Terence Z. Wong

Journal Article J Geriatr Oncol · April 2023 INTRODUCTION: Pancreatic cancer is the fourth leading cause of cancer-related death in the US with an increasing incidence in older adults (OA) over age 70. There are currently no treatment guidelines for OA with metastatic pancreatic cancer (mPCA) and sel ... Full text Link to item Cite

Microwave hyperthermia for benign prostatic hyperplasia and adenocarcinoma of the prostate

Chapter · January 1, 2023 Prostatic disease, malignant or benign, is relatively common in men over 50 years of age. The anatomical location of the prostate permits various approaches to be used for treating localized prostatic disease with hyperthermia. Intracavitary approaches to ... Full text Cite

Increased tryptophan, but not increased glucose metabolism, predict resistance of pembrolizumab in stage III/IV melanoma.

Journal Article Oncoimmunology · 2023 Clinical trials of combined IDO/PD1 blockade in metastatic melanoma (MM) failed to show additional clinical benefit compared to PD1-alone inhibition. We reasoned that a tryptophan-metabolizing pathway other than the kynurenine one is essential. We immunohi ... Full text Open Access Link to item Cite

Novel use of alternate (Alt) response (Rp) criteria (Cr) for early prediction of outcomes in pancreatic (P) neuroendocrine tumors (NETs): Utilizing banked imaging data from the ECOG-ACRIN E2211 study

Conference JOURNAL OF CLINICAL ONCOLOGY · 2023 Cite

Phase III study of local or systemic therapy intensification directed by PET in prostate cancer patients with post-prostatectomy biochemical recurrence (INDICATE): ECOG-ACRIN EA8191

Conference JOURNAL OF CLINICAL ONCOLOGY · 2023 Cite

Phase III study of local or systemic therapy intensification directed by PET in prostate cancer patients with post-prostatectomy biochemical recurrence (INDICATE): ECOG-ACRIN EA8191.

Conference JOURNAL OF CLINICAL ONCOLOGY · 2023 Cite

IV Contrast Material for PET/CT: Point-Putting the CT Into PET/CT.

Journal Article AJR Am J Roentgenol · December 2022 Full text Link to item Cite

Randomized phase II study of platinum and etoposide (EP) versus temozolomide and capecitabine (CAPTEM) in patients (pts) with advanced G3 non-small cell gastroenteropancreatic neuroendocrine neoplasms (GEPNENs): ECOG-ACRIN EA2142.

Conference JOURNAL OF CLINICAL ONCOLOGY · 2022 Cite

A phase II study of biomarker-driven early discontinuation of anti-PD-1 therapy in patients with advanced melanoma (PET-Stop): ECOG-ACRIN EA6192.

Conference JOURNAL OF CLINICAL ONCOLOGY · 2022 Cite

A randomized phase II study of gemcitabine and nab-paclitaxel compared with 5-fluorouracil, leucovorin, and liposomal irinotecan in older patients with treatmentnaive metastatic pancreatic cancer (GIANT): ECOG-ACRIN EA2186-Trials in progress

Conference JOURNAL OF CLINICAL ONCOLOGY · 2022 Cite

A randomized study of temozolomide or temozolomide and capecitabine in patients with advanced pancreatic neuroendocrine tumors: Final analysis of efficacy and evaluation of MGMT as a predictive biomarker (ECOG-ACRIN E2211).

Conference JOURNAL OF CLINICAL ONCOLOGY · 2022 Cite

Tumor protein p53 mutation in archived tumor samples from a 12-year survivor of stage 4 pancreatic ductal adenocarcinoma may predict long-term survival with DeltaRex-G: A case report and literature review.

Journal Article Mol Clin Oncol · September 2021 DeltaRex-G is a replication-incompetent amphotropic murine leukemia virus-based retroviral vector that displays a collagen-matrix-targeting decapeptide on its surface envelope protein, gp70, and encodes a cytocidal 'dominant negative', i.e. a truncated con ... Full text Open Access Link to item Cite

18F-FDG-PET/CT Imaging for Gastrointestinal Malignancies.

Journal Article Radiol Clin North Am · September 2021 Gastrointestinal malignancies encompass a variety of primary tumor sites, each with different staging criteria and treatment approaches. In this review we discuss technical aspects of 18F-FDG-PET/CT scanning to optimize information from both the PET and co ... Full text Open Access Link to item Cite

Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · July 28, 2021 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Neuroendocrine and Adrenal Gland Tumors focus on the diagnosis, treatment, and management of patients with neuroendocrine tumors (NETs), adrenal tumors, pheochromocytomas, paragangliom ... Full text Link to item Cite

Evaluating Alzheimer Disease With Flortaucipir and Florbetapir PET: A Clinical Case Series.

Journal Article Clin Nucl Med · July 1, 2021 Early, accurate diagnosis of Alzheimer disease (AD) is essential but remains challenging. Neuropathological hallmarks of AD are β-amyloid neuritic plaques and tau protein neurofibrillary tangles. 18F-Florbetapir is one of several available PET tracers for ... Full text Open Access Link to item Cite

Complete Evaluation of Dementia: PET and MRI Correlation and Diagnosis for the Neuroradiologist.

