Scholars@Duke
Shreyansh Shah

Shreyansh Shah

Assistant Professor of Neurology
Neurology, Neurocritical Care
shreyansh.shah@duke.edu
Duke University Medical Center, Box 3824, Durham, NC 27710
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Selected Publications

Genetic Variation and Stroke Recovery: The STRONG Study.

Journal Article Stroke · August 2024 BACKGROUND: Genetic association studies can reveal biology and treatment targets but have received limited attention for stroke recovery. STRONG (Stroke, Stress, Rehabilitation, and Genetics) was a prospective, longitudinal (1-year), genetic study in adult ... Full text Link to item Cite

Regionalization of stroke systems of care in the stroke belt states: The IMPROVE stroke care quality improvement program.

Journal Article Am Heart J · March 2024 BACKGROUND: Despite guidelines and strong evidence supporting intravenous thrombolysis and endovascular thrombectomy for acute stroke, access to these interventions remains a challenge. The objective of the IMPROVE stroke care program was to accelerate acu ... Full text Link to item Cite

Revisiting Transcranial Light Stimulation as a Stroke Therapeutic-Hurdles and Opportunities.

Journal Article Transl Stroke Res · December 2023 Near-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are man ... Full text Link to item Cite

Antithrombotic and Statin Prescription After Intracerebral Hemorrhage in the Get With The Guidelines-Stroke Registry.

Journal Article Stroke · December 2023 BACKGROUND: Survivors of intracerebral hemorrhage (ICH) face an increased risk of ischemic cardiovascular events. Current ICH guidelines do not provide definitive recommendations regarding the use of antithrombotic and statin therapies. We, therefore, soug ... Full text Link to item Cite

Recent Vitamin K Antagonist Use and Intracranial Hemorrhage After Endovascular Thrombectomy for Acute Ischemic Stroke.

Journal Article JAMA · June 20, 2023 IMPORTANCE: Use of oral vitamin K antagonists (VKAs) may place patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke caused by large vessel occlusion at increased risk of complications. OBJECTIVE: To determine the association betwee ... Full text Link to item Cite

Rehabilitation Therapy Doses Are Low After Stroke and Predicted by Clinical Factors.

Journal Article Stroke · March 2023 BACKGROUND: Stroke is a leading cause of long-term disability. Greater rehabilitation therapy after stroke is known to improve functional outcomes. This study examined therapy doses during the first year of stroke recovery and identified factors that predi ... Full text Link to item Cite

Recurrent Cryptogenic Stroke in a Young Woman: Congenital Thrombotic Thrombocytopenic Purpura Unmasked

Journal Article Annals of Internal Medicine Clinical Cases · December 1, 2022 Cryptogenic stroke of undetermined cause should warrant an exhaustive neurologic and cardiovascular workup. If no cause is identified, additional investigations should be individualized on the basis of clinical history and objective findings. Herein, we pr ... Full text Open Access Cite

Initial antihypertensive agent effects on acute blood pressure after intracerebral haemorrhage.

Journal Article Stroke Vasc Neurol · October 2022 INTRODUCTION: Current guidelines recommend blood pressure (BP) lowering in patients after acute intracerebral haemorrhage (ICH) without guidance on initial choice of antihypertensive class. This study sought to determine if initial antihypertensive class d ... Full text Link to item Cite

Mechanical thrombectomy for perioperative ischemic stroke following elective inpatient surgery in the United States.

Journal Article J Clin Neurosci · July 2022 Perioperative ischemic stroke significantly increases morbidity and mortality in patients undergoing elective surgery. Mechanical thrombectomy can improve ischemic stroke outcomes, but frequency and trend of its utilization for treatment of perioperative i ... Full text Open Access Link to item Cite

Race-Ethnic Disparities in Rates of Declination of Thrombolysis for Stroke.

Journal Article Neurology · April 19, 2022 BACKGROUND AND OBJECTIVES: Prior regional or single-center studies have noted that 4% to 7% of eligible patients with acute ischemic stroke (AIS) decline IV tissue plasminogen activator (tPA). We sought to determine the prevalence of tPA declination in a n ... Full text Open Access Link to item Cite

Comparison of intermittent versus continuous infusion antihypertensives in acute ischemic stroke.

