Scholars@Duke
Yvonne Marie Mowery

Yvonne Marie Mowery

Adjunct Assistant Professor in the Department of Radiation Oncology
Radiation Oncology
DUMC Box 3085, Durham, NC 27710

Selected Publications

Clinical commissioning and introduction of an in-house artificial intelligence (AI) platform for automated head and neck intensity modulated radiation therapy (IMRT) treatment planning.

Conference J Appl Clin Med Phys · November 6, 2024 BACKGROUND AND PURPOSE: To describe the clinical commissioning of an in-house artificial intelligence (AI) treatment planning platform for head-and-neck (HN) Intensity Modulated Radiation Therapy (IMRT). MATERIALS AND METHODS: The AI planning platform has ... Full text Link to item Cite

CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer: A Review.

Journal Article JCO Precis Oncol · October 2024 CD8+ tumor-infiltrating lymphocytes (TILs) are increasingly used in oncology as a prognostic and predictive tool to guide patient management. This review summarizes current literature on CD8+ TILs in head and neck squamous cell carcinoma (SCC). Published m ... Full text Link to item Cite

Abstract PR004: Differential gene expression analysis comparing Black and White patients with HPV-positive oropharyngeal squamous cell carcinoma reveals suppressed immune response and higher rates P16/HPV DNA discordance in Black patients

Conference Cancer Epidemiology, Biomarkers & Prevention · September 21, 2024 AbstractBackground-Human papilloma virus (HPV-positive (+)) oropharynx cancer (OPC) are a distinct neoplastic entity associated with a significant survival advantage compared to HPV- OPCs. The survival advan ... Full text Cite

Abstract C107: Differential gene expression analysis comparing Black and White patients with HPV-positive oropharyngeal squamous cell carcinoma reveals suppressed immune response and higher rates P16/HPV DNA discordance in Black patients

Conference Cancer Epidemiology, Biomarkers & Prevention · September 21, 2024 AbstractThis abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR004) of the Conference Program/Proceedings. Cell, Molecula ... Full text Cite

NETosis Impact on Tumor Biology, Radiation, and Systemic Therapy Resistance.

Journal Article Clin Cancer Res · September 13, 2024 Neutrophil extracellular trap (NET)osis via lytic neutrophil death or neutrophil activation is associated with standard cancer therapies, notably including radiotherapy; is immunosuppressive; and may enhance metastasis and treatment resistance. This emergi ... Full text Link to item Cite

Pharyngeal Constrictor-Sparing Salvage Stereotactic Body Radiation Therapy With Tongue-Out for In-Field Recurrence After Definitive Radiation Therapy for Head and Neck Cancer: Guide to Tongue-Out Radiation Therapy.

Journal Article Pract Radiat Oncol · July 22, 2024 This report details a pharyngeal constrictor muscle (PCM)-sparing stereotactic body radiation therapy (SBRT) using our institutional technique of "tongue-out" radiation therapy (TORT) for treating a local recurrent cancer in the uvula (GTVuvula) in a patie ... Full text Link to item Cite

Enhancing radiotherapy response via intratumoral injection of a TLR9 agonist in autochthonous murine sarcomas.

Journal Article JCI Insight · June 13, 2024 Radiation therapy (RT) is frequently used to treat cancers, including soft-tissue sarcomas. Prior studies established that the toll-like receptor 9 (TLR9) agonist cytosine-phosphate-guanine oligodeoxynucleotide (CpG) enhances the response to RT in transpla ... Full text Link to item Cite

Evaluating Tumor Hypoxia Radiosensitization Via Electron Paramagnetic Resonance Oxygen Imaging (EPROI).