Journal Article AJNR Am J Neuroradiol · June 2021 This article will familiarize neuroradiologists with the pathophysiology, clinical findings, and standard MR imaging and PET imaging features of multiple forms of dementia as well as new emerging techniques. Cases were compiled from multiple institutions w ... Full text Open Access Link to item Cite

Phase III study of local or systemic therapy INtensification DIrected by PET in prostate CAncer patients with post-prostaTEctomy biochemical recurrence (INDICATE): ECOG-ACRIN EA8191.

Conference Journal of Clinical Oncology · May 20, 2021 TPS5098 Background: Radiation therapy (RT) to the prostate bed and pelvic nodes with short-term androgen deprivation therapy (STAD) is considered a standard of care (SOC) salvage therapy (ST) paradigm for prostate cancer (PC) pat ... Full text Cite

A phase II/III study of perioperative nivolumab and ipilimumab in patients (pts) with locoregional esophageal (E) and gastroesophageal junction (GEJ) adenocarcinoma: Results of a safety run-in—A trial of the ECOG-ACRIN Cancer Research Group (EA2174).

Conference Journal of Clinical Oncology · May 20, 2021 4064 Background: E/GEJ adenocarcinoma has a high mortality rate despite curative intent therapy. The use of immune checkpoint inhibition is beneficial for treatment of this cancer in the metastatic and adjuvant settings but the r ... Full text Cite

PET-directed local or systemic therapy intensification in prostate cancer patients with post-prostatectomy biochemical recurrence: A trial of the ECOG-ACRIN Cancer Research Group (EA8191).

Conference Journal of Clinical Oncology · February 20, 2021 TPS267 Background: Radiation therapy (RT) to the prostate bed and pelvic nodes with short-term androgen deprivation therapy (STAD) is considered a standard of care (SOC) salvage therapy (ST) paradigm for prostate cancer (PC) pati ... Full text Cite

Implementation of a Hepatic Artery Infusion Program: Initial Patient Selection and Perioperative Outcomes of Concurrent Hepatic Artery Infusion and Systemic Chemotherapy for Colorectal Liver Metastases.

Journal Article Ann Surg Oncol · December 2020 BACKGROUND: Hepatic artery infusion (HAI) combined with systemic chemotherapy is a treatment strategy for patients with unresectable liver-only or liver-dominant colorectal liver metastases (CRLM). Although HAI has previously been performed in only a few c ... Full text Link to item Cite

Early 18F-FDG-PET Response During Radiation Therapy for HPV-Related Oropharyngeal Cancer May Predict Disease Recurrence.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2020 PURPOSE: Early indication of treatment outcome may guide therapeutic de-escalation strategies in patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC). This study investigated the relationships between tumor volume and 18F-fluorodeoxy ... Full text Open Access Link to item Cite

Pilot Study of [18F] Fluorodeoxyglucose Positron Emission Tomography (FDG-PET)/Magnetic Resonance Imaging (MRI) for Staging of Muscle-invasive Bladder Cancer (MIBC).

Journal Article Clin Genitourin Cancer · October 2020 INTRODUCTION: Computed tomography (CT) has limited diagnostic accuracy for staging of muscle-invasive bladder cancer (MIBC). [18F] Fluorodeoxyglucose positron emission tomography (FDG-PET)/magnetic resonance imaging (MRI) is a novel imaging modality incorp ... Full text Open Access Link to item Cite

Long-Term Outcomes of 125 Patients With Metastatic Pheochromocytoma or Paraganglioma Treated With 131-I MIBG.

Conference J Clin Endocrinol Metab · March 1, 2020 CONTEXT: Prognosis of metastatic pheochromocytoma/paraganglioma following 131-Iodine metaiodobenzylguanidine (MIBG) is incompletely characterized due to small samples and shorter follow-up in these rare, often indolent tumors. OBJECTIVE: To describe long-t ... Full text Link to item Cite

A phase II/III study of perioperative nivolumab and ipilimumab in patients (pts) with locoregional esophageal (E) and gastroesophageal junction (GEJ) adenocarcinoma: A trial of the ECOG-ACRIN Cancer Research Group (EA2174).

Conference JOURNAL OF CLINICAL ONCOLOGY · 2020 Cite

Quality Improvement Initiatives to Assess and Improve PET/CT Injection Infiltration Rates at Multiple Centers.

Journal Article J Nucl Med Technol · December 2019 PET/CT radiotracer infiltration is not uncommon and is often outside the imaging field of view. Infiltration can negatively affect image quality, image quantification, and patient management. Until recently, there has not been a simple way to routinely pra ... Full text Link to item Cite

Changes on Midchemoradiation Therapy Fluorodeoxyglucose Positron Emission Tomography for Cervical Cancer Are Associated with Prognosis.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2019 PURPOSE: To assess whether radiographic and metabolic changes on midchemoradiation therapy (CRT) fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) for cervical cancer predict outcome. METHODS AND MATERIALS: Women with Int ... Full text Link to item Cite

Molecular Imaging and Therapy for Neuroendocrine Tumors.

Journal Article Curr Treat Options Oncol · August 29, 2019 Neuroendocrine tumors (NETs) are relatively rare, with 12,000-15,000 new cases diagnosed annually in the USA. Although NETs are a diverse group of neoplasms, they share common molecular targets that can be exploited using nuclear medicine techniques for bo ... Full text Link to item Cite

Visual and semiquantitative analysis of 82Rb uptake in malignant tumors on PET/CT: first systematic analysis.