Journal Article Am J Emerg Med · February 2022 BACKGROUND: The optimal approach to blood pressure (BP) management in acute ischemic stroke remains unclear. The purpose of this study was to determine if an intermittent (labetalol or hydralazine) or continuous infusion (nicardipine or clevidipine) antihy ... Full text Link to item Cite

Frequency, Characteristics, and Outcomes of Endovascular Thrombectomy in Patients With Stroke Beyond 6 Hours of Onset in US Clinical Practice.

Journal Article Stroke · December 2021 BACKGROUND AND PURPOSE: In 2018, 2 randomized controlled trials showed the benefit of endovascular thrombectomy (EVT) in acute ischemic stroke patients treated 6 to 24 hours from last known well using imaging-guided selection. However, little is known abou ... Full text Link to item Cite

Outcomes of Endovascular Therapy in Patients With Prestroke Mobility Impairment.

Conference Stroke · November 2021 BACKGROUND AND PURPOSE: Patients with prestroke mobility impairment (PSMI) were excluded from endovascular clinical trials. There are limited data regarding safety and outcomes of endovascular thrombectomy in this population. We used a large, national data ... Full text Link to item Cite

Outcomes of Endovascular Therapy in Patients With Prestroke Mobility Impairment

Journal Article Stroke · November 2021 Background and Purpose:Patients with prestroke mobility impairment (PSMI) were excluded from endovascular clinical trials. There are limited data regarding safety and outcomes of endovasc ... Full text Cite

Socioeconomic Influence on Emergency Medical Services Utilization for Acute Stroke: Think Nationally, Act Locally.

Journal Article Neurohospitalist · October 2021 BACKGROUND AND PURPOSE: Rates of emergency medical services (EMS) utilization for acute stroke remain low nationwide, despite the time-sensitive nature of the disease. Prior research suggests several demographic and social factors are associated with EMS u ... Full text Link to item Cite

Patterns of antidepressant therapy and clinical outcomes among ischaemic stroke survivors.

Journal Article Stroke Vasc Neurol · September 2021 BACKGROUND AND PURPOSE: Depression is common after stroke and is often treated with antidepressant medications (AD). ADs have also been hypothesised to improve stroke recovery, although recent randomised trials were neutral. We investigated the patterns of ... Full text Link to item Cite

Oral Anticoagulation and Adverse Outcomes after Ischemic Stroke in Heart Failure Patients without Atrial Fibrillation.

Journal Article J Card Fail · August 2021 BACKGROUND: The safety and effectiveness of oral anticoagulation (OAC) after an ischemic stroke in older patients with heart failure (HF) without atrial fibrillation remains uncertain. METHODS: Utilizing Get With The Guidelines Stroke national clinical reg ... Full text Link to item Cite

Outcomes of Medicare beneficiaries hospitalised with transient ischaemic attack and stratification using the ABCD2 score.

Journal Article Stroke Vasc Neurol · June 2021 BACKGROUND: Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack (TIA) and role of ABCD2 score in identifying high-risk individuals are not studied. METHODS: We identified 40 825 Medicare beneficiaries hospitalised fro ... Full text Link to item Cite

Socio-ecological perspective on factors influencing acute recovery of younger stroke survivors: A mixed methods study.

Journal Article J Adv Nurs · June 2021 AIMS: Stroke is affecting an increasing number of young and middle-aged adults. Given the substantial diversion from anticipated life trajectories that younger stroke survivors experience as a result of their stroke deficits, their health-related quality o ... Full text Link to item Cite

Genetic Variation and Stroke Recovery: The STRONG Study.

Journal Article Stroke · August 2024 BACKGROUND: Genetic association studies can reveal biology and treatment targets but have received limited attention for stroke recovery. STRONG (Stroke, Stress, Rehabilitation, and Genetics) was a prospective, longitudinal (1-year), genetic study in adult ... Full text Link to item Cite

Regionalization of stroke systems of care in the stroke belt states: The IMPROVE stroke care quality improvement program.

Journal Article Am Heart J · March 2024 BACKGROUND: Despite guidelines and strong evidence supporting intravenous thrombolysis and endovascular thrombectomy for acute stroke, access to these interventions remains a challenge. The objective of the IMPROVE stroke care program was to accelerate acu ... Full text Link to item Cite

Revisiting Transcranial Light Stimulation as a Stroke Therapeutic-Hurdles and Opportunities.

