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Sneha Arun Mantri

Associate Professor of Neurology
Neurology, Movement Disorders

Selected Publications


What Parkinson's disease patients say in their own words about their mood and anxiety symptoms.

Journal Article Parkinsonism Relat Disord · January 2025 OBJECTIVE: To understand what Parkinson's Disease (PD) patients report in their own words about their mood and anxiety problems using the Parkinson's Disease Patient Report of Problems (PD-PROP). METHODS: Patient-reported data from the PD-PROP (reporting m ... Full text Link to item Cite

Analysis of Faculty Gender and Race in Scholarly Achievements in Academic Neurology.

Journal Article J Womens Health (Larchmt) · November 2024 Background: Intersection of gender and race and/or ethnicity in academic medicine is understudied; we aim to understand these factors in relation to scholarly achievements for neurology faculty. Methods: Faculty from 19 US neurology departments completed a ... Full text Link to item Cite

Cognitive Symptoms in Cross-Sectional Parkinson Disease Cohort Evaluated by Human-in-the-Loop Machine Learning and Natural Language Processing.

Journal Article Neurol Clin Pract · October 2024 BACKGROUND AND OBJECTIVES: Cognitive impairment is experienced by up to 80% of people with Parkinson disease (PD). Little is known regarding the subjective experience and frequency of bothersome cognitive problems across the range of disease duration as ex ... Full text Link to item Cite

Improving Parkinson's Disease Care through Systematic Screening for Depression.

Journal Article Mov Disord Clin Pract · October 2024 BACKGROUND: Depression is common in Parkinson's disease (PD) but is underrecognized clinically. Although systematic screening is a recommended strategy to improve depression recognition in primary care practice, it has not been widely used in PD care. METH ... Full text Link to item Cite

Portals to the past and bridges to the future: exploring the impact of doulas on the birthing experiences of black and Latinx women.

Journal Article Med Humanit · August 14, 2024 INTRODUCTION: In the USA, maternal morbidity and mortality is markedly higher for women of colour than for white women. The presence of a doula has been associated with positive birthing outcomes for white individuals, but the experiences of women of colou ... Full text Link to item Cite

Association between Subjective Cognitive Complaints and Incident Functional Impairment in Parkinson's Disease.

Journal Article Mov Disord · April 2024 BACKGROUND: Early identification of subjective cognitive complaints (SCC) in Parkinson's disease (PD) may improve patient care if it predicts cognition-related functional impairment (CFI). OBJECTIVES: The aim was to determine the cross-sectional and longit ... Full text Link to item Cite

Racial Disparities in Low-Value Care in the Last Year of Life for Medicare Beneficiaries With Neurodegenerative Disease.

Journal Article Neurol Clin Pract · April 2024 BACKGROUND AND OBJECTIVES: There are racial disparities in health care services received by patients with neurodegenerative diseases, but little is known about disparities in the last year of life, specifically in high-value and low-value care utilization. ... Full text Link to item Cite

In Their Own Words: Fears Expressed by People with Parkinson's Disease in an Online Symptom Database.

Journal Article J Parkinsons Dis · 2024 Parkinson's disease (PD) carries substantial psychosocial burden. Using a database of responses by people with PD reporting up to five "most bothersome problems," we identified 225 fear-based verbatims, which were organized using the framework method into ... Full text Link to item Cite

Development of a curricular thread to foster medical students' critical reflection and promote action on climate change, health, and equity.

Journal Article PLoS One · 2024 INTRODUCTION: Due to the health consequences arising from climate change, medical students will inevitably interact with affected patients during their training and careers. Accordingly, medical schools must incorporate education on the impacts of climate ... Full text Open Access Link to item Cite

Health Care Needs of Individuals with Parkinson's Disease Living in Eastern North Carolina: Insights for Multidisciplinary Care and Telemedicine.

Journal Article J Allied Health · 2024 Parkinson's disease (PD) is a complex condition, and individuals living in rural areas often face challenges accessing the specialized care they require. To better understand the specific healthcare needs of individuals with PD in Eastern North Carolina (E ... Link to item Cite

A Qualitative Study on Perspectives of Parkinson's Disease Medications: Insights from Patient Focus Groups.

