Scholars@Duke
Shu Shiuh-Shi Lin

Shu Shiuh-Shi Lin

Associate Professor of Surgery
Surgery, Cardiovascular and Thoracic Surgery
shu.lin@duke.edu
Box 3392 Med Ctr, Durham, NC 27710
40 Duke Medicine Cr, Duke University Medical Center, Durham, NC 27710

Selected Publications

The effect of levofloxacin on the lung microbiota of laboratory rats.

Journal Article Exp Lung Res · September 2019 Aim: The aim of this study was to investigate the short-term effect of levofloxacin on the microbiota of healthy lungs. Material and methods: Male F344 rats received either no levofloxacin (nā€‰=ā€‰9), intravenous levofloxacin (nā€‰=ā€‰12), oral levofloxacin (nā€‰=ā€‰ ... Full text Link to item Cite

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.

Journal Article Anesthesiology · June 2019 BACKGROUND: Cognitive decline after cardiac surgery occurs frequently and persists in a significant proportion of patients. Preclinical studies and human trials suggest that intravenous lidocaine may confer protection in the setting of neurologic injury. I ... Full text Open Access Link to item Cite

A mole rat's gut microbiota suggests selective influence of diet on microbial niche space and evolution.

Journal Article Exp Biol Med (Maywood) · April 2019 The composition of the microbiota is of critical importance for health and disease, and is receiving increased scientific and medical scrutiny. Of particular interest is the role of changing diets as a function of agriculture and, perhaps to an even greate ... Full text Link to item Cite

Early Immune Response to Acute Gastric Fluid Aspiration in a Rat Model of Lung Transplantation.

Journal Article Exp Clin Transplant · February 2019 OBJECTIVES: Chronic aspiration of gastric fluid contents can decrease long-term survival of pulmonary transplants due to development of obliterative bronchiolitis. However, little is known about the early immune response and the cascade of events involved ... Full text Link to item Cite

Temporary autonomic modulation with botulinum toxin type A to reduce atrial fibrillation after cardiac surgery.

Journal Article Heart Rhythm · February 2019 BACKGROUND: Postoperative atrial fibrillation (POAF) frequently complicates cardiac surgery and is associated with worse outcomes. The cardiac autonomic nervous system is implicated in the pathogenesis of POAF. OBJECTIVE: The purpose of this study was to d ... Full text Link to item Cite

Respiratory Complications of Gastroesophageal Reflux Disease

Chapter · January 1, 2019 Gastroesophageal reflux refers to the reflux of stomach contents into the esophagus. Gastroesophageal reflux disease (GERD) describes the presence of excessive reflux of acid or nonacid stomach contents, with unwanted resultant manifestations. Although tra ... Full text Cite

18F-florbetapir Positron Emission Tomography-determined Cerebral Ī²-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.

Journal Article Anesthesiology · April 2018 BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patie ... Full text Link to item Cite

Effect of gastric fluid aspiration on the lung microbiota of laboratory rats.

Journal Article Exp Lung Res · 2018 AIM OF THE STUDY: The pulmonary microbiota is important for both normal homeostasis and the progression of disease, and may be affected by aspiration of gastric fluid. The aim of this study was to investigate changes in the lung microbiota induced by aspir ... Full text Link to item Cite

Production and Use of Hymenolepis diminuta Cysticercoids as Anti-Inflammatory Therapeutics.

Journal Article J Clin Med · October 24, 2017 Helminthic therapy has shown considerable promise as a means of alleviating some inflammatory diseases that have proven resistant to pharmaceutical intervention. However, research in the field has been limited by a lack of availability to clinician scienti ... Full text Link to item Cite

Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.

Journal Article Anesth Analg · October 2017 BACKGROUND: Declining platelet counts may reveal platelet activation and aggregation in a postoperative prothrombotic state. Therefore, we hypothesized that nadir platelet counts after on-pump coronary artery bypass grafting (CABG) surgery are associated w ... Full text Open Access Link to item Cite

TRALI by proxy.

Journal Article J Thorac Cardiovasc Surg · May 2017 Full text Link to item Cite

Clinical predictors and outcome implications of early readmission in lung transplant recipients.

Journal Article J Heart Lung Transplant · May 2017 BACKGROUND: The purpose of this study was to identify risk factors and outcome implications for 30-day hospital readmission in lung transplant recipients. METHODS: We conducted a retrospective cohort study of lung transplant cases from a single, high-volum ... Full text Link to item Cite

The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism.

