Journal Article Circulation · October 3, 2000 BACKGROUND: Myocardial salvage after acute myocardial infarction is defined clinically by early restoration of flow and long-term improvement in contractile function. We hypothesized that contrast-enhanced magnetic resonance imaging (MRI), performed early ... Full text Link to item Cite

Evaluation of myocardial viability by MRI.

Journal Article Herz · June 2000 Distinguishing between viable and non-viable myocardium is an important clinical issue. Several magnetic resonance (MR) techniques to address this issue have been proposed. Spectroscopy of phosphorus-31 and hydrogen-1 from creatine as well as imaging of so ... Full text Link to item Cite

Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function.

Journal Article Circulation · November 9, 1999 BACKGROUND: Contrast MRI enhancement patterns in several pathophysiologies resulting from ischemic myocardial injury are controversial or have not been investigated. We compared contrast enhancement in acute infarction (AI), after severe but reversible isc ... Full text Link to item Cite

Relationship of elevated 23Na magnetic resonance image intensity to infarct size after acute reperfused myocardial infarction.

Journal Article Circulation · July 13, 1999 BACKGROUND: Elevated 23Na MR image intensity after acute myocardial infarction has previously been shown to correspond to high tissue [Na+] and loss of myocardial viability. In this study, we explored the potential of in vivo 23Na MRI to assess infarct siz ... Full text Link to item Cite

Physiological basis for potassium (39K) magnetic resonance imaging of the heart.

Journal Article Circ Res · April 30, 1999 The potassium cation (K+) is fundamentally involved in myocyte metabolism. To explore the potential utility of direct MRI of the most abundant natural isotope of potassium, 39K, we compared 39K magnetic resonance (MR) image intensity with regional myocardi ... Full text Link to item Cite

Quantification and time course of microvascular obstruction by contrast-enhanced echocardiography and magnetic resonance imaging following acute myocardial infarction and reperfusion.

Journal Article J Am Coll Cardiol · November 15, 1998 OBJECTIVES: We aimed to validate contrast-enhanced echocardiography (CE) in the quantification of microvascular obstruction (MO) against magnetic resonance imaging (MRI) and the histopathologic standards of radioactive microspheres and thioflavin-S stainin ... Full text Link to item Cite

Fast 23Na magnetic resonance imaging of acute reperfused myocardial infarction. Potential to assess myocardial viability.

Journal Article Circulation · April 1, 1997 BACKGROUND: The ability of the myocyte to maintain an ionic concentration gradient is perhaps the best indication of myocardial viability. We studied the relationship of 23Na MRI intensity to viability and explored the potential of fast-imaging techniques ... Full text Link to item Cite

Fast 23Na magnetic resonance imaging of acute reperfused myocardial infarction: Potential to assess myocardial viability

Journal Article Circulation · 1997 Background: The ability of the myocyte to maintain an ionic concentration gradient is perhaps the best indication of myocardial viability. We studied the relationship of 23Na MRI intensity to viability and explored the potential of fast-imaging techniques ... Cite

Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction.

Journal Article Circulation · December 15, 1996 BACKGROUND: Contrast medium-enhanced magnetic resonance images of acute, reperfused infarcts have shown hypoenhanced and hyperenhanced regions in areas of injured myocardium. The precise mechanisms that lead to these altered enhancement patterns are unknow ... Full text Link to item Cite

Correlation of cardiac MRI and PET images using lung cavities as landmarks

Journal Article Computers in Cardiology · May 1, 1991 Magnetic resonance images (MRI) are overlapped with positron emission tomography (PET) images to allow a correlation between structure and function of the heart. This is done by using the structural information inherent in PET attenuation images which are ... Cite

Phase Sensitive Fat Darkening by TI-Minimized Double SPAIR (PHATTI DeSPAIR) for Robust and Highly Effective Fat Suppression in Clinical T1-Weighted Imaging of Ischemic and Non-Ischemic Heart Disease

Conference We present a highly effective and robust fat suppression technique for T1-weighted inversion recovery (IR) imaging such as delayed enhancement, that is compatible with phase sensitive IR (PSIR) imaging. It combines a double-SPAIR (Spectral Selection Attenu ... Cite