Scholars@Duke
Stephanie Greene

Stephanie Greene

Professor of Neurosurgery
Neurosurgery

Selected Publications

Current trends, molecular insights, and future directions toward precision medicine in the management of pediatric cerebral arteriovenous malformations.

Journal Article J Neurosurg Pediatr · November 1, 2024 Pediatric arteriovenous malformations (AVMs) are rare but carry a risk of devastating neurological morbidity and mortality. Rupture of a cerebral AVM is the most common cause of spontaneous intracranial hemorrhage in children, with an unruptured AVM having ... Full text Link to item Cite

Indications for cerebral revascularization for moyamoya syndrome in pediatric sickle cell disease determined by Delphi methodology.

Journal Article J Neurosurg Pediatr · October 1, 2024 OBJECTIVE: Cerebral revascularization surgery (CRS) has been used to prevent stroke in children with sickle cell disease (SCD) and cerebral vasculopathy (e.g., moyamoya syndrome). While results suggest that it may be an effective treatment, surgical indica ... Full text Link to item Cite

Neurosurgical Management of Rubinstein-Taybi Syndrome: An Institutional Experience.

Journal Article Pediatric neurosurgery · August 2024 IntroductionRubinstein-Taybi syndrome (RTS) is a rare genetic condition with a distinctive set of physical features. This case series reports a single institutional experience of RTS cases, highlighting the role of neurosurgery in the comprehensiv ... Full text Cite

The role of occipital condyle and atlas anomalies on occipital cervical fusion outcomes in Chiari malformation type I with syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium.

Journal Article J Neurosurg Pediatr · July 1, 2024 OBJECTIVE: Congenital anomalies of the atlanto-occipital articulation may be present in patients with Chiari malformation type I (CM-I). However, it is unclear how these anomalies affect the biomechanical stability of the craniovertebral junction (CVJ) and ... Full text Link to item Cite

A re-evaluation of the Endoscopic Third Ventriculostomy Success Score: a Hydrocephalus Clinical Research Network study.

Journal Article J Neurosurg Pediatr · May 1, 2024 OBJECTIVE: The Hydrocephalus Clinical Research Network (HCRN) conducted a prospective study 1) to determine if a new, better-performing version of the Endoscopic Third Ventriculostomy Success Score (ETVSS) could be developed, 2) to explore the performance ... Full text Link to item Cite

Long-term outcomes of deep pediatric arteriovenous malformations.

Journal Article J Neurosurg Pediatr · January 1, 2024 OBJECTIVE: Multimodality treatment has been shown to be the optimal management strategy for pediatric arteriovenous malformations (AVMs). Deep AVMs represent a subset of AVMs for which optimal management may be achieved with a combination of radiosurgery a ... Full text Link to item Cite

Patterns in Follow-Up Imaging Usage for Pediatric Patients with Whiplash-Associated Disorder.

Journal Article World Neurosurg · December 2023 BACKGROUND: A clinical concern exists that pediatric patients with whiplash-associated disorder (WAD) might have missed structural injuries or, alternatively, subsequently develop structural injuries over time, despite initially negative imaging findings. ... Full text Link to item Cite

Clinical characteristics of familial and sporadic pediatric cerebral cavernous malformations and outcomes.

Journal Article J Neurosurg Pediatr · October 1, 2023 OBJECTIVE: Cerebral cavernous malformation (CCM) is a subtype of the vascular malformations found within the cerebral cortex. Although rare and usually discovered incidentally, these vascular abnormalities can predispose patients to spontaneous cerebral he ... Full text Link to item Cite

Cerebral revascularization surgery reduces cerebrovascular events in children with sickle cell disease and moyamoya syndrome: Results of the stroke in sickle cell revascularization surgery retrospective study.

Journal Article Pediatr Blood Cancer · July 2023 BACKGROUND: Recent studies suggest that cerebral revascularization surgery may be a safe and effective therapy to reduce stroke risk in patients with sickle cell disease and moyamoya syndrome (SCD-MMS). METHODS: We performed a multicenter, retrospective st ... Full text Link to item Cite

Treatment of hydrocephalus following posterior fossa tumor resection: a multicenter collaboration from the Hydrocephalus Clinical Research Network.

