Rebekah Jakel

Journal Article Clin Geriatr Med · May 2020 Posttraumatic stress disorder (PTSD) can occur at any point in the life span and can last for decades. Chronic PTSD can affect quality of life and have a negative impact on physical function and health in the elderly and may be associated with premature ag ... Full text Link to item Cite

Posttraumatic Stress Disorder in the Elderly.

Journal Article Psychiatr Clin North Am · March 2018 Posttraumatic stress disorder (PTSD) can occur at any point in the life span and can last for decades. Chronic PTSD can affect quality of life and have a negative impact on physical function and health in the elderly and may be associated with premature ag ... Full text Link to item Cite

Psychosis and Parkinson's disease

Journal Article Advances in Biological Psychiatry · December 4, 2012 Parkinson's disease (PD) psychosis is a common phenomenon that affects quality of life, caregiver burden, and disability in patients with PD. Although there may be an increased risk of psychosis inherent to the disease itself, current research suggests tha ... Full text Cite

Psychosis and Parkinson's disease

Chapter · January 9, 2012 Parkinson's disease (PD) psychosis is a common phenomenon that affects quality of life, caregiver burden, and disability in patients with PD. Although there may be an increased risk of psychosis inherent to the disease itself, current research suggests tha ... Full text Cite

Neurotoxicant-Induced Oxidative Events and Antioxidative Interventions in the Central Nervous System

Chapter · August 12, 2010 Exposure to some environmental neurotoxicants produces an increased concentration of reactive oxygen species (ROS) in the brain. These reactive molecules form macromolecular adducts, subsequently deplete the cell of endogenous antioxidative factors, and pr ... Full text Cite

Serotonin syndrome after a massive overdose of controlled-release paroxetine.

Journal Article Psychosomatics · 2010 Featured Publication BACKGROUND: Serotonin syndrome is a condition resulting from an overabundance of serotonin at postsynaptic receptors. The syndrome usually responds to cyproheptadine and benzodiazepines. However, some patients do not respond to conventional treatment. OBJE ... Full text Link to item Cite

The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration.

Journal Article Ann N Y Acad Sci · December 2008 Featured Publication Transcriptional activation of protective genes is mediated by a cis-acting element called the antioxidant responsive element (ARE). The transcription factor Nrf2 (NF-E2-related factor 2) binds to the ARE. Activation of this pathway protects cells from oxid ... Full text Link to item Cite

The Nrf2-ARE pathway: A potential therapeutic target for neurodegenerative diseases

Journal Article International Congress Series · June 1, 2007 NF-E2-related factor 2 (Nrf2) is the primary transcription factor required for the induction of a battery of phase II detoxification genes through activation of a cis-acting enhance termed the antioxidant response element (ARE). The genes regulated by the ... Full text Cite

Nrf2-mediated protection against 6-hydroxydopamine.

Journal Article Brain Res · May 4, 2007 Featured Publication Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by cell loss in the substantia nigra resulting in striatal dopamine depletion. Although the cause of sporadic PD is unknown, oxidative stress is thought to contribute to diseas ... Full text Link to item Cite

Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro.

Journal Article Toxicol Sci · September 2005 Featured Publication Parkinson's disease, a progressive neurodegenerative disorder, is characterized by loss of midbrain dopaminergic neurons. The etiology of sporadic Parkinson's disease is unknown; however, oxidative stress is thought to play a major role in disease pathogen ... Full text Link to item Cite

Nrf2, a multi-organ protector?

Journal Article FASEB J · July 2005 Featured Publication NF-E2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor that binds to the promoter sequence "antioxidant responsive element (ARE)" leading to coordinated up-regulation of ARE-driven detoxification and antioxidant genes. Since the expre ... Full text Link to item Cite

Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription.

Journal Article Proc Natl Acad Sci U S A · January 4, 2005 Featured Publication Complex II inhibitors 3-nitropropionic acid (3NP) and malonate cause striatal damage reminiscent of Huntington's disease and have been shown to involve oxidative stress in their pathogenesis. Because nuclear factor erythroid 2-related factor 2 (Nrf2)-depen ... Full text Link to item Cite

Human neural stem cell transplants improve motor function in a rat model of Huntington's disease.

Journal Article J Comp Neurol · July 19, 2004 Featured Publication The present study investigated the neuroanatomical and behavioral effects of human stem cell transplants into the striatum of quinolinic acid (QA)-lesioned rats. Twenty-four rats received unilateral QA (200 nM/microl) injections into the striatum. One week ... Full text Link to item Cite

Using human neural stem cells to model neurological disease.

Journal Article Nat Rev Genet · February 2004 Featured Publication Full text Link to item Cite

Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase.

Journal Article Brain Res · September 29, 2000 Featured Publication We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and pr ... Full text Link to item Cite

Neuronal cell death in Huntington's disease: a potential role for dopamine.

Journal Article Trends Neurosci · June 2000 Featured Publication Huntington's disease is an inherited neurodegenerative disorder, the cause of which is unknown. Excitotoxicity, mitochondrial dysfunction and oxidative stress are all likely to contribute to the striatal cell death that occurs in this disorder. There are a ... Full text Link to item Cite

Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions.

Journal Article Brain Res · July 10, 1999 Featured Publication We have previously shown that dopamine depletion reduces striatal damage elicited by the mitochondrial neurotoxins malonate and 3-nitropropionic acid (3NP). Metabolism of dopamine by monoamine oxidase results in the formation of hydrogen peroxide, which ma ... Full text Link to item Cite

Evidence that Par-4 participates in the pathogenesis of HIV encephalitis.

Journal Article Am J Pathol · July 1999 Featured Publication Progressive neuronal degeneration in brain regions involved in learning and memory processes is a common occurrence in patients infected with human immunodeficiency virus type 1 (HIV-1). We now report that levels of Par-4, a protein recently linked to neur ... Full text Link to item Cite

Does dopamine contribute to striatal damage caused by impaired mitochondrial function?

Journal Article Ann N Y Acad Sci · 1999 Featured Publication Full text Link to item Cite

6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions.

Journal Article Exp Neurol · December 1998 Featured Publication The mitochondrial inhibitors malonate and 3-nitropropionic (3NP) acid are potent neurotoxins in vivo. Administration of these compounds results in neuronal loss similar to that seen in Huntington's disease. Although the mechanism of cell death produced by ... Full text Link to item Cite