Scholars@Duke
Susan Crawford

Susan Crawford

Adjunct Professor in the Department of Pathology
Pathology

Selected Publications

DGAT1 Inhibition Enhances Olaparib-Induced Lipotoxic Apoptosis in Metastatic Castration-Resistant Prostate Cancer.

Journal Article FASEB J · August 15, 2025 Despite the initial success of poly (ADP-ribose) polymerase (PARP) inhibitors, achieving durable responses and effective treatment outcomes in metastatic castration-resistant prostate cancer (mCRPC) remains challenging. Resistance to the PARP inhibitor Ola ... Full text Link to item Cite

Obesity-Facilitated Colon Cancer Progression Is Mediated by Increased Diacylglycerol O-Acyltransferases 1 and 2 Levels.

Journal Article Gastroenterology · February 2025 BACKGROUND & AIMS: The obesity epidemic is associated with increased colon cancer progression. As lipid droplets (LDs) fuel tumor growth, we aimed to determine the significance of diacyltransferases (diacylglycerol o-acyltransferases 1 and 2 [DGAT1/2]), re ... Full text Link to item Cite

Gut-liver axis calibrates intestinal stem cell fitness.

Journal Article Cell · February 15, 2024 The gut and liver are recognized to mutually communicate through the biliary tract, portal vein, and systemic circulation. However, it remains unclear how this gut-liver axis regulates intestinal physiology. Through hepatectomy and transcriptomic and prote ... Full text Link to item Cite

Infiltrating lipid-rich macrophage subpopulations identified as a regulator of increasing prostate size in human benign prostatic hyperplasia.

Journal Article Front Immunol · 2024 INTRODUCTION: Macrophages exhibit marked phenotypic heterogeneity within and across disease states, with lipid metabolic reprogramming contributing to macrophage activation and heterogeneity. Chronic inflammation has been observed in human benign prostatic ... Full text Link to item Cite

Shared Inherited Genetics of Benign Prostatic Hyperplasia and Prostate Cancer.

Journal Article Eur Urol Open Sci · September 2022 BACKGROUND: The association between benign prostatic hyperplasia (BPH) and prostate cancer (PCa) remains controversial, largely due to a detection bias in traditional observational studies. OBJECTIVE: To assess the association between BPH and PCa using inh ... Full text Open Access Link to item Cite

PEDF Deletion Induces Senescence and Defects in Phagocytosis in the RPE.

Journal Article Int J Mol Sci · July 13, 2022 The retinal pigment epithelium (RPE) expresses the Serpinf1 gene to produce pigment epithelium-derived factor (PEDF), a retinoprotective protein that is downregulated with cell senescence, aging and retinal degenerations. We determined the expression of se ... Full text Open Access Link to item Cite

Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer.

Journal Article Cancers (Basel) · May 9, 2022 Through stromal-epithelial interactions, carcinoma associated fibroblasts (CAF) play a critical role in tumor growth and progression. Activation of erythrophoyetin-producing human hepatocellular (Eph) receptors has been implicated in cancer. Eph receptor i ... Full text Open Access Link to item Cite

Antagonism Between PEDF and TGF-β Contributes to Type VI Osteogenesis Imperfecta Bone and Vascular Pathogenesis.

Journal Article J Bone Miner Res · May 2022 Osteogenesis imperfecta (OI) is a heterogeneous genetic disorder of bone and connective tissue, also known as brittle bone disease. Null mutations in SERPINF1, which encodes pigment epithelium-derived factor (PEDF), cause severe type VI OI, characterized b ... Full text Link to item Cite

TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease.

Journal Article Nat Commun · April 19, 2022 Autoimmune (AI) diseases can affect many organs; however, the prostate has not been considered to be a primary target of these systemic inflammatory processes. Here, we utilize medical record data, patient samples, and in vivo models to evaluate the impact ... Full text Open Access Link to item Cite

Pigment epithelium-derived factor induces CRX alterations in the mouse retina

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022 Cite

Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity.

Journal Article Oncogenesis · November 29, 2021 Obesity is a worldwide epidemic associated with increased risk and progression of colon cancer. Here, we aimed to determine the role of adipose triglyceride lipase (ATGL), responsible for intracellular lipid droplet (LD) utilization, in obesity-driven colo ... Full text Open Access Link to item Cite

Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells.

Journal Article Lab Invest · July 2021 Lipid droplet (LD) accumulation in cancer results from aberrant metabolic reprograming due to increased lipid uptake, diminished lipolysis and/or de novo lipid synthesis. Initially implicated in storage and lipid trafficking in adipocytes, LDs are more rec ... Full text Open Access Link to item Cite

Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells.

Journal Article Lab Invest · July 2021 Lipid droplet (LD) accumulation in cancer results from aberrant metabolic reprograming due to increased lipid uptake, diminished lipolysis and/or de novo lipid synthesis. Initially implicated in storage and lipid trafficking in adipocytes, LDs are more rec ... Full text Link to item Cite

Feasibility and performance of a novel probe panel to detect somatic DNA copy number alterations in clinical specimens for predicting prostate cancer progression.

Journal Article Prostate · October 2020 BACKGROUND: To assess the feasibility of a novel DNA-based probe panel to detect copy number alterations (CNAs) in prostate tumor DNA and its performance for predicting clinical progression. METHODS: A probe panel was developed and optimized to measure CNA ... Full text Link to item Cite

PEDF deficiency increases the susceptibility of rd10 mice to retinal degeneration.

Journal Article Exp Eye Res · September 2020 The SERPINF1 gene encodes pigment epithelium-derived factor (PEDF), a member of the serpin superfamily with neurotrophic and antiangiogenic properties in the retina. We hypothesized that absence of PEDF would lead to increased stress-associated retinal deg ... Full text Link to item Cite

Propagation of human prostate tissue from induced pluripotent stem cells.

Journal Article Stem Cells Transl Med · July 2020 Primary culture of human prostate organoids and patient-derived xenografts is inefficient and has limited access to clinical tissues. This hampers their use for translational study to identify new treatments. To overcome this, we established a complementar ... Full text Link to item Cite

Heterogeneity of human prostate carcinoma-associated fibroblasts implicates a role for subpopulations in myeloid cell recruitment.

Journal Article Prostate · February 2020 BACKGROUND: Carcinoma-associated fibroblasts (CAF) are a heterogeneous group of cells within the tumor microenvironment (TME) that can promote tumorigenesis in the prostate. By understanding the mechanism(s) by which CAF contributes to tumor growth, new th ... Full text Link to item Cite

Injection molded open microfluidic well plate inserts for user-friendly coculture and microscopy.

Journal Article Lab Chip · January 7, 2020 Open microfluidic cell culture systems are powerful tools for interrogating biological mechanisms. We have previously presented a microscale cell culture system, based on spontaneous capillary flow of biocompatible hydrogels, that is integrated into a stan ... Full text Link to item Cite

Lipid droplet velocity is a microenvironmental sensor of aggressive tumors regulated by V-ATPase and PEDF.

Journal Article Lab Invest · December 2019 Lipid droplets (LDs) utilize microtubules (MTs) to participate in intracellular trafficking of cargo proteins. Cancer cells accumulate LDs and acidify their tumor microenvironment (TME) by increasing the proton pump V-ATPase. However, it is not known wheth ... Full text Link to item Cite

Influence of maternal obesity and metabolic and vascular mediators in twin-twin transfusion syndrome.

Journal Article Reprod Biol · June 2019 Obesity is a risk factor for complications in singleton and twin pregnancies; however, there are limited data regarding maternal body mass index (BMI) in the setting of twin-twin transfusion syndrome (TTTS). We hypothesized that increased BMI in TTTS is as ... Full text Link to item Cite

Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse.

Journal Article Prostate · June 2019 BACKGROUND: Prostatic inflammation and various proinflammatory systemic comorbidities, such as diabetes and obesity are associated with human benign prostatic hyperplasia (BPH). There is a paucity of in vivo models reflecting specific aspects of BPH pathog ... Full text Link to item Cite

DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130.

Journal Article Sci Rep · February 28, 2019 Acyl-CoA:diacylglycerol acyltransferase I (DGAT1) is a key enzyme in lipogenesis which is increased in metabolically active cells to meet nutrient requirements. DGAT1 has been recognized as an anti-obesity target; however, its role in the tumor microenviro ... Full text Link to item Cite

Tyrosine kinase inhibitor therapy prescribed for non-urologic diseases can modify PSA titers in urology patients.

Journal Article Prostate · February 2019 BACKGROUND: The tyrosine kinase inhibitors (TKI), imatinib and nilotinib, are used to treat chronic myelogenous leukemia (CML). In three CML patients being monitored for urologic diseases, we observed that switching of TKI therapy affected prostate-specifi ... Full text Link to item Cite

Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets.

