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Scott L Sanoff

Associate Professor of Medicine
Medicine, Nephrology
136 Hanes Hse, Box 3512, Durham, NC 27710
136 Hanes Hse, Box 3512, Durham, NC 27710

Selected Publications


Incidence of Kidney Failure after Primary Organ Transplant.

Journal Article Kidney360 · January 1, 2024 KEY POINTS: Incidence of ESKD in the first year after primary organ transplant ranges from 2.4% to 3.6% and from 1.4% to 1.8% in the second year post-transplant. National data sources do not currently collect sufficiently reliable follow-up data to identif ... Full text Link to item Cite

Improving Health Equity in Living Donor Kidney Transplant: Application of an Implementation Science Framework.

Journal Article Transplant Proc · 2024 BACKGROUND: Interventions to improve racial equity in access to living donor kidney transplants (LDKT) have focused primarily on patients, ignoring the contributions of clinicians, transplant centers, and health system factors. Obtaining access to LDKT is ... Full text Link to item Cite

One size does not fit all: Differential benefits of simultaneous liver-kidney transplantation by eligibility criteria.

Journal Article Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · November 2023 Standard eligibility criteria for simultaneous liver-kidney transplantation (SLK) are in place in the United States. We hypothesize that the benefit associated with SLK over liver transplant alone differs by patient, depending on the specific SLK criteria ... Full text Cite

Real-world Experiences in the Transplantation of Hepatitis C-NAAT-positive Organs.

Journal Article Transplant Direct · November 2023 BACKGROUND: Hepatitis C virus (HCV) nucleic acid amplification test (NAAT)-positive donors have increased the organ pool. Direct-acting antivirals (DAAs) have led to high rates of treatment success and sustained virologic response (SVR) in recipients with ... Full text Link to item Cite

Daratumumab Use Prior to Kidney Transplant and T Cell-Mediated Rejection: A Case Report.

Journal Article Am J Kidney Dis · May 2023 There is growing interest in daratumumab in the solid organ transplant realm owing to the potential immunomodulatory effects on CD38-expressing cells, primarily plasma cells, as they have a key role in antibody production. In particular there is interest i ... Full text Link to item Cite

Attitudes of patients with renal disease on xenotransplantation: A systematic review.

Journal Article Xenotransplantation · March 2023 BackgroundRecent years have seen major advancements in xenotransplantation: the first pig-to-human heart transplant, the development of a brain-dead recipient model for kidney xenotransplantation, and the registration of the first xenokidney clini ... Full text Cite

Evaluation of Weight-Based Dose During Transition From Immediate-Release to Extended-Release Tacrolimus in Kidney Transplant Recipients.

Journal Article J Pharm Pract · February 2023 BACKGROUND: Manufacturer recommendations for conversion from immediate-release to extended-release tacrolimus, Envarsus XR®, suggests 80% of the total daily dose of the immediate-release formulation. This conversion has not consistently achieved therapeuti ... Full text Link to item Cite

Transcriptional responses define dysregulated immune activation in Hepatitis C (HCV)-naïve recipients of HCV-infected donor kidneys.

Journal Article PLoS One · 2023 Renal transplantation from hepatitis C (HCV) nucleic acid amplification test-positive (NAAT-positive) donors to uninfected recipients has greatly increased the organ donation pool. However, there is concern for adverse outcomes in these recipients due to d ... Full text Link to item Cite

Center variations in patient selection for simultaneous heart-kidney transplantation.

Journal Article Clin Transplant · May 2022 UNLABELLED: There are no established regulations governing patient selection for simultaneous heart-kidney (SHK) transplantation, creating the potential for significant center-level variations in clinical practice. METHODS: Using the United Network for Org ... Full text Link to item Cite

Impact of Covid-19 on kidney transplant and waiting list patients: Lessons from the first wave of the pandemic.

Journal Article Nephrol Ther · August 2021 BACKGROUND: The first wave of the Covid-19 pandemic resulted in a drastic reduction in kidney transplantation and a profound change in transplant care in France. It is critical for kidney transplant centers to understand the behaviors, concerns and wishes ... Full text Link to item Cite

The Impact of the 2017 Kidney Allocation Policy Change on Simultaneous Liver-Kidney Utilization and Outcomes.

Journal Article Liver Transpl · August 2021 Historically in the United States, kidneys for simultaneous liver-kidney transplantation (SLKT) candidates were allocated with livers, prioritizing SLKT recipients over much of the kidney waiting list. A 2017 change in policy delineated renal function crit ... Full text Link to item Cite

Need for improvements in simultaneous heart-kidney allocation: The limitation of pretransplant glomerular filtration rate.

