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Michael Hugh Sketch Jr.

Professor of Medicine
Medicine, Cardiology
Duke Box 3157, Durham, NC 27710
7402 Hosp North, Durham, NC 27710

Selected Publications


Technical consideration in acute myocardial infarction with cardiogenic shock: A review of antithrombotic and PCI therapies.

Journal Article Catheter Cardiovasc Interv · April 1, 2020 In this review, we report a contemporary appraisal of the available evidence focusing on adjunctive antithrombotic therapy and technical aspects of percutaneous coronary interventions (PCI) in patients with acute myocardial infarction and cardiogenic shock ... Full text Link to item Cite

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.

Journal Article Anesthesiology · June 2019 BACKGROUND: Cognitive decline after cardiac surgery occurs frequently and persists in a significant proportion of patients. Preclinical studies and human trials suggest that intravenous lidocaine may confer protection in the setting of neurologic injury. I ... Full text Open Access Link to item Cite

Identifying the Infarct-Related Artery in Patients With Non-ST-Segment-Elevation Myocardial Infarction.

Journal Article Circ Cardiovasc Interv · May 2019 BACKGROUND: Determining the infarct-related artery (IRA) in non-ST-segment-elevation myocardial infarction (MI) can be challenging. Delayed-enhancement cardiac magnetic resonance (DE-CMR) can accurately identify small MIs. The purpose of this study was to ... Full text Link to item Cite

Predicting risk of cardiac events among ST-segment elevation myocardial infarction patients with conservatively managed non-infarct-related artery coronary artery disease: An analysis of the Duke Databank for Cardiovascular Disease.

Journal Article Am Heart J · December 2017 BACKGROUND: Recent randomized evidence has demonstrated benefit with complete revascularization during the index hospitalization for multivessel coronary artery disease ST-segment elevation myocardial infarction (STEMI) patients; however, this benefit like ... Full text Link to item Cite

Morbidity and Mortality Conference for Percutaneous Coronary Intervention.

Journal Article Circ Cardiovasc Qual Outcomes · August 2017 BACKGROUND: Morbidity and mortality conference is a common educational and quality improvement activity performed in cardiac catheterization laboratories, but best practices for case selection and for maximizing the effectiveness of peer review have not be ... Full text Link to item Cite

Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease.

Journal Article Cochrane Database Syst Rev · May 3, 2017 BACKGROUND: Multi-vessel coronary disease in people with ST elevation myocardial infarction (STEMI) is common and is associated with worse prognosis after STEMI. Based on limited evidence, international guidelines recommend intervention on only the culprit ... Full text Link to item Cite

Safety and clinical effectiveness of drug-eluting stents for saphenous vein graft intervention in older individuals: Results from the medicare-linked National Cardiovascular Data Registry(®) CathPCI Registry(®) (2005-2009).

Journal Article Catheter Cardiovasc Interv · January 1, 2016 OBJECTIVES: To evaluate the safety of drug-eluting stents (DES) when treating patients with failing saphenous vein grafts (SVG). BACKGROUND: DES reduce target vessel revascularization in patients with failing SVGs; however, compared with bare metal stents ... Full text Link to item Cite

Early invasive versus conservative strategy for non-infarct related artery lesions in ST elevation myocardial infarction with multi-vessel disease

Journal Article Cochrane Database of Systematic Reviews · December 17, 2015 This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effects of early invasive compared to conservative (medical management) strategy for treating non-infarct related artery lesions in ST elevation myocar ... Full text Cite

A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience.

Journal Article J Cardiovasc Transl Res · November 2015 The CATHeterization GENetics (CATHGEN) biorepository was assembled in four phases. First, project start-up began in 2000. Second, between 2001 and 2010, we collected clinical data and biological samples from 9334 individuals undergoing cardiac catheterizat ... Full text Link to item Cite

Three-year outcomes associated with embolic protection in saphenous vein graft intervention: results in 49 325 senior patients in the Medicare-linked National Cardiovascular Data Registry CathPCI Registry.

Journal Article Circ Cardiovasc Interv · March 2015 BACKGROUND: Information is limited on contemporary use and outcomes of embolic protection devices (EPDs) in saphenous vein graft interventions. METHODS AND RESULTS: We formed a longitudinal cohort (2005-2009; n=49 325) by linking National Cardiovascular Da ... Full text Link to item Cite

Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery.

Journal Article Stroke · December 2013 BACKGROUND AND PURPOSE: Neurocognitive decline occurs frequently after cardiac surgery and persists in a significant number of patients. Magnesium is thought to provide neuroprotection by preservation of cellular energy metabolism, blockade of the N-methyl ... Full text Link to item Cite

The "final" 5-year follow-up from the ENDEAVOR IV trial comparing a zotarolimus-eluting stent with a paclitaxel-eluting stent.

Conference JACC Cardiovasc Interv · April 2013 OBJECTIVES: This study sought to report the final 5-year outcomes of the ENDEAVOR IV (A Randomized, Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Taxus Paclitaxel-Eluting Coronary Stent System in De Novo ... Full text Link to item Cite

Association of anxiety and depression with all-cause mortality in individuals with coronary heart disease.

Journal Article J Am Heart Assoc · March 19, 2013 BACKGROUND: Depression has been related to mortality in coronary heart disease (CHD) patients, but few studies have evaluated the role of anxiety or the role of the co-occurrence of depression and anxiety. We examined whether anxiety is associated with inc ... Full text Open Access Link to item Cite

Percutaneous coronary interventions and cardiovascular outcomes for patients with chronic total occlusions.

Journal Article Catheter Cardiovasc Interv · March 1, 2012 OBJECTIVES: This study sought to assess the benefits of a coronary chronic total occlusion CTO recanalization after adjusting for the case-mix and the propensity to undergo the CTO intervention in a population of patients with stable coronary artery diseas ... Full text Link to item Cite

Five-year follow-up of the Sirolimus-Eluting Stents vs Vascular Brachytherapy for Bare Metal In-Stent Restenosis (SISR) trial.

Journal Article Am Heart J · March 2012 OBJECTIVES: The aim of this study was to evaluate the 5-year clinical safety and efficacy outcomes of patients treated for in-stent restenosis of bare-metal stents (BMSs). BACKGROUND: The SISR trial is a prospective, randomized trial that compared the safe ... Full text Link to item Cite

Technical consideration in acute myocardial infarction with cardiogenic shock: A review of antithrombotic and PCI therapies.

Journal Article Catheter Cardiovasc Interv · April 1, 2020 In this review, we report a contemporary appraisal of the available evidence focusing on adjunctive antithrombotic therapy and technical aspects of percutaneous coronary interventions (PCI) in patients with acute myocardial infarction and cardiogenic shock ... Full text Link to item Cite

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.

Journal Article Anesthesiology · June 2019 BACKGROUND: Cognitive decline after cardiac surgery occurs frequently and persists in a significant proportion of patients. Preclinical studies and human trials suggest that intravenous lidocaine may confer protection in the setting of neurologic injury. I ... Full text Open Access Link to item Cite

Identifying the Infarct-Related Artery in Patients With Non-ST-Segment-Elevation Myocardial Infarction.

Journal Article Circ Cardiovasc Interv · May 2019 BACKGROUND: Determining the infarct-related artery (IRA) in non-ST-segment-elevation myocardial infarction (MI) can be challenging. Delayed-enhancement cardiac magnetic resonance (DE-CMR) can accurately identify small MIs. The purpose of this study was to ... Full text Link to item Cite

Predicting risk of cardiac events among ST-segment elevation myocardial infarction patients with conservatively managed non-infarct-related artery coronary artery disease: An analysis of the Duke Databank for Cardiovascular Disease.

Journal Article Am Heart J · December 2017 BACKGROUND: Recent randomized evidence has demonstrated benefit with complete revascularization during the index hospitalization for multivessel coronary artery disease ST-segment elevation myocardial infarction (STEMI) patients; however, this benefit like ... Full text Link to item Cite

Morbidity and Mortality Conference for Percutaneous Coronary Intervention.

Journal Article Circ Cardiovasc Qual Outcomes · August 2017 BACKGROUND: Morbidity and mortality conference is a common educational and quality improvement activity performed in cardiac catheterization laboratories, but best practices for case selection and for maximizing the effectiveness of peer review have not be ... Full text Link to item Cite

Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease.

Journal Article Cochrane Database Syst Rev · May 3, 2017 BACKGROUND: Multi-vessel coronary disease in people with ST elevation myocardial infarction (STEMI) is common and is associated with worse prognosis after STEMI. Based on limited evidence, international guidelines recommend intervention on only the culprit ... Full text Link to item Cite

Safety and clinical effectiveness of drug-eluting stents for saphenous vein graft intervention in older individuals: Results from the medicare-linked National Cardiovascular Data Registry(®) CathPCI Registry(®) (2005-2009).