Journal Article Patient Prefer Adherence · 2024 PURPOSE: Medication is an important component of the management of Parkinson's disease (PD), yet few studies investigate factors that inform medication decision-making from the perspective of those who use these therapies. This qualitative study aimed to b ... Full text Link to item Cite

TULIP: Multi-Camera 3D Precision Assessment of Parkinson's Disease

Conference Proceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition · January 1, 2024 Parkinson's disease (PD) is a devastating movement disorder accelerating in global prevalence, but a lack of precision symptom measurement has made the development of effective therapies challenging. The Unified Parkinson's Disease Rating Scale (UPDRS) is ... Full text Cite

Prevalence of Moral Injury, Burnout, Anxiety, and Depression in Healthcare Workers 2 Years in to the COVID-19 Pandemic.

Journal Article J Nerv Ment Dis · December 1, 2023 COVID-19 has led to marked increases in healthcare worker distress. Studies of these phenomena are often limited to a particular element of distress or a specific subset of healthcare workers. We administered the Moral Injury Symptom Scale for Healthcare P ... Full text Link to item Cite

Racial/ethnic disparities in dementia incidence, outcomes, and health-care utilization.

Journal Article Alzheimers Dement · June 2023 INTRODUCTION: Racial/ethnic disparities exist in many aspects of health care, but data on racial/ethnic disparities for neurodegenerative diseases (NDDs), such as dementia and Parkinson's disease (PD), are limited. METHODS: We used North and South Carolina ... Full text Link to item Cite

Examining the Role of Narrative in Palliative Care for Parkinson Disease: Changing the Story.

Journal Article Neurol Clin Pract · June 2023 Recent years have seen growing interest in neuropalliative care as a subspecialty. Simultaneously, the rise of narrative medicine in patient support groups and clinician training programs offers a way to listen deeply to the stories of those living with ch ... Full text Link to item Cite

Transformative Learning and Critical Consciousness: A Model for Preclerkship Medical School Substance Use Disorder Education.

Journal Article Acad Psychiatry · April 2023 OBJECTIVE: Preparing medical students to provide compassionate person-centered care for people with substance use disorders (SUD) requires a re-envisioning of preclerkship SUD education to allow for discussions on stigma, social determinants of health, sys ... Full text Open Access Link to item Cite

What Patients Say: Large-Scale Analyses of Replies to the Parkinson's Disease Patient Report of Problems (PD-PROP).

Journal Article J Parkinsons Dis · 2023 BACKGROUND: Free-text, verbatim replies in the words of people with Parkinson's disease (PD) have the potential to provide unvarnished information about their feelings and experiences. Challenges of processing such data on a large scale are a barrier to an ... Full text Link to item Cite

Internal tremor in people with Parkinson's Disease: Demographic characteristics and comorbid symptoms.

Journal Article Clin Park Relat Disord · 2023 INTRODUCTION: Internal tremor (IT) occurs in > 30 % of people with Parkinson's Disease (PwPD), but remains largely uninvestigated. Our objective was to describe demographic characteristics and associated symptoms in PwPD who reported IT. METHODS: This was ... Full text Link to item Cite

My last patient.

Journal Article J Am Geriatr Soc · August 2022 Full text Link to item Cite

Initial Clinical Outcome With Bilateral, Dual-Target Deep Brain Stimulation Trial in Parkinson Disease Using Summit RC + S.

Journal Article Neurosurgery · July 1, 2022 BACKGROUND: Deep brain stimulation (DBS) is an effective therapy in advanced Parkinson disease (PD). Although both subthalamic nucleus (STN) and globus pallidus (GP) DBS show equivalent efficacy in PD, combined stimulation may demonstrate synergism. OBJECT ... Full text Open Access Link to item Cite

Validation of the German Version of the Moral Injury Symptom and Support Scale for Health Professionals (G-MISS-HP) and Its Correlation to the Second Victim Phenomenon.

