Scholars@Duke
Tracey C. Holsinger

Tracey C. Holsinger

Professor of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology
tracey.holsinger@duke.edu
Box 3862 Med Ctr, Durham, NC 27710
4553 Stead Bldg, Durham, NC 27710

Selected Publications

In treatment-resistant major depression, ketamine was noninferior to ECT for treatment response.

Journal Article Ann Intern Med · September 2023 Anand A, Mathew SJ, Sanacora G, et al. Ketamine versus ECT for nonpsychotic treatment-resistant major depression. N Engl J Med. 2023;388:2315-2325. 37224232. ... Full text Link to item Cite

A Randomized Controlled Study of Paroxetine and Cognitive Behavioral Therapy for Late-Life Panic Disorder

Chapter · January 1, 2022 In this study the investigators evaluated the effectiveness of paroxetine and cognitive behavioral therapy (CBT) among individuals 60+ years in age with a primary diagnosis of panic disorder with or without agoraphobia. ... Full text Cite

Do Antipsychotics Lead to Cognitive Impairment in Dementia? A Meta-analysis of Randomized Placebo-Controlled Trials

Chapter · January 1, 2022 In this meta-analysis, the investigators reviewed the use of antipsychotics for treating behavioral and psychological symptoms in dementia (BPSD) and the potential side effect of decline in cognitive function from ten randomized placebo-controlled trials ( ... Full text Cite

Delirium in Elderly Patients and the Risk of Post-Discharge Mortality, Institutionalization, and Dementia: A Meta-Analysis

Chapter · January 1, 2022 In this study, the investigators reviewed the association between delirium in elderly patients and long-term poor outcomes including mortality, institutionalization, and dementia, from a meta-analysis of 42 high-quality studies. ... Full text Cite

Meta-analysis Comparing Different Behavioral Treatments for Late-Life Anxiety

Chapter · January 1, 2022 In this study, the investigators completed a meta-analysis to evaluate the efficacy of different types of behavioral treatments on geriatric anxiety. ... Full text Cite

Maintenance Treatment of Major Depression in Old Age

Chapter · January 1, 2022 In this study, the investigators evaluated the efficacy of maintenance paroxetine and monthly interpersonal psychotherapy in elderly patients with depression in a 2-by-2 randomized double-blind placebo-controlled trial. ... Full text Cite

Predictors of Progression from Mild Cognitive Impairment to Alzheimer’s Disease

Chapter · January 1, 2022 In this study, the investigators reviewed the role of neuropsychiatric symptoms in the progression of mild cognitive impairment (MCI) to Alzheimer’s disease (AD). ... Full text Cite

Stability of Diagnoses of Cognitive Impairment, Not Dementia in a Veterans Affairs Primary Care Population.

Journal Article J Am Geriatr Soc · June 2015 OBJECTIVES: To describe the stability of cognitive impairment, not dementia (CIND) in a longitudinal cohort of primary care veterans. To examine the association between baseline brief cognitive screening tests, demographic and clinical characteristics, and ... Full text Open Access Link to item Cite

Screening for cognitive impairment: comparing the performance of four instruments in primary care.

Journal Article J Am Geriatr Soc · June 2012 OBJECTIVES: To determine whether brief cognitive screening tests perform as well as a longer screening test in diagnosis of cognitive impairment, no dementia (CIND) or dementia. DESIGN: A cross-sectional comparison of cognitive screening tests to an indepe ... Full text Link to item Cite

Cognitive impairment and outcomes in older adult survivors of acute myocardial infarction: findings from the translational research investigating underlying disparities in acute myocardial infarction patients' health status registry.

Journal Article Am Heart J · November 2011 BACKGROUND: Cognitive impairment without dementia (CIND) and acute myocardial infarction (AMI) are prevalent in older adults; however, the association of CIND with outcomes after AMI is unknown. METHODS: We used a multicenter registry to study 772 patients ... Full text Link to item Cite

Acceptability of dementia screening in primary care patients.