Journal Article Catheter Cardiovasc Interv · January 1, 2016 OBJECTIVES: To evaluate the safety of drug-eluting stents (DES) when treating patients with failing saphenous vein grafts (SVG). BACKGROUND: DES reduce target vessel revascularization in patients with failing SVGs; however, compared with bare metal stents ... Full text Link to item Cite

Early invasive versus conservative strategy for non-infarct related artery lesions in ST elevation myocardial infarction with multi-vessel disease

Journal Article Cochrane Database of Systematic Reviews · December 17, 2015 This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effects of early invasive compared to conservative (medical management) strategy for treating non-infarct related artery lesions in ST elevation myocar ... Full text Cite

A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience.

Journal Article J Cardiovasc Transl Res · November 2015 The CATHeterization GENetics (CATHGEN) biorepository was assembled in four phases. First, project start-up began in 2000. Second, between 2001 and 2010, we collected clinical data and biological samples from 9334 individuals undergoing cardiac catheterizat ... Full text Link to item Cite

Three-year outcomes associated with embolic protection in saphenous vein graft intervention: results in 49 325 senior patients in the Medicare-linked National Cardiovascular Data Registry CathPCI Registry.

Journal Article Circ Cardiovasc Interv · March 2015 BACKGROUND: Information is limited on contemporary use and outcomes of embolic protection devices (EPDs) in saphenous vein graft interventions. METHODS AND RESULTS: We formed a longitudinal cohort (2005-2009; n=49 325) by linking National Cardiovascular Da ... Full text Link to item Cite

Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery.

Journal Article Stroke · December 2013 BACKGROUND AND PURPOSE: Neurocognitive decline occurs frequently after cardiac surgery and persists in a significant number of patients. Magnesium is thought to provide neuroprotection by preservation of cellular energy metabolism, blockade of the N-methyl ... Full text Link to item Cite

The "final" 5-year follow-up from the ENDEAVOR IV trial comparing a zotarolimus-eluting stent with a paclitaxel-eluting stent.

Conference JACC Cardiovasc Interv · April 2013 OBJECTIVES: This study sought to report the final 5-year outcomes of the ENDEAVOR IV (A Randomized, Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Taxus Paclitaxel-Eluting Coronary Stent System in De Novo ... Full text Link to item Cite

Association of anxiety and depression with all-cause mortality in individuals with coronary heart disease.

Journal Article J Am Heart Assoc · March 19, 2013 BACKGROUND: Depression has been related to mortality in coronary heart disease (CHD) patients, but few studies have evaluated the role of anxiety or the role of the co-occurrence of depression and anxiety. We examined whether anxiety is associated with inc ... Full text Open Access Link to item Cite

Percutaneous coronary interventions and cardiovascular outcomes for patients with chronic total occlusions.

Journal Article Catheter Cardiovasc Interv · March 1, 2012 OBJECTIVES: This study sought to assess the benefits of a coronary chronic total occlusion CTO recanalization after adjusting for the case-mix and the propensity to undergo the CTO intervention in a population of patients with stable coronary artery diseas ... Full text Link to item Cite

Five-year follow-up of the Sirolimus-Eluting Stents vs Vascular Brachytherapy for Bare Metal In-Stent Restenosis (SISR) trial.

Journal Article Am Heart J · March 2012 OBJECTIVES: The aim of this study was to evaluate the 5-year clinical safety and efficacy outcomes of patients treated for in-stent restenosis of bare-metal stents (BMSs). BACKGROUND: The SISR trial is a prospective, randomized trial that compared the safe ... Full text Link to item Cite

Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5.

Journal Article BMC Genet · February 27, 2012 BACKGROUND: Coronary artery disease (CAD), and one of its intermediate risk factors, dyslipidemia, possess a demonstrable genetic component, although the genetic architecture is incompletely defined. We previously reported a linkage peak on chromosome 5q31 ... Full text Link to item Cite

Effect of heparin administration on metabolomic profiles in samples obtained during cardiac catheterization.

Journal Article Circ Cardiovasc Genet · December 2011 BACKGROUND: Metabolic profiling holds promise for early detection of coronary artery disease and assessing risk for ischemic events. Heparin is frequently administered (1) to treat acute coronary syndromes; and (2) during routine cardiac catheterization pr ... Full text Link to item Cite

Relationship of the time interval between cardiac catheterization and elective coronary artery bypass surgery with postprocedural acute kidney injury.

Journal Article Circulation · September 13, 2011 BACKGROUND: Some prior studies have suggested that the time to cardiac surgery after cardiac catheterization is inversely related to postoperative acute kidney injury (AKI). However, these studies, because of the small number of patients, were unable to ad ... Full text Link to item Cite

Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease.

Journal Article Hum Genet · June 2011 Tenascin-C (TNC) is an extracellular matrix protein implicated in biological processes important for atherosclerotic plaque development and progression, including smooth muscle cell migration and proliferation. Previously, we observed differential expressi ... Full text Link to item Cite

Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.

Journal Article Ann Thorac Surg · June 2011 BACKGROUND: Inclusion of a measure of left ventricular diastolic dysfunction (LVDD) may improve risk prediction after cardiac surgery. Current LVDD grading guidelines rely on echocardiographic variables that are not always available or aligned to allow gra ... Full text Link to item Cite

Impact of recovery of renal function on long-term mortality after coronary artery bypass grafting.

Journal Article Am J Cardiol · December 15, 2010 Whether prognosis differs in acute renal failure (ARF) after coronary artery bypass grafting (CABG) in patients with and without recovery of renal function is not known. We studied patients who had CABG at Duke University Medical Center (1995 to 2008). ARF ... Full text Link to item Cite

Phobic anxiety and increased risk of mortality in coronary heart disease.

Journal Article Psychosom Med · September 2010 OBJECTIVES: To evaluate whether phobic anxiety is associated with increased risk of cardiac mortality in individuals with established coronary heart disease (CHD) and to examine the role of reduced heart rate variability (HRV) in mediating this risk. Previ ... Full text Open Access Link to item Cite

Ranolazine-related dyspnea on exertion.

Journal Article Am J Geriatr Pharmacother · February 2010 BACKGROUND: Ranolazine is increasingly being prescribed for the treatment of chronic stable angina. This report describes an adverse effect that may be related to ranolazine. CASE SUMMARY: A 77-year-old white man with chronic renal insufficiency was evalua ... Full text Link to item Cite

Percutaneous coronary intervention or coronary artery bypass surgery for cardiogenic shock and multivessel coronary artery disease?

Journal Article Am Heart J · January 2010 BACKGROUND: Despite advances in treatment of cardiogenic shock (CS), the incidence of this serious complication of acute ST-elevation myocardial infarction (STEMI) has stayed relatively constant, and rates of mortality, although somewhat improved in recent ... Full text Link to item Cite

Gene expression patterns in peripheral blood correlate with the extent of coronary artery disease.

Journal Article PLoS One · September 14, 2009 Systemic and local inflammation plays a prominent role in the pathogenesis of atherosclerotic coronary artery disease, but the relationship of whole blood gene expression changes with coronary disease remains unclear. We have investigated whether gene expr ... Full text Link to item Cite

Influence of body mass index on the efficacy of revascularization in patients with coronary artery disease.

Journal Article J Thorac Cardiovasc Surg · June 2009 OBJECTIVE: We examined the effect of body mass index on the association between revascularization strategy and survival in patients with coronary artery disease. METHODS: Using the Duke Database for Cardiovascular Disease, we selected 22,877 patients who u ... Full text Link to item Cite

Association between n-3 fatty acid consumption and ventricular ectopy after myocardial infarction.

Journal Article Am J Clin Nutr · May 2009 BACKGROUND: n-3 (omega-3) Fatty acids are associated with a reduced risk of cardiovascular disease; however, the relation between dietary intake of n-3 fatty acids and ventricular arrhythmias has not been investigated among acute post-myocardial infarction ... Full text Link to item Cite

Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.

Journal Article PLoS Genet · January 2009 Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We have previously identified genetic linkage to familial CAD in the genomic region of NPY. We performed follow-up genetic, biostatistical, and functional analysis of NPY in ... Full text Open Access Link to item Cite

Ethnic differences in the treatment of depression in patients with ischemic heart disease.

Journal Article Am Heart J · January 2009 OBJECTIVE: The aim of this study is to examine ethnic differences in depressive symptoms and antidepressant treatment in a cohort of patients undergoing diagnostic coronary angiography. BACKGROUND: Coronary heart disease (CHD) is the leading cause of morta ... Full text Link to item Cite

Clinical characteristics associated with poor long-term survival among patients with diabetes mellitus undergoing saphenous vein graft interventions.

Journal Article Am Heart J · October 2008 BACKGROUND: Limited data exist on the long-term outcomes among diabetic patients undergoing saphenous vein graft (SVG) interventions. Thus, the baseline clinical factors associated with long-term adverse events in these patients are less known. METHODS: Ac ... Full text Link to item Cite

3-year follow-up of the SISR (Sirolimus-Eluting Stents Versus Vascular Brachytherapy for In-Stent Restenosis) trial.

