Scholars@Duke
Sandip Madhusudan Swain

Sandip Madhusudan Swain

Assistant Professor in Medicine
Medicine, Gastroenterology

Selected Publications

Loss of TRPV4 reduces pancreatic cancer growth and metastasis.

Journal Article JCI Insight · December 8, 2025 Pancreatic ductal adenocarcinoma (PDAC) is a rapidly metastasizing cancer characterized by a dense desmoplastic stroma composed of extracellular matrix (ECM) proteins, which complicates treatment. Upon stimulation, pancreatic stellate cells (PSCs) differen ... Full text Link to item Cite

Phosphate Improves Mitochondrial Function and Reduces Pancreatitis in Hypertriglyceridemia.

Journal Article FASEB J · August 31, 2025 Hypertriglyceridemia-associated pancreatitis (HTGP) accounts for 9% to 10% of acute pancreatitis; however, the exact cause and associated factors advancing HTGP are unclear. Clinical studies have revealed that hypophosphatemia is a common factor in many pa ... Full text Link to item Cite

Piezo1-induced durotaxis of pancreatic stellate cells depends on TRPC1 and TRPV4 channels.

Journal Article J Cell Sci · April 15, 2025 Pancreatic stellate cells (PSCs) are primarily responsible for producing the stiff tumor tissue in pancreatic ductal adenocarcinoma (PDAC). Thereby, PSCs generate a stiffness gradient between the healthy pancreas and the tumor. This gradient induces durota ... Full text Link to item Cite

LRG1 inhibition promotes acute pancreatitis recovery by inducing cholecystokinin Type 1 receptor expression via Akt.

Journal Article Theranostics · 2025 Rationale: Acute pancreatitis (AP) is a common gastrointestinal disease affecting nearly 3 million people annually worldwide. Although AP is typically self-limiting, up to 20% of patients may develop life-threatening complications. Individuals who suffer f ... Full text Link to item Cite

Piezo1-induced durotaxis of pancreatic stellate cells depends on TRPC1 and TRPV4 channels.

Journal Article bioRxiv · April 15, 2024 Pancreatic stellate cells (PSCs) are primarily responsible for producing the stiff tumor tissue in pancreatic ductal adenocarcinoma (PDAC). Thereby, PSCs generate a stiffness gradient between the healthy pancreas and the tumor. This gradient induces durota ... Full text Link to item Cite

Mechanosensing Piezo channels in gastrointestinal disorders.

Journal Article J Clin Invest · October 2, 2023 All cells in the body are exposed to physical force in the form of tension, compression, gravity, shear stress, or pressure. Cells convert these mechanical cues into intracellular biochemical signals; this process is an inherent property of all cells and i ... Full text Link to item Cite

Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1.

Journal Article Sci Rep · August 27, 2022 Heme, an iron-protoporphyrin IX complex, is a cofactor bound to various hemoproteins and supports a broad range of functions, such as electron transfer, oxygen transport, signal transduction, and drug metabolism. In recent years, there has been a growing r ... Full text Link to item Cite

Initiation and severity of experimental pancreatitis are modified by phosphate.

Journal Article Am J Physiol Gastrointest Liver Physiol · June 1, 2022 Proper mitochondrial function and adequate cellular ATP are necessary for normal pancreatic protein synthesis and sorting, maintenance of intracellular organelles and enzyme secretion. Inorganic phosphate is required for generating ATP and its limited avai ... Full text Link to item Cite

Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice.

Journal Article JCI Insight · April 22, 2022 Pancreatic fibrosis is a complication of chronic pancreatitis and is a prominent feature of pancreatic cancer. Pancreatic fibrosis is commonly observed in patients with prolonged pancreatic duct obstruction, which elevates intrapancreatic pressure. We show ... Full text Link to item Cite

The Role of Phosphate in Alcohol-Induced Experimental Pancreatitis.

Journal Article Gastroenterology · September 2021 BACKGROUND & AIMS: Heavy alcohol consumption is a common cause of acute pancreatitis; however, alcohol abuse does not always result in clinical pancreatitis. As a consequence, the factors responsible for alcohol-induced pancreatitis are not well understood ... Full text Link to item Cite

Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.

