Journal ArticleStroke · August 2024
BACKGROUND: Genetic association studies can reveal biology and treatment targets but have received limited attention for stroke recovery. STRONG (Stroke, Stress, Rehabilitation, and Genetics) was a prospective, longitudinal (1-year), genetic study in adult ...
Full textLink to itemCite
Journal ArticleAm Heart J · March 2024
BACKGROUND: Despite guidelines and strong evidence supporting intravenous thrombolysis and endovascular thrombectomy for acute stroke, access to these interventions remains a challenge. The objective of the IMPROVE stroke care program was to accelerate acu ...
Full textLink to itemCite
Journal ArticleTransl Stroke Res · December 2023
Near-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are man ...
Full textLink to itemCite
Journal ArticleStroke · December 2023
BACKGROUND: Survivors of intracerebral hemorrhage (ICH) face an increased risk of ischemic cardiovascular events. Current ICH guidelines do not provide definitive recommendations regarding the use of antithrombotic and statin therapies. We, therefore, soug ...
Full textLink to itemCite
Journal ArticleJAMA · June 20, 2023
IMPORTANCE: Use of oral vitamin K antagonists (VKAs) may place patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke caused by large vessel occlusion at increased risk of complications. OBJECTIVE: To determine the association betwee ...
Full textLink to itemCite
Journal ArticleStroke · March 2023
BACKGROUND: Stroke is a leading cause of long-term disability. Greater rehabilitation therapy after stroke is known to improve functional outcomes. This study examined therapy doses during the first year of stroke recovery and identified factors that predi ...
Full textLink to itemCite
Journal ArticleAnnals of Internal Medicine Clinical Cases · December 1, 2022
Cryptogenic stroke of undetermined cause should warrant an exhaustive neurologic and cardiovascular workup. If no cause is identified, additional investigations should be individualized on the basis of clinical history and objective findings. Herein, we pr ...
Full textOpen AccessCite
Journal ArticleStroke Vasc Neurol · October 2022
INTRODUCTION: Current guidelines recommend blood pressure (BP) lowering in patients after acute intracerebral haemorrhage (ICH) without guidance on initial choice of antihypertensive class. This study sought to determine if initial antihypertensive class d ...
Full textLink to itemCite
Journal ArticleJ Clin Neurosci · July 2022
Perioperative ischemic stroke significantly increases morbidity and mortality in patients undergoing elective surgery. Mechanical thrombectomy can improve ischemic stroke outcomes, but frequency and trend of its utilization for treatment of perioperative i ...
Full textOpen AccessLink to itemCite
Journal ArticleNeurology · April 19, 2022
BACKGROUND AND OBJECTIVES: Prior regional or single-center studies have noted that 4% to 7% of eligible patients with acute ischemic stroke (AIS) decline IV tissue plasminogen activator (tPA). We sought to determine the prevalence of tPA declination in a n ...
Full textOpen AccessLink to itemCite
Journal ArticleAm J Emerg Med · February 2022
BACKGROUND: The optimal approach to blood pressure (BP) management in acute ischemic stroke remains unclear. The purpose of this study was to determine if an intermittent (labetalol or hydralazine) or continuous infusion (nicardipine or clevidipine) antihy ...
Full textLink to itemCite
Journal ArticleStroke · December 2021
BACKGROUND AND PURPOSE: In 2018, 2 randomized controlled trials showed the benefit of endovascular thrombectomy (EVT) in acute ischemic stroke patients treated 6 to 24 hours from last known well using imaging-guided selection. However, little is known abou ...
Full textLink to itemCite
ConferenceStroke · November 2021
BACKGROUND AND PURPOSE: Patients with prestroke mobility impairment (PSMI) were excluded from endovascular clinical trials. There are limited data regarding safety and outcomes of endovascular thrombectomy in this population. We used a large, national data ...
Full textLink to itemCite
Journal ArticleStroke · November 2021
Background and Purpose:Patients with prestroke mobility impairment (PSMI) were excluded from endovascular clinical trials. There are limited data regarding safety and outcomes of endovasc ...
Full textCite
Journal ArticleNeurohospitalist · October 2021
BACKGROUND AND PURPOSE: Rates of emergency medical services (EMS) utilization for acute stroke remain low nationwide, despite the time-sensitive nature of the disease. Prior research suggests several demographic and social factors are associated with EMS u ...
