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William Dean Matthew

William Dean Matthew

Adjunct Professor in the Department of Neurology
Neurology
wmatthew@duke.edu
Duke Box 2900, Durham, NC 27710
311 Research Drive, Bryan Research Center, Durham, NC 27710

Selected Publications

Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice.

Journal Article Exp Neurol · May 2001 Featured Publication Apolipoprotein E (apoE) is well characterized as a plasma lipoprotein involved in lipid and cholesterol metabolism. Recent studies implicating apoE in Alzheimer's disease and successful recovery from neurological injury have stimulated much interest in the ... Full text Link to item Cite

Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.

Journal Article J Neuroimmunol · March 1, 2001 Featured Publication Apolipoprotein E (apoE) is a 299 amino acid protein that is associated with risk of developing Alzheimer's Disease (AD) and outcome after acute brain injury. To investigate the possibility that apoE modulates glial activation we studied the effect of endog ... Full text Link to item Cite

Peripheral sensory nerve defects in apolipoprotein E knockout mice.

Journal Article Exp Neurol · September 1998 Featured Publication Apolipoprotein E (apoE), a plasma lipoprotein involved in lipid metabolism, is also proposed to have important functions within the central and peripheral nervous systems. To investigate the function of apoE in the peripheral nervous system, we examined th ... Full text Link to item Cite

Apolipoprotein E and neural survival

Journal Article EXPERIMENTAL NEUROLOGY · May 1, 1998 Link to item Cite

Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production.

Journal Article Neuroreport · March 9, 1998 Featured Publication The human apolipoprotein (apo) E4 isoform is associated with an increased risk for Alzheimer's disease (AD) and poor prognosis after acute CNS injury. Addition of human apoE inhibits murine microglial activation in culture, suggesting that microglia might ... Full text Link to item Cite

Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor.

Journal Article J Neurosci · August 15, 1997 Featured Publication Expression of apolipoprotein E (apoE) and ciliary neurotrophic factor (CNTF), a pleiotropic neuron survival factor, increases in the CNS in response to injury. Although CNTF is believed to act as a survival factor after injury in the CNS, the functions of ... Full text Link to item Cite

Apolipoprotein E suppresses glial cell secretion of TNF alpha.

Journal Article J Neuroimmunol · June 1997 Featured Publication Apolipoprotein E (apoE) is a 299 amino acid protein with multiple biological functions. Initially described in the context of cholesterol metabolism, apoE also has immunomodulatory properties and recent evidence has implicated a role for apoE in neurologic ... Full text Link to item Cite

Neurite outgrowth is enhanced by anti-idiotypic monoclonal antibodies to the ganglioside GM1.

Journal Article Exp Neurol · May 1997 Featured Publication Exogenously added gangliosides enhance sprouting, neurite outgrowth, and other neuronal activities; this effect may be initiated when a ganglioside binds to a membrane protein or when a ganglioside intercalates into the plasma membrane. To test whether bin ... Full text Link to item Cite

Generating monoclonal antibodies to neuronal antigens.

Journal Article J Neurosci Methods · October 1996 Methods for generating monoclonal antibodies directed to the functional sites of neuronal antigens are reviewed. These methods include optimal antigen preparation and presentation as well as selective targeting and manipulation of the antigenic response. W ... Full text Link to item Cite

Anti-idiotypic monoclonal antibodies to GM1 identify ganglioside binding proteins.

Journal Article Glycobiology · September 1996 Ganglioside stimulated neurite outgrowth may be due to ganglioside binding to membrane proteins or to intercalation into the membrane. To test that ganglioside binding proteins could be found on neuronal surfaces, anti-idiotypic ganglioside monoclonal anti ... Full text Link to item Cite

Glial growth factor 2, a soluble neuregulin, directly increases Schwann cell motility and indirectly promotes neurite outgrowth.

Journal Article J Neurosci · August 1, 1996 Schwann cells proliferate, migrate, and act as sources of neurotrophic support during development and regeneration of peripheral nerves. Recent studies have demonstrated that neuregulins, a family of growth factors secreted by developing motor and peripher ... Full text Link to item Cite

Neuregulins as potential drugs for neurological disorders.