Journal Article Nucl Med Commun · May 2019 OBJECTIVE: The objective of this study was to analyze the uptake of rubidium in malignant tumors. PARTICIPANTS AND METHODS: Sixteen malignant lesions were included. Two radiologists compared each lesion to four references (subcutaneous fat, lung, mediastin ... Full text Link to item Cite

Financial Management Skills in Aging, MCI and Dementia: Cross Sectional Relationship to 18F-Florbetapir PET Cortical β-amyloid Deposition.

Journal Article J Prev Alzheimers Dis · 2019 BACKGROUND: There is a need to more fully characterize financial capacity losses in the preclinical and prodromal stages of Alzheimer's disease (AD) and their pathological substrates. OBJECTIVES: To test the association between financial skills and cortica ... Full text Link to item Cite

How Good Is Positron Emission Tomography at Detecting Previously-Occult Metastatic Lung Cancer at Diagnosis?

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2018 Full text Link to item Cite

Predictors of Survival in 211 Patients with Stage IV Pulmonary and Gastroenteropancreatic MIBG-Positive Neuroendocrine Tumors Treated with 131I-MIBG.

Journal Article J Nucl Med · November 2018 This retrospective analysis identifies predictors of survival in a cohort of patients with meta-iodobenzylguanidine (MIBG)-positive stage IV pulmonary and gastroenteropancreatic neuroendocrine tumor (P/GEP-NET) treated with 131I-MIBG therapy, to inform tre ... Full text Open Access Link to item Cite

NCCN Guidelines Insights: Neuroendocrine and Adrenal Tumors, Version 2.2018.

Journal Article J Natl Compr Canc Netw · June 2018 The NCCN Guidelines for Neuroendocrine and Adrenal Tumors provide recommendations for the management of adult patients with neuroendocrine tumors (NETs), adrenal gland tumors, pheochromocytomas, and paragangliomas. Management of NETs relies heavily on the ... Full text Link to item Cite

Pitfalls of post-treatment PET after de-intensified chemoradiotherapy for HPV-associated oropharynx cancer: Secondary analysis of a phase 2 trial.

Journal Article Oral Oncol · March 2018 OBJECTIVES: We evaluated patterns of nodal response and positive predictive value (PPV) of 3 month post-treatment PET in patients with HPV-associated oropharyngeal cancer treated on a multi-institutional de-intensification trial. MATERIALS AND METHODS: Eli ... Full text Open Access Link to item Cite

Early cardiac perfusion defects after left-sided radiation therapy for breast cancer: is there a volume response?

Journal Article Breast Cancer Res Treat · July 2017 PURPOSE: Cardiac single-photon emission computed tomography (SPECT) is often used to identify defects in myocardial perfusion due to atherosclerotic coronary artery disease. It was also used in studies to evaluate radiation therapy (RT)-associated cardiac ... Full text Link to item Cite

Imaging modalities in the diagnosis of recurrent or metastatic thyroid cancer

Chapter · June 24, 2017 Full text Cite

Integration of PET/MR Hybrid Imaging into Radiation Therapy Treatment.

Journal Article Magn Reson Imaging Clin N Am · May 2017 Hybrid PET/MR imaging is in early development for treatment planning. This article briefly reviews research and clinical applications of PET/MR imaging in radiation oncology. With improvements in workflow, more specific tracers, and fast and robust acquisi ... Full text Link to item Cite

Hybrid PET/MR: State-of-the-Art and Future Challenges.

Journal Article Magn Reson Imaging Clin N Am · May 2017 Full text Link to item Cite

Utility of Deep Inspiration Breath Hold for Left-Sided Breast Radiation Therapy in Preventing Early Cardiac Perfusion Defects: A Prospective Study.

Conference Int J Radiat Oncol Biol Phys · April 1, 2017 PURPOSE: To evaluate early cardiac single photon computed tomography (SPECT) findings after left breast/chest wall postoperative radiation therapy (RT) in the setting of deep inspiration breath hold (DIBH). METHODS AND MATERIALS: We performed a prospective ... Full text Link to item Cite

Patient and tumor characteristics predictive of an elevated hepatopulmonary shunt fraction before radioembolization of hepatic tumors.

Journal Article Nucl Med Commun · September 2016 OBJECTIVE: To determine whether any patient or hepatic tumor characteristics are predictive of hepatopulmonary shunt fraction when performed before radioembolization. MATERIALS AND METHODS: A retrospective review was performed on 190 patients who underwent ... Full text Link to item Cite

ACR-ASNR Practice Parameter for Brain PET/CT Imaging Dementia.

Journal Article Clin Nucl Med · February 2016 This practice parameter is for both FDG and amyloid brain PET or PET/computed tomography (CT) for patients with cognitive decline, and has been developed collaboratively by the American College of Radiology (ACR) and the American Society for Neuroradiology ... Full text Link to item Cite

Are Long-term Cardiac Outcomes Predicted by Short-term Postradiation Cardiac Perfusion Deficits: An 8–15 Year Follow-up of a Prospective Study

Conference International Journal of Radiation Oncology*Biology*Physics · November 2015 Full text Cite

MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations.