Full textLink to itemCite
Journal ArticleStroke Vasc Neurol · September 2021
BACKGROUND AND PURPOSE: Depression is common after stroke and is often treated with antidepressant medications (AD). ADs have also been hypothesised to improve stroke recovery, although recent randomised trials were neutral. We investigated the patterns of ...
Full textLink to itemCite
Journal ArticleJ Card Fail · August 2021
BACKGROUND: The safety and effectiveness of oral anticoagulation (OAC) after an ischemic stroke in older patients with heart failure (HF) without atrial fibrillation remains uncertain. METHODS: Utilizing Get With The Guidelines Stroke national clinical reg ...
Full textLink to itemCite
Journal ArticleStroke Vasc Neurol · June 2021
BACKGROUND: Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack (TIA) and role of ABCD2 score in identifying high-risk individuals are not studied. METHODS: We identified 40 825 Medicare beneficiaries hospitalised fro ...
Full textLink to itemCite
Journal ArticleJ Adv Nurs · June 2021
AIMS: Stroke is affecting an increasing number of young and middle-aged adults. Given the substantial diversion from anticipated life trajectories that younger stroke survivors experience as a result of their stroke deficits, their health-related quality o ...
Full textLink to itemCite
Journal ArticleStroke · August 2024
BACKGROUND: Genetic association studies can reveal biology and treatment targets but have received limited attention for stroke recovery. STRONG (Stroke, Stress, Rehabilitation, and Genetics) was a prospective, longitudinal (1-year), genetic study in adult ...
Full textLink to itemCite
Journal ArticleAm Heart J · March 2024
BACKGROUND: Despite guidelines and strong evidence supporting intravenous thrombolysis and endovascular thrombectomy for acute stroke, access to these interventions remains a challenge. The objective of the IMPROVE stroke care program was to accelerate acu ...
Full textLink to itemCite
Journal ArticleTransl Stroke Res · December 2023
Near-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are man ...
Full textLink to itemCite
Journal ArticleStroke · December 2023
BACKGROUND: Survivors of intracerebral hemorrhage (ICH) face an increased risk of ischemic cardiovascular events. Current ICH guidelines do not provide definitive recommendations regarding the use of antithrombotic and statin therapies. We, therefore, soug ...
Full textLink to itemCite
Journal ArticleJAMA · June 20, 2023
IMPORTANCE: Use of oral vitamin K antagonists (VKAs) may place patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke caused by large vessel occlusion at increased risk of complications. OBJECTIVE: To determine the association betwee ...
Full textLink to itemCite
Journal ArticleStroke · March 2023
BACKGROUND: Stroke is a leading cause of long-term disability. Greater rehabilitation therapy after stroke is known to improve functional outcomes. This study examined therapy doses during the first year of stroke recovery and identified factors that predi ...
Full textLink to itemCite
Journal ArticleAnnals of Internal Medicine Clinical Cases · December 1, 2022
Cryptogenic stroke of undetermined cause should warrant an exhaustive neurologic and cardiovascular workup. If no cause is identified, additional investigations should be individualized on the basis of clinical history and objective findings. Herein, we pr ...
Full textOpen AccessCite
Journal ArticleStroke Vasc Neurol · October 2022
INTRODUCTION: Current guidelines recommend blood pressure (BP) lowering in patients after acute intracerebral haemorrhage (ICH) without guidance on initial choice of antihypertensive class. This study sought to determine if initial antihypertensive class d ...
Full textLink to itemCite
Journal ArticleJ Clin Neurosci · July 2022
Perioperative ischemic stroke significantly increases morbidity and mortality in patients undergoing elective surgery. Mechanical thrombectomy can improve ischemic stroke outcomes, but frequency and trend of its utilization for treatment of perioperative i ...
Full textOpen AccessLink to itemCite
Journal ArticleNeurology · April 19, 2022
BACKGROUND AND OBJECTIVES: Prior regional or single-center studies have noted that 4% to 7% of eligible patients with acute ischemic stroke (AIS) decline IV tissue plasminogen activator (tPA). We sought to determine the prevalence of tPA declination in a n ...
Full textOpen AccessLink to itemCite
Journal ArticleAm J Emerg Med · February 2022
BACKGROUND: The optimal approach to blood pressure (BP) management in acute ischemic stroke remains unclear. The purpose of this study was to determine if an intermittent (labetalol or hydralazine) or continuous infusion (nicardipine or clevidipine) antihy ...
