Journal ArticleParkinsonism Relat Disord · January 2025
OBJECTIVE: To understand what Parkinson's Disease (PD) patients report in their own words about their mood and anxiety problems using the Parkinson's Disease Patient Report of Problems (PD-PROP). METHODS: Patient-reported data from the PD-PROP (reporting m ...
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Journal ArticleJ Womens Health (Larchmt) · November 2024
Background: Intersection of gender and race and/or ethnicity in academic medicine is understudied; we aim to understand these factors in relation to scholarly achievements for neurology faculty. Methods: Faculty from 19 US neurology departments completed a ...
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Journal ArticleNeurol Clin Pract · October 2024
BACKGROUND AND OBJECTIVES: Cognitive impairment is experienced by up to 80% of people with Parkinson disease (PD). Little is known regarding the subjective experience and frequency of bothersome cognitive problems across the range of disease duration as ex ...
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Journal ArticleMov Disord Clin Pract · October 2024
BACKGROUND: Depression is common in Parkinson's disease (PD) but is underrecognized clinically. Although systematic screening is a recommended strategy to improve depression recognition in primary care practice, it has not been widely used in PD care. METH ...
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Journal ArticleMed Humanit · August 14, 2024
INTRODUCTION: In the USA, maternal morbidity and mortality is markedly higher for women of colour than for white women. The presence of a doula has been associated with positive birthing outcomes for white individuals, but the experiences of women of colou ...
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Journal ArticleMov Disord · April 2024
BACKGROUND: Early identification of subjective cognitive complaints (SCC) in Parkinson's disease (PD) may improve patient care if it predicts cognition-related functional impairment (CFI). OBJECTIVES: The aim was to determine the cross-sectional and longit ...
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Journal ArticleNeurol Clin Pract · April 2024
BACKGROUND AND OBJECTIVES: There are racial disparities in health care services received by patients with neurodegenerative diseases, but little is known about disparities in the last year of life, specifically in high-value and low-value care utilization. ...
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Journal ArticleJ Parkinsons Dis · 2024
Parkinson's disease (PD) carries substantial psychosocial burden. Using a database of responses by people with PD reporting up to five "most bothersome problems," we identified 225 fear-based verbatims, which were organized using the framework method into ...
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Journal ArticlePLoS One · 2024
INTRODUCTION: Due to the health consequences arising from climate change, medical students will inevitably interact with affected patients during their training and careers. Accordingly, medical schools must incorporate education on the impacts of climate ...
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Journal ArticleJ Allied Health · 2024
Parkinson's disease (PD) is a complex condition, and individuals living in rural areas often face challenges accessing the specialized care they require. To better understand the specific healthcare needs of individuals with PD in Eastern North Carolina (E ...
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Journal ArticlePatient Prefer Adherence · 2024
PURPOSE: Medication is an important component of the management of Parkinson's disease (PD), yet few studies investigate factors that inform medication decision-making from the perspective of those who use these therapies. This qualitative study aimed to b ...
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ConferenceProceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition · January 1, 2024
Parkinson's disease (PD) is a devastating movement disorder accelerating in global prevalence, but a lack of precision symptom measurement has made the development of effective therapies challenging. The Unified Parkinson's Disease Rating Scale (UPDRS) is ...
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Journal ArticleJ Nerv Ment Dis · December 1, 2023
COVID-19 has led to marked increases in healthcare worker distress. Studies of these phenomena are often limited to a particular element of distress or a specific subset of healthcare workers. We administered the Moral Injury Symptom Scale for Healthcare P ...
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Journal ArticleAlzheimers Dement · June 2023
INTRODUCTION: Racial/ethnic disparities exist in many aspects of health care, but data on racial/ethnic disparities for neurodegenerative diseases (NDDs), such as dementia and Parkinson's disease (PD), are limited. METHODS: We used North and South Carolina ...
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Journal ArticleNeurol Clin Pract · June 2023
Recent years have seen growing interest in neuropalliative care as a subspecialty. Simultaneously, the rise of narrative medicine in patient support groups and clinician training programs offers a way to listen deeply to the stories of those living with ch ...
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Journal ArticleAcad Psychiatry · April 2023
OBJECTIVE: Preparing medical students to provide compassionate person-centered care for people with substance use disorders (SUD) requires a re-envisioning of preclerkship SUD education to allow for discussions on stigma, social determinants of health, sys ...
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Journal ArticleJ Parkinsons Dis · 2023
BACKGROUND: Free-text, verbatim replies in the words of people with Parkinson's disease (PD) have the potential to provide unvarnished information about their feelings and experiences. Challenges of processing such data on a large scale are a barrier to an ...