Journal Article Cell Mol Gastroenterol Hepatol · 2019 BACKGROUND & AIMS: Diminished forkhead box O3 (FOXO3) function drives inflammation and cancer growth; however, mechanisms fostering these pathobiologies are unclear. Here, we aimed to identify in colon loss of FOXO3-dependent cellular and molecular changes ... Full text Link to item Cite

Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men.

Journal Article Cancer Res · November 1, 2018 Progress in prostate cancer racial disparity research has been hampered by a lack of appropriate research tools and better understanding of the tumor biology. Recent gene expression studies suggest that the tumor microenvironment (TME) may contribute to ra ... Full text Link to item Cite

PEDF regulates plasticity of a novel lipid-MTOC axis in prostate cancer-associated fibroblasts.

Journal Article J Cell Sci · July 11, 2018 Prostate tumors make metabolic adaptations to ensure adequate energy and amplify cell cycle regulators, such as centrosomes, to sustain their proliferative capacity. It is not known whether cancer-associated fibroblasts (CAFs) undergo metabolic re-programm ... Full text Link to item Cite

Abstract 5068: Distinct pro-inflammatory cytokines in prostate fibroblasts from African-Americans with prostate cancer increase the tumorigenicity of cancer cells

Conference Cancer Research · July 1, 2018 AbstractIntroduction: African-American (AA) men are disproportionately affected by prostate cancer (PCa) compared with Caucasian (CA) men. AA men have higher PCa incidence and, once diagnosed, a higher stage ... Full text Cite

Abstract 1451: A novel lipid-centrosomal axis in prostate cancer is regulated by PEDF

Conference Cancer Research · July 1, 2018 AbstractBackground: Prostate tumor cells undergo metabolic adaptations and revert to lipid stores to meet the energy demands of their high proliferative capacity. To fuel progression, cancer cells accumulate ... Full text Cite

A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer.

Journal Article Oncogene · April 2018 The N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) mouse model is an attractive model system of muscle-invasive bladder cancer (MIBC) as it recapitulates the histology of human tumors in a background with intact immune system. However, it was unknown whether ... Full text Link to item Cite

In colonic ρ0 (rho0) cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer.

Journal Article Oncoscience · November 2017 BACKGROUND: Mitochondrial reprogramming has emerged as a hallmark of cancer pathobiology. Although it is believed this reprogramming is essential for cancer cells to thrive, how it supports cancer pathobiology is unclear. We previously generated colonic ρ0 ... Full text Link to item Cite

Hormonal and Growth Regulation of Epithelial and Stromal Cells From the Normal and Malignant Endometrium by Pigment Epithelium-Derived Factor.

Journal Article Endocrinology · September 1, 2017 We discovered that pigment epithelium-derived factor (PEDF)-null mice have endometrial hyperplasia, the precursor to human type I endometrial cancer (ECA), which is etiologically linked to unopposed estrogen (E2), suggesting that this potent antiangiogenic ... Full text Link to item Cite

A genetic variant near GATA3 implicated in inherited susceptibility and etiology of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS).

Journal Article Prostate · August 2017 BACKGROUND: Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS) are common conditions. Little is known about their etiologies except that studies have suggested a substantial heritable component. Our objective is to provid ... Full text Link to item Cite

In Vivo Effects of Long-Term Cigarette Smoke Exposure on Mammary Tissue in Mice.

Journal Article Am J Pathol · June 2017 Cigarette smoking is the leading cause of preventable death worldwide and has been linked to the development and progression of cancer. Many cohort studies have described the link between patients with breast cancer and those with long-term smoking history ... Full text Link to item Cite

Reduced mitochondrial activity in colonocytes facilitates AMPKα2-dependent inflammation.

Journal Article FASEB J · May 2017 Intestinal inflammation is associated with low levels of mucosal ATP, highlighting the importance of mitochondrial function associated with ATP production in the pathophysiology of the disease. In the inflamed colon of humans and mice, we found decreased l ... Full text Link to item Cite

High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors.

Journal Article Carcinogenesis · March 1, 2017 Obesity, an immense epidemic affecting approximately half a billion adults, has doubled in prevalence in the last several decades. Epidemiological data support that obesity, due to intake of a high-fat, western diet, increases the risk of colon cancer; how ... Full text Link to item Cite

Adipose Triglyceride Lipase (ATGL) Expression Is Associated with Adiposity and Tumor Stromal Proliferation in Patients with Pancreatic Ductal Adenocarcinoma.

Journal Article Anticancer Res · February 2017 BACKGROUND: Obesity is an established risk factor for the development of pancreatic ductal adenocarcinoma (PDAC). However, the pathophysiology of how increased adiposity increases the risk for PDAC has not been fully elucidated. Adipose triglyceride lipase ... Full text Link to item Cite

Altered TGF-α/β signaling drives cooperation between breast cancer cell populations.

Journal Article FASEB J · October 2016 The role of tumor heterogeneity in regulating disease progression is poorly understood. We hypothesized that interactions between subpopulations of cancer cells can affect the progression of tumors selecting for a more aggressive phenotype. We developed an ... Full text Link to item Cite

Intestinal inflammation requires FOXO3 and prostaglandin E2-dependent lipogenesis and elevated lipid droplets.

Journal Article Am J Physiol Gastrointest Liver Physiol · May 15, 2016 Intestinal inflammation has been recently characterized by the dysregulation of lipids as metabolic and energy sources, revealing a novel feature of its pathophysiology. Because intracellular lipids, stored in dynamic lipid droplets (LDs), provide energy f ... Full text Link to item Cite

Restoration of the serum level of SERPINF1 does not correct the bone phenotype in Serpinf1 null mice.

Journal Article Mol Genet Metab · March 2016 Osteogenesis imperfecta (OI) is a group of genetic disorders characterized by bone fragility and deformity. OI type VI is unique owing to the mineralization defects observed in patient biopsies. Furthermore, it has been reported to respond less well to sta ... Full text Link to item Cite

Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6.

Journal Article Biochem Biophys Res Commun · January 15, 2016 The proliferation of colon cancer cells is mediated in part by epidermal growth factor receptor (EGFR) signaling and requires sustained levels of cellular energy to meet its high metabolic needs. Intracellular lipid droplets (LDs) are a source of energy us ... Full text Link to item Cite

Depletion of polymorphonuclear leukocytes has no effect on preterm delivery in a mouse model of Escherichia coli-induced labor.

Conference Am J Obstet Gynecol · November 2015 OBJECTIVE: The objective of the study was to investigate the role of polymorphonuclear leukocytes (PMNs) in a mouse model of Escherichia coli-induced labor. STUDY DESIGN: Intraperitoneal injection of rabbit antimouse PMN antiserum or control was performed ... Full text Link to item Cite

MRS measured fatty acid composition of periprostatic adipose tissue correlates with pathological measures of prostate cancer aggressiveness.

Journal Article J Magn Reson Imaging · September 2015 PURPOSE: To investigate the association between magnetic resonance (MR) spectroscopically measured fatty acid composition of periprostatic adipose tissue and pathological markers of prostate cancer aggressiveness. MATERIALS AND METHODS: Periprostatic adipo ... Full text Link to item Cite

Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver

Journal Article Cellular and Molecular Gastroenterology and Hepatology · September 1, 2015 Background & Aims: Pigment epithelium-derived factor (PEDF) is a secretory protein that inhibits multiple tumor types. PEDF inhibits the Wnt coreceptor, low-density lipoprotein receptor-related protein 6 (LRP6), in the eye, but whether the tumor-suppressiv ... Full text Cite

The Importance of Genetic Testing in a Case of Sudden Death in Hypertrophic Cardiomyopathy due to Troponin I Mutation

Journal Article Academic Forensic Pathology · March 1, 2015 Sudden death due to hypertrophic cardiomyopathy (HCM) is uncommon. Most cases of HCM are due to mutations in sarcomeric proteins. Mutations of the cardiac troponin I gene TNNI3 are rare. Over 15 mutations of the TNNI3 gene have been identified; the clinica ... Full text Cite

Identification of molecular signature of head and neck cancer stem-like cells.

Journal Article Sci Rep · January 15, 2015 Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer in the world. HNSCC remains difficult to treat, and despite advances in treatment, overall survival rate has modestly improved over the past several years. Poor survival rate ... Full text Link to item Cite

Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1.

Journal Article Oncotarget · November 30, 2014 Plant flavonoid apigenin prevents and inhibits UVB-induced carcinogenesis in the skin and has strong anti-proliferative and anti-angiogenic properties. Here we identify mechanisms, by which apigenin controls these oncogenic events. We show that apigenin ac ... Full text Link to item Cite

Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender.