Journal Article J Int Med Res · April 2017 The wide range of factors associated with the induction of autism is invariably linked with either inflammation or oxidative stress, and sometimes both. The use of acetaminophen in babies and young children may be much more strongly associated with autism ... Full text Link to item Cite

Murine model of oropharyngeal gastric fluid aspiration-A new assessment method for intrapulmonary liquid distribution using digital pixel calculation.

Journal Article Exp Lung Res · 2017 AIM OF THE STUDY: The aim of this study was to investigate a new method for visualization and quantification of intrapulmonary liquid distribution after oropharyngeal gastric fluid aspiration in mice. MATERIAL AND METHODS: Eleven mice received oropharyngea ... Full text Link to item Cite

Reduction of hexavalent chromium by fasted and fed human gastric fluid. II. Ex vivo gastric reduction modeling.

Journal Article Toxicol Appl Pharmacol · September 1, 2016 To extend previous models of hexavalent chromium [Cr(VI)] reduction by gastric fluid (GF), ex vivo experiments were conducted to address data gaps and limitations identified with respect to (1) GF dilution in the model; (2) reduction of Cr(VI) in fed human ... Full text Link to item Cite

The role of soluble and insoluble gastric fluid components in the pathogenesis of obliterative bronchiolitis in rat lung allografts.

Journal Article Transpl Int · February 2016 Repetitive gastric fluid aspirations have been shown to lead to obliterans bronchiolitis (OB), but the component or components of gastric fluid that are responsible are unknown. This study investigates the role of particulates and, separately, soluble mate ... Full text Link to item Cite

Clearance of bile and trypsin in rat lungs following aspiration of human gastric fluid.

Journal Article Exp Lung Res · 2016 PURPOSE: In the clinical setting, there is no reliable tool for diagnosing gastric aspiration. A potential way of diagnosing gastric fluid aspiration entails bronchoalveolar lavage (BAL) with subsequent examination of the BAL fluid for gastric fluid compon ... Full text Link to item Cite

ECMO in Lung Transplantation

Chapter · January 1, 2016 I. Introduction Extracorporeal membrane oxygenation (ECMO) is a necessary component of a lung transplant program to provide physiologic support for patients that suffer severe primary graft dysfunction (PGD). However, the role of ECMO in the support of lun ... Full text Cite

Epigenetic profiling identifies novel genes for ascending aortic aneurysm formation with bicuspid aortic valves.

Journal Article Heart Surg Forum · August 30, 2015 BACKGROUND: Ā  Bicuspid aortic valves predispose to ascending aortic aneurysms, but the mechanisms underlying this aortopathy remain incompletely characterized.Ā  We sought to identify epigenetic pathways predisposing to aneurysm formation in bicuspid patien ... Full text Link to item Cite

Reflux and allograft dysfunction: is there a connection?

Journal Article Thorac Surg Clin · 2015 Despite improving outcomes following lung transplantation, chronic rejection continues to limit survival. The predominant form of chronic rejection, bronchiolitis obliterans syndrome, has been associated with multiple etiologies including aspiration from g ... Full text Link to item Cite

An assessment of human gastric fluid composition as a function of PPI usage.

Journal Article Physiol Rep · January 1, 2015 The standard of care for chronic gastro-esophageal reflux disease (GERD), which affects up to 40% of the population, is the use of drugs such as proton pump inhibitors (PPIs) that block the production of stomach acid. Despite widespread use, the effects of ... Full text Link to item Cite

Increased biodiversity in the environment improves the humoral response of rats.

Journal Article PLoS One · 2015 Previous studies have compared the immune systems of wild and of laboratory rodents in an effort to determine how laboratory rodents differ from their naturally occurring relatives. This comparison serves as an indicator of what sorts of changes might exis ... Full text Link to item Cite

Differential outcomes with early and late repeatĀ transplantation in the era of the lung allocation score.

Journal Article Ann Thorac Surg · December 2014 BACKGROUND: Rates of repeat lung transplantation have increased since implementation of the lung allocation score (LAS). The purpose of this study is to compare survival between repeat (ReTx) and primary (LTx) lung transplant recipients in the LAS era. MET ... Full text Link to item Cite

Preprocedural ECG-gated computed tomography for prevention of complications during lead extraction.