Journal Article Int J Environ Res Public Health · April 16, 2022 INTRODUCTION: Comparable to second victim phenomenon (SVP), moral injury (MI) affects health professionals (HP) working in stressful environments. Information on how MI and SVP intercorrelate and their part in a psychological trauma complex is limited. We ... Full text Link to item Cite

Demographic Influences on the Relationship Between Fatigue and Quality of Life in Parkinson's Disease.

Journal Article Mov Disord Clin Pract · January 2022 BACKGROUND: Fatigue has a major impact on health-related quality of life (HR-QOL) in Parkinson's disease (PD). OBJECTIVES: To determine whether demographic characteristics modify the relationship between fatigue and HR-QOL. METHODS: Patients with PD in the ... Full text Open Access Link to item Cite

Falling down the digital divide: A cautionary tale.

Journal Article Parkinsonism Relat Disord · December 2021 The disruptions of the coronavirus pandemic have enabled new opportunities for telehealth expansion within movement disorders. However, inadequate internet infrastructure has, unfortunately, led to fragmented implementation and may worsen disparities in so ... Full text Link to item Cite

Morally Injurious Experiences and Emotions of Health Care Professionals During the COVID-19 Pandemic Before Vaccine Availability.

Journal Article JAMA Netw Open · November 1, 2021 IMPORTANCE: Moral injury in health care professionals (HPs) has worsened over the course of the COVID-19 pandemic. The trauma and burnout associated with moral injury has profound implications for the mental health of HPs. OBJECTIVE: To explore the potenti ... Full text Link to item Cite

Moral Injury and Burnout in Health Care Professionals During the COVID-19 Pandemic.

Journal Article J Nerv Ment Dis · October 1, 2021 The coronavirus pandemic (COVID-19) is predicted to increase burnout in health professionals (HPs), but little is known about moral injury (MI) in this context. We administered the Moral Injury Symptoms Scale for Health Professionals (MISS-HP) and the abbr ... Full text Open Access Link to item Cite

Contribution of neuropsychiatric symptoms in Parkinson's disease to different domains of caregiver burden.

Journal Article J Neurol · August 2021 INTRODUCTION: Caregiver burden is high among caregivers of PD patients (CPD). Neuropsychiatric symptoms are leading contributors to CPD burden, but whether different symptoms differentially impact domains of caregiver burden is not known. Our objective was ... Full text Link to item Cite

Use of Figurative Language by People With Parkinson Disease to Describe "Off" Periods: Clear as Mud.

Journal Article Neurol Clin Pract · August 2021 OBJECTIVE: "Off" periods are characterized by the reemergence of motor and nonmotor symptoms in individuals with Parkinson disease (PD) and often negatively affect daily functioning. Individuals' experiences are diverse and may be difficult to articulate; ... Full text Link to item Cite

Prevalence and Predictors of Moral Injury Symptoms in Health Care Professionals.

Journal Article J Nerv Ment Dis · March 1, 2021 This study examined the prevalence and predictors of moral injury (MI) symptoms in 181 health care professionals (HPs; 71% physicians) recruited from Duke University Health Systems in Durham, NC. Participants completed an online questionnaire between Novem ... Full text Link to item Cite

Triggers and alleviating factors for fatigue in Parkinson s disease

Conference PLoS ONE · February 1, 2021 Background Fatigue is common in Parkinson s Disease, but few effective treatments are available for it. Exploring triggers and alleviating factors, including effects of exercise, could inform development of management strategies for Parkinson s Disease fat ... Full text Cite

Modifiable Comorbidities Associated with Cognitive Decline in Parkinson's Disease.

Journal Article Mov Disord Clin Pract · February 2021 BACKGROUND: Cognitive impairment (CI) is one of the most feared and debilitating complications of PD. No therapy has been shown to slow or prevent CI in PD. OBJECTIVE: To determine associations between modifiable comorbidities, including cardiovascular dis ... Full text Link to item Cite

Triggers and alleviating factors for fatigue in Parkinson's disease.

Journal Article PLoS One · 2021 BACKGROUND: Fatigue is common in Parkinson's Disease, but few effective treatments are available for it. Exploring triggers and alleviating factors, including effects of exercise, could inform development of management strategies for Parkinson's Disease fa ... Full text Link to item Cite

Knowledge, Responsibilities, and Peer Advice From Care Partners of Patients With Parkinson Disease Psychosis.