Journal Article Acta Neuropathol · April 2021 α-Synuclein aggregation underlies pathological changes in Lewy body dementia. Recent studies highlight structural variabilities associated with α-synuclein aggregates in patient populations. Here, we develop a quantitative real-time quaking-induced convers ... Full text Link to item Cite

Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress.

Journal Article J Biol Chem · 2021 The ion channels Piezo1 and TRPV4 have both, independently, been implicated in high venous pressure- and fluid shear stress-induced vascular hyperpermeability in endothelial cells. However, the mechanism by which Piezo1 and TRPV4 channels execute the same ... Full text Link to item Cite

Pressure-sensing Piezo1: the eyes have it.

Journal Article J Physiol · January 2021 Full text Link to item Cite

TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.

Journal Article J Clin Invest · May 1, 2020 Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and gallstones. In the pancreas, excessive intracellular calcium causes mitochondrial dysfun ... Full text Link to item Cite

Impact of intracellular hemin on N-type inactivation of voltage-gated K+ channels.

Journal Article Pflugers Arch · May 2020 N-type inactivation of voltage-gated K+ channels is conferred by the N-terminal "ball" domains of select pore-forming α subunits or of auxiliary β subunits, and influences electrical cellular excitability. Here, we show that hemin impairs inactivation of K ... Full text Link to item Cite

Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis.

Journal Article Nat Commun · April 30, 2018 Merely touching the pancreas can lead to premature zymogen activation and pancreatitis but the mechanism is not completely understood. Here we demonstrate that pancreatic acinar cells express the mechanoreceptor Piezo1 and application of pressure within th ... Full text Link to item Cite

CO-independent modification of K+ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2).

Journal Article Eur J Pharmacol · November 15, 2017 Although toxic when inhaled in high concentrations, the gas carbon monoxide (CO) is endogenously produced in mammals, and various beneficial effects are reported. For potential medicinal applications and studying the molecular processes underlying the phar ... Full text Link to item Cite

Ca(2+)/calmodulin regulates Kvβ1.1-mediated inactivation of voltage-gated K(+) channels.

Journal Article Sci Rep · October 21, 2015 A-type K(+) channels open on membrane depolarization and undergo subsequent rapid inactivation such that they are ideally suited for fine-tuning the electrical signaling in neurons and muscle cells. Channel inactivation mostly follows the so-called ball-an ... Full text Link to item Cite

Coupling of proton binding in extracellular domain to channel gating in acid-sensing ion channel.

Journal Article J Mol Neurosci · September 2013 Protonation of several amino acid residues in the extracellular domain (ECD) of acid-sensing ion channel (ASIC) causes conformational changes that lead to opening of the channel. It is not clear how conformational changes in ECD are coupled to channel gati ... Full text Link to item Cite

Proton-gated ion channels in mouse bone marrow stromal cells.

Journal Article Stem Cell Res · September 2012 A variety of ion channels like acid sensing ion channels (ASICs) and several members of the transient receptor potential (TRP) cation channel family are known to be activated by protons. The present study describes proton-gated current in mouse bone marrow ... Full text Link to item Cite

NO donors subunit and state‐dependently increase desensitization of acid sensitive ion channels

Journal Article The FASEB Journal · April 2012 Nitric oxide donors were studied on acid‐sensing channels (ASICs) of rat striatal neurons and CHO cells expressing recombinant receptors. S‐nitroso‐acetyl‐penicillamine (SNAP) potentiate or inhibit ASICs depending on their functional state. It pote ... Full text Cite

Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death.

Journal Article Nitric Oxide · April 1, 2010 Acid sensing ion channels (ASICs) are widely expressed in central and peripheral nervous system. They are involved in a variety of physiological and pathophysiological processes: synaptic transmission, learning and memory, pain perception, ischemia, etc. D ... Full text Link to item Cite

Inhibitory activity of probiotics Streptococcus phocae PI80 and Enterococcus faecium MC13 against Vibriosis in shrimp Penaeus monodon

Journal Article World Journal of Microbiology and Biotechnology · April 1, 2009 Occurrence of widespread epizootics among larval and cultured shrimp has put on viable preventive approaches such as application of probiotics on a high priority in aquaculture. In the present study, four probiotics bacteria were isolated from marine fish ... Full text Cite