Journal Article Transl Stroke Res · December 2023 Near-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are man ... Full text Link to item Cite

Antithrombotic and Statin Prescription After Intracerebral Hemorrhage in the Get With The Guidelines-Stroke Registry.

Journal Article Stroke · December 2023 BACKGROUND: Survivors of intracerebral hemorrhage (ICH) face an increased risk of ischemic cardiovascular events. Current ICH guidelines do not provide definitive recommendations regarding the use of antithrombotic and statin therapies. We, therefore, soug ... Full text Link to item Cite

Recent Vitamin K Antagonist Use and Intracranial Hemorrhage After Endovascular Thrombectomy for Acute Ischemic Stroke.

Journal Article JAMA · June 20, 2023 IMPORTANCE: Use of oral vitamin K antagonists (VKAs) may place patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke caused by large vessel occlusion at increased risk of complications. OBJECTIVE: To determine the association betwee ... Full text Link to item Cite

Rehabilitation Therapy Doses Are Low After Stroke and Predicted by Clinical Factors.

Journal Article Stroke · March 2023 BACKGROUND: Stroke is a leading cause of long-term disability. Greater rehabilitation therapy after stroke is known to improve functional outcomes. This study examined therapy doses during the first year of stroke recovery and identified factors that predi ... Full text Link to item Cite

Recurrent Cryptogenic Stroke in a Young Woman: Congenital Thrombotic Thrombocytopenic Purpura Unmasked

Journal Article Annals of Internal Medicine Clinical Cases · December 1, 2022 Cryptogenic stroke of undetermined cause should warrant an exhaustive neurologic and cardiovascular workup. If no cause is identified, additional investigations should be individualized on the basis of clinical history and objective findings. Herein, we pr ... Full text Open Access Cite

Initial antihypertensive agent effects on acute blood pressure after intracerebral haemorrhage.

Journal Article Stroke Vasc Neurol · October 2022 INTRODUCTION: Current guidelines recommend blood pressure (BP) lowering in patients after acute intracerebral haemorrhage (ICH) without guidance on initial choice of antihypertensive class. This study sought to determine if initial antihypertensive class d ... Full text Link to item Cite

Mechanical thrombectomy for perioperative ischemic stroke following elective inpatient surgery in the United States.

Journal Article J Clin Neurosci · July 2022 Perioperative ischemic stroke significantly increases morbidity and mortality in patients undergoing elective surgery. Mechanical thrombectomy can improve ischemic stroke outcomes, but frequency and trend of its utilization for treatment of perioperative i ... Full text Open Access Link to item Cite

Race-Ethnic Disparities in Rates of Declination of Thrombolysis for Stroke.

Journal Article Neurology · April 19, 2022 BACKGROUND AND OBJECTIVES: Prior regional or single-center studies have noted that 4% to 7% of eligible patients with acute ischemic stroke (AIS) decline IV tissue plasminogen activator (tPA). We sought to determine the prevalence of tPA declination in a n ... Full text Open Access Link to item Cite

Comparison of intermittent versus continuous infusion antihypertensives in acute ischemic stroke.

Journal Article Am J Emerg Med · February 2022 BACKGROUND: The optimal approach to blood pressure (BP) management in acute ischemic stroke remains unclear. The purpose of this study was to determine if an intermittent (labetalol or hydralazine) or continuous infusion (nicardipine or clevidipine) antihy ... Full text Link to item Cite

Frequency, Characteristics, and Outcomes of Endovascular Thrombectomy in Patients With Stroke Beyond 6 Hours of Onset in US Clinical Practice.

Journal Article Stroke · December 2021 BACKGROUND AND PURPOSE: In 2018, 2 randomized controlled trials showed the benefit of endovascular thrombectomy (EVT) in acute ischemic stroke patients treated 6 to 24 hours from last known well using imaging-guided selection. However, little is known abou ... Full text Link to item Cite

Outcomes of Endovascular Therapy in Patients With Prestroke Mobility Impairment.