Journal Article Am J Transplant · July 2021 The incidence of simultaneous heart-kidney transplant (SHK) has increased markedly in the last 15 years. There are no universally agreed upon indications for SHK vs. heart alone (HA) transplant, and center evaluation processes vary widely. We utilized Scie ... Full text Link to item Cite

Definition and Analysis of Textbook Outcome: A Novel Quality Measure in Kidney Transplantation.

Journal Article World J Surg · May 2021 BACKGROUND: "Textbook outcome" (TO) is a novel composite quality measure that encompasses multiple postoperative endpoints, representing the ideal "textbook" hospitalization for complex surgical procedures. We defined TO for kidney transplantation using a ... Full text Link to item Cite

BK virus nephropathy in non-renal solid organ transplant recipients: Are we looking hard enough?

Journal Article Clin Transplant · May 2021 We retrospectively examined the clinical characteristics, pathological features, and outcomes of BK viremia and nephropathy in a population of non-renal solid organ transplant patients (NRSOT) referred for outpatient nephrology consultation over a period o ... Full text Link to item Cite

Effects of Sofosbuvir-Based Hepatitis C Treatment Regimens on Calcineurin Inhibitor Dosing in Liver and Kidney Transplant Recipients.

Journal Article Exp Clin Transplant · February 2021 OBJECTIVES: Available data have suggested that directacting antivirals for hepatitis C virus may decrease calcineurin inhibitor concentrations. In this study, our aim was to determine the effects of hepatitis C directacting antivirals on calcineurin inhibi ... Full text Link to item Cite

Kidney transplant in the COVID era: Cautious optimism and continued vigilance.

Journal Article Am J Transplant · November 2020 The authors comment on the usefulness of a new model to advise centers on risks versus benefits of kidney transplantation during the COVID epidemic. See page 2997 for Massie et al's article. ... Full text Link to item Cite

Decreased graft loss following implementation of the kidney allocation score (KAS).

Journal Article Am J Surg · November 2020 BACKGROUND: The Kidney Allocation System (KAS) was developed to improve equity and utility in organ allocation. We examine the effect of this change on kidney graft distribution and survival. METHODS: UNOS data was used to identify first-time adult recipie ... Full text Link to item Cite

Lymphocyte depletion and risk of acute rejection in renal transplant recipients at increased risk for delayed graft function.

Journal Article Am J Transplant · March 2019 Delayed graft function (DGF) is a risk factor for acute rejection (AR) in renal transplant recipients, and KDIGO guidelines suggest use of lymphocyte-depletion induction when DGF is anticipated. We analyzed the United Network for Organ Sharing/Organ Procur ... Full text Link to item Cite

Incidence of Kidney Failure after Primary Organ Transplant.

Journal Article Kidney360 · January 1, 2024 KEY POINTS: Incidence of ESKD in the first year after primary organ transplant ranges from 2.4% to 3.6% and from 1.4% to 1.8% in the second year post-transplant. National data sources do not currently collect sufficiently reliable follow-up data to identif ... Full text Link to item Cite

Improving Health Equity in Living Donor Kidney Transplant: Application of an Implementation Science Framework.

Journal Article Transplant Proc · 2024 BACKGROUND: Interventions to improve racial equity in access to living donor kidney transplants (LDKT) have focused primarily on patients, ignoring the contributions of clinicians, transplant centers, and health system factors. Obtaining access to LDKT is ... Full text Link to item Cite

One size does not fit all: Differential benefits of simultaneous liver-kidney transplantation by eligibility criteria.

Journal Article Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · November 2023 Standard eligibility criteria for simultaneous liver-kidney transplantation (SLK) are in place in the United States. We hypothesize that the benefit associated with SLK over liver transplant alone differs by patient, depending on the specific SLK criteria ... Full text Cite

Real-world Experiences in the Transplantation of Hepatitis C-NAAT-positive Organs.

Journal Article Transplant Direct · November 2023 BACKGROUND: Hepatitis C virus (HCV) nucleic acid amplification test (NAAT)-positive donors have increased the organ pool. Direct-acting antivirals (DAAs) have led to high rates of treatment success and sustained virologic response (SVR) in recipients with ... Full text Link to item Cite

Daratumumab Use Prior to Kidney Transplant and T Cell-Mediated Rejection: A Case Report.