Journal Article Cancer Epidemiol Biomarkers Prev · November 2014 BACKGROUND: We have previously reported that colonic pericryptal microvascular blood flow is augmented in the premalignant colonic epithelium, highlighting the increased metabolic demand of the proliferative epithelium as a marker of field carcinogenesis. ... Full text Link to item Cite

Elevated neonatal insulin-like growth factor I is associated with fetal hypertrophic cardiomyopathy in diabetic women.

Conference Am J Obstet Gynecol · September 2014 OBJECTIVE: We sought to determine if fetal hypertrophic cardiomyopathy (HCM) or cardiac dysfunction is associated with elevated maternal or neonatal insulin-like growth factor (IGF)-I levels in women with diabetes. STUDY DESIGN: In a prospective cohort stu ... Full text Link to item Cite

Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.

Journal Article Endocrinology · April 2014 Pigment epithelium-derived factor (PEDF) is an antiinflammatory protein that circulates at high levels in the metabolic syndrome. Metabolic studies of PEDF knockout (KO) mice were conducted to investigate the relationship between PEDF, inflammatory markers ... Full text Link to item Cite

Periprostatic adipose tissue from obese prostate cancer patients promotes tumor and endothelial cell proliferation: a functional and MR imaging pilot study.

Journal Article Prostate · February 2014 BACKGROUND: Obesity, particularly visceral adiposity, confers a worse prognosis for prostate cancer (PCa) patients, and increasing periprostatic adipose (PPA) tissue thickness or density is positively associated with more aggressive disease. However, the c ... Full text Link to item Cite

PEDF & stem cells: niche vs. nurture.

Journal Article Curr Drug Deliv · 2014 Anti-angiogenic pigment epithelium-derived factor (PEDF) is a multifunctional 50kD secreted glycoprotein emerging as a key factor in stem cell renewal. Characteristics of the stem cell niche can be highly dependent on location, access to the vasculature, o ... Full text Link to item Cite

79: Elevated neonatal IGF-I is associated with fetal hypertrophic cardiomyopathy

Conference American Journal of Obstetrics and Gynecology · January 2014 Full text Cite

Peritumoral expression of adipokines and fatty acids in breast cancer.

Journal Article Ann Surg Oncol · December 2013 BACKGROUND: Adipokines in the tumor microenvironment may contribute to cancer growth. We hypothesized that peritumoral fat can be a source of lipid-derived energy for tumors by increasing adipose triglyceride lipase (ATGL)-mediated lipolysis and down-regul ... Full text Link to item Cite

Host pigment epithelium-derived factor (PEDF) prevents progression of liver metastasis in a mouse model of uveal melanoma.

Journal Article Clin Exp Metastasis · December 2013 Uveal melanoma (UM) has a 30 % 5-year mortality rate, primarily due to liver metastasis. Both angiogenesis and stromagenesis are important mechanisms for the progression of liver metastasis. Pigment epithelium-derived factor (PEDF), an anti-angiogenic and ... Full text Link to item Cite

Nano-architectural alterations in mucus layer fecal colonocytes in field carcinogenesis: potential for screening.

Journal Article Cancer Prev Res (Phila) · October 2013 Current fecal tests (occult blood, methylation, DNA mutations) target minute amounts of tumor products among a large amount of fecal material and thus have suboptimal performance. Our group has focused on exploiting field carcinogenesis as a modality to am ... Full text Link to item Cite

A mouse model for human osteogenesis imperfecta type VI.

Journal Article J Bone Miner Res · July 2013 Osteogenesis imperfecta type VI (OI type VI) has recently be linked to a mutation in the SERPINF1 gene, which encodes pigment epithelium-derived factor (PEDF), a ubiquitously expressed protein originally described for its neurotrophic and antiangiogenic pr ... Full text Link to item Cite

FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density.

Journal Article J Biol Chem · June 7, 2013 Forkhead transcription factor FOXO3 plays a critical role in suppressing tumor growth, in part, by increasing the cell cycle inhibitor p27kip1, and Foxo3 deficiency in mice results in marked colonic epithelial proliferation. Here, we show in Foxo3-deficien ... Full text Link to item Cite

Impact of toll-like receptor 4 deficiency on the response to uterine ischemia/reperfusion in mice.

Journal Article Reproduction · May 2013 Our objective was to determine the role of toll-like receptor 4 (TLR4) in uterine ischemia/reperfusion (I/R)-induced fetal growth restriction (FGR). Pregnant TLR4-deficient and wild-type mice were subjected to I/R or a sham procedure. Fetal and placental w ... Full text Link to item Cite

Abstract 5075: Targeting TSP1 and inhibiting angiogenesis in UV-induced skin cancer by apigenin.

Conference Cancer Research · April 15, 2013 AbstractNon-melanoma skin cancer (NMSC) is a major health problem in the United States, with over two million new cases diagnosed yearly. Among many genetic and environmental factors contributed to NMSC, ult ... Full text Cite

Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction.

Journal Article PLoS One · 2013 The actin-associated protein Pdlim7 is essential for heart and fin development in zebrafish; however, the expression and function of this PDZ-LIM family member in the mammal has remained unclear. Here, we show that Pdlim7 predominantly localizes to actin-r ... Full text Link to item Cite

280: Gestational diabetes induces fetal hypertrophic cardiomyopathy in a rat model

Conference American Journal of Obstetrics and Gynecology · January 2013 Full text Cite

Bitter melon reduces head and neck squamous cell carcinoma growth by targeting c-Met signaling.

Journal Article PLoS One · 2013 Head and neck squamous cell carcinoma (HNSCC) remains difficult to treat, and despite of advances in treatment, the overall survival rate has only modestly improved over the past several years. Thus, there is an urgent need for additional therapeutic modal ... Full text Link to item Cite

Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients.

Journal Article Acta Diabetol · December 2012 Obesity is a significant risk factor for developing diabetes. Pigment epithelium-derived factor (PEDF) has been identified by experimental and clinical studies as both a causative and counter-regulatory factor in the metabolic syndrome. We set out to deter ... Full text Link to item Cite

Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice.

Journal Article Gut · October 2012 BACKGROUND AND AIMS: Pigment epithelium-derived factor (PEDF), a non-inhibitory SERPIN with potent antiangiogenic activity, has been recently implicated in metabolism and adipogenesis, both of which are known to influence pancreatic cancer progression. Inc ... Full text Link to item Cite

PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum.

Journal Article J Neurosci · August 29, 2012 Pigment epithelium-derived factor (PEDF) is a serine protease inhibitor (serpin) protein with well established neuroprotective and anti-angiogenic properties. Recent studies have also shown that PEDF enhances renewal of adult subventricular zone (SVZ) neur ... Full text Link to item Cite

Abstract 4117: Increased pancreatic adipocyte hypertrophy in EL-Kras/PEDF null mice with versus without pancreatic cancer

Conference Cancer Research · April 15, 2012 AbstractUnderstanding non-parenchymal contributions to disease etiology and factors that assess risk and prognosis are currently key points of interest in pancreatic cancer research. One such focus is in reg ... Full text Cite

Abstract 545: Autocrine growth regulation by PEDF is mediated by ovarian steroid hormones: Implications in the pathogenesis of endometrial carcinoma

Conference Cancer Research · April 15, 2012 AbstractThe angiogenic inhibitor and neurotrophic factor, pigment epithelium-derived factor (PEDF) was first shown in the eye and is now shown to be expressed in a number of tissues and to function in apopto ... Full text Cite

Abstract 1499: Periprostatic fat from obese patients promotes prostate cancer growth

Conference Cancer Research · April 15, 2012 AbstractBackground: Obesity, particularly visceral obesity, increases the risk of prostate cancer (PCa) progression. However, the mechanism of this remains unclear. Here, we hypothesized that the visceral pe ... Full text Cite

Abstract 1523: Trafficking of intracytoplasmic lipid droplets in pancreatic cancer cells by pigment epithelium-derived factor alters triacylglycerol metabolism and cellular invasion

Conference Cancer Research · April 15, 2012 AbstractBackground: Pancreatic ductal adenocarcinoma (PDAC) is a rapidly progressing disease with high metastatic potential, thus, it requires a robust and renewable source of energy to meet its metabolic de ... Full text Cite

Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene.

Journal Article Mech Dev · 2012 PIMT (also known as PIPMT/NCOA6IP/Tgs1), first isolated as a transcription coactivator PRIP (NCOA6)-interacting 96-kDa protein with RNA-binding property, possesses RNA methyltransferase activity. As a transcription coactivator binding protein, PIMT enhance ... Full text Link to item Cite

183: Maternal obesity and evidence of fetal programming of lipid metabolism

Conference American Journal of Obstetrics and Gynecology · January 2012 Full text Cite

Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1.

Journal Article Am J Pathol · December 2011 Pigment epithelium-derived factor (PEDF) is important for maintaining the normal extracellular matrix. We hypothesized that the initiation of pancreatic fibrosis is dependent on the loss of PEDF. Pancreatic PEDF expression was assessed in wild-type mice fe ... Full text Link to item Cite

Mutations in SERPINF1 cause osteogenesis imperfecta type VI.