Journal Article Pacing Clin Electrophysiol · October 2014 BACKGROUND: Preprocedural multidetector computed tomography (MDCT) may identify patients at risk for mechanical complications during lead extraction. METHODS: To describe the use and feasibility of computed tomography scanning for preprocedural planning of ... Full text Link to item Cite

Ambulatory ECMO as a bridge to lung transplant in a previously well pediatric patient with ARDS.

Journal Article Pediatrics · August 2014 Extracorporeal membrane oxygenation (ECMO) is increasingly implemented in patients with end-stage pulmonary disease as a bridge to lung transplant. Several centers have instituted an approach that involves physical rehabilitation and ambulation for patient ... Full text Link to item Cite

Preoperative mild-to-moderate coronary artery disease does not affect long-term outcomes of lung transplantation.

Conference Transplantation · May 27, 2014 BACKGROUND: Coronary artery disease has a high prevalence among lung transplant recipients and has historically been a contraindication to transplant at many institutions. In patients with mild-to-moderate coronary artery disease (Mod-CAD) undergoing lung ... Full text Link to item Cite

Donor and Recipient Hepatitis C Status in Lung Transplant

Conference The Journal of Heart and Lung Transplantation · April 2014 Full text Cite

Cryoanalgesia Complements Thoracic Epidural Use Following Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2014 Full text Cite

Coronary revascularization in lung transplant recipients with concomitant coronary artery disease.

Conference Am J Transplant · November 2013 Coronary artery disease (CAD) is not uncommon among lung transplant candidates. Several small, single-center series have suggested that short-term outcomes are acceptable in selected patients who undergo coronary revascularization prior to, or concomitant ... Full text Link to item Cite

Physiologically based pharmacokinetic model for humans orally exposed to chromium.

Journal Article Chem Biol Interact · June 25, 2013 A multi-compartment physiologically based pharmacokinetic (PBPK) model was developed to describe the behavior of Cr(III) and Cr(VI) in humans. Compartments were included for gastrointestinal lumen, oral mucosa, stomach, small intestinal tissue, blood, live ... Full text Link to item Cite

Optimizing the Estimation of Renal Function in Lung Transplant Candidates

Conference The Journal of Heart and Lung Transplantation · April 2013 Full text Cite

Reply: To PMID 22632483.

Other Ann Thorac Surg · February 2013 Full text Link to item Cite

In the face of chronic aspiration, prolonged ischemic time exacerbates obliterative bronchiolitis in rat pulmonary allografts.

Journal Article Am J Transplant · November 2012 Aspiration of gastric fluid into the lung mediates the development of obliterative bronchiolitis (OB) in orthotopic WKY-to-F344 rat pulmonary transplants that have been subjected to immunosuppression with cyclosporine. However, the contribution of ischemic ... Full text Link to item Cite

Chronic aspiration shifts the immune response from adaptive immunity to innate immunity in a murine model of asthma.

Journal Article Inflamm Res · August 2012 OBJECTIVE AND DESIGN: The hypothesis that aspiration of gastric fluid drives the anti-ovalbumin response toward a Th2 reaction even in animals not prone to Th2 responses was evaluated. SUBJECTS: Forty-eight male C57BL/6 mice were used. METHODS: Mice were s ... Full text Link to item Cite

276 Paired Donor Lung Expression Suggest Key Effectors in Primary Graft Dysfunction

Conference The Journal of Heart and Lung Transplantation · April 2012 Full text Cite

85 Lung Transplantation Is an Effective Treatment Option for Patients over the Age of 70

Conference The Journal of Heart and Lung Transplantation · April 2012 Full text Cite

Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments.

Journal Article Cell Mol Immunol · March 2012 The immune systems of wild rats and of laboratory rats can been utilized as models of the human immune system in pre-industrial and post-industrial societies, respectively. In this study, lymphocyte phenotypes in wild rats were broadly characterized, and t ... Full text Link to item Cite

Improved survival but marginal allograft function in patients treated with extracorporeal membrane oxygenation after lung transplantation.

Journal Article Ann Thorac Surg · February 2012 BACKGROUND: Previous reports demonstrate that 1-year survival is severely compromised in patients with severe primary graft dysfunction (PGD) after lung transplantation. We examined if advances in extracorporeal membrane oxygenation (ECMO) support, includi ... Full text Link to item Cite

Active rehabilitation and physical therapy during extracorporeal membrane oxygenation while awaiting lung transplantation: a practical approach.