Conference Stroke · November 2021 BACKGROUND AND PURPOSE: Patients with prestroke mobility impairment (PSMI) were excluded from endovascular clinical trials. There are limited data regarding safety and outcomes of endovascular thrombectomy in this population. We used a large, national data ... Full text Link to item Cite

Outcomes of Endovascular Therapy in Patients With Prestroke Mobility Impairment

Journal Article Stroke · November 2021 Background and Purpose:Patients with prestroke mobility impairment (PSMI) were excluded from endovascular clinical trials. There are limited data regarding safety and outcomes of endovasc ... Full text Cite

Socioeconomic Influence on Emergency Medical Services Utilization for Acute Stroke: Think Nationally, Act Locally.

Journal Article Neurohospitalist · October 2021 BACKGROUND AND PURPOSE: Rates of emergency medical services (EMS) utilization for acute stroke remain low nationwide, despite the time-sensitive nature of the disease. Prior research suggests several demographic and social factors are associated with EMS u ... Full text Link to item Cite

Patterns of antidepressant therapy and clinical outcomes among ischaemic stroke survivors.

Journal Article Stroke Vasc Neurol · September 2021 BACKGROUND AND PURPOSE: Depression is common after stroke and is often treated with antidepressant medications (AD). ADs have also been hypothesised to improve stroke recovery, although recent randomised trials were neutral. We investigated the patterns of ... Full text Link to item Cite

Oral Anticoagulation and Adverse Outcomes after Ischemic Stroke in Heart Failure Patients without Atrial Fibrillation.

Journal Article J Card Fail · August 2021 BACKGROUND: The safety and effectiveness of oral anticoagulation (OAC) after an ischemic stroke in older patients with heart failure (HF) without atrial fibrillation remains uncertain. METHODS: Utilizing Get With The Guidelines Stroke national clinical reg ... Full text Link to item Cite

Outcomes of Medicare beneficiaries hospitalised with transient ischaemic attack and stratification using the ABCD2 score.

Journal Article Stroke Vasc Neurol · June 2021 BACKGROUND: Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack (TIA) and role of ABCD2 score in identifying high-risk individuals are not studied. METHODS: We identified 40 825 Medicare beneficiaries hospitalised fro ... Full text Link to item Cite

Socio-ecological perspective on factors influencing acute recovery of younger stroke survivors: A mixed methods study.

Journal Article J Adv Nurs · June 2021 AIMS: Stroke is affecting an increasing number of young and middle-aged adults. Given the substantial diversion from anticipated life trajectories that younger stroke survivors experience as a result of their stroke deficits, their health-related quality o ... Full text Link to item Cite

Thrombolytic therapy for wake-up stroke: A systematic review and meta-analysis.

Journal Article Eur J Neurol · June 2021 BACKGROUND AND PURPOSE: According to evidence-based clinical practice guidelines, patients presenting with disabling stroke symptoms should be treated with intravenous tissue plasminogen activator (IV tPA) within 4.5 h of time last known well. However, 25% ... Full text Link to item Cite

Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure.

Journal Article N Engl J Med · January 14, 2021 BACKGROUND: The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS: We randomly assigne ... Full text Link to item Cite

Antiplatelet patterns and outcomes in patients with atrial fibrillation not prescribed an anticoagulant after stroke.

Journal Article Int J Cardiol · December 15, 2020 BACKGROUND: To determine association of discharge antiplatelet therapy prescription with 1-year outcomes among patients with AF admitted with acute ischemic stroke and discharged without oral anticoagulation. METHODS: In a retrospective cohort study from t ... Full text Link to item Cite

Trends in Reperfusion Therapy for In-Hospital Ischemic Stroke in the Endovascular Therapy Era.

Journal Article JAMA Neurol · December 1, 2020 IMPORTANCE: A significant proportion of acute ischemic strokes occur while patients are hospitalized. Limited contemporary data exist on the utilization rates of intravenous thrombolysis or endovascular therapy for in-hospital stroke. OBJECTIVE: To use a n ... Full text Open Access Link to item Cite

Disease Burden Following Non-Cardioembolic Minor Ischemic Stroke or High-Risk TIA: A GWTG-Stroke Study.

Journal Article J Stroke Cerebrovasc Dis · December 2020 BACKGROUND: Limited real-world data are available on outcomes following non-cardioembolic minor ischemic stroke (IS) or high-risk transient ischemic attack (TIA), particularly in the United States (US). We examined outcomes and Medicare payments following ... Full text Link to item Cite

Investigation of S-Nitrosoglutathione in stroke: A systematic review and meta-analysis of literature in pre-clinical and clinical research.