Full textLink to itemCite
Journal ArticleStroke · December 2021
BACKGROUND AND PURPOSE: In 2018, 2 randomized controlled trials showed the benefit of endovascular thrombectomy (EVT) in acute ischemic stroke patients treated 6 to 24 hours from last known well using imaging-guided selection. However, little is known abou ...
Full textLink to itemCite
ConferenceStroke · November 2021
BACKGROUND AND PURPOSE: Patients with prestroke mobility impairment (PSMI) were excluded from endovascular clinical trials. There are limited data regarding safety and outcomes of endovascular thrombectomy in this population. We used a large, national data ...
Full textLink to itemCite
Journal ArticleStroke · November 2021
Background and Purpose:Patients with prestroke mobility impairment (PSMI) were excluded from endovascular clinical trials. There are limited data regarding safety and outcomes of endovasc ...
Full textCite
Journal ArticleNeurohospitalist · October 2021
BACKGROUND AND PURPOSE: Rates of emergency medical services (EMS) utilization for acute stroke remain low nationwide, despite the time-sensitive nature of the disease. Prior research suggests several demographic and social factors are associated with EMS u ...
Full textLink to itemCite
Journal ArticleStroke Vasc Neurol · September 2021
BACKGROUND AND PURPOSE: Depression is common after stroke and is often treated with antidepressant medications (AD). ADs have also been hypothesised to improve stroke recovery, although recent randomised trials were neutral. We investigated the patterns of ...
Full textLink to itemCite
Journal ArticleJ Card Fail · August 2021
BACKGROUND: The safety and effectiveness of oral anticoagulation (OAC) after an ischemic stroke in older patients with heart failure (HF) without atrial fibrillation remains uncertain. METHODS: Utilizing Get With The Guidelines Stroke national clinical reg ...
Full textLink to itemCite
Journal ArticleStroke Vasc Neurol · June 2021
BACKGROUND: Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack (TIA) and role of ABCD2 score in identifying high-risk individuals are not studied. METHODS: We identified 40 825 Medicare beneficiaries hospitalised fro ...
Full textLink to itemCite
Journal ArticleJ Adv Nurs · June 2021
AIMS: Stroke is affecting an increasing number of young and middle-aged adults. Given the substantial diversion from anticipated life trajectories that younger stroke survivors experience as a result of their stroke deficits, their health-related quality o ...
Full textLink to itemCite
Journal ArticleEur J Neurol · June 2021
BACKGROUND AND PURPOSE: According to evidence-based clinical practice guidelines, patients presenting with disabling stroke symptoms should be treated with intravenous tissue plasminogen activator (IV tPA) within 4.5 h of time last known well. However, 25% ...
Full textLink to itemCite
Journal ArticleN Engl J Med · January 14, 2021
BACKGROUND: The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS: We randomly assigne ...
Full textLink to itemCite
Journal ArticleInt J Cardiol · December 15, 2020
BACKGROUND: To determine association of discharge antiplatelet therapy prescription with 1-year outcomes among patients with AF admitted with acute ischemic stroke and discharged without oral anticoagulation. METHODS: In a retrospective cohort study from t ...
Full textLink to itemCite
Journal ArticleJAMA Neurol · December 1, 2020
IMPORTANCE: A significant proportion of acute ischemic strokes occur while patients are hospitalized. Limited contemporary data exist on the utilization rates of intravenous thrombolysis or endovascular therapy for in-hospital stroke. OBJECTIVE: To use a n ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Stroke Cerebrovasc Dis · December 2020
BACKGROUND: Limited real-world data are available on outcomes following non-cardioembolic minor ischemic stroke (IS) or high-risk transient ischemic attack (TIA), particularly in the United States (US). We examined outcomes and Medicare payments following ...
Full textLink to itemCite
Journal ArticleExp Neurol · June 2020
BACKGROUND: S-Nitrosoglutathione (GSNO) is a nitric oxide donor that has been investigated for neuroprotective and neuro-recovery effect. We aimed to conduct a systematic review on the published literatures using GSNO in both pre-clinical and clinical stro ...
Full textLink to itemCite
Journal ArticleAnn Neurol · June 2020
OBJECTIVE: Elevated systolic blood pressure (SBP) after successful revascularization (SR) via endovascular therapy (EVT) is a known predictor of poor outcome. However, the optimal SBP goal following EVT is still unknown. Our objective was to compare functi ...