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Journal ArticleClin Park Relat Disord · 2023
INTRODUCTION: Internal tremor (IT) occurs in > 30 % of people with Parkinson's Disease (PwPD), but remains largely uninvestigated. Our objective was to describe demographic characteristics and associated symptoms in PwPD who reported IT. METHODS: This was ...
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Journal ArticleNeurosurgery · July 1, 2022
BACKGROUND: Deep brain stimulation (DBS) is an effective therapy in advanced Parkinson disease (PD). Although both subthalamic nucleus (STN) and globus pallidus (GP) DBS show equivalent efficacy in PD, combined stimulation may demonstrate synergism. OBJECT ...
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Journal ArticleInt J Environ Res Public Health · April 16, 2022
INTRODUCTION: Comparable to second victim phenomenon (SVP), moral injury (MI) affects health professionals (HP) working in stressful environments. Information on how MI and SVP intercorrelate and their part in a psychological trauma complex is limited. We ...
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Journal ArticleMov Disord Clin Pract · January 2022
BACKGROUND: Fatigue has a major impact on health-related quality of life (HR-QOL) in Parkinson's disease (PD). OBJECTIVES: To determine whether demographic characteristics modify the relationship between fatigue and HR-QOL. METHODS: Patients with PD in the ...
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Journal ArticleParkinsonism Relat Disord · December 2021
The disruptions of the coronavirus pandemic have enabled new opportunities for telehealth expansion within movement disorders. However, inadequate internet infrastructure has, unfortunately, led to fragmented implementation and may worsen disparities in so ...
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Journal ArticleJAMA Netw Open · November 1, 2021
IMPORTANCE: Moral injury in health care professionals (HPs) has worsened over the course of the COVID-19 pandemic. The trauma and burnout associated with moral injury has profound implications for the mental health of HPs. OBJECTIVE: To explore the potenti ...
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Journal ArticleJ Nerv Ment Dis · October 1, 2021
The coronavirus pandemic (COVID-19) is predicted to increase burnout in health professionals (HPs), but little is known about moral injury (MI) in this context. We administered the Moral Injury Symptoms Scale for Health Professionals (MISS-HP) and the abbr ...
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Journal ArticleJ Neurol · August 2021
INTRODUCTION: Caregiver burden is high among caregivers of PD patients (CPD). Neuropsychiatric symptoms are leading contributors to CPD burden, but whether different symptoms differentially impact domains of caregiver burden is not known. Our objective was ...
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Journal ArticleNeurol Clin Pract · August 2021
OBJECTIVE: "Off" periods are characterized by the reemergence of motor and nonmotor symptoms in individuals with Parkinson disease (PD) and often negatively affect daily functioning. Individuals' experiences are diverse and may be difficult to articulate; ...
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Journal ArticleJ Nerv Ment Dis · March 1, 2021
This study examined the prevalence and predictors of moral injury (MI) symptoms in 181 health care professionals (HPs; 71% physicians) recruited from Duke University Health Systems in Durham, NC. Participants completed an online questionnaire between Novem ...
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ConferencePLoS ONE · February 1, 2021
Background Fatigue is common in Parkinson s Disease, but few effective treatments are available for it. Exploring triggers and alleviating factors, including effects of exercise, could inform development of management strategies for Parkinson s Disease fat ...
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Journal ArticleMov Disord Clin Pract · February 2021
BACKGROUND: Cognitive impairment (CI) is one of the most feared and debilitating complications of PD. No therapy has been shown to slow or prevent CI in PD. OBJECTIVE: To determine associations between modifiable comorbidities, including cardiovascular dis ...
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Journal ArticlePLoS One · 2021
BACKGROUND: Fatigue is common in Parkinson's Disease, but few effective treatments are available for it. Exploring triggers and alleviating factors, including effects of exercise, could inform development of management strategies for Parkinson's Disease fa ...
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Journal ArticleFront Neurol · 2021
Introduction: Care partners (CPs) of individuals with Parkinson disease psychosis (PDP) experience increased strain and rely on informal support networks. The objective of this study was to characterize CP responsibilities, sources of support, and peer adv ...
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Journal ArticlePLoS One · 2021
BACKGROUND: Parkinson's disease psychosis (PDP) has a major impact on quality of life and care partner burden; however, little is known about the lived experiences of care partners in managing PDP. OBJECTIVE: To understand how care partners of individuals ...
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Journal ArticleJ Patient Cent Res Rev · 2021
PURPOSE: Wearing off of Parkinson's disease medication is common, but triggers and coping strategies for this transient phenomenon are poorly understood. We aimed to assess the lived experience of OFF periods for people with Parkinson's disease. METHODS: P ...
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Journal ArticleEpilepsy Behav · November 2020
OBJECTIVE: The objectives of the study were to 1) investigate how patients with epilepsy describe the subjective, conscious experience of having a seizure and 2) determine whether certain themes and descriptions correspond to specific types of epilepsy. ME ...