Journal Article J Neurooncol · May 2023 OBJECTIVE: Persistent hydrocephalus following posterior fossa brain tumor (PFBT) resection is a common cause of morbidity in pediatric brain tumor patients, for which the optimal treatment is debated. The purpose of this study was to compare treatment outc ... Full text Link to item Cite

In vitro and in vivo assessment of a novel ultra-flexible ventriculoamniotic shunt for treating fetal hydrocephalus.

Journal Article J Biomater Appl · March 2023 Fetal aqueductal stenosis (AS) is one of the most common causes of congenital hydrocephalus, which increases intracranial pressure due to partial or complete obstruction of cerebrospinal fluid (CSF) flow within the ventricular system. Approximately 2-4 inf ... Full text Link to item Cite

Serial Neuroendoscopic Lavage for the Treatment of Elevated Cerebrospinal Fluid Protein Levels in Infants with Gram-Negative Rod Ventriculitis.

Journal Article Pediatr Neurosurg · 2023 INTRODUCTION: Gram-negative rod (GNR) bacterial ventriculitis is a rare complication of shunt-dependent hydrocephalus, often requiring an extended and invasive treatment course. Accumulation of purulent material, as well as empyema and septation formation, ... Full text Link to item Cite

Complications and outcomes of posterior fossa decompression with duraplasty versus without duraplasty for pediatric patients with Chiari malformation type I and syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium.

Journal Article J Neurosurg Pediatr · July 1, 2022 OBJECTIVE: The aim of this study was to determine differences in complications and outcomes between posterior fossa decompression with duraplasty (PFDD) and without duraplasty (PFD) for the treatment of pediatric Chiari malformation type I (CM1) and syring ... Full text Link to item Cite

Endoscopic third ventriculostomy revision after failure of initial endoscopic third ventriculostomy and choroid plexus cauterization.

Journal Article J Neurosurg Pediatr · July 1, 2022 OBJECTIVE: Primary treatment of hydrocephalus with endoscopic third ventriculostomy (ETV) and choroid plexus cauterization (CPC) is well described in the neurosurgical literature, with wide reported ranges of success and complication rates. The purpose of ... Full text Link to item Cite

Socioeconomic and demographic factors in the diagnosis and treatment of Chiari malformation type I and syringomyelia.

Journal Article Journal of neurosurgery. Pediatrics · March 2022 ObjectiveThe goal of this study was to assess the social determinants that influence access and outcomes for pediatric neurosurgical care for patients with Chiari malformation type I (CM-I) and syringomyelia (SM).MethodsThe authors used r ... Full text Cite

The Eyebrow Approach for the Management of Pediatric Frontal Epidural Abscesses Secondary to Diffuse Sinusitis.

Journal Article Pediatr Neurosurg · 2022 BACKGROUND: Minimally invasive approaches to the anterior cranial fossa have evolved over the past few decades. The management of frontal epidural abscesses (EDAs) secondary to diffuse sinusitis in the pediatric population using minimally invasive techniqu ... Full text Link to item Cite

Neuroophthalmological manifestations of congenital aqueductal stenosis.

Journal Article J Neurosurg Pediatr · September 1, 2021 OBJECTIVE: Congenital aqueductal stenosis (CAS) is a common etiology of hydrocephalus that occurs in a subset of infants and may be linked to an increased incidence of ophthalmological abnormalities and delayed developmental milestones. Although hydrocepha ... Full text Link to item Cite

Extradural decompression versus duraplasty in Chiari malformation type I with syrinx: outcomes on scoliosis from the Park-Reeves Syringomyelia Research Consortium.

Journal Article J Neurosurg Pediatr · August 1, 2021 OBJECTIVE: Scoliosis is common in patients with Chiari malformation type I (CM-I)-associated syringomyelia. While it is known that treatment with posterior fossa decompression (PFD) may reduce the progression of scoliosis, it is unknown if decompression wi ... Full text Link to item Cite

Shunt infection and malfunction in patients with myelomeningocele.

