Scholars@Duke
Shiyu Zhang

Shiyu Zhang

Postdoctoral Associate
Duke Global Health Institute

Selected Publications

Associations of fine particulate matter and its chemical constituents with outpatient visits for pediatric seizures

Journal Article Atmospheric Environment · February 15, 2026 Growing epidemiological evidence has reported neurological effects of fine particulate matter (PM2.5), showing stronger effects of certain PM2.5 constituents. Among the neurologic outcomes examined so far, pediatric seizure has been r ... Full text Cite

Habitual Physical Activity and All-Cause Mortality Among Individuals with and Without Impaired Lung Function: Findings from a Prospective Cohort Study

Journal Article Green Health · June 23, 2025 Background: The associations between physical activity (PA) and all-cause mortality remain under-investigated among individuals with impaired lung function. Methods: With 201,596 participants from the UK Biobank cohort, baseline pre-bronchodilation ... Full text Cite

Interactive effects of air pollutants and viral exposure on daily influenza hospital visits in Mongolia.

Journal Article Environ Res · March 1, 2025 BACKGROUND: Air pollution is a well-documented public health hazard linked to various adverse health outcomes. While studies have shown associations between elevated levels of air pollutants and increased influenza incidence, there is a notable knowledge g ... Full text Link to item Cite

Effects of ambient temperature on pediatric incident seizure: A case-crossover analysis using distributed lag non-linear models.

Journal Article Environmental research · October 2024 ObjectiveEmerging evidence supports that brain dysfunction may be attributable to environmental factors. This study aims to examine associations of ambient temperature and temperature variability (TV) with seizure incidence in children, which has ... Full text Cite

Associations between air pollution and the risk of first admission and multiple readmissions for cardiovascular diseases.

Journal Article Heart (British Cardiac Society) · February 2024 ObjectivesWe aimed to investigate the associations between air pollutants and the risk of admission and multiple readmission events for cardiovascular disease (CVD).MethodsA total of 285 009 participants free of CVD at baseline from the U ... Full text Cite

The effects of long-term exposure to air pollution on incident mental disorders among patients with prediabetes and diabetes: Findings from a large prospective cohort.

Journal Article The Science of the total environment · November 2023 BackgroundThe association between air pollution and mental disorders has been widely documented in the general population. However, the evidence among susceptible populations, such as individuals with prediabetes or diabetes, is still insufficient ... Full text Cite

Associations of Sleep Patterns With Dynamic Trajectory of Cardiovascular Multimorbidity and Mortality: A Multistate Analysis of a Large Cohort.

Journal Article Journal of the American Heart Association · October 2023 Background The purpose of this study was to explore the association of sleep patterns with the development of first cardiovascular diseases (FCVD), progression to cardiovascular multimorbidity (CVM), and subsequently to mortality. Methods and Results This ... Full text Cite

Dynamic association of ambient air pollution with incidence and mortality of pulmonary hypertension: A multistate trajectory analysis.

Journal Article Ecotoxicology and environmental safety · June 2023 BackgroundThere is little evidence regarding the association between ambient air pollution and incidence and the mortality of pulmonary hypertension (PH).MethodsWe included 494,750 participants at baseline in the UK Biobank study. Exposur ... Full text Cite

Dietary Diversity and Inflammatory Diet Associated with All-Cause Mortality and Incidence and Mortality of Type 2 Diabetes: Two Prospective Cohort Studies.

Journal Article Nutrients · April 2023 A higher dietary diversity score (DDS) and a lower energy-adjusted dietary inflammatory index (E-DII) may be associated with lower risks of type 2 diabetes (T2D) and mortality. This cohort study aimed to investigate the associations of DDS and E-DII with a ... Full text Cite

Long-term exposure to ambient fine particulate matter chemical composition and in-hospital case fatality among patients with stroke in China.

Journal Article The Lancet regional health. Western Pacific · March 2023 BackgroundThere is little evidence on the association between PM2.5 chemical components and fatality among hospitalized stroke patients.MethodsThis study used an inpatient discharge database from 2013 to 2019 in four provinces ... Full text Cite

Cold spells linked with respiratory disease hospitalization, length of hospital stay, and hospital expenses: Exploring cumulative and harvesting effects.

Journal Article The Science of the total environment · March 2023 BackgroundPrevious studies have revealed the relationship between cold spells and morbidity and mortality due to respiratory diseases, while the detrimental effects of cold spells on the length of hospital stay and hospitalization expenses remain ... Full text Cite

Size-specific particulate matter and outpatient visits for allergic conjunctivitis in children: a time-stratified case-crossover study in Guangzhou, China.

Journal Article Environmental science and pollution research international · March 2023 This time-stratified case-crossover study aims to quantify the risk of allergic conjunctivitis (AC) associated with short-term exposure to PMs (i.e., PM1, PM2.5, PMc, and PM10) among children in Guangzhou, China. ... Full text Cite

Ambient air pollution associated with incidence and progression trajectory of cardiometabolic diseases: A multi-state analysis of a prospective cohort.

Journal Article The Science of the total environment · March 2023 BackgroundPrevious studies on the association between ambient air pollution and cardiometabolic diseases (CMDs) focused on a single disease, without considering cardiometabolic multimorbidity (CMM) and the progression trajectory of CMDs.Method ... Full text Cite

Mediation Effect of Brain Volume on the Relationship Between Peripheral Inflammation and Cognitive Decline.