Journal Article Crit Care Med · December 2011 OBJECTIVE: Extracorporeal membrane oxygenation as a bridge to lung transplantation has traditionally been associated with substantial morbidity and mortality. A major contributor to these complications may be weakness and overall deconditioning secondary t ... Full text Link to item Cite

Study of gastric fluid induced cytokine and chemokine expression in airway smooth muscle cells and airway remodeling.

Journal Article Cytokine · December 2011 Asthma is a chronic airway inflammatory disease. Chronic aspiration by gastric fluid in gastroesophageal reflux disease (GERD) is considered a primary inflammatory factor exacerbating or predisposing patients to asthma. Airway smooth muscle cells (SMCs) ar ... Full text Link to item Cite

Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle.

Journal Article BMC Med Genomics · October 5, 2011 BACKGROUND: The accurate diagnosis of idiopathic pulmonary fibrosis (IPF) is a major clinical challenge. We developed a model to diagnose IPF by applying Bayesian probit regression (BPR) modelling to gene expression profiles of whole lung tissue. METHODS: ... Full text Link to item Cite

Fundoplication after lung transplantation prevents the allograft dysfunction associated with reflux.

Journal Article Ann Thorac Surg · August 2011 BACKGROUND: Gastroesophageal reflux disease (GERD) in lung recipients is associated with decreased survival and attenuated allograft function. This study evaluates fundoplication in preventing GERD-related allograft dysfunction. METHODS: Prospectively coll ... Full text Link to item Cite

Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.

Journal Article Ann Thorac Surg · June 2011 BACKGROUND: Inclusion of a measure of left ventricular diastolic dysfunction (LVDD) may improve risk prediction after cardiac surgery. Current LVDD grading guidelines rely on echocardiographic variables that are not always available or aligned to allow gra ... Full text Link to item Cite

Spontaneous bacterial cell lysis and biofilm formation in the colon of the Cape Dune mole-rat and the laboratory rabbit.

Journal Article Appl Microbiol Biotechnol · June 2011 A wide range of techniques, including high-throughput DNA sequencing methods, have been applied to the evaluation of the normal intestinal flora. However, the inability to grow many of those species in culture imposes substantial constraints on the techniq ... Full text Link to item Cite

Coagulopathy in Ī±-galactosyl transferase knockout pulmonary xenotransplants.

Journal Article Xenotransplantation · 2011 BACKGROUND: After substantial progress on many fronts, one of the remaining barriers still opposing the clinical application of xenotransplantation is a disseminated intravascular coagulopathy (DIC) that is observed in the pre-clinical model of porcine-to- ... Full text Link to item Cite

Impact of oropharyngeal dysphagia on long-term outcomes of lung transplantation.

Journal Article Ann Thorac Surg · November 2010 BACKGROUND: Lung transplantation, definitive therapy for end-stage lung disease, is limited long-term by allograft dysfunction including bronchiolitis obliterans syndrome (BOS). Few modifiable risk factors for pulmonary transplant-related mortality are rec ... Full text Link to item Cite

Short-lived alpha-helical intermediates in the folding of beta-sheet proteins.

Journal Article Biochemistry · July 6, 2010 Several lines of evidence point strongly toward the importance of highly alpha-helical intermediates in the folding of all globular proteins, regardless of their native structure. However, experimental refolding studies demonstrate no observable alpha-heli ... Full text Open Access Link to item Cite

Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1,000 days.

Journal Article Appl Environ Microbiol · July 2010 Although mice associated with a single bacterial species have been used to provide a simple model for analysis of host-bacteria relationships, bacteria have been shown to display adaptability when grown in a variety of novel environments. In this study, ch ... Full text Link to item Cite

Gastroesophageal reflux-associated aspiration alters the immune response in asthma.

Journal Article Surg Endosc · May 2010 BACKGROUND: A large number of studies point toward chronic aspiration associated with gastroesophageal reflux disease (GERD) as an important factor involved in the development of asthma, the incidence of which has increased dramatically in industrially dev ... Full text Link to item Cite

Temporal trends in lung transplant center volume and outcomes in the United States.

Journal Article Transplantation · March 27, 2010 Publicly available program-specific data from the scientific registry of transplant recipients were used to determine the association between adult lung transplant center volume and 1-year recipient mortality from 2000 to 2007. We found a significant inver ... Full text Link to item Cite

Macrophage activation by gastric fluid suggests MMP involvement in aspiration-induced lung disease.