Journal Article J Neurosurg Pediatr · May 1, 2021 OBJECTIVE: Myelomeningocele (MMC) is frequently complicated by symptomatic hydrocephalus, necessitating early permanent CSF diversion and revision surgeries. Shunt infections are a common cause of shunt malfunction. This study aims to characterize long-ter ... Full text Link to item Cite

Dural augmentation approaches and complication rates after posterior fossa decompression for Chiari I malformation and syringomyelia: a Park-Reeves Syringomyelia Research Consortium study.

Journal Article J Neurosurg Pediatr · April 1, 2021 OBJECTIVE: Posterior fossa decompression with duraplasty (PFDD) is commonly performed for Chiari I malformation (CM-I) with syringomyelia (SM). However, complication rates associated with various dural graft types are not well established. The objective of ... Full text Link to item Cite

Occipital-Cervical Fusion and Ventral Decompression in the Surgical Management of Chiari-1 Malformation and Syringomyelia: Analysis of Data From the Park-Reeves Syringomyelia Research Consortium.

Journal Article Neurosurgery · January 13, 2021 BACKGROUND: Occipital-cervical fusion (OCF) and ventral decompression (VD) may be used in the treatment of pediatric Chiari-1 malformation (CM-1) with syringomyelia (SM) as adjuncts to posterior fossa decompression (PFD) for complex craniovertebral junctio ... Full text Link to item Cite

Para-Gangliomas

Chapter · January 1, 2021 Paragangliomas are highly vascular tumors of neural crest origin, arising along the migratory pathway of the paraganglia during embryogenesis anywhere from the skull base to the floor of the pelvis [Boedeker, CC. Paragangliomas and paraganglioma syndromes. ... Full text Cite

Comparison of Follow-Up Length-Matched Single-Center Myelomeningocele Postnatal Closure Cohort to the Management of Myelomeningocele Study (MOMS) Trial Results.

Journal Article Pediatr Neurosurg · 2021 OBJECTIVE: We sought to compare our large single-institution cohort of postnatal myelomeningocele closure to the 2 arms of the Management of Myelomeningocele Study (MOMS) trial at the designated trial time points, as well as assess outcomes at long-term fo ... Full text Link to item Cite

Long-term outcomes of pediatric arteriovenous malformations: the 30-year Pittsburgh experience.

Journal Article J Neurosurg Pediatr · September 1, 2020 OBJECTIVE: The study of pediatric arteriovenous malformations (pAVMs) is complicated by the rarity of the entity. Treatment choice has often been affected by the availability of different modalities and the experience of the providers present. The Universi ... Full text Link to item Cite

Factors associated with syrinx size in pediatric patients treated for Chiari malformation type I and syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium.

Journal Article J Neurosurg Pediatr · June 1, 2020 OBJECTIVE: Factors associated with syrinx size in pediatric patients undergoing posterior fossa decompression (PFD) or PFD with duraplasty (PFDD) for Chiari malformation type I (CM-I) with syringomyelia (SM; CM-I+SM) are not well established. METHODS: Usin ... Full text Link to item Cite

Familial Cerebral Cavernous Malformation Syndrome with Concomitant Fourth Ventricular Ependymoma: True Association or Mere Coincidence?

Journal Article Cancer Genet · June 2020 Familial cerebral cavernous malformation syndromes are most commonly caused by mutations in one of three genes. The overlap of these genetic malformations with other acquired neoplastic lesions and congenital malformations is still under investigation. To ... Full text Link to item Cite

Fetal aqueductal stenosis: Prenatal diagnosis and intervention.

Journal Article Prenat Diagn · January 2020 Fetal severe central nervous system ventriculomegaly is associated with poor neurologic outcomes, usually driven by a primary malformation, deformation, or disruption of brain parenchyma. In utero shunting of excess cerebrospinal fluid (CSF) in hopes of im ... Full text Link to item Cite

Histologic Appearance of Iatrogenic Obstructive Hydrocephalus in the Fetal Lamb Model.

Journal Article Fetal Diagn Ther · 2020 INTRODUCTION: Documentation of histologic findings associated with congenital hydrocephalus in the fetal lamb model is a critical step in evaluating the efficacy of ventriculoamniotic shunting in the human fetus. METHODS: Four fetal sheep had hydrocephalus ... Full text Link to item Cite

Radiological and clinical predictors of scoliosis in patients with Chiari malformation type I and spinal cord syrinx from the Park-Reeves Syringomyelia Research Consortium.