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Journal ArticleJ Relig Health · October 2020
This study aims to develop and assess the psychometric properties of a measure of moral injury (MI) symptoms for identifying clinically significant MI in health professionals (HPs), one that might be useful in the current COVID-19 pandemic and beyond. A to ...
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Journal ArticleMov Disord Clin Pract · April 2020
INTRODUCTION: The off periods in Parkinson's disease have a significantly negative impact on quality of life. What the most bothersome aspects of off periods are from the patient's perspective are not well studied, nor is the degree to which screening tool ...
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Journal ArticleParkinsonism Relat Disord · January 2020
INTRODUCTION: Deep brain stimulation (DBS) surgery is an efficacious, underutilized treatment for Parkinson's disease (PD). Studies of DBS post-operative outcomes are often restricted to data from a single center and consider DBS in isolation. National est ...
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Journal ArticleJ Parkinsons Dis · 2020
BACKGROUND: Clinical research in Parkinson's disease (PD) faces practical and ethical challenges due to two interrelated problems: participant under-recruitment and lack of diversity. Fox Insight (FI) is a web-based longitudinal study collecting patient-re ...
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Journal ArticleJ Parkinsons Dis · 2020
BACKGROUND: Fatigue in Parkinson's disease (PD) is multifaceted and associated with reduced quality of life. In turn, the language used by people with PD to describe fatigue is variable and poorly understood. We sought to elucidate the lexicon of fatigue u ...
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Journal ArticleParkinsonism Relat Disord · October 2019
INTRODUCTION: Monitoring physical activity is important in Parkinson disease (PD), but patient recall may be unreliable. We examined relationships between self-reported activity, objective monitoring, and clinical characteristics. METHODS: Participants com ...
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Journal ArticleParkinsonism Relat Disord · July 2019
Given the increasing recognition that neurodegeneration begins decades before the appearance of motor symptoms of Parkinson disease (PD), recent attention has turned to methods of preclinical or prodromal diagnosis. Accurate preclinical diagnosis of indivi ...
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Journal ArticleInt J Geriatr Psychiatry · June 2019
OBJECTIVES: Screening tests of global cognition detect racial differences in scores even after adjustment for educational attainment. Differential educational environments in adolescence may affect individual cognitive function. This study examines the imp ...
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Journal ArticleFed Pract · June 2019
Early and accurate identification and management of veterans at risk for Parkinson disease is an important priority area for the US Department of Veterans Affairs because of the substantial impact on quality of life and disability-adjusted life years. ...
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Journal ArticleParkinsonism Relat Disord · April 2019
INTRODUCTION: Physical activity is critical in Parkinson disease (PD) management, but barriers and motivators of activity in Veterans with PD may be unique. We examined activity habits, including barriers and motivators, in this population. METHODS: Partic ...
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Journal ArticleNeurology · January 22, 2019
Neurologic disorders are among the most frequent causes of morbidity and mortality in the United States. Moreover, the current shortfall of neurologists is expected to worsen over the coming decade. As a consequence, many patients with neurologic disorders ...
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Journal ArticleJAMA Neurol · January 1, 2019
IMPORTANCE: Dementia is common in Parkinson disease, but few data exist on dementia treatment patterns or the concurrent use of acetylcholinesterase inhibitors (ACHEIs) and anticholinergic medications, a frank prescribing error. OBJECTIVES: To describe dem ...
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Journal ArticleNPJ Parkinsons Dis · 2019
State-level variations in disease, healthcare utilization, and spending influence healthcare planning at federal and state levels and should be examined to understand national disparities in health outcomes. This descriptive study examined state-level vari ...
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Journal ArticleAnn Neurol · January 2019
OBJECTIVE: Agonism of protease-activated receptor (PAR) 1 by activated protein C (APC) provides neuro- and vasculoprotection in experimental neuroinjury models. The pleiotropic PAR1 agonist, 3K3A-APC, reduces neurological injury and promotes vascular integ ...
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Journal ArticleJ Parkinsons Dis · 2018
BACKGROUND: Physical activity and exercise improve outcomes in Parkinson disease (PD), however little is known about activity levels in early PD patients. OBJECTIVE AND METHODS: We examined self-reported activity scores and examined associations with clini ...
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Journal ArticleJ Neurovirol · August 2016
Enterovirus in the nervous system can present with protean manifestations, including polio-like paralysis, movement disorders, and seizures. This is a report of a single case of a rapidly progressive dementing illness in a young woman with common variable ...
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Journal ArticleProc Natl Acad Sci U S A · June 22, 2010
The endogenous signaling molecule S-nitrosoglutathione (GSNO) and other S-nitrosylating agents can cause full maturation of the abnormal gene product DeltaF508 cystic fibrosis (CF) transmembrane conductance regulator (CFTR). However, the molecular mechanis ...
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