Journal Article J Bone Miner Res · December 2011 Osteogenesis imperfecta (OI) is a spectrum of genetic disorders characterized by bone fragility. It is caused by dominant mutations affecting the synthesis and/or structure of type I procollagen or by recessively inherited mutations in genes responsible fo ... Full text Link to item Cite

Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis.

Journal Article Cancer Lett · July 28, 2011 Spectroscopic techniques have demonstrated that in the microscopically normal mucosa, there is an increase in mucosal micro-circulation in patients harboring neoplasia elsewhere in the colon (i.e. marker of field carcinogenesis). However, the physiological ... Full text Link to item Cite

The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.

Journal Article Lab Invest · May 2011 The vacuolar-ATPase (v-ATPase) is a proton transporter found on many intracellular organelles and the plasma membrane (PM). The v-ATPase on PMs of cancer cells may contribute to their invasive properties in vitro. Its relevance to human cancer tissues rema ... Full text Link to item Cite

Abstract LB-321: Metabolic profiles of periprostatic adipose tissue from prostate cancer patients using MR spectroscopy

Conference Cancer Research · April 15, 2011 AbstractObesity is associated with more aggressive prostate cancer (PCa), with visceral obesity conferring an even higher risk than generalized obesity. However, the mechanism by which obesity fuels PCa prog ... Full text Cite

Abstract 387: Prostate cancer cell invasion is stimulated by cross communication with human monocyte-lineage cells

Conference Cancer Research · April 15, 2011 AbstractTumor-associated macrophages (TAMs) produce factors that may stimulate tumor growth, angiogenesis and progression. In this study, co-cultures with monocyte-derived THP-1, U-937 cells or normal periph ... Full text Cite

196: Maternal adiposity reduces fetal growth in a leptin-deficient murine model

Conference American Journal of Obstetrics and Gynecology · January 2011 Full text Cite

Assays for the antiangiogenic and neurotrophic serpin pigment epithelium-derived factor.

Chapter · 2011 Pigment epithelium-derived factor (PEDF) is a secreted serpin that exhibits a variety of interesting biological activities. The multifunctional PEDF has neurotrophic and antiangiogenic properties, and acts in retinal differentiation, survival, and maintena ... Full text Link to item Cite

Overexpression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor.

Journal Article Urology · December 2010 OBJECTIVES: To elucidate the mechanism of transforming growth factor (TGF)-β1 overexpression in prostate cancer cells. METHODS: Malignant (PC3, DU145) and benign (RWPE1, BPH1) prostate epithelial cells were used. Phosphatase activity was measured using a c ... Full text Link to item Cite

Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation.

Journal Article Lab Invest · July 2010 Castration experiments in rodents show that the stromal vasculature is critical to the androgen-mediated prostate growth regulation. However, the role of angiogenesis inhibitors, such as thrombospondin-1 (TSP-1), in this process is unclear. TSP-1 is a mult ... Full text Link to item Cite

Urethroplasty with abdominal skin grafts for long segment urethral strictures.

Journal Article J Urol · May 2010 PURPOSE: Buccal derived graft tissue has been proven to be useful in urethral reconstruction. However, nonbuccal sources are often needed for long segment strictures or for those with prior buccal harvest. We describe a technique using full-thickness abdom ... Full text Link to item Cite

Ehd4 is required to attain normal prepubertal testis size but dispensable for fertility in male mice.

Journal Article Genesis · May 2010 The four highly homologous members of the C-terminal EH domain-containing (EHD) protein family (EHD1-4) regulate endocytic recycling. To delineate the role of EHD4 in normal physiology and development, mice with a conditional knockout of the Ehd4 gene were ... Full text Link to item Cite

The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in mice.

Journal Article BMC Dev Biol · April 2, 2010 BACKGROUND: The C-terminal Eps15 homology domain-containing protein 1 (EHD1) is ubiquitously expressed and regulates the endocytic trafficking and recycling of membrane components and several transmembrane receptors. To elucidate the function of EHD1 in ma ... Full text Link to item Cite

Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment.

Journal Article Neoplasia · April 2010 Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis but whether it has additional effects on the tumor microenvironment is largely unexplored. We show that overexpression of PEDF in orthotopic MatLyLu rat prostate tumors increase ... Full text Link to item Cite

Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression.

Journal Article Mol Cancer Res · February 2010 Oral squamous cell carcinoma (OSCC) has 50% 5-year survival rate, highlighting our limited understanding of the molecular events that contribute to disease progression. Microarray analyses of primary oral tumors have identified urinary-type plasminogen act ... Full text Link to item Cite

Shepherd Hook Anomaly of Ductus Arteriosus With Sudden Intrapartum Fetal Demise: Two Case Reports

Journal Article World Journal for Pediatric and Congenital Heart Surgery · January 1, 2010 Patency of the ductus arteriosus is critical in maintaining fetal circulation, and premature closure is associated with fetal and early neonatal death. We present 2 cases of sudden demise in the delivery room associated with atypical ductal anatomy with ob ... Full text Cite

Decreased expression of pigment epithelium derived factor (PEDF), an inhibitor of angiogenesis, in placentas of unexplained stillbirths.

Journal Article Reprod Biol · July 2008 Normal placental vascular development depends upon the complex interactions between angiogenic inducers and inhibitors within the placenta. Alterations within the placental microenvironment can promote an imbalance in angiogenic mediators which may be asso ... Full text Link to item Cite

Dysregulated angiogenesis in B-chronic lymphocytic leukemia: morphologic, immunohistochemical, and flow cytometric evidence.

Journal Article Diagn Pathol · April 18, 2008 BACKGROUND: The extent of enhanced bone marrow angiogenesis in chronic lymphocytic leukemia (CLL) and relationship to proangiogenic factors and prognostic indicators is largely unexplored. METHODS: To further investigate the role of angiogenesis in CLL by ... Full text Link to item Cite

Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL).

Journal Article J Hepatol · March 2008 BACKGROUND/AIMS: Anti-angiogenic pigment epithelium-derived factor (PEDF) is a 50 kDa secreted glycoprotein that is highly expressed in hepatocytes. Adipose triglyceride lipase (ATGL), a novel lipase critical for triglyceride metabolism, is a receptor for ... Full text Link to item Cite

RNA-containing cytoplasmic inclusion bodies in ciliated bronchial epithelium months to years after acute Kawasaki disease.

Journal Article PLoS One · February 13, 2008 BACKGROUND: Kawasaki Disease (KD) is the most common cause of acquired heart disease in children in developed nations. The KD etiologic agent is unknown but likely to be a ubiquitous microbe that usually causes asymptomatic childhood infection, resulting i ... Full text Link to item Cite

Neural substrate for atrial fibrillation: implications for targeted parasympathetic blockade in the posterior left atrium.

Journal Article Am J Physiol Heart Circ Physiol · January 2008 The parasympathetic (P) nervous system is thought to contribute significantly to focal atrial fibrillation (AF). Thus we hypothesized that P nerve fibers [and related muscarinic (M(2)) receptors] are preferentially located in the posterior left atrium (PLA ... Full text Link to item Cite

Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.

Conference Adv Exp Med Biol · 2008 Pigment epithelium-derived factor (PEDF) is an endogenous antiangiogenic protein that also possesses antitumor activity. The mechanisms by which PEDF exerts its actions remains poorly understood. We sought to understand the role of PEDF in hepatocellular c ... Full text Link to item Cite

Case-control study of risk factors for the development of post-transplant lymphoproliferative disease in a pediatric heart transplant cohort.

Journal Article Pediatr Transplant · February 2007 PTLD is an important complication following heart transplantation. To better define the risk factors of PTLD in children, we performed a case-control study. All pediatric cardiac transplant recipients who developed their first episode of PTLD were matched ... Full text Link to item Cite

Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model.

Journal Article Thromb Res · 2007 INTRODUCTION: Tissue Factor (TF) expression is observed in many types of cancer, associated with more aggressive disease, and thrombosis. Alternatively-spliced human tissue factor (asHTF) has recently been identified in which exon 5 is deleted. asHTF is so ... Full text Link to item Cite

Gene transfer of pigment epithelium-derived factor suppresses tumor growth and angiogenesis in a hepatoblastoma xenograft model.

Journal Article Pediatr Res · September 2006 Normal hepatocytes express pigment epithelium-derived factor (PEDF), an endogenous antiangiogenic factor. We hypothesized that decreased PEDF expression may be one mechanism driving hepatoblastoma growth, and in vivo gene transfer of PEDF could suppress ne ... Full text Link to item Cite

Pigment epithelium-derived factor targets endothelial and epithelial cells in Wilms' tumor.