Journal Article Immunobiology · March 2010 Asthma occurs in more than 5% of the population in industrialized countries and is now characterized as a chronic inflammatory disease. The chronic aspiration of gastric fluid is considered by many investigators to be a primary inflammatory factor exacerba ... Full text Link to item Cite

34: Post Lung Transplant Peak Allograft Function Predictors. A Regression Model

Conference The Journal of Heart and Lung Transplantation · February 2010 Full text Cite

Co-existence of posttraumatic empyema thoracis and lung abscess in a child after blunt chest trauma: a case report.

Journal Article Kaohsiung J Med Sci · January 2010 Posttraumatic empyema is a rare complication of trauma with an incidence of 1.6-2.4% in trauma patients. However, it is rarely reported in children. We report the case of a 15-year-old boy who was involved in a traffic accident and diagnosed with a pulmona ... Full text Link to item Cite

Laser-assisted extraction of pacemaker and defibrillator leads: the role of the cardiac surgeon.

Journal Article Ann Thorac Surg · May 2009 BACKGROUND: The development of laser-assisted extraction techniques for chronically implanted pacemaker and defibrillator leads has reduced the need for open surgical removal. Reports of the mortality from laser-assisted extraction range from 1.9% to 3.4%. ... Full text Link to item Cite

Aprotinin's effect on blood product transfusion in off-pump bilateral lung transplantation.

Journal Article Interact Cardiovasc Thorac Surg · January 2009 In lung transplants necessitating cardiopulmonary bypass (CPB), aprotinin has been shown to decrease transfusion requirements. More recently, off-pump transplantation has become the standard of care. The efficacy of aprotinin use in this population has yet ... Full text Link to item Cite

Lung transplantation at Duke University.

Journal Article Clin Transpl · 2009 Clinical lung transplantation continues to grow worldwide. Advances in donor selection and management have been critical to support the expanded growth of lung transplant as a therapeutic option for patients with advanced lung disease. In recent years, all ... Link to item Cite

The Role of Macrophages in the Response to Aspirated Gastric Fluid in Lung Allografts

Conference AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2009 Link to item Cite

Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity.

Journal Article Exp Biol Med (Maywood) · October 2008 Gastroesophageal reflux has become a major health concern in industrialized countries, with drugs aimed at blocking acid production being more frequently prescribed than any other drug. Damage to lung tissue as a result of chronic aspiration of gastric flu ... Full text Link to item Cite

Chronic aspiration shifts the immune response from Th1 to Th2 in a murine model of asthma.

Journal Article Eur J Clin Invest · August 2008 BACKGROUND: Chronic aspiration associated with gastro oesophageal reflux disease (GERD) is thought to play a substantial role in the development of asthma, the incidence of which is dramatically increasing in industrially developed countries. The majority ... Full text Link to item Cite

Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants.

Journal Article Am J Transplant · August 2008 Long-term survival of a pulmonary allograft is currently hampered by obliterative bronchiolitis (OB), a form of chronic rejection that is unique to lung transplantation. While tracheobronchial aspiration from gastroesophageal reflux disease (GERD) has clin ... Full text Link to item Cite

Rabbit anti-thymocyte globulin induction therapy does not prolong survival after lung transplantation.

Journal Article J Heart Lung Transplant · May 2008 BACKGROUND: Lung transplant survival is limited by the development of bronchiolitis obliterans syndrome (BOS). The strongest risk factor for BOS is acute rejection (AR). We have previously shown that rabbit anti-thymocyte globulin (RATG) induction therapy ... Full text Link to item Cite

Echocardiographic risk stratification for early surgery with endocarditis: a cost-effectiveness analysis.

Journal Article Heart · May 2008 BACKGROUND: Despite widespread acceptance of echocardiography for diagnosis of infective endocarditis, few investigators have evaluated its utility as a risk-stratification tool to aid therapeutic decision-making. METHODS: A decision tree and Markov analys ... Full text Link to item Cite

Biofilms in the large bowel suggest an apparent function of the human vermiform appendix.

Journal Article J Theor Biol · December 21, 2007 The human vermiform ("worm-like") appendix is a 5-10cm long and 0.5-1cm wide pouch that extends from the cecum of the large bowel. The architecture of the human appendix is unique among mammals, and few mammals other than humans have an appendix at all. Th ... Full text Link to item Cite

Alemtuzumab in the treatment of refractory acute rejection and bronchiolitis obliterans syndrome after human lung transplantation.