Journal Article J Neurosurg Pediatr · November 1, 2019 OBJECTIVE: Scoliosis is frequently a presenting sign of Chiari malformation type I (CM-I) with syrinx. The authors' goal was to define scoliosis in this population and describe how radiological characteristics of CM-I and syrinx relate to the presence and ... Full text Link to item Cite

Pipeline Embolization of an Infectious Basilar Artery Aneurysm in a 2-Year-Old Child: Case Report, Discussion of the Literature and Perioperative Considerations.

Journal Article Oper Neurosurg (Hagerstown) · November 1, 2019 BACKGROUND AND IMPORTANCE: Flow diversion of intracranial aneurysms has been rarely described in the pediatric population. Here we discuss the technical and perioperative complexities inherent in the flow diversion of an infectious basilar apex aneurysm in ... Full text Link to item Cite

Intracranial Myxoid Mesenchymal Tumor with Rare EWSR1-CREM Translocation.

Journal Article Pediatr Neurosurg · 2019 Translocations between EWSR1 and members of the CREB family of transcription factors (CREB1, ATF1, and CREM) are rare genetic findings occurring in various sarcomas. Of these, the EWSR1-CREM translocation is the most rarely reported. We present the case of ... Full text Link to item Cite

Ruptured intracranial aneurysm in a patient with autosomal recessive polycystic kidney disease.

Journal Article J Neurosurg Pediatr · January 1, 2019 Aneurysmal rupture can result in devastating neurological consequences and can be complicated by comorbid disease processes. Patients with autosomal recessive polycystic kidney disease (ARPKD) have a low rate of reported aneurysms, but this may be due to t ... Full text Link to item Cite

Is Schimmelpenning Syndrome Associated with Intracranial Tumors? A Case Report.

Journal Article Pediatr Neurosurg · 2019 Schimmelpenning syndrome is a rare, well-defined constellation of clinical phenotypes associated with the presence of nevus sebaceous and multisystem abnormalities most commonly manifested as cerebral, ocular, and skeletal defects [ Full text Link to item Cite

Imaging Review of Common and Rare Causes of Stroke in Children.

Journal Article Top Magn Reson Imaging · December 2018 Vascular injury is increasingly recognized as an important cause of mortality and morbidity in children (29 days to 18 years of age). Since vascular brain injury in children appears to be less common than in adults, the index of suspicion for vascular brai ... Full text Link to item Cite

Twenty years' experience with myelomeningocele management at a single institution: lessons learned.

Journal Article J Neurosurg Pediatr · October 2018 OBJECTIVE: The authors reviewed 20 years' experience with the surgical management of open myelomeningocele in a well-defined retrospective cohort from a single large academic medical center. Their goal was to define the characteristics of a modern cohort o ... Full text Link to item Cite

Complications following pediatric cranioplasty after decompressive craniectomy: a multicenter retrospective study.

Journal Article J Neurosurg Pediatr · September 2018 OBJECTIVE In children, the repair of skull defects arising from decompressive craniectomy presents a unique set of challenges. Single-center studies have identified different risk factors for the common complications of cranioplasty resorption and infectio ... Full text Link to item Cite

Predictors of mortality in children with myelomeningocele and symptomatic Chiari type II malformation.

Journal Article J Neurosurg Pediatr · June 2018 OBJECTIVE Chiari malformation type II (CM-II) in myelomeningocele is associated with a significant rate of mortality and poor outcome. Death is frequently heralded by the onset or progression of neurological symptoms. The authors sought to identify predict ... Full text Link to item Cite

Coincident myelomeningocele and gastroschisis: report of 2 cases.

Journal Article J Neurosurg Pediatr · June 2018 Myelomeningocele and gastroschisis, on their own, are both relatively common entities encountered in pediatric surgical care. Coexistence of these pathologies, however, is exceedingly rare. The authors report on 2 patients who presented with myelomeningoce ... Full text Link to item Cite

Clinical Outcomes of Isolated Congenital Aqueductal Stenosis.