Journal Article J Pediatr Surg · August 2006 PURPOSE: Loss of pigment epithelium-derived factor (PEDF), a potent inhibitor of angiogenesis, has been linked to progression of angiogenesis-dependent diseases. We postulated that decreased levels of endogenous PEDF in the kidney creates a tumor permissiv ... Full text Link to item Cite

Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine.

Journal Article Mol Cell Biol · July 2006 Protein tyrosine kinase 6 (PTK6) (also called Brk or Sik) is an intracellular tyrosine kinase that is expressed in breast cancer and normal epithelial linings. In adult mice, PTK6 expression is high in villus epithelial cells of the small intestine. To exp ... Full text Link to item Cite

Cytoplasmic inclusion bodies are detected by synthetic antibody in ciliated bronchial epithelium during acute Kawasaki disease.

Journal Article J Infect Dis · November 15, 2005 BACKGROUND: In developed nations, Kawasaki disease (KD) is the most common cause of acquired heart disease in children. An infectious etiology is likely but has not yet been identified. We have previously reported that oligoclonal immunoglobulin A plasma c ... Full text Link to item Cite

Altered pigment epithelium-derived factor and vascular endothelial growth factor levels in lymphangioma pathogenesis and clinical recurrence.

Journal Article Arch Otolaryngol Head Neck Surg · November 2005 OBJECTIVE: To determine the role of angiogenesis in the clinical behavior and pathogenesis of lymphangioma tumors. DESIGN: A retrospective study. Median follow-up period was 44.5 months. SETTING: Children's Memorial Hospital, Chicago, Ill. PATIENTS: Tumor ... Full text Link to item Cite

Detection of Kawasaki disease-associated antigen in inflamed gastrointestinal tract in acute Kawasaki disease.

Journal Article Pediatr Infect Dis J · October 2005 We performed immunohistochemistry experiments using synthetic antibodies on the gastrointestinal tract and kidney from acute Kawasaki disease patients. Significant gastrointestinal tract inflammation was present in only 2/7 patients, who had antigen detect ... Full text Link to item Cite

Urorectal septum malformation sequence.

Journal Article Urology · September 2005 The urorectal septum malformation sequence consists of absent perineal and anal openings in association with ambiguous genitalia and urogenital, colonic, and lumbosacral anomalies. The full sequence is highly lethal, and the partial sequence, characterized ... Full text Link to item Cite

Neointimal inflammation and adventitial angiogenesis correlate with severity of cardiac allograft vasculopathy in pediatric recipients.

Journal Article J Heart Lung Transplant · August 2005 BACKGROUND: Chronic inflammation and angiogenesis have been implicated in the pathogenesis of both cardiac allograft vasculopathy (CAV) and age-related vasculopathy. Because concurrent atherosclerosis does not complicate assessment of CAV in children, we s ... Full text Link to item Cite

Local delivery of osteopontin attenuates vascular remodeling by altering matrix metalloproteinase-2 in a rabbit model of aortic injury.

Journal Article J Thorac Cardiovasc Surg · August 2005 OBJECTIVE: Vascular remodeling, often accelerated after cardiovascular procedures, may result in stenosis or aneurysm formation. The bone-associated protein osteopontin has been suggested to be involved in vascular remodeling, yet the effect of locally app ... Full text Link to item Cite

Osteopontin expression and adventitial angiogenesis induced by local vascular endothelial growth factor 165 reduces experimental aortic calcification.

Journal Article J Thorac Cardiovasc Surg · April 2005 BACKGROUND: Vascular calcification is a common pathologic and precisely regulated process involving bone-associated proteins such as osteopontin. In this study, we investigated mechanisms by which recombinant human vascular endothelial growth factor 165 pr ... Full text Link to item Cite

Cross-talk between Schwann cells and neuroblasts influences the biology of neuroblastoma xenografts.

Journal Article Am J Pathol · March 2005 Neuroblastoma (NB) tumors with abundant schwannian stroma have a differentiated phenotype, low vascularity, and are associated with a favorable prognosis. These observations suggest that cross-talk between Schwann cells and neuroblasts may influence tumor ... Full text Link to item Cite

Angiogenesis in fatal acute Kawasaki disease coronary artery and myocardium.

Journal Article Pediatr Cardiol · 2005 Angiogenesis has been shown to be dysregulated in coronary artery (CA) aneurysms in the chronic phase of Kawasaki disease (KD). Neovascularization may occur in inflammatory-related vascular diseases because many angiogenesis mediators are secreted by infla ... Full text Link to item Cite

Neoangiogenesis and placental vasculopathy in placentas of stillborn infants.

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · 2005 Cite

Cell adhesion molecule expression in coronary artery aneurysms in acute Kawasaki disease.

Journal Article Pediatr Infect Dis J · October 2004 BACKGROUND: The pathogenesis of coronary artery aneurysm (CAA) formation in acute Kawasaki disease (KD) remains unclear. Cell adhesion molecules mediate cell-cell and cell-matrix interactions and regulate leukocyte migration, angiogenesis and tissue remode ... Full text Link to item Cite

Detection of antigen in bronchial epithelium and macrophages in acute Kawasaki disease by use of synthetic antibody.

Journal Article J Infect Dis · August 15, 2004 BACKGROUND: Kawasaki disease (KD) is the most common acquired cardiac disease in children in developed nations. The etiology is unknown, but a ubiquitous infectious agent appears to be likely. Immunoglobulin A plasma cells infiltrate inflamed tissues in ac ... Full text Link to item Cite

Decreased pigment epithelium-derived factor is associated with metastatic phenotype in human and rat prostate tumors.

Journal Article Cancer Res · August 15, 2004 Pigment epithelium-derived factor, a potent angiogenesis inhibitor in the eye, is also expressed in the prostate. Prostate size and angiogenesis is increased in pigment epithelium-derived factor knockout mice, and pigment epithelium-derived factor is down- ... Full text Link to item Cite

Captopril suppresses post-transplantation angiogenic activity in rat allograft coronary vessels.

Journal Article J Heart Lung Transplant · June 2004 BACKGROUND: The development of transplant coronary artery disease is associated with neovascularization in the thickened neointima. We previously reported that captopril inhibits neointimal proliferation in a rat allograft model. We postulated that angioge ... Full text Link to item Cite

Sirenomelia with an angiomatous lumbosacral myelocystocele in a full-term infant.

Journal Article J Perinatol · May 2004 Sirenomelia, also known as the mermaid syndrome, is a rare congenital malformation of uncertain etiology. It is characterized by fusion of the lower limbs and commonly associated with severe urogenital and gastrointestinal malformations. In this report, we ... Full text Link to item Cite

Hypercholesterolemia is common after pediatric heart transplantation: initial experience with pravastatin.

Journal Article J Heart Lung Transplant · March 2004 BACKGROUND: Coronary allograft vasculopathy (CAV) is a progressive complication after cardiac transplantation and limits survival. Hyperlipidemia is a known risk factor for CAV, and pravastatin is effective in decreasing cholesterol levels in adults after ... Full text Link to item Cite

Pigment epithelium-derived factor, a human testis epididymis secretory product, promotes human prostate stromal cell growth in culture.

Journal Article J Urol · January 2004 PURPOSE: We identified and characterized unrecognized testicular secretory proteins that impact human prostate growth. MATERIALS AND METHODS: Human spermatocele fluid served as a source of testicular epididymal secretions and prostatectomy specimen benign ... Full text Link to item Cite

Cardiac plasma cell granulomas: response to oral steroid treatment.

Journal Article Pediatr Cardiol · 2004 Plasma cell granulomas are lesions of uncertain histogenesis arising in a variety of locations, most commonly the lung. Treatment for these lesions is complete surgical excision if possible. Unresectable pulmonary lesions respond to oral corticosteroids an ... Full text Link to item Cite

Macrophage infiltration of pancreatic acini and islets in acute Kawasaki disease.

Journal Article Pediatr Infect Dis J · December 2003 A report of 2 patients who developed diabetes after Kawasaki disease (KD) led us to determine whether macrophages and/or T cells infiltrate acute KD pancreas. Three of 10 acute fatal KD cases had diffuse macrophage infiltration of the pancreas; T cells wer ... Full text Link to item Cite

Topical VEGF enhances healing of thoracic aortic anastomosis for coarctation in a rabbit model.

Journal Article Circulation · September 9, 2003 BACKGROUND: Recurrent stenosis after extended end-to-end anastomosis for aortic coarctation is the primary indication for further interventions in children. Tension because of the extended resection and local arterial wall hypoxia are possible pathogenetic ... Full text Link to item Cite

Congenital pulmonary capillary hemangiomatosis: Report of two cases and review of the literature.