Full textLink to itemCite
Journal ArticleAm Heart J · April 2020
The AHA Guidelines recommend developing multi-tiered systems for the care of patients with acute stroke.1 An ideal stroke system of care should ensure that all patients receive the most efficient and timely care, regardless of how they first enter or acces ...
Full textLink to itemCite
Journal ArticleStroke · April 2020
Background and Purpose- Selective serotonin reuptake inhibitors (SSRIs) have a well-established association with bleeding complications and conflicting reports on outcome after stroke. We sought to evaluate whether pre-intracerebral hemorrhage (ICH) SSRI u ...
Full textLink to itemCite
Journal ArticleNeurocrit Care · February 2020
The Fifth Neurocritical Care Research Network (NCRN) Conference held in Boca Raton, Florida, in September of 2018 was devoted to challenging the current status quo and examining the role of the Neurocritical Care Society (NCS) in driving the science and re ...
Full textLink to itemCite
Journal ArticleCirc Cardiovasc Qual Outcomes · January 2020
Background Guidelines recommend against the use of intravenous tPA (tissue-type plasminogen activator; IV tPA) in acute ischemic stroke patients with prior ischemic stroke within 3 months. However, there are limited data on the safety of IV tPA in this pop ...
Full textLink to itemCite
Journal ArticleJAMA Neurol · October 1, 2019
IMPORTANCE: Current guidelines recommend direct oral anticoagulants (DOACs) over warfarin for stroke prevention in patients with atrial fibrillation (AF) who are at high risk. Despite demonstrated efficacy in clinical trials, real-world data of DOACs vs wa ...
Full textOpen AccessLink to itemCite
Journal ArticleNeurology · August 20, 2019
OBJECTIVE: To determine whether lower socioeconomic status (SES) and longer home to hospital driving time are associated with reductions in tissue plasminogen activator (tPA) administration and timeliness of the treatment. METHODS: We conducted a retrospec ...
Full textOpen AccessLink to itemCite
Journal ArticleCirculation · March 26, 2019
BACKGROUND: The use of endovascular therapy (EVT) in patients with acute ischemic stroke who have large vessel occlusion has rapidly increased in the United States following pivotal trials demonstrating its benefit. Information about the contribution of in ...
Full textLink to itemCite
Journal ArticleCirc Cardiovasc Qual Outcomes · June 2018
BACKGROUND: To improve stroke care, the Brain Attack Coalition recommended establishing primary stroke center (PSC) and comprehensive stroke center (CSC) certification. This study aimed to compare ischemic stroke care and in-hospital outcomes between CSCs ...
Full textLink to itemCite
Journal ArticlePLoS One · 2017
INTRODUCTION: Interpretation of the extent of perfusion deficits in stroke MRI is highly dependent on the method used for analyzing the perfusion-weighted signal intensity time-series after gadolinium injection. In this study, we introduce a new model-free ...
Full textLink to itemCite
Journal ArticleSemin Neurol · December 2016
Brain swelling is an urgent clinical problem that frequently accompanies ischemic stroke, brain hemorrhage, and traumatic brain injury; it increases morbidity and mortality associated with them. It occurs due to failure of membrane transporters and leakage ...
Full textLink to itemCite
Journal ArticleTransl Stroke Res · December 2015
Most early phase trials in stroke and brain trauma have failed in phase 3, including efforts to improve acute ischemic stroke outcomes beyond that achieved by intravenous recombinant tissue plasminogen activator (t-PA) (IVT). With the exception of more rec ...
Full textLink to itemCite
Journal ArticleJ Intensive Care Med · September 2015
Neurogenic stunned myocardium (NSM) is a triad of transient left ventricular dysfunction, electrocardiogram changes, and elevation in cardiac enzymes, often mimicking a myocardial infarction. It has been described following acute brain injury. The purporte ...
Full textLink to itemCite
Journal ArticleNeurology · July 21, 2015
This review addresses decision-making underlying the frequent failure to confirm early-phase positive trial results and how to prioritize which early agents to transition to late phase. While unexpected toxicity is sometimes responsible for late-phase fail ...