Journal Article Am J Transplant · December 2007 Despite substantial improvements in early survival after lung transplantation, refractory acute rejection (RAR) and bronchiolitis obliterans syndrome (BOS) remain major contributors to transplant-related morbidity and mortality. We have utilized alemtuzuma ... Full text Link to item Cite

Characterization of the innate immune response to chronic aspiration in a novel rodent model.

Journal Article Respir Res · November 27, 2007 BACKGROUND: Although chronic aspiration has been associated with several pulmonary diseases, the inflammatory response has not been characterized. A novel rodent model of chronic aspiration was therefore developed in order to investigate the resulting inna ... Full text Link to item Cite

Assessing oropharyngeal dysphagia after lung transplantation: altered swallowing mechanisms and increased morbidity.

Journal Article J Heart Lung Transplant · November 2007 BACKGROUND: Gastroesophageal reflux is associated with lung transplantation (LT) and bronchiolitis obliterans syndrome, limiting allograft functional longevity. LT patients may also develop post-operative oropharyngeal dysphagia, exposing the allograft to ... Full text Link to item Cite

Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors.

Journal Article J Cardiovasc Pharmacol · September 2007 Galphaq-coupled receptors such as alpha1-adrenergic, angiotensin, and endothelin receptors, play key roles in cardiac physiology. These receptors have also been shown to couple to G proteins of the G12 family, including Galpha12 and Galpha13. In this repor ... Full text Link to item Cite

Xenotransplantation of thoracic organs

Journal Article Current Opinion in Organ Transplantation · April 1, 2007 PURPOSE OF REVIEW: While clinical allotransplantation is the preferred method of providing replacement organs for people with end-stage heart and lung disease, this procedure, under current donation rates, cannot supply the required demands. Thoracic organ ... Full text Cite

380: Chronic aspiration in lung allotransplantation induces a donor-specific hyperimmune state

Conference The Journal of Heart and Lung Transplantation · February 2007 Full text Cite

157: Perioperative predictors of renal failure following off-pump primary double lung transplantation

Conference The Journal of Heart and Lung Transplantation · February 2007 Full text Cite

Lung transplantation at Duke University Medical Center.

Journal Article Clin Transpl · 2007 Lung transplantation has undergone remarkable changes in clinical practice to address the higher rate of rejection and mortality. Our protocols include increased immunosuppression and strategies to address non-alloimmune injury, including GER. New and inno ... Link to item Cite

Lung transplantation: advances in immunosuppression.

Journal Article Thorac Surg Clin · November 2006 Since the advent of various novel immunosuppressants, including tacrolimus, rapamycin, and daclixumab. expanding variations of protocols have been developed. Little evidence exists to substantially support a single agent over another. or a combination regi ... Full text Link to item Cite

Histopathology and transmurality of acute microwave lesions on the beating human atrium.

Journal Article Interact Cardiovasc Thorac Surg · June 2006 Microwave energy allows thoracoscopic beating-heart ablation for the treatment of atrial fibrillation. However, there is a paucity of data on the histologic effects of microwave energy on the beating human heart. This study aims to histopathologically char ... Full text Link to item Cite

Successful bilateral lung transplant outcomes in recipients 61 years of age and older.

Journal Article Transplantation · March 27, 2006 BACKGROUND: Controversy exists regarding the optimal use of bilateral lung transplant (BLT) in older recipients in diseases where either single or bilateral transplant is appropriate. International Society for Heart and Lung Transplant (ISHLT) guidelines s ... Full text Link to item Cite

Which patients with previous bypass surgery benefit most from repeat revascularization?

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 21, 2006 Link to item Cite

247

Conference The Journal of Heart and Lung Transplantation · February 2006 Full text Cite

Chronic aspiration of gastric fluid accelerates pulmonary allograft dysfunction in a rat model of lung transplantation.

Journal Article J Thorac Cardiovasc Surg · January 2006 OBJECTIVE: Emerging clinical evidence suggests that gastroesophageal reflux disease is associated with pulmonary allograft dysfunction. In this study, we used a model of rat lung transplantation to test the hypothesis that chronic aspiration of gastric con ... Full text Link to item Cite

Improved results treating lung allograft failure with venovenous extracorporeal membrane oxygenation.

Journal Article Ann Thorac Surg · November 2005 BACKGROUND: Primary graft failure remains a significant source of mortality after lung transplantation. Extracorporeal membrane oxygenation (ECMO) provides treatment for affected recipients. We hypothesized that venovenous membrane oxygenation provides a s ... Full text Link to item Cite

Left ventricular assist device as destination therapy in doxorubicin-induced cardiomyopathy.