Journal Article World Neurosurg · June 2018 INTRODUCTION: Hydrocephalus due to congenital aqueductal stenosis (CAS) has significant long-term clinical implications. Previous reports on outcomes after treatment of congenital hydrocephalus are heterogenous and lack specificity for the subgroup of pati ... Full text Link to item Cite

Case Series: Pediatric Shunt Tunnel Catheter Infection.

Journal Article Pediatr Neurosurg · 2018 Shunt infections are common pediatric neurosurgical cases with high morbidity that almost always requires surgical removal of the shunt, external ventricular drain placement, and delayed shunt replacement. Tunnel infections are well-described clinical enti ... Full text Link to item Cite

A Neurenteric Cyst Presenting as a Brainstem Tumor: Imaging and Clinical Findings

Journal Article Journal of Pediatric Neurology · January 1, 2018 An 11-year-old girl presented with vomiting, nystagmus, and ataxia. MRI showed a partially enhancing medulla oblongata lesion and an adjacent nonenhancing cystic exophytic lesion. An exophytic brainstem tumor was suspected. Histologically, the lesion was i ... Full text Cite

The Use of External Ventricular Drainage to Reduce the Frequency of Wound Complications in Myelomeningocele Closure.

Journal Article Pediatr Neurosurg · 2018 INTRODUCTION: Myelomeningocele (MMC) is an open neural tube defect routinely surgically closed within 48 h of birth to prevent secondary infection. Up to 18% of patients experience wound complications, and 85% require shunting for hydrocephalus. We hypothe ... Full text Link to item Cite

Encephalocele development from a congenital meningocele: case report.

Journal Article J Neurosurg Pediatr · November 2017 A fetal MRI study obtained at 21 weeks' gestation revealed a suboccipital meningocele without hydrocephalus. One day after term birth, MRI demonstrated an acquired cerebellar encephalocele, and MRI obtained 5 months later showed progressive enlargement of ... Full text Link to item Cite

A Low-Profile Flow Sensing System for Monitoring of Cerebrospinal Fluid with a New Ventriculoamniotic Shunt

Conference Proceedings - Electronic Components and Technology Conference · August 1, 2017 Fetal hydrocephalus is a condition involvingexcessive accumulation of intraventricular cerebrospinal fluidwith ventricular dilation. It often leads to malformation ordevastating neurological consequences of developing fetalbrains. Recent advances in fetal ... Full text Cite

Severe cerebral edema following nivolumab treatment for pediatric glioblastoma: case report.

Journal Article J Neurosurg Pediatr · February 2017 Nivolumab is an immune checkpoint inhibitor (ICI) currently undergoing Phase III clinical trials for the treatment of glioblastoma. The authors present the case of a 10-year-old girl with glioblastoma treated with nivolumab under compassionate-use guidelin ... Full text Link to item Cite

Developmental venous anomaly presenting as a spontaneous intraparenchymal hematoma without thrombosis.

Journal Article Neuroradiol J · December 2016 INTRODUCTION: Developmental venous anomalies (DVAs) are cited as the most common cerebral vascular malformations. Still, intracerebral hematomas are rarely thought to be caused by DVAs. In this report, the authors present a unique case of a DVA that hemorr ... Full text Link to item Cite

The impact of mode of delivery on infant neurologic outcomes in myelomeningocele.

Journal Article Am J Obstet Gynecol · October 2016 BACKGROUND: Controversy exists regarding the optimal route of delivery for fetuses who are diagnosed prenatally with myelomeningocele. Current recommendations are based partly on antiquated studies with questionable methods. All studies that have been publ ... Full text Link to item Cite

PHACE syndrome is associated with intracranial cavernous malformations.

Journal Article Childs Nerv Syst · August 2016 INTRODUCTION: PHACE syndrome is a neurocutaneous disorder involving large facial hemangiomas in association with posterior fossa abnormalities, cerebral arterial anomalies, cardiac defects, and eye abnormalities. A recent consensus statement has delineated ... Full text Link to item Cite

A case of spinal epidural venous malformation with mediastinal extension: management with combined surgery and percutaneous sclerotherapy.