Journal Article Abdom Imaging · August 2015 PURPOSE: The purpose of the study was to evaluate the feasibility and protocol optimization of whole-body hybrid MR-PET system performed 1-month after post-locoregional thermoablative procedures for hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: ... Full text Link to item Cite

MR-PET co-registration in upper abdominal imaging: quantitative comparison of two different T1-weighted gradient echo sequences: initial observations.

Journal Article Abdom Imaging · August 2015 PURPOSE: The purpose of this study is to quantitatively compare the accuracy of spatial registration of Cartesian breath-hold 3D-GRE and non-respiratory-triggered free-breathing radial 3D-GRE images with PET data acquisition on whole-body hybrid MR-PET sys ... Full text Link to item Cite

Impact of delayed lymphoscintigraphy for sentinel lymphnode biopsy for breast cancer.

Journal Article J Surg Oncol · June 2015 BACKGROUND: Despite universal adoption of sentinel lymph node biopsy (SLNB) for breast cancer, there remains no standardized protocol for preoperative lymphoscintographic assessment of sentinel nodes. Both immediate and delayed lymphoscintigraphy are curre ... Full text Link to item Cite

Nuclear Medicine

Chapter · January 1, 2015 Full text Cite

Florbetapir F 18 amyloid PET and 36-month cognitive decline: a prospective multicenter study.

Journal Article Mol Psychiatry · September 2014 This study was designed to evaluate whether subjects with amyloid beta (Aβ) pathology, detected using florbetapir positron emission tomorgraphy (PET), demonstrated greater cognitive decline than subjects without Aβ pathology. Sixty-nine cognitively normal ... Full text Link to item Cite

Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making.

Journal Article Neurocase · August 2014 ¹⁸F-florbetapir positron emission tomography (PET) imaging of the brain is now approved by the Food and Drug Administration (FDA) approved for estimation of β -amyloid neuritic plaque density when evaluating patients with cognitive impairment. However, its ... Full text Link to item Cite

A phase 1 study of 131I-CLR1404 in patients with relapsed or refractory advanced solid tumors: dosimetry, biodistribution, pharmacokinetics, and safety.

Journal Article PLoS One · 2014 INTRODUCTION: (131)I-CLR1404 is a small molecule that combines a tumor-targeting moiety with a therapeutic radioisotope. The primary aim of this phase 1 study was to determine the administered radioactivity expected to deliver 400 mSv to the bone marrow. T ... Full text Link to item Cite

PET with 62Cu-ATSM and 62Cu-PTSM is a useful imaging tool for hypoxia and perfusion in pulmonary lesions.

Journal Article AJR Am J Roentgenol · November 2013 OBJECTIVE: Hypoxia is a characteristic of many tumors and portends a worse prognosis in lung, cervical, prostate, and rectal cancers. Unlike the others, lung cancers present a unique challenge in measuring hypoxia, with invasive biopsies and higher rates o ... Full text Link to item Cite

Cortical β-amyloid levels and neurocognitive performance after cardiac surgery.

Journal Article BMJ Open · September 20, 2013 INTRODUCTION: Neurological and neurocognitive dysfunction occurs frequently in the large number of increasingly elderly patients undergoing cardiac surgery every year. Perioperative cognitive deficits have been shown to persist after discharge and up to se ... Full text Open Access Link to item Cite

Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth.

Journal Article Neuroimage · September 2013 BACKGROUND: Although it is well known that many clinical and genetic factors have been associated with beta-amyloid deposition, few studies have examined the interactions of such factors across different stages of Alzheimer's pathogenesis. METHODS: We used ... Full text Link to item Cite

Positron emission tomography in radiation treatment planning: the potential of metabolic imaging.

Journal Article Radiol Clin North Am · September 2013 Treatment planning and delivery of radiation therapy has benefited from new technology and techniques. Given the convergence of the improved ability to image active tumor and the delivery of radiation to very specific targets, the implications for a tighte ... Full text Link to item Cite

FDG-PET/CT characterization of adrenal nodules: diagnostic accuracy and interreader agreement using quantitative and qualitative methods.

Journal Article Acad Radiol · August 2013 PURPOSE: To determine interreader agreement and diagnostic accuracy across varying levels of reader experience using qualitative and quantitative methods of evaluating adrenal nodules using ((18)F)-fluorodeoxyglucose-positron emission tomography/computed t ... Full text Link to item Cite

Does the preparation and utilization of 99mTc-sulfur colloid affect the outcomes of breast lymphoscintigraphy?

Journal Article J Nucl Med Technol · June 2013 UNLABELLED: The purpose of this study was to determine whether certain factors in the preparation and use of (99m)Tc-sulfur colloid affected the number of sentinel lymph nodes (SLNs) detected during SLN mapping and during intraoperative SLN identification. ... Full text Link to item Cite

Radium-223 chloride: a potential new treatment for castration-resistant prostate cancer patients with metastatic bone disease.

Journal Article Cancer Manag Res · 2013 BACKGROUND: Radium-223 chloride ((223)Ra; Alpharadin) is an alpha-emitting radioisotope that targets areas of osteoblastic metastasis and is excreted by the small intestine. When compared with beta-emitters (eg, strontium-89, samarium-153), (223)Ra deliver ... Full text Link to item Cite

Assessing the impact of radiation-induced changes in soft tissue density ∕ thickness on the study of radiation-induced perfusion changes in the lung and heart.