Journal Article Exp Neurol · June 2020 BACKGROUND: S-Nitrosoglutathione (GSNO) is a nitric oxide donor that has been investigated for neuroprotective and neuro-recovery effect. We aimed to conduct a systematic review on the published literatures using GSNO in both pre-clinical and clinical stro ... Full text Link to item Cite

Blood Pressure Goals and Clinical Outcomes after Successful Endovascular Therapy: A Multicenter Study.

Journal Article Ann Neurol · June 2020 OBJECTIVE: Elevated systolic blood pressure (SBP) after successful revascularization (SR) via endovascular therapy (EVT) is a known predictor of poor outcome. However, the optimal SBP goal following EVT is still unknown. Our objective was to compare functi ... Full text Link to item Cite

Implementation of Best Practices-Developing and Optimizing Regional Systems of Stroke Care: Design and Methodology.

Journal Article Am Heart J · April 2020 The AHA Guidelines recommend developing multi-tiered systems for the care of patients with acute stroke.1 An ideal stroke system of care should ensure that all patients receive the most efficient and timely care, regardless of how they first enter or acces ... Full text Link to item Cite

Selective Serotonin Reuptake Inhibitors and Intracerebral Hemorrhage Risk and Outcome.

Journal Article Stroke · April 2020 Background and Purpose- Selective serotonin reuptake inhibitors (SSRIs) have a well-established association with bleeding complications and conflicting reports on outcome after stroke. We sought to evaluate whether pre-intracerebral hemorrhage (ICH) SSRI u ... Full text Link to item Cite

The Future of Neurocritical Care Research: Proceedings and Recommendations from the Fifth Neurocritical Care Research Network Conference.

Journal Article Neurocrit Care · February 2020 The Fifth Neurocritical Care Research Network (NCRN) Conference held in Boca Raton, Florida, in September of 2018 was devoted to challenging the current status quo and examining the role of the Neurocritical Care Society (NCS) in driving the science and re ... Full text Link to item Cite

Safety and Outcomes of Intravenous tPA in Acute Ischemic Stroke Patients With Prior Stroke Within 3 Months: Findings From Get With The Guidelines-Stroke.

Journal Article Circ Cardiovasc Qual Outcomes · January 2020 Background Guidelines recommend against the use of intravenous tPA (tissue-type plasminogen activator; IV tPA) in acute ischemic stroke patients with prior ischemic stroke within 3 months. However, there are limited data on the safety of IV tPA in this pop ... Full text Link to item Cite

Clinical Effectiveness of Direct Oral Anticoagulants vs Warfarin in Older Patients With Atrial Fibrillation and Ischemic Stroke: Findings From the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study.

Journal Article JAMA Neurol · October 1, 2019 IMPORTANCE: Current guidelines recommend direct oral anticoagulants (DOACs) over warfarin for stroke prevention in patients with atrial fibrillation (AF) who are at high risk. Despite demonstrated efficacy in clinical trials, real-world data of DOACs vs wa ... Full text Open Access Link to item Cite

Hospital distance, socioeconomic status, and timely treatment of ischemic stroke.

Journal Article Neurology · August 20, 2019 OBJECTIVE: To determine whether lower socioeconomic status (SES) and longer home to hospital driving time are associated with reductions in tissue plasminogen activator (tPA) administration and timeliness of the treatment. METHODS: We conducted a retrospec ... Full text Open Access Link to item Cite

Use, Temporal Trends, and Outcomes of Endovascular Therapy After Interhospital Transfer in the United States.

Journal Article Circulation · March 26, 2019 BACKGROUND: The use of endovascular therapy (EVT) in patients with acute ischemic stroke who have large vessel occlusion has rapidly increased in the United States following pivotal trials demonstrating its benefit. Information about the contribution of in ... Full text Link to item Cite

Comparison of Acute Ischemic Stroke Care and Outcomes Between Comprehensive Stroke Centers and Primary Stroke Centers in the United States.