Journal Article Am J Kidney Dis · May 2023 There is growing interest in daratumumab in the solid organ transplant realm owing to the potential immunomodulatory effects on CD38-expressing cells, primarily plasma cells, as they have a key role in antibody production. In particular there is interest i ... Full text Link to item Cite

Attitudes of patients with renal disease on xenotransplantation: A systematic review.

Journal Article Xenotransplantation · March 2023 BackgroundRecent years have seen major advancements in xenotransplantation: the first pig-to-human heart transplant, the development of a brain-dead recipient model for kidney xenotransplantation, and the registration of the first xenokidney clini ... Full text Cite

Evaluation of Weight-Based Dose During Transition From Immediate-Release to Extended-Release Tacrolimus in Kidney Transplant Recipients.

Journal Article J Pharm Pract · February 2023 BACKGROUND: Manufacturer recommendations for conversion from immediate-release to extended-release tacrolimus, Envarsus XR®, suggests 80% of the total daily dose of the immediate-release formulation. This conversion has not consistently achieved therapeuti ... Full text Link to item Cite

Transcriptional responses define dysregulated immune activation in Hepatitis C (HCV)-naïve recipients of HCV-infected donor kidneys.

Journal Article PLoS One · 2023 Renal transplantation from hepatitis C (HCV) nucleic acid amplification test-positive (NAAT-positive) donors to uninfected recipients has greatly increased the organ donation pool. However, there is concern for adverse outcomes in these recipients due to d ... Full text Link to item Cite

Center variations in patient selection for simultaneous heart-kidney transplantation.

Journal Article Clin Transplant · May 2022 UNLABELLED: There are no established regulations governing patient selection for simultaneous heart-kidney (SHK) transplantation, creating the potential for significant center-level variations in clinical practice. METHODS: Using the United Network for Org ... Full text Link to item Cite

Impact of Covid-19 on kidney transplant and waiting list patients: Lessons from the first wave of the pandemic.

Journal Article Nephrol Ther · August 2021 BACKGROUND: The first wave of the Covid-19 pandemic resulted in a drastic reduction in kidney transplantation and a profound change in transplant care in France. It is critical for kidney transplant centers to understand the behaviors, concerns and wishes ... Full text Link to item Cite

The Impact of the 2017 Kidney Allocation Policy Change on Simultaneous Liver-Kidney Utilization and Outcomes.

Journal Article Liver Transpl · August 2021 Historically in the United States, kidneys for simultaneous liver-kidney transplantation (SLKT) candidates were allocated with livers, prioritizing SLKT recipients over much of the kidney waiting list. A 2017 change in policy delineated renal function crit ... Full text Link to item Cite

Need for improvements in simultaneous heart-kidney allocation: The limitation of pretransplant glomerular filtration rate.

Journal Article Am J Transplant · July 2021 The incidence of simultaneous heart-kidney transplant (SHK) has increased markedly in the last 15 years. There are no universally agreed upon indications for SHK vs. heart alone (HA) transplant, and center evaluation processes vary widely. We utilized Scie ... Full text Link to item Cite

Definition and Analysis of Textbook Outcome: A Novel Quality Measure in Kidney Transplantation.

Journal Article World J Surg · May 2021 BACKGROUND: "Textbook outcome" (TO) is a novel composite quality measure that encompasses multiple postoperative endpoints, representing the ideal "textbook" hospitalization for complex surgical procedures. We defined TO for kidney transplantation using a ... Full text Link to item Cite

BK virus nephropathy in non-renal solid organ transplant recipients: Are we looking hard enough?

Journal Article Clin Transplant · May 2021 We retrospectively examined the clinical characteristics, pathological features, and outcomes of BK viremia and nephropathy in a population of non-renal solid organ transplant patients (NRSOT) referred for outpatient nephrology consultation over a period o ... Full text Link to item Cite

Effects of Sofosbuvir-Based Hepatitis C Treatment Regimens on Calcineurin Inhibitor Dosing in Liver and Kidney Transplant Recipients.

Journal Article Exp Clin Transplant · February 2021 OBJECTIVES: Available data have suggested that directacting antivirals for hepatitis C virus may decrease calcineurin inhibitor concentrations. In this study, our aim was to determine the effects of hepatitis C directacting antivirals on calcineurin inhibi ... Full text Link to item Cite

Kidney transplant in the COVID era: Cautious optimism and continued vigilance.

Journal Article Am J Transplant · November 2020 The authors comment on the usefulness of a new model to advise centers on risks versus benefits of kidney transplantation during the COVID epidemic. See page 2997 for Massie et al's article. ... Full text Link to item Cite

Decreased graft loss following implementation of the kidney allocation score (KAS).