Journal Article Journal of Alzheimer's disease : JAD · January 2023 BackgroundStudies have reported the associations between inflammation, brain volume, and cognition separately. It is reasonable to assume peripheral inflammation may contribute to cognitive decline through brain volume atrophy.ObjectiveTo ... Full text Cite

Short-term air pollution exposure associated with death from kidney diseases: a nationwide time-stratified case-crossover study in China from 2015 to 2019.

Journal Article BMC medicine · January 2023 BackgroundLong-term exposure to air pollution has been associated with the onset and progression of kidney diseases, but the association between short-term exposure to air pollution and mortality of kidney diseases has not yet been reported.Me ... Full text Cite

Ambient particulate matter pollution of different sizes associated with recurrent stroke hospitalization in China: A cohort study of 1.07 million stroke patients.

Journal Article The Science of the total environment · January 2023 BackgroundTo estimate the associations between ambient particulate matter (PM) pollution of different sizes (PM1, PM2.5, and PM10) and risk of rehospitalization among stroke patients, as well as the attributable bu ... Full text Cite

Exposure to Air Pollution during Pre-Hypertension and Subsequent Hypertension, Cardiovascular Disease, and Death: A Trajectory Analysis of the UK Biobank Cohort.

Journal Article Environmental health perspectives · January 2023 BackgroundThe associations between air pollution exposure and morbidity and mortality of cardiovascular diseases (CVDs) have been widely reported; however, evidence on such associations across different dynamic disease trajectories remain unknown. ... Full text Cite

Physical Activity and Different Recommendations Associated with the Dynamic Trajectory of Cardiometabolic Diseases - UK, 2006-2021.

Journal Article China CDC weekly · December 2022 What is already known about this topic?Previous studies have illustrated the benefits of physical activity on cardiometabolic multimorbidity (CMM), while limited studies have concentrated on the trajectory of CMM progression.What is added by t ... Full text Cite

Ambient air pollution associated with incidence and dynamic progression of type 2 diabetes: a trajectory analysis of a population-based cohort.

Journal Article BMC medicine · October 2022 BackgroundThough the association between air pollution and incident type 2 diabetes (T2D) has been well documented, evidence on the association with development of subsequent diabetes complications and post-diabetes mortality is scarce. We investi ... Full text Cite

Associations of Ambient NO2 with Daily Hospitalization, Hospitalization Expenditure and Length of Hospital Stay of Cause-Specific Respiratory Diseases - Shanxi, China, 2017-2019.

Journal Article China CDC weekly · September 2022 What is already known about this topic?Numerous epidemiological studies have documented the association between ambient nitrogen dioxide (NO2) and mortality and morbidity of respiratory diseases, however, research on the effect of NO Full text Cite

Association of Ambient Particulate Matter Pollution of Different Sizes With In-Hospital Case Fatality Among Stroke Patients in China.

Journal Article Neurology · June 2022 Background and objectivesTo characterize the association of ambient particulate matter (PM) pollution of different sizes (PM ≤1 µm in aerodynamic diameter [PM1], PM2.5, and PM10) with in-hospital case fatality amon ... Full text Cite

High-Temperature Soup Foods in Plastic Packaging Are Associated with Phthalate Body Burden and Expression of Inflammatory mRNAs: A Dietary Intervention Study.

Journal Article Environmental science & technology · June 2022 Plastic packaging material is widely used to package high-temperature soup food in China, but this combination might lead to increased exposure to phthalates. The health effects and potential biological mechanisms have not been well studied. This study aim ... Full text Cite

Empirical dynamic modeling of the association between ambient PM2.5 and under-five mortality across 2851 counties in Mainland China, 1999-2012.

Journal Article Ecotoxicology and environmental safety · June 2022 BackgroundAmbient fine particulate matter (PM2.5) pollution has been associated with mortality from various diseases, however, its association with under-five mortality rate (U5MR) has remained largely unknown.MethodsBased on t ... Full text Cite

Global burden of chronic obstructive pulmonary disease attributable to ambient particulate matter pollution and household air pollution from solid fuels from 1990 to 2019.

Journal Article Environmental science and pollution research international · May 2022 We aimed to estimate the spatiotemporal trends in the global burden of chronic obstructive pulmonary disease (COPD) attributable to both household air pollution from solid fuels (HAP) and ambient particulate matter (APM) from 1990 to 2019 and compared the ... Full text Cite

Interactive effects of cold spell and air pollution on outpatient visits for anxiety in three subtropical Chinese cities.

Journal Article The Science of the total environment · April 2022 BackgroundAlthough low temperature and air pollution exposures have been associated with the risk of anxiety, their combined effects remain unclear.ObjectiveTo investigate the independent and interactive effects of low temperature and air ... Full text Cite

Comparison of 19 major infectious diseases during COVID-19 epidemic and previous years in Zhejiang, implications for prevention measures.

Journal Article BMC infectious diseases · March 2022 BackgroundThe global pandemic of coronavirus disease 2019 (COVID-19) has attracted great public health efforts across the world. Few studies, however, have described the potential impact of these measures on other important infectious diseases. Full text Cite