Journal Article J Neurosurg Pediatr · May 2016 While spinal epidural arteriovenous malformations, fistulas, and shunts are well reported, the presence of a venous malformation in the spinal epidural space is a rare phenomenon. Herein, the authors report the clinical presentation, imaging findings, path ... Full text Link to item Cite

Obstetrical brachial plexus palsy: Can excision of upper trunk neuroma and nerve grafting improve function in babies with adequate elbow flexion at nine months of age?

Journal Article J Plast Reconstr Aesthet Surg · May 2016 Accepted indications for exploration in obstetrical brachial plexus palsy (OBPP) vary by center. Most agree that full elbow flexion against gravity at nine months of age implies high chance of spontaneous recovery and thus excludes a baby from surgical int ... Full text Link to item Cite

Pial Synangiosis Ameliorates Movement Disorders in the Absence of Prior Stroke in Moyamoya Disease.

Conference J Child Neurol · April 2016 BACKGROUND: Moyamoya disease is a rare cerebrovascular disease characterized by progressive stenosis of the bilateral distal internal carotid arteries and their proximal branches. Both chorea and dystonia have been reported as the initial presentation of m ... Full text Link to item Cite

A 34-Day-Old With Fever, Cerebrospinal Fluid Pleocytosis, and Staphylococcus aureus Bacteremia.

Journal Article Pediatrics · January 2016 A 34-day-old previously healthy boy born full term presented to the emergency department with fever at home (38.1°C), fussiness, and decreased oral intake for 1 day. He was difficult to console at home. He had decreased oral intake without emesis, diarrhea ... Full text Link to item Cite

The relationship between obesity and symptomatic Chiari i malformation in the pediatric population

Journal Article Journal of Pediatric Neurosciences · October 1, 2015 Background: Concomitant with the rise in childhood obesity in the United States is an increase in the diagnosis of Chiari I malformation (CM1). Objective: To discern a correlation between obesity and CM1, defined as >5 mm of cerebellar tonsillar descent on ... Full text Cite

microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma.

Journal Article PLoS One · 2015 This study demonstrates the effects of miRNA-10b on medulloblastoma proliferation through transcriptional induction of the anti-apoptotic protein BCL2. Using a cancer specific miRNA-array, high expression of miRNA-10b in medulloblastoma cell lines compared ... Full text Link to item Cite

Thrombosis and spontaneous recanalization of a giant intracranial aneurysm: diagnostic and management pearls in a pediatric patient.

Journal Article J Neurosurg Pediatr · January 2015 The authors present the case of a boy who was successfully managed through the spontaneous thrombosis of a cavernous internal carotid artery (ICA) aneurysm, the subsequent occlusion of the ICA, its recanalization, and ultimate endovascular sacrifice, using ... Full text Link to item Cite

Fetal Therapy for Isolated Aqueductal Stenosis.

Journal Article Fetal Diagn Ther · 2015 Aqueductal stenosis (AS) is a form of noncommunicating hydrocephalus, which causes increased intracranial pressure secondary to obstruction of the aqueduct of Sylvius. Relief of intracranial pressure in the fetus by ventriculoamniotic shunting may diminish ... Full text Link to item Cite

Neurocutaneous melanosis is associated with tethered spinal cord.

Journal Article Childs Nerv Syst · January 2015 PURPOSE: Neurocutaneous melanosis (NCM) is a rare congenital disorder occurring in children born with multiple or large congenital melanocytic nevi (CMN) in association with melanocytic deposits in the leptomeninges. Multiple associations between NCM and o ... Full text Link to item Cite

Putative height acceleration following tethered cord release in children.

Journal Article J Neurosurg Pediatr · December 2014 OBJECT: Tethered cord (TC) is a neurological disorder caused by tissue attachments that limit the normal movement of the spinal cord. A TC can be unmasked by a cutaneous abnormality or manifest clinically in myriad neurological, urological, and orthopedic ... Full text Link to item Cite

The development of Moyamoya syndrome after proton beam therapy.