Journal Article JACC Cardiovasc Interv · August 2008 OBJECTIVES: The aim of this study was to evaluate long-term outcome of patients treated for in-stent restenosis of bare-metal stents (BMS). BACKGROUND: Treatment of restenosis of BMS is characterized by high recurrence rates. Vascular brachytherapy (VBT) i ... Full text Link to item Cite

Clinical and angiographic correlates of short- and long-term mortality in patients undergoing coronary artery bypass grafting.

Journal Article Am J Cardiol · November 15, 2007 Differences in the clinical and angiographic factors associated with short- and long-term outcomes in patients undergoing coronary artery bypass grafting (CABG) are less known. Accordingly, differences were examined in clinical and angiographic correlates ... Full text Link to item Cite

The relation between clinical features, angiographic findings, and the target lesion revascularization rate in patients receiving the endeavor zotarolimus-eluting stent for treatment of native coronary artery disease: an analysis of ENDEAVOR I, ENDEAVOR II, ENDEAVOR II Continued Access Registry, and ENDEAVOR III.

Journal Article Am J Cardiol · October 22, 2007 The clinical and angiographic factors that predict clinically driven target lesion revascularization (TLR) in patients treated with the zotarolimus-eluting stent (ZES) are not known. Accordingly, the differences between ZES-treated patients who required TL ... Full text Link to item Cite

Mobile cardiac catheterization laboratories increase use of cardiac care in women and African Americans.

Journal Article Am Heart J · September 2007 BACKGROUND: Women and minorities traditionally have shown less use of diagnostic cardiac catheterization. We sought to determine whether mobile cardiac catheterization laboratories may increase the use of catheterization among women and minorities by bring ... Full text Link to item Cite

Paramedic transtelephonic communication to cardiologist of clinical and electrocardiographic assessment for rapid reperfusion of ST-elevation myocardial infarction.

Journal Article J Electrocardiol · July 2007 BACKGROUND/PURPOSE: We tested the hypothesis that paramedic recognition of ST-elevation myocardial infarction (STEMI) and cardiologist activation of the cardiac catheterization laboratory without transmission of the electrocardiogram reduces door-to-balloo ... Full text Link to item Cite

Hemolytic anemia: a rare but potentially serious adverse effect of captopril.

Journal Article Herz · February 2007 Captopril was the first oral angiotensin-converting enzyme (ACE) inhibitor available and, as such, has been extensively studied and in clinical use for many years. Several studies have defined captopril's efficacy in the treatment of congestive heart failu ... Full text Link to item Cite

Ventricular ectopy: impact of self-reported stress after myocardial infarction.

Journal Article Am Heart J · January 2007 BACKGROUND: Although psychologic stress has been implicated in the pathogenesis of ventricular arrhythmias, the relationship between self-reported stress and ventricular ectopy has not been evaluated under naturalistic conditions in acute post-myocardial i ... Full text Link to item Cite

Simultaneous restenosis of Taxus and Cypher drug-eluting stents.

Journal Article J Invasive Cardiol · November 2006 Link to item Cite

Selection of surgical or percutaneous coronary intervention provides differential longevity benefit.

Journal Article Ann Thorac Surg · October 2006 BACKGROUND: Treatment of coronary artery disease (CAD) is evolving with better medications, improvements in percutaneous coronary intervention (PCI), and enhanced techniques for coronary artery bypass grafting (CABG). METHODS: In this study, 18,481 patient ... Full text Link to item Cite

Clinical correlates of long-term mortality after percutaneous interventions of saphenous vein grafts.

Journal Article Am Heart J · October 2006 BACKGROUND: Increasing number of patients undergo percutaneous intervention of saphenous vein grafts (SVGs). However, the clinical factors associated with long-term mortality after SVG interventions are currently less known. Accordingly, the goal of presen ... Full text Link to item Cite

Acute myocardial infarction: safety of cardiac MR imaging after percutaneous revascularization with stents.

Journal Article Radiology · September 2006 PURPOSE: To retrospectively determine the safety of cardiac magnetic resonance (MR) imaging performed early (<14 days) after coronary stent implantation in patients with acute myocardial infarction (AMI). MATERIALS AND METHODS: This HIPPA-compliant study w ... Full text Link to item Cite

Impact of internal mammary artery conduit on long-term outcomes after percutaneous intervention of saphenous vein graft.

Journal Article Circulation · July 4, 2006 BACKGROUND: The influence of an internal mammary artery (IMA) graft on long-term outcomes after percutaneous saphenous vein graft (SVG) intervention is currently unknown. METHODS AND RESULTS: To examine the impact of IMA on outcomes in patients undergoing ... Full text Link to item Cite

Improved detection of coronary artery disease by stress perfusion cardiovascular magnetic resonance with the use of delayed enhancement infarction imaging.

Journal Article J Am Coll Cardiol · April 18, 2006 OBJECTIVES: We tested a pre-defined visual interpretation algorithm that combines cardiovascular magnetic resonance (CMR) data from perfusion and infarction imaging for the diagnosis of coronary artery disease (CAD). BACKGROUND: Cardiovascular magnetic res ... Full text Link to item Cite

Sirolimus-eluting stents vs vascular brachytherapy for in-stent restenosis within bare-metal stents: the SISR randomized trial.

Journal Article JAMA · March 15, 2006 CONTEXT: Although vascular brachytherapy is the only approved therapy for restenosis following bare-metal stent implantation, drug-eluting stents are now being used. Data on the relative merits of each are limited. OBJECTIVE: To determine the safety and ef ... Full text Link to item Cite

Phobic anxiety, depression, and risk of ventricular arrhythmias in patients with coronary heart disease.

Journal Article Psychosom Med · 2006 OBJECTIVE: Findings of an association between phobic anxiety and elevated risks of sudden cardiac death suggest that phobic anxiety may be related to increased risk of ventricular arrhythmias. The purpose of this study was to examine whether phobic anxiety ... Full text Link to item Cite

A new anatomic score for prognosis after cardiac catheterization in patients with previous bypass surgery.

Journal Article J Am Coll Cardiol · November 1, 2005 OBJECTIVES: The purpose of this study was to determine the value of a new anatomic score for prognosis after diagnostic catheterization in patients with previous coronary artery bypass grafting (CABG). BACKGROUND: Previous CABG patients comprise a growing ... Full text Link to item Cite

Reply

Journal Article Journal of the American College of Cardiology · October 2005 Full text Cite

Late thrombosis following treatment of in-stent restenosis with drug-eluting stents after discontinuation of antiplatelet therapy.

Journal Article Catheter Cardiovasc Interv · August 2005 Drug-eluting stent usage has become commonplace for the percutaneous treatment of de novo coronary lesions, but the safety and efficacy profile for their evolving usage in restenotic lesions is largely unknown. We report three cases of angiographically con ... Full text Link to item Cite

Music, imagery, touch, and prayer as adjuncts to interventional cardiac care: the Monitoring and Actualisation of Noetic Trainings (MANTRA) II randomised study.

Journal Article Lancet · July 16, 2005 BACKGROUND: Data from a pilot study suggested that noetic therapies-healing practices that are not mediated by tangible elements-can reduce preprocedural distress and might affect outcomes in patients undergoing percutaneous coronary intervention. We under ... Full text Link to item Cite

Outcomes following elective percutaneous coronary intervention without on-site surgical backup in a community hospital.

Journal Article Am J Cardiol · May 1, 2005 Despite guidelines to the contrary, limited numbers of elective percutaneous coronary intervention (PCI) procedures without on-site surgical backup are being performed, particularly in Europe and Canada. In the United States, many hospitals are considering ... Full text Link to item Cite

Reperfusion strategies for acute myocardial infarction in the elderly: benefits and risks.

Journal Article J Am Coll Cardiol · February 15, 2005 The optimal reperfusion strategy in elderly patients with ST-segment elevation myocardial infarction (STEMI) remains a topic of debate. This lack of consensus stems from the exclusion or under-representation of the elderly in clinical trials. This review e ... Full text Link to item Cite

Economic effects of prolonged clopidogrel therapy after percutaneous coronary intervention.

Journal Article J Am Coll Cardiol · February 1, 2005 OBJECTIVES: This study examined the incremental cost-effectiveness of extending clopidogrel therapy from one month to one year after percutaneous coronary intervention (PCI) in an unselected, heterogeneous patient population. BACKGROUND: Clinical trials su ... Full text Link to item Cite

Evaluation of the Medtronic (Driver) cobalt-chromium alloy coronary stent system.

Journal Article Am J Cardiol · January 1, 2005 The Driver Registry was a prospective, multicenter, nonrandomized study to evaluate the clinical safety and efficacy of the Driver cobalt-chromium alloy stent. Use of the cobalt-chromium alloy in place of stainless steel offers enhanced visibility and radi ... Full text Link to item Cite

Social support and religiosity as coping strategies for anxiety in hospitalized cardiac patients.