Full textLink to itemCite
Journal ArticleNeurology · June 16, 2015
OBJECTIVE: The objective of this study was to demonstrate the feasibility of timely multimodal MRI screening before thrombolysis in acute stroke patients. METHODS: Quality improvement processes were initiated in 2013 to reduce door-to-needle (DTN) time at ...
Full textLink to itemCite
Journal ArticleJ Clin Neurosci · March 2015
Featured Publication
Data on thrombolysis outcomes in patients with primary brain tumors are limited. Our aim was to study stroke outcomes following thrombolysis in these patients in a population-based study. Patients with acute ischemic stroke who received thrombolysis were i ...
Full textLink to itemCite
Journal ArticleJ Clin Neurosci · December 2014
Featured Publication
Cocaine use is associated with higher mortality in small retrospective studies of brain-injured patients. We aimed to explore in-hospital outcomes in a large population based study of aneurysmal subarachnoid hemorrhage (aSAH) with cocaine use. aSAH patient ...
Full textLink to itemCite
Journal ArticleJ Clin Neurosci · August 2014
Featured Publication
Neurogenic stunned myocardium (NSM) after subarachnoid hemorrhage (SAH) is well known, but there is a paucity of data regarding its occurrence following acute stroke. The aim of this study is to investigate the clinical characteristics of NSM in acute non- ...
Full textLink to itemCite
Journal ArticleJ Clin Neurosci · February 2014
Featured Publication
The SILK flow diverter (SFD; Balt Extrusion, Montmorency, France) is a flow diverting stent used in the endovascular treatment of intracranial aneurysms. It works on the principle of redirecting flow away from the aneurysm sac, leading to occlusion over ti ...
Full textLink to itemCite
Journal ArticleJ Clin Neurosci · January 2014
Featured Publication
The pipeline embolization device (PED; ev3 Endovascular, Plymouth, MN, USA) is a flow-diverter used in the endovascular treatment of intracranial aneurysms, particularly those with unfavorable configurations. It causes progressive flow redirection leading ...
Full textLink to itemCite
Journal ArticleStroke · December 2013
Featured Publication
BACKGROUND AND PURPOSE: The safety of thrombolysis for acute stroke in patients with cancer is not well established. Our aim is to study the outcomes after thrombolysis in patients with stroke with cancer. METHODS: Patients with acute ischemic stroke who r ...
Full textLink to itemCite
Journal ArticleJ Neurointerv Surg · November 2013
Featured Publication
Thrombosed aneurysms are difficult to visualize with digital subtraction angiography. We report a case of subarachnoid hemorrhage from a thrombosed ruptured aneurysm which was undetected on digital subtraction angiography but was visualized with cone beam ...
Full textLink to itemCite
Journal ArticleBMJ Case Rep · January 11, 2013
Thrombosed aneurysms are difficult to visualize with digital subtraction angiography. We report a case of subarachnoid hemorrhage from a thrombosed ruptured aneurysm which was undetected on digital subtraction angiography but was visualized with cone beam ...
Full textLink to itemCite
Journal ArticleJ Clin Neurosci · January 2013
Infarctions of the corpus callosum are rare. The clinical picture varies from an acute onset to slow evolving symptoms, frequently with poor localizing signs; however, the location of the infarct in the callosum often correlates with a specific etiology. W ...
Full textLink to itemCite
Journal ArticleWorld Neurosurg · 2013
Featured Publication
OBJECTIVE: Malignant middle cerebral artery infarction (mMCAI) is a life-threatening condition in pediatric patients. Despite strong evidence showing decreased morbidity and mortality in adult mMCAI patients with decompressive hemicraniectomy (DCH), there ...
Full textLink to itemCite
Journal ArticleLearn Mem · 2011
Featured Publication
Long-term memory and plasticity, including long-term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse, depend on the activation of transcription factors that regulate genes necessary for synaptic plasticity. In the present study we found tha ...
Full textLink to itemCite
Journal ArticleCases J · June 16, 2009
Fungal infections of the central nervous system are an uncommon cause of rapid decline in consciousness. We describe the case of central nervous system aspergillosis in a patient on immunosupressants whose clinical course highlights the need for an aggress ...
Full textLink to itemCite
Journal ArticleJ Neurosci · February 20, 2008
The transcription factor cAMP response element (CRE)-binding protein (CREB) plays an essential role in the induction of many forms of long-term synaptic plasticity. Levels of CREB1, the Aplysia homolog of CREB, show sustained elevations for several hours a ...
Full textLink to itemCite