Journal Article Pediatr Blood Cancer · August 2014 The development of Moyamoya syndrome (MMS) after cranial irradiation for pediatric tumors has been well established. However, information on the development of MMS after proton beam radiotherapy is sparse. We present the case of a 2-year-old child who deve ... Full text Link to item Cite

Meningiomas

Chapter · January 1, 2014 Meningiomas are fascinating and important benign tumors of the coverings of the brain whose understanding and management are changing significantly. New knowledge of their biology helps to explain the role of sex hormones, growth factors, radiation, and ch ... Full text Cite

The impact of attention deficit hyperactivity disorder on recovery from mild traumatic brain injury.

Journal Article J Neurosurg Pediatr · August 2013 OBJECT: Attention deficit hyperactivity disorder (ADHD) and traumatic brain injury (TBI) are significant independent public health concerns in the pediatric population. This study explores the impact of a premorbid diagnosis of ADHD on outcome following mi ... Full text Link to item Cite

Meconium staining of the brainstem with open myelomeningocele.

Journal Article J Neurosurg Pediatr · February 2013 Meconium staining of open myelomeningoceles has been reported to occur both prenatally and postnatally, but meconium staining of the brainstem has not been previously documented. The authors present a case of meconium staining of the brainstem in an infant ... Full text Link to item Cite

Symptomatic thoracic arachnoid cyst with coexisting tick paralysis: case report and review of the literature.

Journal Article Pediatr Neurosurg · 2013 Tick paralysis is an uncommon phenomenon resulting from the release of a neurotoxin from the salivary glands of an engorged, gravid female tick about 5-7 days after attachment. The neurotoxin produces ascending weakness, mimicking other ascending paralytic ... Full text Link to item Cite

Neuromuscular hamartoma of the sciatic nerve: Case report and review of the literature

Journal Article Surgical Neurology International · January 1, 2013 Background: Neuromuscular hamartomas are rare benign tumors with mature skeletal elements mixed with mature neural elements. They present typically as solitary lesions in childhood and have been reported to be associated with cranial nerves or large periph ... Full text Cite

Coexistence of dermal sinus tract, dermoid cyst, and encephalocele in a patient presenting with nasal cellulitis.

Journal Article J Neurosurg Pediatr · January 2013 Dermoid cysts, encephaloceles, and dermal sinus tracts represent abnormalities that develop during the process of embryogenesis. The elucidation of the precise timing of formation for these malformations has remained elusive at the molecular level of study ... Full text Link to item Cite

Meningiomas in children and adolescents: a meta-analysis of individual patient data.

Journal Article Lancet Oncol · December 2011 BACKGROUND: The epidemiological, prognostic, and therapeutic features of child and adolescent meningioma are poorly defined. Clinical knowledge has been drawn from small case series and extrapolation from adult studies. This study was done to pool and anal ... Full text Link to item Cite

Intracranial pressure-monitoring systems in children with traumatic brain injury: Combining therapeutic and diagnostic tools

Journal Article Pediatric Critical Care Medicine · January 1, 2011 Objective: To compare the correlation of intracranial pressure (ICP) measurement and time to detection of ICP crises (defined as ICP ≥20 mm Hg for ≥5 mins) between an intraparenchymal (IP) monitor and external ventricular drain (EVD) in children for whom c ... Full text Cite

Is postoperative CT scanning predictive of subdural electrode placement complications in pediatric epileptic patients?

Journal Article Pediatr Neurosurg · 2009 AIMS: To understand the reliability of postoperative CT scans to predict the development of intracranial hemorrhagic complications associated with subdural electrode implants for monitoring intractable seizure, we reviewed the data of a consecutive series ... Full text Link to item Cite

Meningiomas in children.

Journal Article Pediatr Neurosurg · 2008 OBJECTIVE: Pediatric meningioma is a rare diagnosis. This retrospective review seeks to elucidate pertinent characteristics of pediatric patients presenting with meningioma. METHODS: The Seattle Children's Hospital and Regional Medical Center brain tumor d ... Full text Link to item Cite

Pediatric intradural extramedullary synovial sarcoma: case report.

Journal Article Neurosurgery · December 2006 OBJECTIVE: The diagnosis of intradural synovial sarcoma has not been previously published. This report provides a summary of the literature on this tumor and on tumors arising in this location, as well as a description of this patient's clinical course. CL ... Full text Link to item Cite