Journal Article Pediatr Pulmonol · September 2003 Pulmonary capillary hemangiomatosis (PCH) is a rare disease characterized by pulmonary hypertension and excessive neovascularization within the pulmonary interstitium, vasculature, and airways. We describe two unusual cases of congenital PCH. Both cases ha ... Full text Link to item Cite

Thyroid carcinoma in the McCune-Albright syndrome: contributory role of activating Gs alpha mutations.

Journal Article J Clin Endocrinol Metab · September 2003 McCune-Albright syndrome (MAS) is defined by the triad of café-au-lait skin pigmentation, polyostotic fibrous dysplasia, and hyperfunctioning endocrinopathies, such as precocious puberty, hyperthyroidism, GH excess, and Cushing's syndrome. This disorder is ... Full text Link to item Cite

Inflammatory pulmonary nodules in Kawasaki disease.

Journal Article Pediatr Pulmonol · August 2003 Symptomatic pulmonary manifestations of Kawasaki disease (KD) are uncommon. However, epidemiologic, radiologic, and histologic studies have indicated that respiratory symptoms and findings occur in KD and suggest that the KD agent may have a respiratory po ... Full text Link to item Cite

Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas.

Journal Article Nat Med · June 2003 Angiogenesis sustains tumor growth and metastasis, and recent studies indicate that the vascular endothelium regulates tissue mass. In the prostate, androgens drive angiogenic inducers to stimulate growth, whereas androgen withdrawal leads to decreased vas ... Full text Link to item Cite

Dexamethasone reduces postoperative troponin levels in children undergoing cardiopulmonary bypass.

Journal Article Crit Care Med · June 2003 OBJECTIVE: We previously demonstrated that dexamethasone treatment before cardiopulmonary bypass in children reduces the postoperative systemic inflammatory response. The purpose of this study was to test the hypothesis that dexamethasone administration be ... Full text Link to item Cite

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

Journal Article Genes Dev · June 1, 2003 To elucidate the functions of the serine/threonine kinase Akt/PKB in vivo, we generated mice lacking both akt1 and akt2 genes. Akt1/Akt2 double-knockout (DKO) mice exhibit severe growth deficiency and die shortly after birth. These mice display impaired sk ... Full text Link to item Cite

Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment.

Journal Article Proc Natl Acad Sci U S A · May 13, 2003 Acute lung injury (ALI) associated with sepsis and iatrogenic ventilator-induced lung injury resulting from mechanical ventilation are major medical problems with an unmet need for small molecule therapeutics. Prevailing hypotheses identify endothelial cel ... Full text Link to item Cite

Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease.

Journal Article Arterioscler Thromb Vasc Biol · April 1, 2003 OBJECTIVE: Coronary artery aneurysms are the major complication of Kawasaki disease (KD). Matrix metalloproteinases (MMPs) regulate remodeling and degradation of the extracellular matrix. We hypothesized that MMP-9 expression is increased in acute KD aneur ... Full text Link to item Cite

Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model.

Journal Article J Pediatr Surg · March 2003 BACKGROUND/PURPOSE: Pigment epithelium-derived factor (PEDF), a potent endogenous inhibitor of angiogenesis, is highly expressed in the kidney. The authors postulated that systemic administration of PEDF would decrease Wilms' tumor growth in a xenograft mo ... Full text Link to item Cite

Increased microvascular density predicts relapse in Wilms' tumor.

Journal Article J Pediatr Surg · March 2003 BACKGROUND/PURPOSE: Tumor stage and histology are the most important prognostic criteria in Wilms' tumors; however, a subset of patients remains who have favorable histology tumors and unexpectedly relapse. The authors postulated that increased microvascul ... Full text Link to item Cite

Dax1 regulates testis cord organization during gonadal differentiation.

Journal Article Development · March 2003 Mutations of the DAX1 nuclear receptor gene cause adrenal hypoplasia congenita, an X-linked disorder characterized by adrenal insufficiency and hypogonadotropic hypogonadism. Targeted deletion of Dax1 in mice also reveals primary testicular dysgenesis, whi ... Full text Link to item Cite

Coactivator PRIP, the peroxisome proliferator-activated receptor-interacting protein, is a modulator of placental, cardiac, hepatic, and embryonic development.

Journal Article J Biol Chem · January 17, 2003 Nuclear receptor coactivator PRIP (peroxisome proliferator-activated receptor (PPAR gamma)-interacting protein) and PRIP-interacting protein with methyltransferase activity, designated PIMT, appear to serve as linkers between cAMP response element-binding ... Full text Link to item Cite

Effects of oral genistein in mice.

Journal Article Pediatr Pathol Mol Med · 2003 In cell culture systems, genistein, a soy-derived isoflavone with chemopreventive and estrogenic effects, enhances cAMP-dependent activation of the most common cystic fibrosis-causing mutation, deltaF508-CFTR, by as much as 20-fold. DeltaF508-CFTR is prese ... Full text Link to item Cite

Inflammatory Pulmonary Nodules in Kawasaki Disease

Conference Pediatric Research · January 2003 Full text Cite

SPARC is a key Schwannian-derived inhibitor controlling neuroblastoma tumor angiogenesis.

Journal Article Cancer Res · December 15, 2002 Neuroblastoma (NB), a common pediatric neoplasm, consists of two main cell populations: neuroblastic/ganglionic cells and Schwann cells. NB tumors with abundant Schwannian stroma display a more benign clinical behavior than stroma-poor tumors. Recent studi ... Link to item Cite

Fetal constrictive pericardial defect with pulmonary capillary hemangiomatosis.

Journal Article J Pediatr Surg · October 2002 Pericardial defect is a rare anomaly that has a variable presentation. Prompt recognition and early surgical intervention are associated with a favorable outcome. The authors present an unusual case of unexpected fetal demise in a 31-week-gestational-age g ... Full text Link to item Cite

Increased plasma thrombospondin-1 (TSP-1) levels are associated with the TNF alpha-308A allele in children with juvenile dermatomyositis.

Journal Article Clin Immunol · June 2002 Vascular occlusion is more frequent in children with juvenile dermatomyositis (JDM) who have the TNF alpha-308A allele. One of the potent anti-angiogenic factors is thrombospondin-1 (TSP-1). This study investigated the association of the TNF alpha-308A all ... Full text Link to item Cite

Inhibition of tumor growth by systemic treatment with thrombospondin-1 peptide mimetics.

Journal Article Int J Cancer · April 10, 2002 Many normal human cells produce thrombospondin-1 (TSP-1), a potent antiangiogenic protein that promotes vascular quiescence. In various organ systems, including the brain, breast and bladder and in fibroblasts, TSP-1 secretion is reduced during tumorigenes ... Full text Link to item Cite

Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors.

Journal Article J Biol Chem · February 1, 2002 Peroxisome proliferator activator receptor (PPAR)-binding protein (PBP) is an important coactivator for PPARgamma and other nuclear receptors. It has been identified as an integral component of a multiprotein thyroid hormone receptor-associated protein/vit ... Full text Link to item Cite

Serum vascular endothelial growth factor as a surveillance marker for cellular rejection in pediatric cardiac transplantation.

Journal Article Transplantation · January 15, 2002 BACKGROUND: Early detection and treatment of acute rejection in cardiac transplant recipients significantly improves long-term survival. Endomyocardial biopsy is used routinely for diagnosing allograft rejection; however, in young children, this procedure ... Full text Link to item Cite

Inflammatory pulmonary nodules in Kawasaki disease

Conference PEDIATRIC RESEARCH · 2002 Cite

Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity.

Journal Article J Cell Sci · December 2001 Neuroblastoma is notable for its cellular heterogeneity and unpredictable outcome. Tumors are a variable mixture of primitive malignant neuroblasts, more differentiated ganglionic cells, Schwann and endothelial cells. Although often fatal, neuroblastomas c ... Full text Link to item Cite

Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostate.

Journal Article Prostate · December 1, 2001 BACKGROUND: Prostate cells secrete many molecules capable of regulating angiogenesis; however, which of these actually function as essential regulators of neovascularization is not yet clear. METHODS: Functional angiogenic mediators secreted by normal and ... Full text Link to item Cite

CD8 T lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease.

Journal Article J Infect Dis · October 1, 2001 The pathogenesis of coronary arterial inflammation in acute Kawasaki disease (KD) is unclear. To test the hypothesis that the KD vascular lesion is an activated T lymphocyte-dependent process, immunohistochemical studies were done on coronary artery aneury ... Full text Link to item Cite

Healing of a free tracheal autograft is enhanced by topical vascular endothelial growth factor in an experimental rabbit model.

Journal Article J Thorac Cardiovasc Surg · September 2001 OBJECTIVE: In 1996, we introduced the free tracheal autograft technique for repair of congenital tracheal stenosis from complete tracheal rings in infants and children. Sources of possible concern with this procedure include the potential for autograft isc ... Full text Link to item Cite

Nonadherence is associated with late rejection in pediatric heart transplant recipients.