Journal Article Ann Behav Med · December 2004 BACKGROUND: Prospective studies have demonstrated that anxiety is associated with an increased risk of mortality and sudden cardiac death. There is therefore a need to understand what factors contribute to anxiety in patients with coronary heart disease (C ... Full text Link to item Cite

Which is the true channel?

Journal Article J Invasive Cardiol · December 2004 Link to item Cite

The bifurcation stent.

Journal Article J Invasive Cardiol · August 2004 Link to item Cite

Rationale and strategies for implementing community-based transfer protocols for primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction.

Journal Article J Am Coll Cardiol · June 16, 2004 The focus for the initial approach to the treatment of acute ST-segment elevation myocardial infarction (STEMI) has shifted toward extending the benefits of mechanical reperfusion with primary percutaneous coronary intervention (PCI) to patients who presen ... Full text Link to item Cite

Incidence and predictors of major vascular complications after percutaneous coronary intervention in the glycoprotein IIb/IIIa platelet inhibitor era.

Journal Article J Interv Cardiol · April 2004 Since the introduction of platelet glycoprotein (GP) IIb/IIIa inhibitors, reports of vascular complications after percutaneous coronary intervention (PCI) have focused on bleeding and the need for surgical repair, whereas specific major vascular complicati ... Full text Link to item Cite

"It's hard to make predictions, especially about the future".

Journal Article Catheter Cardiovasc Interv · March 2004 Full text Link to item Cite

Economic impact of drug-eluting stents on hospital systems: a disease-state model.

Journal Article Am Heart J · March 2004 BACKGROUND: Drug-eluting intracoronary stents decrease restenosis and later revascularization. The US Department of Health and Human Services (HHS), recognizing the financial and clinical impact of this technology, recently proposed accelerated reimburseme ... Full text Link to item Cite

Cerebral embolization during cardiac surgery: impact of aortic atheroma burden.

Other British journal of anaesthesia · November 2003 BACKGROUND: Aortic atheromatous disease is known to be associated with an increased risk of perioperative stroke in the setting of cardiac surgery. In this study, we sought to determine the relationship between cerebral microemboli and aortic atheroma burd ... Cite

Trained and supervised physician assistants can safely perform diagnostic cardiac catheterization with coronary angiography.

Journal Article Catheter Cardiovasc Interv · June 2003 Using a prospectively collected database of patients undergoing cardiac catheterization, we sought to compare the outcomes of procedures performed by supervised physician assistants (PAs) with those performed by supervised cardiology fellows-in-training. O ... Full text Link to item Cite

Clinical and angiographic efficacy of a self-expanding nitinol stent in saphenous vein graft atherosclerotic disease: the Stent Comparative Restenosis (SCORES) Saphenous Vein Graft Registry.

Journal Article Am Heart J · May 2003 BACKGROUND: The Stent Comparative Restenosis (SCORES) Saphenous Vein Graft (SVG) Registry was a multicenter, prospective registry designed to evaluate the safety and efficacy of a self-expanding, nickel-titanium (nitinol) stent for de novo SVG lesions. MET ... Full text Link to item Cite

Implementing a New Method for Activated Clotting Time

Journal Article Plastic Surgical Nursing · January 1, 2003 Point-of-care determination of the activated clotting time (ACT) has become the standard of care in a number of clinical situations. The authors converted from ACT done by the Hemochron 801 analyzer, which uses tubes containing either celite, kaolin, or gl ... Full text Cite

Radiocontrast nephropathy: a time for affirmative action.

Journal Article J Invasive Cardiol · January 2003 Link to item Cite

Contrast nephropathy : an evidence-based approach to prevention.

Journal Article Am J Cardiovasc Drugs · 2003 Contrast-induced nephropathy occurs in 2-10% of patients exposed to intravascular radiographic contrast agents and results in significant morbidity and mortality. Although the exact mechanism of this disorder has not been fully elucidated, contrast nephrop ... Full text Link to item Cite

Assessing quality in the cardiac catheterization laboratory.

Journal Article Am Heart Hosp J · 2003 Quality assurance and improvement have increasingly been the focus of health care providers, third-party payers, and patients. Because cardiovascular procedures are common, easily identifiable with claims data, and account for a relatively large proportion ... Full text Link to item Cite

Inflammation, platelets, and glycoprotein IIb/IIIa inhibitors.

Journal Article J Invasive Cardiol · December 2002 Atherosclerosis, with its thromboembolic complications (including sudden cardiac death, myocardial infarction, and other ischemic organ damage such as stroke and ischemic renovascular disease), represents by far the major cause of death, morbidity, and dis ... Link to item Cite

Randomized COMparison of platelet inhibition with abciximab, tiRofiban and eptifibatide during percutaneous coronary intervention in acute coronary syndromes: the COMPARE trial. Comparison Of Measurements of Platelet aggregation with Aggrastat, Reopro, and Eptifibatide.

Journal Article Circulation · September 17, 2002 BACKGROUND: The relative anti-aggregatory effects of currently prescribed platelet glycoprotein IIb/IIIa receptor antagonists during and after percutaneous coronary intervention for acute coronary syndromes have not been established. METHODS AND RESULTS: W ... Full text Link to item Cite

Removal of thrombus by catheter aspiration prior to stenting.

Journal Article J Invasive Cardiol · August 2002 Link to item Cite

Successful percutaneous coronary intervention with stent implantation in anomalous right coronary arteries arising from the left sinus of valsalva: a report of two cases.

Journal Article Catheter Cardiovasc Interv · January 2002 Percutaneous coronary intervention (PCI) in an anomalous right coronary artery arising from the left sinus of valsalva can be technically challenging because of difficulty in selectively cannulating the vessel. We present two cases of successful stent impl ... Full text Link to item Cite

The bent stent.

Journal Article J Invasive Cardiol · January 2002 Link to item Cite

The impact of statistical adjustment on economic profiles of interventional cardiologists.

Journal Article J Am Coll Cardiol · November 1, 2001 OBJECTIVES: The objective of this study was to identify preprocedure patient factors associated with percutaneous intervention costs and to examine the impact of these patient factors on economic profiles of interventional cardiologists. BACKGROUND: There ... Full text Link to item Cite

Saphenous vein graft disease: a left main equivalent.

Journal Article J Invasive Cardiol · September 2001 Link to item Cite

Sonographically guided thrombin injection of iatrogenic femoral pseudoaneurysms: further experience of a single institution.

Journal Article AJR Am J Roentgenol · August 2001 OBJECTIVE: In September 1998, we began to treat iatrogenic femoral pseudoaneurysms with direct thrombin injection under sonographic guidance. Our purpose was to determine the success and complication rate of this technique. SUBJECTS AND METHODS: We treated ... Full text Link to item Cite

Acute myocardial infarction in a young female.

Journal Article J Invasive Cardiol · August 2001 Link to item Cite

Comparison of self-expanding and balloon-expandable stents for the reduction of restenosis.

Journal Article Am J Cardiol · August 1, 2001 To compare the efficacy of self-expanding (SE) and balloon-expandable (BE) stents in native coronary arteries, we randomly assigned 1,096 patients with new and restenotic lesions to receive either device. Baseline demographics and coronary angiographic cha ... Full text Link to item Cite

No jacket required.

Journal Article J Invasive Cardiol · July 2001 Link to item Cite

Achieving optimal results with standard balloon angioplasty: can baseline and angiographic variables predict stent-like outcomes?

Journal Article J Am Coll Cardiol · June 1, 2001 OBJECTIVES: To predict which patients might not require stent implantation, we identified clinical and angiographic characteristics associated with repeat revascularization after standard balloon angioplasty. BACKGROUND: Stents reduce the risk of repeat re ... Full text Link to item Cite

Apolipoprotein E polymorphisms and age at first coronary artery bypass graft.

Journal Article Anesth Analg · April 2001 UNLABELLED: Apolipoprotein E (apoE) polymorphisms are heritable determinants of total and low-density lipoprotein cholesterol. The impact of apoE4 genotypes on the severity of atherosclerosis has been debated; however, recent studies have identified a corr ... Full text Link to item Cite

Outcome of acute ST-segment elevation myocardial infarction in patients with prior coronary artery bypass surgery receiving thrombolytic therapy.

Journal Article Am Heart J · March 2001 BACKGROUND: Patients with prior coronary bypass surgery with acute ST-segment elevation myocardial infarction (MI) pose an increasingly common clinical problem. We assessed the characteristics and outcomes of such patients undergoing thrombolysis for acute ... Full text Link to item Cite

Effectiveness and safety of abciximab after failed thrombolytic therapy.

Journal Article Am J Cardiol · February 15, 2001 Among 214 patients treated with abciximab within 24 hours of full-dose thrombolytic therapy, major bleeding occurred in 50 patients (23%; 95% confidence interval [CI] 18% to 30%) and intracranial hemorrhage occurred in 3 patients (1.4%; 95% CI 0.3% to 4%). ... Full text Link to item Cite

Prevention of contrast media-induced renal dysfunction with prostaglandin E1: a randomized, double-blind, placebo-controlled study.

