Translation of therapeutic strategies to modulate B cell reponses from non-human primate models to human kidney transplantation.
Publication
, Journal Article
Knechtle, S; Kwun, J; Song, S; Jackson, A; Williams, K; Sanoff, S
Published in: Front Transplant
2023
Using novel drugs targeting lymphocyte costimulation, cytokines, antibody, complement, and plasma cells, we have developed strategies in a non-human primate model to modulate the B cell response to incompatible kidney transplants. After more than two decades of research supported by mechanistic studies, this has resulted in clinically relevant approaches that are currently enrolling in clinical trials or preparing for such. In this manner, we aim to address the problems of HLA sensitization for very highly sensitized patients awaiting transplantation and the unmet need of effective treatment for antibody-mediated rejection.
Duke Scholars
Published In
Front Transplant
DOI
EISSN
2813-2440
Publication Date
2023
Volume
2
Start / End Page
1176796
Location
Switzerland
Citation
APA
Chicago
ICMJE
MLA
NLM
Knechtle, S., Kwun, J., Song, S., Jackson, A., Williams, K., & Sanoff, S. (2023). Translation of therapeutic strategies to modulate B cell reponses from non-human primate models to human kidney transplantation. Front Transplant, 2, 1176796. https://doi.org/10.3389/frtra.2023.1176796
Knechtle, Stuart, Jean Kwun, Shengli Song, Annette Jackson, Kitza Williams, and Scott Sanoff. “Translation of therapeutic strategies to modulate B cell reponses from non-human primate models to human kidney transplantation.” Front Transplant 2 (2023): 1176796. https://doi.org/10.3389/frtra.2023.1176796.
Knechtle S, Kwun J, Song S, Jackson A, Williams K, Sanoff S. Translation of therapeutic strategies to modulate B cell reponses from non-human primate models to human kidney transplantation. Front Transplant. 2023;2:1176796.
Knechtle, Stuart, et al. “Translation of therapeutic strategies to modulate B cell reponses from non-human primate models to human kidney transplantation.” Front Transplant, vol. 2, 2023, p. 1176796. Pubmed, doi:10.3389/frtra.2023.1176796.
Knechtle S, Kwun J, Song S, Jackson A, Williams K, Sanoff S. Translation of therapeutic strategies to modulate B cell reponses from non-human primate models to human kidney transplantation. Front Transplant. 2023;2:1176796.
Published In
Front Transplant
DOI
EISSN
2813-2440
Publication Date
2023
Volume
2
Start / End Page
1176796
Location
Switzerland