Scholars@Duke
Shashank Shekhar

Shashank Shekhar

Assistant Professor of Neurology
Neurology, Stroke and Vascular Neurology
shashank.shekhar@duke.edu
40 Duke Medicine Circle, Basement Level, Suite 0109, Durham, NC 27710

Selected Publications

Maternal prenatal depressive symptoms and child brain responses to affective touch at two years of age.

Journal Article J Affect Disord · July 1, 2024 BACKGROUND: Touch is an essential form of mother-child interaction, instigating better social bonding and emotional stability. METHODS: We used diffuse optical tomography to explore the relationship between total haemoglobin (HbT) responses to affective to ... Full text Link to item Cite

Prospective Validation of Glial Fibrillary Acidic Protein, ‐Dimer, and Clinical Scales for Acute Large‐Vessel Occlusion Ischemic Stroke Detection

Journal Article Stroke: Vascular and Interventional Neurology · July 2024 Background Large‐vessel occlusion (LVO) ischemic stroke is responsible for significant morbidity and mortality. We have previously described a no ... Full text Cite

Neuromodulation for Post-Stroke Motor Recovery: a Narrative Review of Invasive and Non‑Invasive Tools.

Journal Article Curr Neurol Neurosci Rep · December 2023 PURPOSE OF REVIEW: Stroke remains a leading disabling condition, and many survivors have permanent disability despite acute stroke treatment and subsequent standard-of-care rehabilitation therapies. Adjunctive neuromodulation is an emerging frontier in the ... Full text Link to item Cite

Abstract TP23: Characteristics Of Patients With Acute Ischemic Stroke And Covid-19 Who Required Intensive Care Unit Admission Versus Ward-only: The Mississippi Academic Center Experience

Conference Stroke · February 2022 Background: Coronavirus disease 2019 (COVID-19) is a viral disease that has primarily been known to cause respiratory symptoms; however, there has also been an association of COVID-19 with neurologica ... Full text Cite

Reversible Cerebral Vasoconstriction Syndrome in Patients with Coronavirus Disease: A Multicenter Case Series.

Journal Article J Stroke Cerebrovasc Dis · December 2021 BACKGROUND AND OBJECTIVES: RCVS (Reversible Cerebral Vasoconstrictive Syndrome) is a condition associated with vasoactive agents that alter endothelial function. There is growing evidence that endothelial inflammation contributes to cerebrovascular disease ... Full text Link to item Cite

A Novel Combination of Blood Biomarkers and Clinical Stroke Scales Facilitates Detection of Large Vessel Occlusion Ischemic Strokes.

Journal Article Diagnostics (Basel) · June 22, 2021 Acute ischemic stroke caused by large vessel occlusions (LVOs) is a major contributor to stroke deaths and disabilities; however, identification for emergency treatment is challenging. We recruited two separate cohorts of suspected stroke patients and scre ... Full text Link to item Cite

Primary Central Nervous System Lymphoma Mimicking Longitudinally Extensive Transverse Myelitis.

Journal Article Neurohospitalist · April 2021 Primary central nervous system lymphoma (PCNSL) is an uncommon variant of extra-nodal non-Hodgkin's lymphoma. Three regions can be involved in PCNSL: the brain, the spine, or the vitreus and retina. Spinal PCNSL is rare. It can mimic neoplasm, infection, a ... Full text Link to item Cite

Novel Mechanistic Insights and Potential Therapeutic Impact of TRPC6 in Neurovascular Coupling and Ischemic Stroke.

Journal Article Int J Mol Sci · February 19, 2021 Ischemic stroke is one of the most disabling diseases and a leading cause of death globally. Despite advances in medical care, the global burden of stroke continues to grow, as no effective treatments to limit or reverse ischemic injury to the brain are av ... Full text Link to item Cite

Association between recent cannabinoid use and acute ischemic stroke.

Journal Article Neurol Clin Pract · August 2020 BACKGROUND: Studies that have analyzed the association between cannabis use and acute ischemic stroke (AIS) have provided conflicting results. In this study, we aim to determine the association of recent cannabis use detected through urine drug screen (UDS ... Full text Link to item Cite

Relationship between maternal pregnancy-related anxiety and infant brain responses to emotional speech - a pilot study.

Journal Article J Affect Disord · February 1, 2020 BACKGROUND: Maternal pregnancy-related anxiety (PRA) is reportedly related to neurodevelopmental outcomes of infants. However, the relationship between maternal PRA and the processing of emotions in the infant brain has not been extensively studied with ne ... Full text Link to item Cite

Conflicting Roles of 20-HETE in Hypertension and Stroke.

Journal Article Int J Mol Sci · September 11, 2019 Hypertension is the most common modifiable risk factor for stroke, and understanding the underlying mechanisms of hypertension and hypertension-related stroke is crucial. 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE), which plays an important rol ... Full text Link to item Cite

Nitrogen Doped Carbon Quantum Dots Modified by Lens culinaris β-Galactosidase as a Fluorescent Probe for Detection of Lactose.