Journal Article Am J Ther · 2001 Preexisting renal impairment is an all-encompassing risk factor for radiocontrast-associated nephrotoxicity. Renal impairment appears to be associated with the inadequate production of renal prostaglandins at the critical time of radiocontrast administrati ... Full text Link to item Cite

Comparison of medicine alone, coronary angioplasty, and left internal mammary artery-coronary artery bypass for one-vessel proximal left anterior descending coronary artery disease.

Journal Article Am J Cardiol · December 15, 2000 Despite the deleterious and sometimes catastrophic consequences of proximal left anterior descending (LAD) artery occlusion, there is a paucity of data to guide the treatment of patients with such disease. Our aim was to describe outcomes with medical ther ... Full text Link to item Cite

Thrombolytic, antithrombin, and antiplatelet treatment of acute coronary syndromes.

Journal Article J Am Osteopath Assoc · November 2000 Acute coronary syndromes are a major public health problem and the leading cause of death in the western world. Acute coronary syndromes consist of unstable angina pectoris, non-ST-segment-elevation myocardial infarction, and ST-segment-elevation myocardia ... Link to item Cite

Provisional stenting strategies: systematic overview and implications for clinical decision-making.

Journal Article J Am Coll Cardiol · October 2000 Coronary stents reduce the rates of abrupt closure, emergency coronary artery bypass graft surgery and restenosis, but do not prevent myocardial infarction or death at six months. The financial burden of increased stent use and the difficulty in managing i ... Full text Link to item Cite

Contrast Agents for Cardiac Angiography: Osmolality and Contrast Complications.

Journal Article Curr Interv Cardiol Rep · August 2000 Radiographic contrast agents have undergone a tremendous evolution over the past several decades. The creation of contrast agents with greater iodine carrying capacity and lower osmolality has improved imaging quality and reduced complications, including n ... Link to item Cite

Treatment of iatrogenic femoral arterial pseudoaneurysms: comparison of US-guided thrombin injection with compression repair.

Journal Article Radiology · May 2000 PURPOSE: To evaluate and compare the treatment of iatrogenic femoral arterial pseudoaneurysms by using ultrasonographically (US) guided direct thrombin injection with US-guided compression repair. MATERIALS AND METHODS: Twenty-six patients with iatrogenic ... Full text Link to item Cite

Local delivery of heparin post-PTCA: a multicenter randomized pilot study.

Journal Article Catheter Cardiovasc Interv · April 2000 Bailout stenting for major dissection and threatened closure has high rates of ischemic complications. We performed a randomized trial of local heparin delivery using the infusion sleeve before bailout stenting for suboptimal angioplasty results. In phase ... Full text Link to item Cite

Outcomes following interventions in small coronary arteries with the use of hand-crimped Palmaz-Schatz stents.

Journal Article Am J Cardiol · February 15, 2000 Although coronary stenting has been shown to be effective, retrospective studies have suggested that stents do not provide better results than angioplasty in small coronary arteries. We sought to examine procedural, in-hospital, and long-term outcomes of p ... Full text Link to item Cite

Efficacy of abciximab readministration in coronary intervention.

Journal Article Am J Cardiol · February 15, 2000 Abciximab, an Fab monoclonal antibody fragment that blocks the platelet glycoprotein IIb/IIIa receptor, is increasingly used as an adjunct to coronary intervention. Little is known, however, about the efficacy and safety of readministration of abciximab. T ... Full text Link to item Cite

Treatment of Palmaz-Schatz in-stent restenosis: 6-Month clinical follow-up

Journal Article Journal of Interventional Cardiology · January 1, 2000 To identify predictors of Palmaz-Schatz in-stent restenosis and determine outcomes of treatment, we assessed 6-month outcomes in 402 patients who had coronary intervention with stent placement; 60 (15%) developed angiographic and clinical evidence of reste ... Full text Cite

To stent or not to stent--that is the question.

Journal Article J Am Coll Cardiol · November 1, 1999 Full text Link to item Cite

Intracoronary thrombus: an ongoing challenge.

Journal Article J Invasive Cardiol · August 1999 Link to item Cite

[Prostaglandin E1 for prevention of contrast medium-induced kidney dysfunction].

Journal Article Rofo · June 1999 PURPOSE: Acute renal failure is a known complication of contrast media (CM) application in risk patients. Therefore an efficient prevention is highly desirable. The purpose of this pilot study was a) to demonstrate the efficacy and safety of prostaglandin ... Full text Link to item Cite

Risk of distal embolization and infarction with transluminal extraction atherectomy in saphenous vein grafts and native coronary arteries. NACI Investigators. New Approaches to Coronary Interventions.

Journal Article Catheter Cardiovasc Interv · June 1999 Lower success rates have been reported when treating high-risk lesions in saphenous vein grafts (SVGs) and native coronary arteries with balloon angioplasty. The transluminal extraction atherectomy catheter (TEC) has been proposed to reduce the incidence o ... Full text Link to item Cite

Gender and drug induced torsades de pointes

Journal Article ACC Current Journal Review · April 20, 1999 Cite

Support for the open-artery hypothesis in survivors of acute myocardial infarction: analysis of 11,228 patients treated with thrombolytic therapy.

Journal Article Am J Cardiol · February 15, 1999 We examined the possible benefits of achieving and maintaining infarct-related artery potency beyond the time when preservation of left ventricular function would be expected. The open-artery hypothesis suggests that a patent infarct-related artery confers ... Full text Link to item Cite

Diagnosing coronary arterial stent thrombosis and arterial closure.

Journal Article Am J Cardiol · September 1, 1998 This single-center review of a consecutive series of patients requiring reexamination by angiography within 1 week of a coronary stent placement due to chest pain reveals that patients treated with a poststent anticoagulation regimen of warfarin and aspiri ... Full text Link to item Cite

Internal mammary artery graft angioplasty: acute and long-term outcome.

Journal Article Cathet Cardiovasc Diagn · June 1998 Secondary to the low attrition rate of internal mammary artery grafts, limited data are available on the clinical and angiographic outcome of patients who have undergone balloon angioplasty of an internal mammary artery stenosis. This study examined a cons ... Full text Link to item Cite

Neovascularization in atherectomy specimens from patients with unstable angina: implications for pathogenesis of unstable angina.

Journal Article Am Heart J · January 1998 Although neovascularization has been noted in atherosclerotic plaque, the presence of neovascularization has not been correlated with clinical syndromes. This study examined the relation between neovascularization in atherosclerotic plaque removed during d ... Full text Link to item Cite

Predictors of acute and long-term outcome with transluminal extraction atherectomy: the New Approaches to Coronary Intervention (NACI) registry.

Journal Article Am J Cardiol · November 20, 1997 The New Approaches to Coronary Intervention (NACI) registry was established to define the role of new coronary devices in overcoming the limitations of balloon angioplasty. The purpose of the present study was to evaluate the acute and long-term efficacy o ... Full text Link to item Cite

Excimer laser coronary angioplasty: the New Approaches to Coronary Intervention (NACI) experience.

Journal Article Am J Cardiol · November 20, 1997 In the New Approaches to Coronary Intervention (NACI) registry, 887 patients were electively treated with excimer laser coronary angioplasty (ELCA) for coronary artery disease. The Advanced Interventional System (AIS) system was used in 487 cases; the Spec ... Full text Link to item Cite

Lossy (15:1) JPEG compression of digital coronary angiograms does not limit detection of subtle morphological features.

Journal Article Circulation · August 19, 1997 BACKGROUND: Development of the "all-digital" cardiac catheterization laboratory has been slowed by substantial computer archival and transfer requirements. Lossy data compression reduces this burden but creates irreversible changes in images, potentially i ... Full text Link to item Cite

The natural history of single-vessel chronic coronary occlusion: a 25-year experience.

Journal Article Am Heart J · April 1997 To determine the natural history of patients with a total occlusion of a single coronary artery, we searched the Duke Databank for Cardiovascular Disease to find all patients who underwent a first coronary angiogram >2 days after a symptomatic myocardial i ... Full text Link to item Cite

Thrombolytic therapy for patients with prior percutaneous transluminal coronary angioplasty and subsequent acute myocardial infarction. GUSTO-I Investigators. Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries.

Journal Article Am J Cardiol · December 15, 1996 Our purpose was to evaluate the outcomes of patients with prior coronary angioplasty who underwent thrombolysis for new acute myocardial infarction (AMI) in the Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries-I trial. Baseline c ... Full text Link to item Cite

The natural history of single vessel chronic total occlusions

Journal Article ACC Current Journal Review · January 1, 1996 Full text Cite

Percutaneous revascularization of chronic coronary occlusions: an overview.