Journal Article Cold Spring Harb Symp Quant Biol · 1996 Link to item Cite

Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology.

Journal Article Exp Neurol · December 1995 The extracellular matrix protein laminin profoundly affects neuronal adhesion, spreading, differentiation, and growth by binding integrin-type cell surface receptors. Laminin binds other basement membrane components, including heparan sulfate proteoglycans ... Full text Link to item Cite

Neurotrophins affect the pattern of DRG neurite growth in a bioassay that presents a choice of CNS and PNS substrates.

Journal Article Development · May 1995 Neurons can be categorized in terms of where their axons project: within the central nervous system, within the peripheral nervous system, or through both central and peripheral environments. Examples of these categories are cerebellar neurons, sympathetic ... Full text Link to item Cite

CD9 plays a role in Schwann cell migration in vitro.

Journal Article J Neurosci · January 1995 To identify molecules that regulate Schwann cell migration, we have generated a panel of monoclonal antibodies against Schwann cell surface antigens that modulate Schwann cell migration in in vitro bioassays. One of these antibodies, SMRA1, recognizes a 26 ... Full text Link to item Cite

Merosin promotes neurite growth and Schwann cell migration in vitro and nerve regeneration in vivo: evidence using an antibody to merosin, ARM-1.

Journal Article Dev Biol · July 1994 Monoclonal antibodies that block the cellular function(s) of specific antigens can provide valuable probes for in vitro and in vivo bioassays. With the goal of understanding the molecular basis of neuron-Schwann cell interactions during development and reg ... Full text Link to item Cite

Nerve growth factor and its low-affinity receptor promote Schwann cell migration.

Journal Article Proc Natl Acad Sci U S A · March 29, 1994 Migrating Schwann cells in developing or regenerating peripheral nerves are known to express dramatically increased levels of nerve growth factor (NGF) and the low-affinity NGF receptor (LNGFR). Schwann cells do not express detectable pp140trk, the NGF-act ... Full text Link to item Cite

An in vitro bioassay for neurite growth using cryostat sections of nervous tissue as a substratum.

Journal Article J Neurosci Methods · September 1991 An in vitro bioassay is described that can be used for studying neurite growth, cell adhesion, and cell migration, as well as other cellular behaviors. The bioassay, which uses tissue sections as substrata for either dissociated cell preparations or explan ... Full text Link to item Cite

Substrate-bound nerve growth factor promotes neurite growth in peripheral nerve.

Journal Article Brain Res · November 10, 1987 Nerve growth factor (NGF), in addition to its well-known effects as a soluble neurite growth-promoting factor, also appears to promote the elongation of neurites when it is adsorbed to tissue culture substrates. Peripheral nerve Schwann cells appear to pos ... Full text Link to item Cite

Identification of a peripheral nerve neurite growth-promoting activity by development and use of an in vitro bioassay.

Journal Article Proc Natl Acad Sci U S A · October 1987 The effective regeneration of severed neuronal axons in the peripheral nerves of adult mammals may be explained by the presence of molecules in situ that promote the effective elongation of neurites. The absence of such molecules in the central nervous sys ... Full text Link to item Cite

An in vitro neurite-promoting antigen functions in axonal regeneration in vivo.

Journal Article Science · September 25, 1987 The function of the neurite growth-promoting antigen INO has been tested in an in vivo neurite regeneration system, the rat iris. The sympathetic innervation of the irides was removed by a single systemic injection of 6-hydroxydopamine. The subsequent rege ... Full text Link to item Cite

Cyclophosphamide treatment used to manipulate the immune response for the production of monoclonal antibodies.

Journal Article J Immunol Methods · June 26, 1987 After immunization with a complex mixture of antigens, a considerable bias toward obtaining monoclonal antibodies to immunodominant determinants exists. By selectively killing antigen-stimulated lymphocytes, the cytotoxic drug cyclophosphamide can be used ... Full text Link to item Cite

Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue.

Journal Article J Cell Biol · October 1981 Two different monoclonal antibodies, characterized initially as binding synaptic terminal regions of rat brain, bind a 65,000-dalton protein, which is exposed on the outer surface of brain synaptic vesicles. Immunocytochemical experiments at the electron m ... Full text Link to item Cite