Journal Article Med Phys · December 2012 PURPOSE: Abnormalities in single photon emission computed tomography (SPECT) perfusion within the lung and heart are often detected following radiation for tumors in∕around the thorax (e.g., lung cancer or left-sided breast cancer). The presence of SPECT p ... Full text Link to item Cite

Quantification of Tc-99m sestamibi distribution in normal breast tissue using dedicated breast SPECT-CT

Journal Article Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics · August 15, 2012 The use of Tc-99m-Sestamibi in molecular breast imaging is common due to its preferential uptake in malignant tissue. However, quantification of the baseline uptake in normal, healthy breast tissue is not possible using planar-imaging devices. Using our de ... Full text Cite

A multicenter prospective evaluation of the clinical utility of F-18 FDG-PET/CT in patients with AJCC stage IIIB or IIIC extremity melanoma.

Journal Article Ann Surg · August 2012 OBJECTIVE/BACKGROUND: There is a high risk of relapse in stage IIIB/IIIC melanoma. The utility of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography integrated with computed tomography (FDG-PET/CT) in these patients to evaluate response ... Full text Link to item Cite

R. Edward Coleman, MD, 1943-2012.

Journal Article J Nucl Med · August 2012 Link to item Cite

Imaging Approaches in Oncology: Update on PET/CT

Conference ONCOLOGIST · January 1, 2012 Link to item Cite

111-In-capromab pendetide imaging using hybrid-γ camera-computer tomography technology is not reliable in detecting seminal vesicle invasion in patients with prostate cancer.

Journal Article Urol Oncol · 2012 OBJECTIVES: In this study, we evaluate the diagnostic utility of a hybrid γ-camera-computer tomography (SPECT-CT) indium-111 (111-In)-capromab pendetide scan in detecting seminal vesicle invasion (SVI) in select patients evaluated for primary surgical trea ... Full text Link to item Cite

Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT.

Journal Article J Oncol · 2012 A pilot study is underway to quantify in vivo the uptake and distribution of Tc-99m Sestamibi in subjects without previous history of breast cancer using a dedicated SPECT-CT breast imaging system. Subjects undergoing diagnostic parathyroid imaging studies ... Full text Open Access Link to item Cite

How much is a picture worth? Putting amyloid imaging to the test.

Journal Article Dement Geriatr Cogn Dis Extra · January 2012 Full text Link to item Cite

Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans.

Journal Article Neurosurgery · September 2011 BACKGROUND: Convection-enhanced delivery (CED) permits site-specific therapeutic drug delivery within interstitial spaces at increased dosages through circumvention of the blood-brain barrier. CED is currently limited by suboptimal methodologies for monito ... Full text Link to item Cite

62CUATSM AND 62CUPTSM PET IS A USEFUL IMAGING TOOL FOR HYPOXIA AND PERFUSION IN LUNG CANCER

Journal Article JOURNAL OF THORACIC ONCOLOGY · June 1, 2011 Link to item Cite

Prognostic significance of parameters derived from co-registered 18F-fluorodeoxyglucose PET and contrast-enhanced MRI in patients with high-grade glioma.

Journal Article Br J Radiol · April 2011 OBJECTIVE: The aim of this study was to determine the prognostic significance of the volume and intensity of abnormal (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) accumulation within areas of contrast enhancement on post-therapeutic volu ... Full text Link to item Cite

Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium.

Journal Article J Nucl Med · February 2011 UNLABELLED: The purpose of this study was to assess (18)F-FDG uptake in children with a newly diagnosed diffuse intrinsic brain stem glioma (BSG) and to investigate associations with progression-free survival (PFS), overall survival (OS), and MRI indices. ... Full text Link to item Cite

Utility of FDG PET/CT in inflammatory cardiovascular disease.

Journal Article Radiographics · 2011 Inflammatory disorders of the cardiovascular system can affect the myocardium, pericardium, or vessel walls. Patients with myocardial and pericardial disease may present with chest pain, palpitations, and shortness of breath, symptoms resembling myocardial ... Full text Link to item Cite

The role of adaptive and functional imaging modalities in radiation therapy: approach and application from a radiation oncology perspective.

Journal Article Semin Ultrasound CT MR · December 2010 The field of radiation oncology relies heavily on imaging modalities. From initial consultation to treatment completion, images are used to guide nearly every step of the patient encounter. Technological advances in diagnostic radiology continue to be read ... Full text Link to item Cite

A systematic review of the factors affecting accuracy of SUV measurements.

Journal Article AJR Am J Roentgenol · August 2010 OBJECTIVE: There is growing interest in using PET/CT for evaluating early response to therapy in cancer treatment. Although widely available and convenient to use, standardized uptake value (SUV) measurements can be influenced by a variety of biologic and ... Full text Link to item Cite

Colonic schwannoma visualized on FDG PET/CT.