Journal Article J Am Coll Cardiol · July 1995 Patients with a chronic coronary occlusion often undergo coronary angiography after weeks to months of occlusion. The published reports underestimate the extent of this problem because such patients are often arbitrarily assigned to receive medical therapy ... Full text Link to item Cite

The role of the perfusion balloon catheter after an initially unsuccessful coronary intervention.

Journal Article J Interv Cardiol · June 1995 Major dissection and acute closure following conventional percutaneous transluminal coronary angioplasty (PTCA) occur in 5%-10% of cases and lead to significant morbidity. Newer percutaneous modalities such as directional coronary atherectomy (DCA), excime ... Full text Link to item Cite

Transluminal extraction catheter for the treatment of diseased saphenous vein grafts: a multicenter experience.

Journal Article Cathet Cardiovasc Diagn · February 1995 To evaluate the efficacy, safety, and long-term results of atherectomy using the Transluminal Extraction catheter (TEC), patients with diseased saphenous vein grafts were enrolled in a prospective nonrandomized trial. Patients were followed to hospital dis ... Full text Link to item Cite

Differential expression of tissue factor protein in directional atherectomy specimens from patients with stable and unstable coronary syndromes.

Journal Article Circulation · February 1, 1995 BACKGROUND: Tissue factor (TF) is a cell membrane-associated protein that catalyzes the rate-limiting step of the extrinsic coagulation pathway, which is the major source of thrombin production in vivo. To explore the potential role that TF may play in isc ... Full text Link to item Cite

Use of the perfusion balloon as a primary dilation device.

Journal Article J Invasive Cardiol · 1995 The development of more user-friendly and versatile perfusion balloon catheters has increased the use of prolonged dilations as a primary catheter treatment for coronary artery disease. In a multicenter randomized trial, the use of these devices to prolong ... Link to item Cite

Thrombolysis or primary angioplasty in acute myocardial infarction?

Journal Article ACC Current Journal Review · January 1, 1995 Full text Cite

Transluminal extraction coronary atherectomy.

Journal Article Cardiol Clin · November 1994 The TEC is a forward-cutting atherectomy catheter that has the unique potential to excise and aspirate atheroma, especially intraluminal thrombus. This device has been under clinical investigation for more than 6 years and received final marketing approval ... Link to item Cite

The impact of autoperfusion on quantitative electrocardiographic parameters of ischemia severity, extent, and "burden" during salvage of elective coronary angioplasty.

Journal Article J Invasive Cardiol · September 1994 Long angioplasty inflations have been reported using an autoperfusion system that delivers oxygenated blood distal to the balloon segment. The safety and efficacy of this system has been demonstrated in anatomically selected patients. The clinical use, how ... Link to item Cite

A randomized comparison of the effects of gradual prolonged versus standard primary balloon inflation on early and late outcome. Results of a multicenter clinical trial. Perfusion Balloon Catheter Study Group.

Journal Article Circulation · March 1994 BACKGROUND: Observational studies have suggested that prolonged balloon inflation during coronary angioplasty is associated with a high clinical success rate. This randomized clinical trial sought to evaluate the impact of primary gradual and prolonged inf ... Full text Link to item Cite

Myocardial perfusion and ventricular function measurements during total coronary artery occlusion in humans. A comparison with rest and exercise radionuclide studies.

Journal Article Circulation · January 1994 BACKGROUND: The purpose of this investigation was to compare the magnitude of change in myocardial perfusion and function during exercise with that obtained during total coronary artery occlusion. Radionuclide studies are widely used for the diagnosis and ... Full text Link to item Cite

Multivariate approach to QRS detection

Journal Article Proceedings of the Annual Conference on Engineering in Medicine and Biology · December 1, 1993 We have developed a QRS detection algorithm based on a multivariate model, in which three independent, normalized measures -- amplitude, first difference, and spatial frequency -- are combined in a weighted sum to generate an indicator variable that is the ... Cite

Baseline characteristics and therapeutic goals in the New Approaches to Coronary Intervention (NACI) registry.

Journal Article Coron Artery Dis · November 1993 BACKGROUND: The New Approaches to Coronary Intervention (NACI) voluntary registry was designed to study the use, safety, and efficacy of new percutaneous transluminal interventional devices including directional coronary atherectomy, the transluminal extra ... Full text Link to item Cite

Structure and function of academic divisions of cardiology. Task Force Reports from the Association of Professors of Cardiology.

Journal Article Arch Intern Med · October 25, 1993 The discipline of cardiovascular medicine has undergone a striking transformation in recent decades. The field has always been of primary importance in medicine, because of the high prevalence of diseases of the cardiovascular system. However, progress in ... Full text Link to item Cite

Loss of efficacy during long-term cifenline therapy: development of antiarrhythmic resistance?

Journal Article Ann Pharmacother · May 1993 OBJECTIVE: To describe the possible development of antiarrhythmic resistance to cifenline, an investigational Class I agent. METHODS: Forty patients with chronic ventricular premature depolarizations (VPDs) underwent dose-ranging studies with cifenline, an ... Full text Link to item Cite

Thermal-perfusion balloon coronary angioplasty: in vivo evaluation.

Journal Article Am Heart J · January 1993 The goal of this study was to develop and test a new radio frequency thermal balloon system to allow longer balloon inflations at lower temperature levels than have been used with standard (laser) thermal balloon angioplasty. Radio frequency thermal capabi ... Full text Link to item Cite

Robust and computational efficient QRS detection

Journal Article Computers in Cardiology · 1993 A QRS detection algorithm has been developed based on a multivariate model. It included three normalized measures - amplitude, first difference, and spatial frequency. The terms are combined in a weighted sum to generate an indicator variable that is then ... Cite

Best feature selection using successive elimination of poor performers

Journal Article Proceedings of the Annual Conference on Engineering in Medicine and Biology · 1993 This paper addresses the issue of feature extraction and selection, focusing particularly ion the feature selection issue. Without assuming any particular classification algorithm it suggests that first one should extract as much information (features) as ... Cite

Thallium-201 myocardial imaging in patients with coronary artery disease: comparison of intravenous adenosine and oral dipyridamole.

Journal Article Ann Pharmacother · November 1992 OBJECTIVE: To compare thallium-201 (201Tl) myocardial perfusion imaging following intravenous adenosine and oral dipyridamole. DESIGN: Open-label, randomized, comparison. SETTING: Outpatient, university-affiliated clinic. PATIENTS: Fifteen patients with an ... Full text Link to item Cite

Prospective analysis of possible myocardial damage or hemolysis occurring as a result of prolonged autoperfusion angioplasty in humans.

Journal Article J Am Coll Cardiol · September 1992 OBJECTIVES: The purpose of this study was to further explore the procedural safety of prolonged (15-min) dilation using an autoperfusion coronary angioplasty balloon by assessing the degree of myocardial damage or hemolysis, if any, occurring as a result o ... Full text Link to item Cite

Ten-year experience with mitral valve replacement in the elderly.

Journal Article Am Heart J · July 1992 Limited data are available on mitral valve replacement in the elderly patient. Therefore we report our 10-year experience including predictors of perioperative mortality and subsequent long-term cardiac mortality in elderly patients with mitral valve repla ... Full text Link to item Cite

Comparative pharmacodynamics of intravenous lidocaine in patients with acute and chronic ventricular arrhythmias.

Journal Article Ann Pharmacother · June 1992 OBJECTIVE: To evaluate the pharmacodynamics of intravenous lidocaine in patients with acute-onset and chronic ventricular arrhythmias. DESIGN: Open-label, pharmacodynamic evaluation. SETTING: Private, university-affiliated, hospital coronary-care unit. PAT ... Full text Link to item Cite

Effects of verapamil on postextrasystolic potentiation.

Journal Article Chest · May 1992 To assess the effects of verapamil on postextrasystolic potentiation (PESP), contrast left ventriculography was performed in ten healthy anesthetized dogs before and after the intravenous administration of verapamil, 0.1 mg/kg. During the contrast ventricu ... Full text Link to item Cite

Efficacy and safety of early versus late initiation of warfarin during heparin therapy in acute thromboembolism.

Journal Article Am Heart J · March 1992 There is no universally accepted approach to the initiation of systemic anticoagulant therapy. In an open, randomized study, two anticoagulant regimens that differed only in the timing of warfarin therapy after the start of heparin were compared. We random ... Full text Link to item Cite

Effect of buspirone on withdrawal symptoms associated with smoking cessation.

Journal Article Arch Intern Med · February 1992 BACKGROUND: Preliminary information suggests that buspirone hydrochloride ameliorates symptoms of nicotine withdrawal. In a double-blind, randomized, placebo-controlled trial, we determined the effects of buspirone on the withdrawal symptoms associated wit ... Link to item Cite

Effect of digoxin on ST-segment changes detected by ambulatory electrocardiographic monitoring in healthy subjects.