Journal Article Front Neurol · 2021 Introduction: Care partners (CPs) of individuals with Parkinson disease psychosis (PDP) experience increased strain and rely on informal support networks. The objective of this study was to characterize CP responsibilities, sources of support, and peer adv ... Full text Link to item Cite

The experience of care partners of patients with Parkinson's disease psychosis.

Journal Article PLoS One · 2021 BACKGROUND: Parkinson's disease psychosis (PDP) has a major impact on quality of life and care partner burden; however, little is known about the lived experiences of care partners in managing PDP. OBJECTIVE: To understand how care partners of individuals ... Full text Link to item Cite

The Experience of OFF Periods in Parkinson's Disease: Descriptions, Triggers, and Alleviating Factors.

Journal Article J Patient Cent Res Rev · 2021 PURPOSE: Wearing off of Parkinson's disease medication is common, but triggers and coping strategies for this transient phenomenon are poorly understood. We aimed to assess the lived experience of OFF periods for people with Parkinson's disease. METHODS: P ... Full text Link to item Cite

Conversational analysis of consciousness during seizures.

Journal Article Epilepsy Behav · November 2020 OBJECTIVE: The objectives of the study were to 1) investigate how patients with epilepsy describe the subjective, conscious experience of having a seizure and 2) determine whether certain themes and descriptions correspond to specific types of epilepsy. ME ... Full text Link to item Cite

Identifying Moral Injury in Healthcare Professionals: The Moral Injury Symptom Scale-HP.

Journal Article J Relig Health · October 2020 This study aims to develop and assess the psychometric properties of a measure of moral injury (MI) symptoms for identifying clinically significant MI in health professionals (HPs), one that might be useful in the current COVID-19 pandemic and beyond. A to ... Full text Open Access Link to item Cite

The Most Bothersome Aspects of Off Periods Reported by Individuals with Parkinson's Disease.

Journal Article Mov Disord Clin Pract · April 2020 INTRODUCTION: The off periods in Parkinson's disease have a significantly negative impact on quality of life. What the most bothersome aspects of off periods are from the patient's perspective are not well studied, nor is the degree to which screening tool ... Full text Link to item Cite

Acute readmission following deep brain stimulation surgery for Parkinson's disease: A nationwide analysis.

Journal Article Parkinsonism Relat Disord · January 2020 INTRODUCTION: Deep brain stimulation (DBS) surgery is an efficacious, underutilized treatment for Parkinson's disease (PD). Studies of DBS post-operative outcomes are often restricted to data from a single center and consider DBS in isolation. National est ... Full text Link to item Cite

Innovative Recruitment Strategies to Increase Diversity of Participation in Parkinson's Disease Research: The Fox Insight Cohort Experience.

Journal Article J Parkinsons Dis · 2020 BACKGROUND: Clinical research in Parkinson's disease (PD) faces practical and ethical challenges due to two interrelated problems: participant under-recruitment and lack of diversity. Fox Insight (FI) is a web-based longitudinal study collecting patient-re ... Full text Link to item Cite

Understanding the Lexicon of Fatigue in Parkinson's Disease.

Journal Article J Parkinsons Dis · 2020 BACKGROUND: Fatigue in Parkinson's disease (PD) is multifaceted and associated with reduced quality of life. In turn, the language used by people with PD to describe fatigue is variable and poorly understood. We sought to elucidate the lexicon of fatigue u ... Full text Open Access Link to item Cite

Comparing self-reported and objective monitoring of physical activity in Parkinson disease.

Journal Article Parkinsonism Relat Disord · October 2019 INTRODUCTION: Monitoring physical activity is important in Parkinson disease (PD), but patient recall may be unreliable. We examined relationships between self-reported activity, objective monitoring, and clinical characteristics. METHODS: Participants com ... Full text Link to item Cite

The importance of preclinical diagnostics in Parkinson disease.