Journal Article Clin Nucl Med · March 2010 Full text Link to item Cite

Radiation-induced reductions in regional lung perfusion: 0.1-12 year data from a prospective clinical study.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2010 PURPOSE: To assess the time and regional dependence of radiation therapy (RT)-induced reductions in regional lung perfusion 0.1-12 years post-RT, as measured by single photon emission computed tomography (SPECT) lung perfusion. MATERIALS/METHODS: Between 1 ... Full text Link to item Cite

Regional lung density changes after radiation therapy for tumors in and around thorax.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2010 Featured Publication PURPOSE: To study the temporal nature of regional lung density changes and to assess whether the dose-dependent nature of these changes is associated with patient- and treatment-associated factors. METHODS AND MATERIALS: Between 1991 and 2004, 118 patients ... Full text Link to item Cite

Utility of functional imaging in prediction or assessment of treatment response and prognosis following thermotherapy.

Journal Article Int J Hyperthermia · 2010 The purpose of this review is to examine the roles that functional imaging may play in prediction of treatment response and determination of overall prognosis in patients who are enrolled in thermotherapy trials, either in combination with radiotherapy, ch ... Full text Link to item Cite

Utilization of (111)In-Capromab pendetide SPECT-CT for detecting seminal vesicle invasion with recurrent prostate cancer after primary in situ therapy.

Journal Article Int J Urol · December 2009 Featured Publication The aim of this study was to evaluate the diagnostic value of a hybrid (111)In-capromab pendetide fused computed tomography (CT) scan in detecting seminal vesicle invasion (SVI) in the setting of recurrent prostate cancer following primary in situ therapy. ... Full text Link to item Cite

Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas.

Journal Article Med Phys · November 2009 Featured Publication PURPOSE: To establish accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas. METHODS: Protocol patients with advanced extremity sarcomas were tr ... Full text Link to item Cite

The Impact of “Low-dose Lung Bath” on the Sensitivity of the Lung to Radiation: Are There Neighborhood Effects in the Lung?

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

The Association between Declines in Pulmonary Function Tests and the Development of Systematic Radiation Pneumonitis following Thoracic Radiation: Results from a Prospective Critical Study

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Use of 111in-capromab pendetide immunoscintigraphy to image localized prostate cancer foci within the prostate gland.

Journal Article J Urol · September 2009 PURPOSE: We compared the results of a preoperative (111)In-capromab pendetide scan co-registered with computerized tomography with pathological findings in the surgically excised prostate to determine whether the scan can efficiently detect cancer in the p ... Full text Link to item Cite

Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy.

Journal Article Clin Cancer Res · August 1, 2009 PURPOSE: This study tests whether dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters obtained from canine patients with soft tissue sarcomas, treated with hyperthermia and radiotherapy, are predictive of therapeutic outcome. EXPERIME ... Full text Link to item Cite

Association between RT-induced changes in lung tissue density and global lung function.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2009 Featured Publication PURPOSE: To assess the association between radiotherapy (RT)-induced changes in computed tomography (CT)-defined lung tissue density and pulmonary function tests (PFTs). METHODS AND MATERIALS: Patients undergoing incidental partial lung RT were prospective ... Full text Link to item Cite

Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.

Journal Article J Clin Oncol · June 20, 2009 Featured Publication PURPOSE: To assess the safety and efficacy of neoadjuvant bevacizumab with standard chemoradiotherapy in locally advanced rectal cancer and explore biomarkers for response. PATIENTS AND METHODS: In a phase I/II study, 32 patients received four cycles of th ... Full text Link to item Cite

Dose-dependent effects of radiation therapy on cerebral blood flow, metabolism, and neurocognitive dysfunction.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2009 PURPOSE: A prospective study was performed to formally relate dose-dependent radiologically defined changes in normal brain induced by radiotherapy (RT) to neurocognitive dysfunction in subjects with primary brain tumors. METHODS AND MATERIALS: Adult patie ... Full text Link to item Cite

Clinical Utility of Magnetic Resonance Thermal Imaging (MRTI) For Realtime Guidance of Deep Hyperthermia.

Journal Article Proc SPIE Int Soc Opt Eng · February 25, 2009 A critical need has emerged for volumetric thermometry to visualize 3D temperature distributions in real time during deep hyperthermia treatments used as an adjuvant to radiation or chemotherapy for cancer. For the current effort, magnetic resonance therma ... Full text Link to item Cite

Adrenal nodules at FDG PET/CT in patients known to have or suspected of having lung cancer: a proposal for an efficient diagnostic algorithm.

Journal Article Radiology · February 2009 Featured Publication PURPOSE: To develop an algorithm to maximize the diagnostic yield of positron emission tomography (PET)/computed tomography (CT) by using defined attenuation and standardized uptake value (SUV) criteria. MATERIALS AND METHODS: An IRB-approved, HIPAA-compli ... Full text Link to item Cite

WE‐C‐BRC‐02: Combined Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE‐MRI) and Magnetic Resonance Thermal Imaging (MRTI) for Optimal Hyperthermia Treatment of Advanced Extremity Sarcomas: Fifteen Patients Update

Conference Medical Physics · January 1, 2009 Purpose: To deliver optimal hyperthermia (HT) treatments for patients with advanced extremity sarcomas using DCE‐MRI and MRTI Method and Materials: Patients were treated on a protocol using radiotherapy consisting of 45 Gy and once a week HT for 5 weeks in ... Full text Cite

DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study.