Journal Article J Fluoresc · September 2019 Nitrogen doped carbon quantum dots (NCQDs) were synthesized via hydrothermal route. The NCQDs are thermally and optically stable with high flouresence yield. For the synthesis of NCQDs, citric acid and urea was taken as carbon and nitrogen sources, respect ... Full text Link to item Cite

Hemodynamic responses to emotional speech in two-month-old infants imaged using diffuse optical tomography.

Journal Article Sci Rep · March 18, 2019 Emotional speech is one of the principal forms of social communication in humans. In this study, we investigated neural processing of emotional speech (happy, angry, sad and neutral) in the left hemisphere of 21 two-month-old infants using diffuse optical ... Full text Link to item Cite

Emotional Processing in the First 2 Years of Life: A Review of Near-Infrared Spectroscopy Studies.

Journal Article J Neuroimaging · September 2018 Emotional stimuli processing during childhood helps us to detect salient cues in our environment and prepares us for our social life. In early childhood, the emotional valences of auditory and visual input are salient and relevant cues of social aspects of ... Full text Link to item Cite

Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches.

Journal Article Eur J Pharmacol · August 15, 2018 Ischemic stroke is a devastating and debilitating medical condition with limited therapeutic options. However, accumulating evidence indicates a central role of inflammation in all aspects of stroke including its initiation, the progression of injury, and ... Full text Link to item Cite

Medical Management of Hemorrhagic Stroke

Chapter · May 2018 Since the management of hemorrhagic stroke differs from that of ischemic stroke, prompt, accurate, and early diagnosis is vital in the management of patients who present with acute onset of focal neurologic symptoms and/or with altered mental status. Di ... Full text Cite

Cerebral Autoregulation in Hypertension and Ischemic Stroke: A Mini Review

Journal Article Journal of Pharmaceutical Sciences and Experimental Pharmacology · January 26, 2018 Full text Cite

Menopause and Ischemic Stroke: A Brief Review.

Journal Article MOJ Toxicol · 2017 Ischemic stroke is one of the leading causes of morbidity and mortality worldwide. Females are protected against stroke before the onset of menopause. Menopause results in increased incidence of stroke when compared to men. The mechanisms of these differen ... Full text Link to item Cite

P884: Diffuse optical imaging of activation in the infant brain

Journal Article Clinical Neurophysiology · June 2014 Full text Cite

Evolution of intracerebral hemorrhage after intravenous tPA: reversal of harmful effects with mast cell stabilization.

Journal Article J Cereb Blood Flow Metab · January 2014 Thrombolysis with tissue plasminogen activator (tPA) traditionally demands baseline imaging to rule out intracerebral hemorrhage (ICH), which causes delays in treatment. Preventing possible adverse effects of tPA on ICH would allow rapid on-site thrombolys ... Full text Link to item Cite

Near Infrared Imaging, a tool to study emotional processing in infant's brain

Conference EUROPEAN CHILD & ADOLESCENT PSYCHIATRY · 2011 Cite

Epidemiology of anxiety disorders in a Spanish school population

Conference EUROPEAN CHILD & ADOLESCENT PSYCHIATRY · 2011 Cite

An optimized mouse model for transient ischemic attack.

Journal Article J Neuropathol Exp Neurol · February 2010 Transient ischemic attacks (TIAs) are brief neurological deficits ofcerebrovascular origin that are followed by complete clinical recovery. Although a plethora of animal models exist for ischemic stroke, a verified TIA model is lacking. We aimed to optimiz ... Full text Link to item Cite

Decompressive craniectomy for intracerebral hemorrhage.

Journal Article Neurosurgery · October 2009 OBJECTIVE: Intracerebral hemorrhage (ICH) has a high mortality rate and leaves most survivors disabled. The dismal outcome is mostly due to the mass effect of hematoma plus edema. Major clinical trials show no benefit from surgical or medical treatment. De ... Full text Link to item Cite

Bioterrorism: Historical prospective

Journal Article Internet Journal of Biological Anthropology · December 1, 2008 Biological weapons have been a threat to human being for many centuries. Many different modes and techniques have been used since ancient times to use the biological warfare agents to kill or harm the enemy and to fulfill their evil intentions. The earlies ... Cite

A prospective study of the long-term efficacy of local methyl prednisolone acetate injection in the management of mild carpal tunnel syndrome.

Journal Article Rheumatology (Oxford) · May 2005 OBJECTIVE: Local glucocorticoid injections are used to treat carpal tunnel syndrome (CTS). However, this treatment is associated with frequent relapses. An important limitation of studies with higher relapse rates is that no attempt has been made to identi ... Full text Link to item Cite