Journal Article Am J Cardiol · December 1, 1991 Digoxin causes false-positive ST depression during exercise stress testing, but it is unknown if digoxin produces ST depression during ambulatory electrocardiographic monitoring. Fifty healthy volunteers underwent both exercise stress testing and ambulator ... Full text Link to item Cite

Pharmacokinetic and tolerance evaluation of actisomide, a new antiarrhythmic agent, in healthy volunteers.

Journal Article DICP · March 1991 The pharmacokinetics and tolerance of actisomide (SC-36602) were determined following intravenous doses of 2.1, 4.2, and 8.4 mg/kg infused over five hours. Plasma concentrations observed in the low-dose group (2.1 mg/kg) were below the assay's limit of det ... Full text Link to item Cite

Coronary transluminal extraction-endarterectomy.

Journal Article J Invasive Cardiol · 1991 Link to item Cite

Efficacy and tolerance of high-dose intravenous amiodarone for recurrent, refractory ventricular tachycardia.

Journal Article Am J Cardiol · March 1, 1990 High-dose intravenous amiodarone was given to 35 patients with recurrent life-threatening ventricular tachycardia (VT) refractory to conventional antiarrhythmic agents. Intravenous amiodarone was given as a 5 mg/kg dose over 30 minutes followed by 20 to 30 ... Full text Link to item Cite

Ten-year results with the St. Jude Medical prosthesis.

Journal Article Am J Cardiol · January 15, 1990 Although the hemodynamic characteristics and durability of the St. Jude valve prosthesis have been reported, the need for and the degree of anticoagulation in patients who receive these valves remain uncertain. Our 10-year experience with 165 patients (100 ... Full text Link to item Cite

Myocardial uptake and clearance of T1-201 in healthy subjects: comparison of adenosine-induced hyperemia and exercise stress.

Journal Article Radiology · December 1989 Pharmacologic stress testing with dipyridamole is useful in patients undergoing thallium-201 myocardial perfusion scintigraphy who cannot adequately exercise. Because dipyridamole increases coronary blood flow by reducing the metabolism of adenosine, the a ... Full text Link to item Cite

Nifedipine in the treatment of hypertensive episodes in the coronary care unit.

Journal Article DICP · November 1989 The effectiveness of nifedipine for the treatment of acute hypertensive episodes in patients already taking chronic calcium-channel blocker therapy is unknown. We report our experience with 43 consecutive patients who received nifedipine for acute hyperten ... Full text Link to item Cite

Previously unreported adverse reaction to encainide.

Journal Article Chest · September 1989 We describe a patient with recurrent atrial fibrillation who suffered a previously unreported adverse reaction to encainide therapy manifested by fever, chills, diaphoresis and myalgia. The patient had a similar response upon rechallenging with encainide, ... Full text Link to item Cite

Long-term follow-up of patients with echocardiographically detected mitral anular calcium and comparison with age- and sex-matched control subjects.

Journal Article Am J Cardiol · February 15, 1989 One hundred seven patients with echocardiographically documented mitral anular calcium (MAC) and 107 age- and sex-matched control subjects without MAC were studied and followed for a mean of 4.4 +/- 2.4 (standard deviation) years. Fourteen (7%) patients we ... Full text Link to item Cite

Acute myocardial infarction.

Journal Article Postgrad Med · February 1, 1989 Full text Link to item Cite

Acute myocardial infarction. Management after discharge from the coronary care unit.

Journal Article Postgrad Med · February 1, 1989 Although interventional techniques have changed the management of acute phases of myocardial infarction, they have not altered the need for evaluating long-term risk factors. As many as 60% of patients with multiple risk factors die within one year after d ... Link to item Cite

A comparison of sublingual nifedipine versus nitroglycerin in the treatment of acute angina pectoris.

Journal Article DICP · 1989 The administration of nifedipine by the sublingual rather than the oral route has been suggested to provide a more rapid onset of effect. We compared the safety and efficacy of sl nifedipine to sl nitroglycerin in patients who developed anginal chest pain ... Full text Link to item Cite

Adverse reaction profiles of long-term class I antiarrhythmic therapy in patients with potentially malignant ventricular arrhythmias

Journal Article Current Therapeutic Research - Clinical and Experimental · 1989 The long-term outcome of 698 patients discharged from the hospital following initiation of successful class I antiarrhythmic agents for potentially malignant ventricular arrhythmias was studied retrospectively. The study population consisted of patients wi ... Cite

Evaluation of a frequency-domain algorithm to detect ventricular fibrillation in the surface elctrocardiogram

Journal Article Computers in Cardiology · September 1, 1988 The authors evaluate a frequency-domain algorithm for use by the CREI-GARD computerized arrhythmia system (F. M. Nolle et al., 1986) to detect ventricular fibrillation (VF) in the surface ECG. This was accomplished using (1) The American Heart Association ... Cite

Mitral annular calcification and coarctation of aorta.

Journal Article Clin Cardiol · August 1988 Although coarctation of the aorta is associated with various cardiac abnormalities, its association with mitral annular calcification (MAC) is not reported. We therefore report a 37-year-old patient with postductal coarctation of the aorta and MAC. Conside ... Full text Link to item Cite

Clinical significance of exercise-induced bundle branch block.

Journal Article Am J Cardiol · February 1, 1988 To evaluate the diagnostic significance and long-term follow-up data of patients with exercise-induced bundle branch block (BBB), 10,176 consecutive patients' exercise test data were reviewed and 50 patients found to have exercise-induced BBB. Clinical, ex ... Full text Link to item Cite

CREI-GARD, A NEW CONCEPT IN COMPUTERIZED ARRHYTHMIA MONITORING SYSTEMS.

Journal Article Computers in Cardiology · December 1, 1987 CREI-GARD is a computer system developed for inpatient ECG monitoring. The system is used to provide real-time data on the frequencies and types of ventricular arrhythmias and to document the occurrences of other arrhythmias. The system is centrally operat ... Cite

Calcific valvular aortic stenosis with and without mitral anular calcium.

Journal Article Am J Cardiol · October 1, 1987 Seventy-six consecutive patients, mean age 66 +/- 9 years (+/- standard deviation), with isolated aortic valve replacement for calcific valvular aortic stenosis (AS) were studied. Mitral anular calcium (MAC) was detected by echocardiography in 45 patients ... Full text Link to item Cite

Double-blind randomized comparison of intravenous tocainide versus lidocaine in the treatment of chronic ventricular arrhythmias.

Journal Article Am Heart J · August 1987 The efficacy and safety of intravenous tocainide were compared with intravenous lidocaine in patients with chronic ventricular arrhythmias in a double-blind, parallel study. Twenty-nine patients were randomized to a tocainide (n = 15) or lidocaine (n = 14) ... Full text Link to item Cite

Frequency of physical activity, exercise capacity, and atherosclerotic heart disease risk factors in male police officers.

Journal Article J Occup Med · July 1987 A total of 171 male police officers volunteered to (1) assess risk factors for developing atherosclerotic heart disease and (2) evaluate the relationship of fitness to risk. Results revealed substantial numbers of officers with elevated risk: 22% were smok ... Link to item Cite

Catecholamine, renin-aldosterone, and glucoregulatory responses to maximal exercise in humans: Effects of prolonged bedrest

Journal Article Journal of Cardiopulmonary Rehabilitation · January 1, 1987 The catecholamine, renin-aldosterone, and glucose-insulin responses to maximal exercise were studied in 18 young, healthy male subjects. Eight of these subjects agreed to further undergo an 18-day period of bedrest, following which the exercise protocol wa ... Full text Cite

Myocardial bridges: effect of propranolol on systolic compression.

Journal Article Can J Cardiol · 1986 Myocardial bridges may exert an ischemic effect on the myocardium and often warrant therapy including surgical correction in selected cases. Decrease in systolic compression after the administration of propranolol has not been reported. We report a patient ... Link to item Cite

Early exercise training in patients older than age 65 years compared with that in younger patients after acute myocardial infarction or coronary artery bypass grafting.

Journal Article Am J Cardiol · February 1, 1985 To evaluate potential benefits that elderly cardiac patients might gain from early exercise programs, 361 such patients were studied: group I--60 patients aged 44 years or younger; group II--114 patients aged 45 to 54 years; group III--111 patients aged 55 ... Full text Link to item Cite

Exercise testing and digitalized patients

Journal Article Primary Cardiology · January 1, 1985 Cite

Aggravation of exercise performance in patients with anemia by 3% carboxyhemoglobin.

Journal Article Environ Res · December 1984 To evaluate the effect of breathing 50 ppm carbon monoxide (CO) on exercise capacity in persons with anemia, 10 nonsmoking subjects with chronic anemia (mean hemoglobin 8.9 g%) were studied. No subject had heart or lung disease. By double-blind, randomized ... Full text Link to item Cite

Clinical characteristics of patients younger than 60 years with mitral anular calcium: comparison with age- and sex-matched control subjects.