Journal Article Int J Hyperthermia · 2009 Featured Publication UNLABELLED: Combined therapies represent a staple of modern medicine. For women treated with neoadjuvant chemotherapy (NA ChT) for locally advanced breast cancer (LABC), early determination of whether the patient will fail to respond can enable the use of ... Full text Link to item Cite

I-131, I-123, and F-18 FDG-PET imaging in a patient with diffuse sclerosing variant of papillary thyroid cancer.

Journal Article Clin Nucl Med · December 2008 Featured Publication PURPOSE: To compare the sensitivity of I-123 total body iodine (TBI) scan, I-131 TBI, and PET scanning with 2-deoxy-2[F-18]fluoro-D-glucose (FDG-PET) scans for detection of residual/recurrent disease in patients with diffuse sclerosing variant of papillary ... Full text Link to item Cite

Are Myocardial Perfusion Defects Noted Soon after RT for Breast Cancer Associated with “Late” Cardiac Events?

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

The Prospective Assessment of RT-Associated Changes in Myocardial Perfusion and Function in Patients Irradiated for Thoracic Malignancies

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

The Association between RT-induced Changes in Lung Tissue Density and Global Lung Function

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

Interpretation and reporting of positron emission tomography-computed tomographic scans.

Journal Article Semin Ultrasound CT MR · August 2008 Featured Publication Body oncology positron emission tomography-computed tomographic (PET-CT) exams are particularly complex and time-consuming studies to interpret and report. An integrated approach is required to provide the referring physician with the full clinical value o ... Full text Link to item Cite

Lipid-poor adenomas on unenhanced CT: does histogram analysis increase sensitivity compared with a mean attenuation threshold?

Journal Article AJR Am J Roentgenol · July 2008 Featured Publication OBJECTIVE: The purpose of our study was to evaluate the efficacy of CT histogram analysis for further characterization of lipid-poor adenomas on unenhanced CT. MATERIALS AND METHODS: One hundred thirty-two adrenal nodules were identified in 104 patients wi ... Full text Link to item Cite

Use of local (111)in-capromab pendetide scan results to predict outcome after salvage radiotherapy for prostate cancer.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2008 Featured Publication PURPOSE: The (111)In-capromab pendetide scan (ProstaScint; Cytogen Corp., Princeton NJ) is approved by the Food and Drug Administration to evaluate increasing prostate-specific antigen (PSA) levels after radical prostatectomy. This study evaluated the role ... Full text Link to item Cite

Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.

Journal Article Neuro Oncol · June 2008 Featured Publication The purpose of this study is to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and intracerebral distribution of a recombinant toxin (TP-38) targeting the epidermal growth factor receptor in patients with recurrent malignant brai ... Full text Link to item Cite

The association between RT-induced changes in lung density and global lung function.

Journal Article J Clin Oncol · May 20, 2008 13543 Background: Radiation (RT)-induced lung injury is a common side effect following thoracic RT. The study of RT-induced lung injury is complicated by the multiple endpoints considered (e.g., radiologic vs. symptomatic vs. functional). The association b ... Link to item Cite

The association between RT-induced changes in lung density and global lung function

Journal Article Journal of Clinical Oncology · May 20, 2008 Full text Cite

A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost.

Journal Article Neuro Oncol · April 2008 Featured Publication The purpose of this study was to determine the feasibility and assess the efficacy and toxicity, among newly diagnosed malignant glioma patients, of administering (131)I-labeled murine antitenascin monoclonal antibody 81C6 ((131)I-81C6) into a surgically c ... Full text Link to item Cite

PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator.

Journal Article AJR Am J Roentgenol · February 2008 Featured Publication OBJECTIVE: Copper-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) and copper-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) are being studied as potential markers of hypoxia and perfusion, respectively. The use of short-lived radionuclides (e.g ... Full text Link to item Cite

WE‐C‐AUD B‐05: Predicting Radiation‐Induced Cardiac Perfusion Defects Using a Fusion Model

Conference Medical Physics · January 1, 2008 Purpose: To predict radiation‐induced cardiac perfusion defects using a fusion model that combines the results of four separate models: feed‐forward neural networks (NNET), self‐organizing maps (SOM), support vector machines (SVM), and multivariate adaptiv ... Full text Cite

TU‐C‐332‐04: Pilot Patient Studies Using a Dedicated Dual‐Modality SPECT‐CT System for Breast Imaging

Conference Medical Physics · January 1, 2008 Purpose: Acknowledging the limitations/discomfort of mammography has inspired the development of a dedicated SPECT‐CT system to detect breast cancer, monitor therapeutic responses, and improve patient comfort. This system provides semi‐quantitative 3D func ... Full text Cite

Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6.

Journal Article J Nucl Med · January 2008 Featured Publication UNLABELLED: alpha-Particle-emitting radionuclides, such as (211)At, with a 7.2-h half-life, may be optimally suited for the molecularly targeted radiotherapy of strategically sensitive tumor sites, such as those in the central nervous system. Because of th ... Full text Link to item Cite

Quantitative effects of contrast enhanced CT attenuation correction on PET SUV measurements.