Journal Article Parkinsonism Relat Disord · July 2019 Given the increasing recognition that neurodegeneration begins decades before the appearance of motor symptoms of Parkinson disease (PD), recent attention has turned to methods of preclinical or prodromal diagnosis. Accurate preclinical diagnosis of indivi ... Full text Link to item Cite

Quality of education impacts late-life cognition.

Journal Article Int J Geriatr Psychiatry · June 2019 OBJECTIVES: Screening tests of global cognition detect racial differences in scores even after adjustment for educational attainment. Differential educational environments in adolescence may affect individual cognitive function. This study examines the imp ... Full text Link to item Cite

Early and Accurate Identification of Parkinson Disease Among US Veterans.

Journal Article Fed Pract · June 2019 Early and accurate identification and management of veterans at risk for Parkinson disease is an important priority area for the US Department of Veterans Affairs because of the substantial impact on quality of life and disability-adjusted life years. ... Link to item Cite

Understanding physical activity in Veterans with Parkinson disease: A mixed-methods approach.

Journal Article Parkinsonism Relat Disord · April 2019 INTRODUCTION: Physical activity is critical in Parkinson disease (PD) management, but barriers and motivators of activity in Veterans with PD may be unique. We examined activity habits, including barriers and motivators, in this population. METHODS: Partic ... Full text Link to item Cite

Neurologic and neuroscience education: Mitigating neurophobia to mentor health care providers.

Journal Article Neurology · January 22, 2019 Neurologic disorders are among the most frequent causes of morbidity and mortality in the United States. Moreover, the current shortfall of neurologists is expected to worsen over the coming decade. As a consequence, many patients with neurologic disorders ... Full text Link to item Cite

Patterns of Dementia Treatment and Frank Prescribing Errors in Older Adults With Parkinson Disease.

Journal Article JAMA Neurol · January 1, 2019 IMPORTANCE: Dementia is common in Parkinson disease, but few data exist on dementia treatment patterns or the concurrent use of acetylcholinesterase inhibitors (ACHEIs) and anticholinergic medications, a frank prescribing error. OBJECTIVES: To describe dem ... Full text Link to item Cite

State-level prevalence, health service use, and spending vary widely among Medicare beneficiaries with Parkinson disease.

Journal Article NPJ Parkinsons Dis · 2019 State-level variations in disease, healthcare utilization, and spending influence healthcare planning at federal and state levels and should be examined to understand national disparities in health outcomes. This descriptive study examined state-level vari ... Full text Open Access Link to item Cite

Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke.

Journal Article Ann Neurol · January 2019 OBJECTIVE: Agonism of protease-activated receptor (PAR) 1 by activated protein C (APC) provides neuro- and vasculoprotection in experimental neuroinjury models. The pleiotropic PAR1 agonist, 3K3A-APC, reduces neurological injury and promotes vascular integ ... Full text Link to item Cite

Physical Activity in Early Parkinson Disease.

Journal Article J Parkinsons Dis · 2018 BACKGROUND: Physical activity and exercise improve outcomes in Parkinson disease (PD), however little is known about activity levels in early PD patients. OBJECTIVE AND METHODS: We examined self-reported activity scores and examined associations with clini ... Full text Open Access Link to item Cite

Physical Activity in Early Parkinson's disease

Conference MOVEMENT DISORDERS · June 1, 2017 Link to item Cite

Enterovirus causes rapidly progressive dementia in a 28-year-old immunosuppressed woman.

Journal Article J Neurovirol · August 2016 Enterovirus in the nervous system can present with protean manifestations, including polio-like paralysis, movement disorders, and seizures. This is a report of a single case of a rapidly progressive dementing illness in a young woman with common variable ... Full text Link to item Cite

Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy.

Journal Article Proc Natl Acad Sci U S A · June 22, 2010 The endogenous signaling molecule S-nitrosoglutathione (GSNO) and other S-nitrosylating agents can cause full maturation of the abnormal gene product DeltaF508 cystic fibrosis (CF) transmembrane conductance regulator (CFTR). However, the molecular mechanis ... Full text Link to item Cite

Holistic medicine and the Western medical tradition.

Journal Article Virtual Mentor · March 1, 2008 Full text Link to item Cite