Journal Article Ann Thorac Surg · August 2005 Doxorubicin-induced cardiomyopathy is not uncommon and may progress to end-stage heart failure. Treatment of this condition with heart transplantation, however, requires that the primary malignancy be deemed "cured." We present the case of a 55- year-old w ... Full text Link to item Cite

Meta-analysis of survival and relief of angina pectoris after transmyocardial revascularization.

Journal Article Am J Cardiol · May 15, 2005 A meta-analysis of 7 randomized trials involving 1,053 patients was performed to evaluate the effect of transmyocardial laser revascularization as the sole procedural intervention on survival and angina relief. At 1 year, transmyocardial laser revasculariz ... Full text Link to item Cite

Acute vascular rejection and accommodation: divergent outcomes of the humoral response to organ transplantation.

Journal Article Transplantation · November 27, 2004 BACKGROUND: The most difficult barrier to organ transplantation is humoral rejection, a condition initiated by binding of antibodies to blood vessels in the graft. Fortunately, humoral rejection is not the only outcome of antibody binding to the graft. In ... Full text Link to item Cite

Human secretory immunoglobulin A may contribute to biofilm formation in the gut.

Journal Article Immunology · August 2003 It is critical, both for the host and for the long-term benefit of the bacteria that colonize the gut, that bacterial overgrowth with subsequent bacterial translocation, which may lead to sepsis and death of the host, be avoided. Secretory IgA (sIgA) is kn ... Full text Link to item Cite

The footprint of antibody bound to pig cells: evidence of complex surface topology.

Journal Article Biochem Biophys Res Commun · February 14, 2003 The disaccharide Gal(alpha)1-3Gal is found on more than 45 different molecules on the endothelium of porcine cells and has recently attracted considerable interest, being the major target recognized by xenoreactive antibodies. In this study, the distributi ... Full text Link to item Cite

Biophysical characteristics of anti-Gal(alpha)1-3Gal IgM binding to cell surfaces: implications for xenotransplantation.

Journal Article Transplantation · February 15, 2001 BACKGROUND: Natural antibodies directed against cell surface carbohydrates are thought to be vital to host defense and to initiate the rejection of xenografts and ABO-incompatible allografts. The biophysical properties underlying the association and dissoc ... Full text Link to item Cite

Antigen expression in xenotransplantation: how low must it go?

Journal Article Transplantation · January 27, 2001 BACKGROUND: Acute vascular rejection (AVR) is an important immunological barrier to xenotransplantation. Thought to be initiated by xenoreactive antibodies, acute vascular rejection might, in principle, be avoided by engineering animals to express low leve ... Full text Link to item Cite

Therapeutic strategies for xenograft rejection.

Journal Article J Card Surg · 2001 The increasing demand for transplantable organs over the past several decades has stimulated the idea of using animal organs in lieu of cadaveric organs in clinical transplantation. Pigs are now considered to be the most suitable source of organs for trans ... Full text Link to item Cite

The role of anti-Galalpha1-3Gal antibodies in acute vascular rejection and accommodation of xenografts.

Journal Article Transplantation · December 2000 BackgroundA major impediment to the transplanting of porcine organs into humans is the susceptibility of porcine organs to acute vascular rejection, which can destroy a vascularized xenograft over a period of hours to days. Acute vascular rejectio ... Full text Cite

The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants.

Journal Article J Thorac Cardiovasc Surg · July 2000 OBJECTIVE: Pulmonary transplantation has become the preferred treatment for end-stage lung disease, but application of the procedure is limited because of a paucity of donors. One way to solve donor limitations is to use animal organs as a donor source or ... Full text Link to item Cite

The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants

Journal Article Journal of Thoracic and Cardiovascular Surgery · January 1, 2000 Objective: Pulmonary transplantation has become the preferred treatment for end-stage lung disease, but application of the procedure is limited because of a paucity of donors. One way to solve donor limitations is to use animal organs as a donor source or ... Full text Cite

Naturally occurring anti-alpha-galactosyl antibodies: relationship to xenoreactive anti-alpha-galactosyl antibodies.

Journal Article Glycobiology · September 1999 Antibodies produced by an individual without a known history of sensitization to the relevant antigen are called "natural" antibodies. Some natural antibodies, called xenoreactive antibodies, react with the cells of foreign species. Most xenoreactive antib ... Full text Link to item Cite

The future promises of xenotransplantation.