Journal Article Mol Imaging Biol · 2008 Featured Publication PURPOSE: The presence of contrast materials on computed tomography (CT) images can cause problems in the attenuation correction of positron emission tomography (PET) images. These are because of errors converting the CT attenuation of contrast to 511-keV a ... Full text Link to item Cite

The significance of a positive PET scan after chemotherapy with ABVD and prior to involved field radiation therapy in Hodgkin's lymphoma

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · January 1, 2008 Link to item Cite

PET in neurology

Chapter · December 1, 2007 Full text Cite

PET in melanoma

Chapter · December 1, 2007 Full text Cite

Initial patient study with dedicated dual-modality SPECT-CT mammotomography

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2007 Dual-modality SPECT-CT dedicated breast imaging offers great promise in the detection/staging of cancer and the monitoring of treatment therapies. The sequential acquisition with emission (nuclear) and transmission (x-ray) 3D imaging systems can aid in loc ... Full text Cite

Is the Development of Symptomatic Radiation Pneumonitis Associated With an Inherent Increased Sensitivity of Lung to Radiation-Induced Injury?

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Comparison of Normal Tissue Radiation Dose Responses for Various Regions of the Lungs

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Prospective assessment of radiotherapy-associated cardiac toxicity in breast cancer patients: analysis of data 3 to 6 years after treatment.

Journal Article Cancer · October 15, 2007 Featured Publication BACKGROUND: Radiation therapy (RT) to the left breast/chest wall has been linked with cardiac dysfunction. Previously, the authors identified cardiac perfusion defects in approximately 50% to 60% of patients 0.5 to 2 years post-RT. In the current study, th ... Full text Link to item Cite

PET/CT Protocols and Practical Issues for the Evaluation of Patients with Head and Neck Cancer.

Journal Article PET Clin · October 2007 This article presents general considerations for optimum PET/CT imaging in patients with head and neck disease. Based on these considerations, the clinical PET/CT imaging protocols currently used at the authors' center are described. ... Full text Link to item Cite

Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions.

Journal Article Neuro Oncol · July 2007 Convection-enhanced delivery (CED) is a novel drug delivery technique that uses positive infusion pressure to deliver therapeutic agents directly into the interstitial spaces of the brain. Despite the promise of CED, clinical trials have demonstrated that ... Full text Link to item Cite

Head and neck cancer: dedicated FDG PET/CT protocol for detection--phantom and initial clinical studies.

Journal Article Radiology · July 2007 Featured Publication PURPOSE: To retrospectively compare the sensitivity of a dedicated fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) protocol versus a standard whole-body PET/CT protocol for detection of head and neck cancer, ... Full text Link to item Cite

Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.

Journal Article Nat Clin Pract Oncol · May 2007 Featured Publication BACKGROUND: Localized rectal cancer responds well to 5-fluorouracil and radiation-based regimens. A phase I-II trial is currently testing the efficacy of adding bevacizumab, a VEGF-specific antibody, to standard chemoradiotherapy. The case presented here i ... Full text Link to item Cite

Updated assessment of the six-minute walk test as predictor of acute radiation-induced pneumonitis.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2007 Featured Publication PURPOSE: To assess the utility of the 6-minute walk test (6MWT) as a predictor of symptomatic radiation-induced pneumonitis (RP). METHODS: As part of a prospective trial to study radiation-induced lung injury, 53 patients receiving thoracic radiotherapy (R ... Full text Link to item Cite

Practical approach to diagnostic CT combined with PET.

Journal Article AJR Am J Roentgenol · March 2007 Featured Publication OBJECTIVE: Protocols for PET/CT are not yet standardized. In particular, image quality, utilization, and reporting of the findings of the CT component of PET/CT can vary widely, making it complicated for physicians to request the appropriate information. I ... Full text Link to item Cite

Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.

Journal Article Neurosurgery · February 2007 OBJECTIVE: Convection-enhanced delivery (CED) holds tremendous potential for drug delivery to the brain. However, little is known about the volume of distribution achieved within human brain tissue or how target anatomy and catheter positioning influence d ... Full text Link to item Cite

Neurosurgical Procedures Monitored by Intraoperative MRI

Journal Article Emagres · January 1, 2007 Full text Cite

Prospective assessment of dosimetric/physiologic-based models for predicting radiation pneumonitis.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2007 PURPOSE: Clinical and 3D dosimetric parameters are associated with symptomatic radiation pneumonitis rates in retrospective studies. Such parameters include: mean lung dose (MLD), radiation (RT) dose to perfused lung (via SPECT), and pre-RT lung function. ... Full text Link to item Cite

Impact of patient-specific factors, irradiated left ventricular volume, and treatment set-up errors on the development of myocardial perfusion defects after radiation therapy for left-sided breast cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2006 Featured Publication PURPOSE: The aim of this study was to assess the impact of patient-specific factors, left ventricle (LV) volume, and treatment set-up errors on the rate of perfusion defects 6 to 60 months post-radiation therapy (RT) in patients receiving tangential RT for ... Full text Link to item Cite

A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation.

Journal Article Clin Cancer Res · November 15, 2006 Featured Publication PURPOSE: A noninvasive method to monitor intratumoral Doxil delivery in individual patients during targeted tumor therapy is important to predict treatment response. The purpose of this study was to determine if a small tracer dose of technetium-99m (99mTc ... Full text Link to item Cite