Journal Article Circ Cardiovasc Qual Outcomes · June 2018 BACKGROUND: To improve stroke care, the Brain Attack Coalition recommended establishing primary stroke center (PSC) and comprehensive stroke center (CSC) certification. This study aimed to compare ischemic stroke care and in-hospital outcomes between CSCs ... Full text Link to item Cite

Temporal similarity perfusion mapping: A standardized and model-free method for detecting perfusion deficits in stroke.

Journal Article PLoS One · 2017 INTRODUCTION: Interpretation of the extent of perfusion deficits in stroke MRI is highly dependent on the method used for analyzing the perfusion-weighted signal intensity time-series after gadolinium injection. In this study, we introduce a new model-free ... Full text Link to item Cite

Today's Approach to Treating Brain Swelling in the Neuro Intensive Care Unit.

Journal Article Semin Neurol · December 2016 Brain swelling is an urgent clinical problem that frequently accompanies ischemic stroke, brain hemorrhage, and traumatic brain injury; it increases morbidity and mortality associated with them. It occurs due to failure of membrane transporters and leakage ... Full text Link to item Cite

An Outcome Model for Intravenous rt-PA in Acute Ischemic Stroke.

Journal Article Transl Stroke Res · December 2015 Most early phase trials in stroke and brain trauma have failed in phase 3, including efforts to improve acute ischemic stroke outcomes beyond that achieved by intravenous recombinant tissue plasminogen activator (t-PA) (IVT). With the exception of more rec ... Full text Link to item Cite

Neurogenic Stunned Myocardium Following Acute Subarachnoid Hemorrhage: Pathophysiology and Practical Considerations.

Journal Article J Intensive Care Med · September 2015 Neurogenic stunned myocardium (NSM) is a triad of transient left ventricular dysfunction, electrocardiogram changes, and elevation in cardiac enzymes, often mimicking a myocardial infarction. It has been described following acute brain injury. The purporte ... Full text Link to item Cite

Improving early clinical trial phase identification of promising therapeutics.

Journal Article Neurology · July 21, 2015 This review addresses decision-making underlying the frequent failure to confirm early-phase positive trial results and how to prioritize which early agents to transition to late phase. While unexpected toxicity is sometimes responsible for late-phase fail ... Full text Link to item Cite

Screening with MRI for Accurate and Rapid Stroke Treatment: SMART.

Journal Article Neurology · June 16, 2015 OBJECTIVE: The objective of this study was to demonstrate the feasibility of timely multimodal MRI screening before thrombolysis in acute stroke patients. METHODS: Quality improvement processes were initiated in 2013 to reduce door-to-needle (DTN) time at ... Full text Link to item Cite

In-hospital outcomes of thrombolysis for acute ischemic stroke in patients with primary brain tumors.

Journal Article J Clin Neurosci · March 2015 Featured Publication Data on thrombolysis outcomes in patients with primary brain tumors are limited. Our aim was to study stroke outcomes following thrombolysis in these patients in a population-based study. Patients with acute ischemic stroke who received thrombolysis were i ... Full text Link to item Cite

Improving early clinical trial phase identification of promising therapeutics

Journal Article Neurology · 2015 Featured Publication Cite

In-hospital outcomes of aneurysmal subarachnoid hemorrhage associated with cocaine use in the USA.

Journal Article J Clin Neurosci · December 2014 Featured Publication Cocaine use is associated with higher mortality in small retrospective studies of brain-injured patients. We aimed to explore in-hospital outcomes in a large population based study of aneurysmal subarachnoid hemorrhage (aSAH) with cocaine use. aSAH patient ... Full text Link to item Cite

Clinical characteristics of myocardial stunning in acute stroke.

Journal Article J Clin Neurosci · August 2014 Featured Publication Neurogenic stunned myocardium (NSM) after subarachnoid hemorrhage (SAH) is well known, but there is a paucity of data regarding its occurrence following acute stroke. The aim of this study is to investigate the clinical characteristics of NSM in acute non- ... Full text Link to item Cite

The SILK flow diverter in the treatment of intracranial aneurysms.

Journal Article J Clin Neurosci · February 2014 Featured Publication The SILK flow diverter (SFD; Balt Extrusion, Montmorency, France) is a flow diverting stent used in the endovascular treatment of intracranial aneurysms. It works on the principle of redirecting flow away from the aneurysm sac, leading to occlusion over ti ... Full text Link to item Cite

Treatment of unruptured intracranial aneurysms with the pipeline embolization device.