Journal Article J Pediatr · July 2001 OBJECTIVES: The objective was to study the impact of nonadherence on late rejection after pediatric heart transplantation. STUDY DESIGN: This was a retrospective cohort study of cardiac transplant recipients surviving >6 months (n = 50). Patients were stra ... Full text Link to item Cite

Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor.

Journal Article Proc Natl Acad Sci U S A · February 27, 2001 Aberrant blood vessel growth in the retina that underlies the pathology of proliferative diabetic retinopathy and retinopathy of prematurity is the result of the ischemia-driven disruption of the normally antiangiogenic environment of the retina. In this s ... Full text Link to item Cite

Apoptosis occurs in isolated and banked primary mouse hepatocytes.

Journal Article Cell Transplant · 2001 Isolation and cryopreservation of freshly isolated hepatocytes is considered a standard procedure for the long-term storage of liver cells. However, most existing methods for banking hepatocytes do not allow sufficient recovery of viable cells to meet the ... Link to item Cite

Apoptosis Occurs in Isolated and Banked Primary Mouse Hepatocytes.

Journal Article Cell Transplant · January 2001 Isolation and cryopreservation of freshly isolated hepatocytes is considered a standard procedure for the long-term storage of liver cells. However, most existing methods for banking hepatocytes do not allow sufficient recovery of viable cells to meet the ... Full text Link to item Cite

IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney, and coronary artery in acute Kawasaki disease.

Journal Article J Infect Dis · October 2000 The etiology and pathogenesis of Kawasaki disease (KD) remain unknown. As previously reported, in US patients with acute KD, IgA plasma cells (PCs) infiltrate the vascular wall. To determine whether IgA PCs are increased at mucosal sites in KD and to deter ... Full text Link to item Cite

Angiogenesis in neuroblastoma.

Journal Article J Clin Oncol · July 2000 Full text Link to item Cite

Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system.

Journal Article Nat Genet · June 2000 Mouse embryos deficient in Gata3 die by 11 days post coitum (d.p.c.) from pathology of undetermined origin. We recently showed that Gata3-directed lacZ expression of a 625-kb Gata3 YAC transgene in mice mimics endogenous Gata3 expression, except in thymus ... Full text Link to item Cite

Serum vascular endothelial growth factor is elevated in cystic fibrosis and decreases with treatment of acute pulmonary exacerbation.

Journal Article Am J Respir Crit Care Med · June 2000 Chronic bacterial infection and neutrophilic inflammation characterize cystic fibrosis (CF) pulmonary disease. In many disorders, inflammation and angiogenesis are codependent phenomena. We previously noted excessive angiogenesis in CF tissues and elevated ... Full text Link to item Cite

Dexamethasone reduces the inflammatory response to cardiopulmonary bypass in children.

Journal Article Ann Thorac Surg · May 2000 BACKGROUND: A randomized, prospective, double-blind study of 29 children was performed to evaluate the hypothesis that dexamethasone administration prior to cardiopulmonary bypass would decrease the inflammatory mediator release and improve the postoperati ... Full text Link to item Cite

Reversal of severe late left ventricular failure after pediatric heart transplantation and possible role of plasmapheresis.

Journal Article Am J Cardiol · March 15, 2000 Late acute cardiac graft failure carries a high mortality in adults. Vascular mediators and factors other than classic T-cell-mediated rejection may play a role in this process, and aggressive multimodality therapy may improve survival. We report experienc ... Full text Link to item Cite

Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.

Journal Article Nat Med · January 2000 Thrombospondin-1 (TSP-1) is a naturally occurring inhibitor of angiogenesis that limits vessel density in normal tissues and curtails tumor growth. Here, we show that the inhibition of angiogenesis in vitro and in vivo and the induction of apoptosis by thr ... Full text Link to item Cite

A six-month-old boy with neonatal lupus and cardiac enlargement.

Journal Article Ann Allergy Asthma Immunol · October 1999 Full text Link to item Cite

Pigment epithelium-derived factor: a potent inhibitor of angiogenesis.

Journal Article Science · July 9, 1999 In the absence of disease, the vasculature of the mammalian eye is quiescent, in part because of the action of angiogenic inhibitors that prevent vessels from invading the cornea and vitreous. Here, an inhibitor responsible for the avascularity of these oc ... Full text Link to item Cite

Dobutamine stress echocardiography: experience in pediatric heart transplant recipients.

Journal Article J Heart Lung Transplant · July 1999 BACKGROUND: Transplant coronary arteriopathy causes late death and is difficult to detect noninvasively. Dobutamine stress echocardiography is being used for risk stratification in adult recipients at some transplant centers, thus we investigated its role ... Full text Link to item Cite

Captopril and platelet-activating factor (PAF) antagonist prevent cardiac allograft vasculopathy in rats: role of endogenous PAF and PAF-like compounds.

Journal Article J Heart Lung Transplant · May 1999 Accelerated coronary artery disease (CAD) is the leading cause of late mortality following cardiac transplantation. The vascular lesions are characterized by myointimal proliferation and perivascular mononuclear inflammatory infiltrates. Platelet-activatin ... Full text Link to item Cite

Plasma clearance and liver uptake of chylomicron remnants generated by hepatic lipase lipolysis: evidence for a lactoferrin-sensitive and apolipoprotein E-independent pathway.

Journal Article J Lipid Res · May 1999 Chylomicrons labeled with [3H]cholesterol and [14C]triglyceride fatty acids were lipolyzed by hepatic lipase (HL) in vitro and then injected intravenously into normal mice fed low- or high-fat diets, and into apolipoprotein (apo) E-deficient mice. In norma ... Link to item Cite

Long-term outcome of patients with intraspinal neuroblastoma.

Journal Article Med Pediatr Oncol · May 1999 BACKGROUND: Chemotherapy, radiotherapy, and surgical decompression with laminectomy are effective therapeutic options in the treatment of cord compression from neuroblastoma (NB). We report the long-term outcome of patients with intraspinal NB treated with ... Full text Link to item Cite

Increased expression of transforming growth factor-beta1 and thrombospondin-1 in congenital hepatic fibrosis: possible role of the hepatic stellate cell.

Journal Article J Pediatr Gastroenterol Nutr · April 1999 BACKGROUND: Congenital hepatic fibrosis is a rare disease characterized by portal tract fibrosis and biliary duct ectasia. It is associated with autosomal recessive polycystic kidney disease and rarely progresses to cirrhosis. The activated stellate cell h ... Full text Link to item Cite

Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats.

Journal Article Am J Physiol · January 1999 To determine whether altered transport of glucose into the hepatocyte may be an important factor contributing to abnormal hepatic glucose metabolism in the intrauterine growth-retarded (IUGR) fetus and newborn, we measured glucose transport (glucose uptake ... Full text Link to item Cite

High angiogenic activity in cells isolated from cystic hygroma: role of bFGF.

Journal Article Arch Otolaryngol Head Neck Surg · January 1999 BACKGROUND: Cystic hygromas are characterized by a proliferation of small vessels and lymphatics with intervening fibrous tissue. Studies have shown malignant tumors and some benign neoplasms are dependent on angiogenesis, the induction of new capillaries ... Full text Link to item Cite

Rapid growth of cutaneous metastases after surgical resection of thrombospondin-secreting small blue round cell tumor of childhood.

Journal Article Hum Pathol · October 1998 In animal models, the importance of tumor-derived antiangiogenic factors in controlling metastases has been demonstrated by the growth acceleration of distant metastases after surgical excision of a primary tumor mass. We report the case of an infant who d ... Full text Link to item Cite

Interaction of platelet-activating factor, spleen and atrial natriuretic peptide in plasma volume regulation during endotoxaemia in rats.

Journal Article J Physiol · October 1, 1998 1. We studied endotoxin (lipopolysaccharide, LPS)-induced platelet-activating factor (PAF) production in various visceral organs, and the effect of PAF antagonists or splenectomy on LPS-induced changes. 2. PAF production in response to LPS was highest in t ... Full text Link to item Cite

Thrombospondin-1 is a major activator of TGF-beta1 in vivo.

Journal Article Cell · June 26, 1998 The activity of TGF-beta1 is regulated primarily extracellularly where the secreted latent form must be modified to expose the active molecule. Here we show that thrombospondin-1 is responsible for a significant proportion of the activation of TGF-beta1 in ... Full text Link to item Cite

Primary aortic intimal sarcoma of the endothelial cell type with long-term survival.

Journal Article J Vasc Surg · March 1998 Primary tumors of the aorta are rare and are difficult to diagnose preoperatively. These tumors are malignant and ultimately fatal. A patient had initial evidence of aortoiliac obstructive disease. Aortic endarterectomy produced an excellent postoperative ... Full text Link to item Cite

Myocardial acoustics in pediatric allograft rejection.