Journal Article Int J Geriatr Psychiatry · April 2011 OBJECTIVES: To determine the acceptability of dementia screening in two populations of older adults in different primary care settings. METHODS: Cross-sectional study of consecutive patients presenting for primary care appointments in the Duke University H ... Full text Link to item Cite

Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life.

Journal Article Ann Intern Med · August 3, 2010 BACKGROUND: Many biological, behavioral, social, and environmental factors may contribute to the delay or prevention of cognitive decline. PURPOSE: To summarize evidence about putative risk and protective factors for cognitive decline in older adults and t ... Full text Link to item Cite

Screening for dementia in primary care

Journal Article Journal of Clinical Outcomes Management · September 1, 2007 Cite

Does this patient have dementia?

Journal Article JAMA · June 6, 2007 CONTEXT: While as many as 5 million individuals in the United States have dementia, many others have memory complaints. Brief tests to screen for cognitive impairment could help guide dementia diagnosis. OBJECTIVE: To review the literature concerning the p ... Full text Link to item Cite

Intelligence in early adulthood and life span up to 65 years later in male elderly twins.

Journal Article Age Ageing · May 2007 BACKGROUND: Previous research has reported that greater intelligence in early life is associated with longer lifespan. Whether this relationship is mediated by genetic factors or environmental factors, some of which could be modified by an individual, is u ... Full text Link to item Cite

Rapid relief of severe major depressive disorder by use of preoperative ketamine and electroconvulsive therapy.

Journal Article J ECT · March 2007 Major depressive disorder is a difficult-to-treat and recurrent debilitating disorder. All approved somatic treatments for major depression to date require a significant time lapse before demonstrating an antidepressant effect. However, emerging evidence i ... Full text Link to item Cite

Systematic review of multifaceted interventions to improve depression care.

Journal Article Gen Hosp Psychiatry · 2007 OBJECTIVE: Depression is a prevalent high-impact illness with poor outcomes in primary care settings. We performed a systematic review to determine to what extent multifaceted interventions improve depression outcomes in primary care and to define key elem ... Full text Link to item Cite

Head injury in early adulthood and the lifetime risk of depression.

Journal Article Arch Gen Psychiatry · January 2002 BACKGROUND: Depressive symptoms are common and can be debilitating in the months after head injury. Head injury can also have long-term cognitive effects, but little is known about the long-term risk of depression associated with head injury. We investigat ... Full text Link to item Cite

Prediction of the utility of a switch from unilateral to bilateral ECT in the elderly using treatment 2 ictal EEG indices.

Journal Article J ECT · December 2000 BACKGROUND: The choice of whether to administer nondominant unilateral (UL) or bilateral (BL) ECT remains controversial. METHODS: A study in which moderately suprathreshold UL nonresponders at treatment 6 were randomized to UL or BL ECT offered the opportu ... Full text Link to item Cite

Changes in seizure threshold over the course of electroconvulsive therapy affect therapeutic response and are detected by ictal EEG ratings.

Journal Article J Neuropsychiatry Clin Neurosci · 1998 Therapeutic effectiveness of electroconvulsive therapy is influenced by the degree to which the stimulus intensity exceeds the seizure threshold. However, the threshold rises variably over the treatment course, confounding maintenance of desired relative s ... Full text Link to item Cite

Olanzapine on trial.

Journal Article Am J Psychiatry · January 1998 Full text Link to item Cite

The relative ability of three ictal EEG frequency bands to differentiate ECT seizures on the basis of electrode placement, stimulus intensity, and therapeutic response.

Journal Article Convuls Ther · March 1996 Ictal EEG indices show promise for separating individual ECT seizures on the basis of treatment electrode placement (ELPL), relative stimulus intensity (Dose), and expected therapeutic response. One factor impeding the effective clinical implementation of ... Link to item Cite

Assessing diagnostic approaches to depression in medically ill older adults: how reliably can mental health professionals make judgments about the cause of symptoms?

Journal Article J Am Geriatr Soc · May 1995 OBJECTIVE: To evaluate the reliability of the DSM-IV approach and five other schemes for counting symptoms toward the diagnosis of depression in hospitalized medically ill older patients and to examine whether mental health professionals can reliably make ... Full text Link to item Cite