Journal Article Ann N Y Acad Sci · December 30, 1998 The use of animals as a source of organs and tissues for humans has been an enduring goal of transplantation. Xenotransplantation, as such, would overcome a shortage of human donors and allow for biochemical or genetic approaches to modification of transpl ... Full text Link to item Cite

Acute vascular rejection.

Journal Article Xenotransplantation · August 1998 Full text Link to item Cite

Differential recognition by proteins of alpha-galactosyl residues on endothelial cell surfaces.

Journal Article Glycobiology · May 1998 The binding of proteins to cell surface carbohydrates contributes to cell-cell interactions in development, immunity, and various physiologic processes. Such interactions are presumably dictated not only by the chemical structure of the carbohydrate but al ... Full text Link to item Cite

The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants.

Journal Article J Clin Invest · April 15, 1998 Long-term success in xenotransplantation is currently hampered by acute vascular rejection. The inciting cause of acute vascular rejection is not yet known; however, a variety of observations suggest that the humoral immune response of the recipient agains ... Full text Link to item Cite

Genetic therapies for xenotransplantation.

Journal Article J Am Coll Surg · April 1998 Full text Link to item Cite

Total respiratory support from swine lungs in primate recipients.

Journal Article J Thorac Cardiovasc Surg · January 1998 UNLABELLED: The use of nonhuman lung donors, such as swine, has the potential to provide an unlimited supply of organs. However, hyperacute rejection has prevented pulmonary xenotransplantation. OBJECTIVE: Our aim was to test the hypothesis that immunodepl ... Full text Link to item Cite

Divergent pathogenesis and manifestations of hyperacute and acute vascular xenograft rejection

Conference FASEB Journal · 1998 A porcine heart transplanted in a human or non-human primate is subject to hyperacute rejection (HAR) which destroys the xenograft within minutes to hours after reperfusion. When HAR is averted, acute vascular rejection (AVR) typically occurs several days ... Cite

Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation.

Journal Article Hum Immunol · December 1997 Organs transplanted between phylogenetically-disparate species, such as from the pig into the primate, are subject to hyperacute and acute vascular rejection. Hyperacute rejection of a porcine organ by a primate is thought to be initiated by the binding of ... Full text Link to item Cite

The role of natural anti-Gal alpha 1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants.

Journal Article Transpl Immunol · September 1997 Xenoreactive natural antibodies in humans and higher primates are directed predominantly at Gal alpha 1-3Gal. These antibodies are thought to initiate hyperacute rejection of porcine organ xenografts. The contribution of anti-Gal alpha 1-3Gal antibodies to ... Full text Link to item Cite

Transplantation of discordant xenografts: a challenge revisited.

Journal Article Immunol Today · August 1996 Six years ago, Jeffrey Platt and colleagues reviewed the biological hurdles to transplanting organs between species. The ensuing years have allowed the concepts advanced at that time to be tested leading to significant progress in understanding the immunol ... Full text Link to item Cite

Immunologic barriers to xenotransplantation.

Journal Article J Heart Lung Transplant · June 1996 Link to item Cite

Quantitative evaluation of porcine endothelial cell antigens recognized by human natural antibodies: An analysis by Western blotting

Journal Article Xenotransplantation · January 1, 1996 Xenoreactive natural antibodies recognize a series of glycoproteins in porcine endothelial cell membranes, the epitopes being GalĪ±1-3Gal substitutions on those proteins. We recently identified the glycoprotein antigens as members of the integrin family, vo ... Full text Cite

Immunologic advances towards clinical xenotransplantation

Conference ADVANCES IN SWINE IN BIOMEDICAL RESEARCH, VOLS 1 AND 2 · January 1, 1996 Link to item Cite

The effect of soluble complement receptor type 1 on hyperacute xenograft rejection.

Journal Article Transplantation · November 1991 In the guinea pig-to-rat model of hyperacute xenograft (Xg) rejection, the effect of complement inhibition using systemically administered soluble complement receptor type 1 (sCR1) on discordant cardiac Xg survival was investigated. In PBS-treated control ... Full text Link to item Cite

Expression of epidermal growth factor receptors in human lung tumors.

Journal Article Cancer · November 1986 Using the adjacent histologically normal tissues obtained from the same patients as controls, six human lung tumors were studied for the activities of epidermal growth factor (EGF) receptor binding, and receptor autophosphorylation. There was a 1.2- to 2.8 ... Cite