Journal Article J Heart Lung Transplant · June 1996 BACKGROUND: Ultrasonographic tissue characterization is the assessment of physical properties of biologic tissue on the basis of quantitative analysis of its acoustic characteristics. Abnormalities in microscopic structure that occur with cardiac allograft ... Link to item Cite

Endotoxin induces PAF production in the rat ileum: quantitation of tissue PAF by an improved method.

Journal Article Prostaglandins · April 1996 PAF (platelet-activating factor) is an endogenous mediator of endotoxin (LPS) shock and intestinal injury. In the present study we used an improved method to quantitate intestinal PAF after LPS injection. Both column and thin layer chromatography (TLC) wer ... Full text Link to item Cite

Tumor angiogenesis correlates with metastatic disease, N-myc amplification, and poor outcome in human neuroblastoma.

Journal Article J Clin Oncol · February 1996 PURPOSE: To determine if the clinical outcome of children with neuroblastoma (NB) is correlated with the degree of tumor neovascularization and to assess the relationship of stage, N-myc copy number, and histology to angiogenesis. MATERIALS AND METHODS: Th ... Full text Link to item Cite

Testing of an intrathoracic artificial lung in a pig model.

Journal Article ASAIO J · 1996 A low input impedance, intrathoracic artificial lung is being developed for use in acute respiratory failure or as a bridge to transplantation. The device uses microporous, hollow fibers in a 0.74 void fraction, 1.83 m2 surface area bundle. The bundle is p ... Full text Link to item Cite

Amylaceous (polyglucosan) bodies in familial cerebral atrophy of early onset.

Journal Article J Child Neurol · January 1996 An 8-year-old girl and her 4-year-old sister presented with psychomotor retardation during the 1st year of life. This was followed by spasticity, seizures, and in the older patient, progressive loss of faculties and death. Computed tomographic and magnetic ... Full text Link to item Cite

Digitate intravascular appendages and aneurysm of the vein of Galen.

Journal Article Acta Neuropathol · 1996 Peculiar intravascular appendages were found in a case of aneurysm of the vein of Galen. Such appendages consisted of finger-like polypoid growths which protruded within the lumen of ectatic cerebral veins and arteries. They were solid, relatively large, a ... Full text Link to item Cite

Diltiazem preserves direct vasodilator response but fails to suppress intimal proliferation in rat allograft coronary artery disease.

Journal Article J Heart Lung Transplant · January 1996 BACKGROUND: We investigated the effect of diltiazem on transplant coronary artery disease in rat cardiac allografts both with standard histologic techniques and by measuring coronary vascular resistance and vasodilator response of the coronary arteries. ME ... Link to item Cite

Persistent respiratory failure due to low cervical cord infarction in newborn babies.

Journal Article J Child Neurol · May 1995 Perinatal infarction of the spinal cord is described in two premature babies who survived for several months. In both cases, there was bilateral, multisegmental infarction at the lower cervicothoracic arterial zone (inferior cervical sector), predominantly ... Full text Link to item Cite

Carcinoma of the tongue in a long-term survivor of clear cell sarcoma of the kidney.

Journal Article Pediatr Pathol Lab Med · 1995 Squamous cell carcinoma (SCC) of the tongue in persons younger than 30 years of age is an extremely rare neoplasm. We report an unusual case of SCC of the tongue as a second malignancy in a young adult with a history of a stage III clear cell sarcoma of th ... Full text Link to item Cite

Influence of gender on allograft rejection in a rat heart transplant model.

Journal Article J Heart Lung Transplant · 1995 BACKGROUND: Clinical studies have reported increased rejection in female heart transplant recipients. Conflicting data exist as to whether rejection is increased with male donors or female donors in these female recipients. METHODS: We investigated in this ... Link to item Cite

Platelet-activating factor and endotoxin induce tumour necrosis factor gene expression in rat intestine and liver.

Journal Article Immunology · September 1994 We have shown previously that endotoxin, tumour necrosis factor (TNF) and platelet-activating factor (PAF) are important in the pathogenesis of bowel injury, and that endotoxin and TNF induce PAF formation in bowel tissue. In the present study we investiga ... Link to item Cite

Role of endomyocardial biopsy in rejection surveillance after heart transplantation in neonates and children.

Journal Article J Am Coll Cardiol · March 1, 1994 OBJECTIVES: The aim of this study was to retrospectively evaluate the sensitivity of noninvasive surveillance (physical examination, echocardiography) of rejection in accurately predicting histologically documented rejection episodes. Additionally, the use ... Full text Link to item Cite

Captopril reduces graft coronary artery disease in a rat heterotopic transplant model.

Conference Circulation · November 1993 BACKGROUND: Transplant coronary artery disease (CAD) is characterized by severe myointimal proliferation causing vascular stenosis. Nontransplant vascular injury models have shown that angiotensin converting enzyme (ACE) inhibitors reduce myointimal prolif ... Link to item Cite

Failure of the Hemashield extension in right ventricle-to-pulmonary artery conduits.

Journal Article Ann Thorac Surg · August 1993 Between 1989 and 1991, 17 children underwent 18 right ventricle-to-pulmonary artery conduit placement operations using a composite of an aortic or pulmonary valved homograft and a Hemashield extension to the ventricle. Hemashield is a collagen-coated knitt ... Full text Link to item Cite

Spectrum of humoral rejection after pediatric heart transplantation.

Journal Article J Heart Lung Transplant · 1993 The deposition of immunoglobulin and complement 3 in the coronary microvasculature (humoral rejection) has been associated with poor outcome after heart transplantation. The purpose of this study is to relate the incidence of immunoglobulin and complement ... Link to item Cite

Juvenile fibromatosis: hormonal receptors.

Journal Article Int J Pediatr Otorhinolaryngol · January 1993 Aggressive juvenile fibromatosis, though allegedly a benign process, is as frustrating to manage as it is perplexing to comprehend. The treatment is primarily surgical, with chemotherapy and radiation therapy recently finding support as adjuncts in selecte ... Full text Link to item Cite

Evidence for molecular heterogeneity in human ganglioneuroblastoma.

Journal Article Pediatr Pathol · 1993 Ganglioneuroblastomas are tumors of sympathetic cell origin that contain both primitive neuroblastomatous and mature ganglioneuromatous elements. It is thought that these tumors arise from a single cellular clone and that the morphologically distinct compo ... Full text Link to item Cite

Pharmacologic reduction of pretransplantation pulmonary vascular resistance predicts outcome after pediatric heart transplantation.

Journal Article J Heart Lung Transplant · 1993 Pulmonary hypertension leading to donor right ventricular dysfunction remains a major risk factor associated with poor outcome after heart transplantation. This study evaluated a pretransplantation protocol to assess pulmonary vascular resistance index and ... Link to item Cite

A new rat infection-heart transplant model: effect of infection on graft survival studies.

Journal Article J Heart Lung Transplant · 1993 Considerable progress has been made in survival rates of heart transplant recipients; however, infections continue to be a major cause of death after transplantation. Although infection itself appears to cause immunologic suppression in some nontransplanta ... Link to item Cite

Computer-aided treatment design of a distal upper extremity soft tissue tumor with electron beam radiotherapy.

Journal Article Med Dosim · 1993 We present here a novel approach for the planning and treatment of a distal upper extremity soft tissue tumor. Utilizing computed tomography (CT) based electron dose calculations, a customized compensating wax bolus was designed in order to deliver suffici ... Full text Link to item Cite

Heart transplantation in neonates and in children.

Conference J Heart Lung Transplant · 1992 Between May 1988 and July 1991, 28 neonates and children underwent orthotopic heart transplantation at Children's Memorial Hospital in Chicago. Indications for heart transplantation were hypoplastic left heart syndrome (10), dilated cardiomyopathy (13), ao ... Link to item Cite

Scleritis and Wegener's granulomatosis in children.

Journal Article Am J Ophthalmol · April 15, 1991 We treated two children with scleritis (one unilateral, one bilateral), in whom Wegener's granulomatosis was diagnosed on the basis of pathologic changes in respiratory tract mucosa. Both patients were girls, 13 and 14 years of age, respectively. One patie ... Full text Link to item Cite

Congenital, infiltrating giant-cell angioblastoma. A new entity?

Journal Article Am J Surg Pathol · February 1991 This report describes histopathologic, immunohistologic, and ultrastructural features of a locally aggressive soft-tissue tumor present since birth in an upper extremity of an infant. Because of extensive infiltration of local structures, the lesion had to ... Full text Link to item Cite

Intraabdominal desmoplastic small-cell tumors with divergent differentiation. Observations on three cases of childhood.

Journal Article Am J Surg Pathol · July 1990 We studied three intraabdominal tumors that manifested in childhood and were attached to peritoneum, and in which the histologic pattern suggested metastatic tumor of epithelial nature but gave no evidence of a primary neoplasm in the major abdominal organ ... Full text Link to item Cite