Journal Article Am J Surg · November 2020 BACKGROUND: The Kidney Allocation System (KAS) was developed to improve equity and utility in organ allocation. We examine the effect of this change on kidney graft distribution and survival. METHODS: UNOS data was used to identify first-time adult recipie ... Full text Link to item Cite

Lymphocyte depletion and risk of acute rejection in renal transplant recipients at increased risk for delayed graft function.

Journal Article Am J Transplant · March 2019 Delayed graft function (DGF) is a risk factor for acute rejection (AR) in renal transplant recipients, and KDIGO guidelines suggest use of lymphocyte-depletion induction when DGF is anticipated. We analyzed the United Network for Organ Sharing/Organ Procur ... Full text Link to item Cite

Effects of Ideal Versus Total Body Weight Dosage of Rabbit Antithymocyte Globulin on Outcomes of Kidney Transplant Patients With High Immunologic Risk.

Journal Article Exp Clin Transplant · October 2016 OBJECTIVES: The optimal dose of rabbit antithymocyte globulin induction therapy in kidney transplant recipients with high immunologic risk lacks consensus. The purpose of this study was to evaluate the effect of using ideal body weight rather than total bo ... Full text Link to item Cite

Outcomes in kidney transplant recipients from older living donors.

Journal Article Transplantation · February 2015 BACKGROUND: Previous studies demonstrate that graft survival from older living kidney donors (LD; age>60 years) is worse than younger LD but similar to deceased standard criteria donors (SCD). Limited sample size has precluded more detailed analyses of tra ... Full text Link to item Cite

A population-based study of prevalence and risk factors of chronic kidney disease in León, Nicaragua.

Journal Article Can J Kidney Health Dis · 2015 BACKGROUND: Recent studies have shown an excess of chronic kidney disease (CKD) among younger adult males in the Pacific coastal region of Nicaragua and suggest a non-conventional CKD etiology in this region. These studies have been conducted in small, non ... Full text Link to item Cite

Infectious disease in kidney transplantation

Chapter · November 1, 2013 Infection is a common and significant source of morbidity and mortality in the kidney transplant population. In a detailed review of Medicare claims data for 64,751 patients receiving kidney transplant between 1991 and 1998, 51 % suffered some type of infe ... Full text Cite

Therapeutic apheresis in kidney transplantation: a review of renal transplant immunobiology and current interventions with apheresis medicine.

Journal Article J Clin Apher · February 2013 Transplantation is the treatment of choice for end stage renal disease. Kidney transplants convey both a significant survival advantage to the individual recipient as well as cost savings to the medical system. Circulating alloantibodies directed against d ... Full text Link to item Cite

The role of therapeutic apheresis in high immunologic risk renal transplantation: a review of current trends.

Journal Article Semin Dial · 2012 Immunologic sensitization, defined by the presence of antibodies directed against donor human leukocyte antigen (or so called donor-specific antibodies [DSA]), is common among those awaiting kidney transplantation, and is associated with worse outcomes fol ... Full text Link to item Cite

Impact of acute kidney injury on chronic kidney disease and its progression.

Journal Article Contrib Nephrol · 2011 Acute kidney injury (AKI) is a devastating clinical problem that affects a growing number of patients, especially elderly ones, and is associated with high morbidity and mortality. It was previously thought that patients who survive an episode of AKI recov ... Full text Link to item Cite

Therapeutic apheresis before and after kidney transplantation.

Journal Article J Clin Apher · 2011 Kidney transplantation is considered the treatment of choice for most individuals with end-stage kidney disease, as well as the most cost-effective renal replacement therapy for the health care system that serves them. Immunologic sensitization, defined by ... Full text Link to item Cite

Care of the undocumented immigrant in the United States with ESRD.

Journal Article Am J Kidney Dis · January 2010 The growth of the undocumented immigrant population in the United States has been explosive. The absence of a uniform policy regarding health care for this population has created a unique problem for nephrologists. How should provision of care for undocume ... Full text Link to item Cite

Positive association of renal insufficiency with agriculture employment and unregulated alcohol consumption in Nicaragua.

Journal Article Ren Fail · 2010 BACKGROUND AND OBJECTIVES: Endemic renal insufficiency (RI) of unknown etiology is a major public health issue with high mortality in the Pacific coastal regions of Central America. We studied RI in León and Chinandega, Nicaragua, evaluating associations w ... Full text Link to item Cite