Journal Article Am J Cardiol · December 1, 1984 The clinical characteristics of 107 patients younger than 60 years with mitral anular calcium (MAC) were compared with those of 107 age- and sex-matched control subjects. The patients with MAC included 55 men and 52 women, mean age 51 years. The control gr ... Full text Link to item Cite

Guidelines for exercise therapy of the elderly after myocardial infarction.

Journal Article Eur Heart J · November 1984 We have previously demonstrated that elderly male cardiac patients benefit from participation in early exercise programmes through enhancement of functional capacity and improved psychological responses to exertion. Based on our experience, we present guid ... Full text Link to item Cite

The value of early out-patient cardiac exercise programmes for the elderly in comparison with other selected age groups.

Journal Article Eur Heart J · November 1984 To evaluate potential benefits that elderly cardiac patients might gain from early exercise programs, 361 cardiac patients were studied. Seventy-six patients were older than 65 years (elderly). All patients participated in a 12 week exercise program within ... Full text Link to item Cite

Carboxyhemoglobin levels in banked blood.

Journal Article Chest · May 1984 To determine the prevalence of carboxyhemoglobin levels in banked blood exceeding Air Quality Standards (level of carboxyhemoglobin greater than 1.5 percent), we analyzed banked blood for the level of carboxyhemoglobin from 101 randomly selected samples. O ... Full text Link to item Cite

Correlation between calcific aortic stenosis diagnosed by two-dimensional echocardiography and cardiac catheterization.

Journal Article Clin Cardiol · May 1984 This retrospective study correlates the severity of calcific aortic stenosis determined by two-dimensional (2-D) echocardiography with the aortic valve area determined by catheterization in 57 patients. Aortic valve leaflet calcification was diagnosed by c ... Full text Link to item Cite

Limitations of exercise testing to screen cardiac patients for early nonmonitored rehabilitation exercise programs

Journal Article Journal of Cardiac Rehabilitation · January 1, 1984 To evaluate whether exercise testing might identify cardiac patients who do not require continuous electrocardiographic (ECG) monitoring during early rehabilitation exercise programs, 202 subjects (88 post-myocardial infarction [MI] patients and 114 post-c ... Cite

Reply

Journal Article The American Journal of Cardiology · January 1, 1984 Full text Cite

Cardiac conduction defects in patients older than 60 years with aortic stenosis with and without mitral anular calcium.

Journal Article Am J Cardiol · January 1, 1984 The prevalence of conduction defects was investigated in 51 patients older than 60 years with aortic stenosis (AS) who underwent aortic valve replacement. Thirty one of the 51 patients, (61%) had associated mitral anular calcium (MAC). The mean age and pre ... Full text Link to item Cite

Tocainide kinetics in congestive heart failure.

Journal Article Clin Pharmacol Ther · November 1983 Our subjects were 20 patients with life-threatening or symptomatic ventricular arrhythmias refractory to standard oral antiarrhythmic drugs but responsive to intravenous lidocaine. After evaluation of arrhythmias and treatment with intravenous lidocaine, o ... Full text Link to item Cite

After myocardial infarction. How to determine future risk and what to do then.

Journal Article Postgrad Med · June 1983 Management of the postinfarction patient should be directed toward identifying and treating individuals at risk of future coronary morbidity or mortality. The history, physical examination, resting ECG, and chest film, supplemented with ambulatory electroc ... Full text Link to item Cite

Diagnostic and prognostic significance of exercise-induced premature ventricular complexes in men and women: a four year follow-up.

Journal Article J Am Coll Cardiol · May 1983 Two hundred eighty patients (197 men and 83 women) with normal rest electrocardiograms and no history of prior myocardial infarction were referred for evaluation of chest pain. It was found that exercise-induced premature ventricular complexes had a lower ... Full text Link to item Cite

Clinical and echocardiographic characteristics of patients with mitral anular calcification. Comparison with age- and sex-matched control subjects.

Journal Article Am J Cardiol · March 15, 1983 The clinical and echocardiographic features of 104 patients (53 women and 51 men) with mitral anular calcification (MAC) were compared with those of 121 age- and sex-matched control subjects (62 women and 59 men) without MAC. The incidence of coronary arte ... Full text Link to item Cite

Continuing medical education: Diagnostic and prognostic value of exercise testing

Journal Article Journal of Cardiac Rehabilitation · January 1, 1983 Exercise testing is useful in evaluating suspected or proven coronary artery disease (CAD) and provides evidence for or against latent myocardial ischemia. The pretest probability of CAD is dependent on sex, age, and symptoms. Exercise testing modifies thi ... Cite

Serial ambulatory monitoring in patients with unstable angina pectoris

Journal Article Clinical Cardiology · 1983 We performed a prospective study by dual-channel ambulatory monitoring performed for 24 to 72 hours immediately after hospitalization for unstable angina. The incidence of ST-segment depression or elevation or ventricular tachycardia or complex premature v ... Cite

High prevalence of symptomatic bradyarrhythmias due to atrioventricular node-fascicular and sinus node-atrial disease in patients with mitral anular calcification.

Journal Article Am Heart J · February 1982 Mitral anular calcification (MAC) is associated with high frequency of conduction defects. To delineate this association in patients with symptomatic bradyarrhythmias, 68 consecutive patients requiring pacemakers (group I) and 56 matched controls (group II ... Full text Link to item Cite

ECHOCARDIOGRAPHIC CORRELATE OF MITRAL ANNUAL CALCIFICATION AND SYMPTOMATIC BRADYARRHYTHMIAS

Journal Article Proceedings of the Annual Meeting of the American Institute of Ultrasound in Medicine · December 1, 1981 Cite

Digoxin-induced positive exercise tests: their clinical and prognostic significance.

Journal Article Am J Cardiol · October 1981 To evaluate the influence of digoxin on the results of exercise testing and the prognostic significance of digoxin-induced positive exercise tests, 98 healthy men, aged 22 to 70 years, were studied. All had normal initial exercise test results. All took di ... Full text Link to item Cite

NON-INVASIVE EVALUATION OF THE AORTIC ST. JUDE VALVE WITH PHONO AND ECHOCARDIOLOGY AND CINE FLUOROGRAPHY.

Journal Article Proceedings of the Annual Meeting of the American Institute of Ultrasound in Medicine · 1981 Cite

Digitalis and exercise testing, a five year followup

Journal Article American Journal of Cardiology · January 1, 1981 Full text Cite

My specialty: cardiology.

Journal Article Nebr Med J · November 1980 Link to item Cite

Automated and nomographic analysis of exercise tests.

Journal Article JAMA · March 14, 1980 A study was conducted to evaluate the validity and usefulness of a commercially available microprocessor for automated exercise ECG analysis and to develop a nomogram for estimating the severity of coronary artery disease. Results of visual analysis, autom ... Link to item Cite

CLINICAL EXPERIENCE WITH AUTOMATED EXERCISE ECG ANALYSIS.

Journal Article Computers in Cardiology · 1977 In order to evaluate the validity of usefulness of commercially available automated exercise ECG analyses systems, 107 patients were studied. Results of automated analysis, visual analysis and coronary arteriography were correlated. Automated analysis was ... Cite

CLINICAL ASSESSMENT OF INTERACTIVE COMPUTER ARRHYTHMIA MONITORING.

Journal Article Computers in Cardiology · 1977 Over the past decade a number of attempts have been made at developing a computer-based system for the detection of arrhythmias, primarily PVC's (Premature Ventricular Contractions). The authors have attempted to overcome a number of the shortcomings by de ... Cite

LDH isoenzymes and myocardial infarction in patients undergoing coronary bypass surgery: an excellent correlation.

Journal Article Am Heart J · November 1976 To evaluate the efficacy of LDH isoenzymes in the detection of myocardial infarction in patients undergoing coronary bypass surgery, 73 patients were studied pre- and postoperatively by ECG, CPK, SGOT, total serum LDH, and LDH isoenzyme measurements. A rev ... Full text Link to item Cite

Reply-I

Journal Article The American Journal of Cardiology · January 1, 1976 Full text Cite

Reply-II

Journal Article The American Journal of Cardiology · January 1, 1976 Full text Cite

Reply-III

Journal Article The American Journal of Cardiology · January 1, 1976 Full text Cite

Hereditary progressive atrioventricular conduction defect.

Journal Article Am J Cardiol · September 1975 New data on genetics, including an extensive pedigree and certain aspects of natural history, have been compiled on Family S, which is characterized by a hereditary progressive atrioventricular (A-V) conduction defect. Concordance analysis of heart block i ... Full text Link to item Cite

Significant sex differences in the correlation of electrocardiographic exercise testing and coronary arteriograms.

Journal Article Am J Cardiol · August 1975 Two hundred fifty-one patients (195 male and 56 females) referred for evaluation of chest pain were studied by multistage submaximal stress testing and selective coronary arteriography. In men with positive exercise tests the incidence rate of true positiv ... Full text Link to item Cite

Left ventricular intracavitary mass--an unusual case.

Journal Article Nebr Med J · September 1974 Link to item Cite