Journal Article J Clin Neurosci · January 2014 Featured Publication The pipeline embolization device (PED; ev3 Endovascular, Plymouth, MN, USA) is a flow-diverter used in the endovascular treatment of intracranial aneurysms, particularly those with unfavorable configurations. It causes progressive flow redirection leading ... Full text Link to item Cite

Thrombolysis for acute ischemic stroke in patients with cancer: a population study.

Journal Article Stroke · December 2013 Featured Publication BACKGROUND AND PURPOSE: The safety of thrombolysis for acute stroke in patients with cancer is not well established. Our aim is to study the outcomes after thrombolysis in patients with stroke with cancer. METHODS: Patients with acute ischemic stroke who r ... Full text Link to item Cite

The utility of cone beam volume CT in the evaluation of thrombosed intracranial aneurysms in subarachnoid hemorrhage.

Journal Article J Neurointerv Surg · November 2013 Featured Publication Thrombosed aneurysms are difficult to visualize with digital subtraction angiography. We report a case of subarachnoid hemorrhage from a thrombosed ruptured aneurysm which was undetected on digital subtraction angiography but was visualized with cone beam ... Full text Link to item Cite

The utility of cone beam volume CT in the evaluation of thrombosed intracranial aneurysms in subarachnoid hemorrhage.

Journal Article BMJ Case Rep · January 11, 2013 Thrombosed aneurysms are difficult to visualize with digital subtraction angiography. We report a case of subarachnoid hemorrhage from a thrombosed ruptured aneurysm which was undetected on digital subtraction angiography but was visualized with cone beam ... Full text Link to item Cite

Clinical and radiologic spectrum of corpus callosum infarctions: clues to the etiology.

Journal Article J Clin Neurosci · January 2013 Infarctions of the corpus callosum are rare. The clinical picture varies from an acute onset to slow evolving symptoms, frequently with poor localizing signs; however, the location of the infarct in the callosum often correlates with a specific etiology. W ... Full text Link to item Cite

Decompressive hemicraniectomy in pediatric patients with malignant middle cerebral artery infarction: case series and review of the literature.

Journal Article World Neurosurg · 2013 Featured Publication OBJECTIVE: Malignant middle cerebral artery infarction (mMCAI) is a life-threatening condition in pediatric patients. Despite strong evidence showing decreased morbidity and mortality in adult mMCAI patients with decompressive hemicraniectomy (DCH), there ... Full text Link to item Cite

Neurogenic Stunned Myocardium Following Acute Subarachnoid Hemorrhage Pathophysiology and Practical Considerations

Journal Article Journal of Intensive Care Medicine · 2013 Featured Publication Cite

Abstract Tp427

Journal Article Stroke · 2013 Cite

Abstract WP68

Journal Article Stroke · 2013 Cite

Intracranial optic nerve enlargement in infantile Krabbe disease.

Journal Article Neurology · May 15, 2012 Featured Publication Full text Link to item Cite

Abstract 3260

Journal Article Stroke · 2012 Cite

Intracranial optic nerve enlargement in infantile Krabbe disease.

Journal Article Neurology · 2012 Featured Publication Cite

Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia.

Journal Article Learn Mem · 2011 Featured Publication Long-term memory and plasticity, including long-term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse, depend on the activation of transcription factors that regulate genes necessary for synaptic plasticity. In the present study we found tha ... Full text Link to item Cite

CNS aspergillosis in a patient with Crohn's disease on immunosuppressants: a case report.

Journal Article Cases J · June 16, 2009 Fungal infections of the central nervous system are an uncommon cause of rapid decline in consciousness. We describe the case of central nervous system aspergillosis in a patient on immunosupressants whose clinical course highlights the need for an aggress ... Full text Link to item Cite

cAMP response element-binding protein 1 feedback loop is necessary for consolidation of long-term synaptic facilitation in Aplysia.

Journal Article J Neurosci · February 20, 2008 The transcription factor cAMP response element (CRE)-binding protein (CREB) plays an essential role in the induction of many forms of long-term synaptic plasticity. Levels of CREB1, the Aplysia homolog of CREB, show sustained elevations for several hours a ... Full text Link to item Cite