Journal Article Mol Imaging Biol · June 2024 PURPOSE: Tumor hypoxia contributes to aggressive phenotypes and diminished therapeutic responses to radiation therapy (RT) with hypoxic tissue being 3-fold less radiosensitive than normoxic tissue. A major challenge in implementing hypoxic radiosensitizers ... Full text Link to item Cite

Prevention and Management of Osteoradionecrosis in Patients With Head and Neck Cancer Treated With Radiation Therapy: ISOO-MASCC-ASCO Guideline.

Journal Article J Clin Oncol · June 1, 2024 PURPOSE: To provide evidence-based recommendations for prevention and management of osteoradionecrosis (ORN) of the jaw secondary to head and neck radiation therapy in patients with cancer. METHODS: The International Society of Oral Oncology-Multinational ... Full text Link to item Cite

Radiomics on spatial-temporal manifolds via Fokker-Planck dynamics.

Conference Med Phys · May 2024 BACKGROUND: Delta radiomics is a high-throughput computational technique used to describe quantitative changes in serial, time-series imaging by considering the relative change in radiomic features of images extracted at two distinct time points. Recent wo ... Full text Link to item Cite

Enhancing in vivo preclinical studies with VivoVist™ and photon-counting micro-CT imaging

Conference Medical Imaging 2024: Clinical and Biomedical Imaging · April 2, 2024 Full text Open Access Cite

Preclinical Evaluation of the ATR Inhibitor BAY 1895344 as a Radiosensitizer for Head and Neck Squamous Cell Carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2024 PURPOSE: Despite aggressive multimodal treatment that typically includes definitive or adjuvant radiation therapy (RT), locoregional recurrence rates approach 50% for patients with locally advanced human papillomavirus (HPV)-negative head and neck squamous ... Full text Link to item Cite

Health Care Cost Reductions with Machine Learning-Directed Evaluations during Radiation Therapy - An Economic Analysis of a Randomized Controlled Study.

Journal Article NEJM AI · April 2024 BACKGROUND: Machine learning (ML) may cost-effectively direct health care by identifying patients most likely to benefit from preventative interventions to avoid negative and expensive outcomes. System for High-Intensity Evaluation During Radiation Therapy ... Full text Link to item Cite

Prognostic value of different discretization parameters in 18fluorodeoxyglucose positron emission tomography radiomics of oropharyngeal squamous cell carcinoma.

Journal Article J Med Imaging (Bellingham) · March 2024 PURPOSE: We aim to interrogate the role of positron emission tomography (PET) image discretization parameters on the prognostic value of radiomic features in patients with oropharyngeal cancer. APPROACH: A prospective clinical trial (NCT01908504) enrolled ... Full text Link to item Cite

Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma.

Journal Article bioRxiv · January 4, 2024 Radiation therapy is frequently used to treat cancers including soft tissue sarcomas. Prior studies established that the toll-like receptor 9 (TLR9) agonist cytosine-phosphate-guanine oligodeoxynucleotide (CpG) enhances the response to radiation therapy (R ... Full text Link to item Cite

Clinical outcomes of oropharyngeal squamous cell carcinoma stratified by human papillomavirus subtype: A systematic review and meta-analysis.

Journal Article Oral Oncol · January 2024 PURPOSE: We aim to determine if there is a survival difference between patients with oropharyngeal squamous cell carcinoma (OPSCC) associated with human papillomavirus (HPV) 16 versus HPV-non16 subtypes. PATIENT AND METHODS: Databases were queried for full ... Full text Link to item Cite

MR histology reveals tissue features beneath heterogeneous MRI signal in genetically engineered mouse models of sarcoma.

Journal Article Front Oncol · 2024 PURPOSE: To identify significant relationships between quantitative cytometric tissue features and quantitative MR (qMRI) intratumorally in preclinical undifferentiated pleomorphic sarcomas (UPS). MATERIALS AND METHODS: In a prospective study of geneticall ... Full text Link to item Cite

Clinical Outcomes of Human papillomavirus (HPV) Testing Discordance in Oropharyngeal Squamous cell Carcinoma

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2024 Cite

Characterization of Heterotopic and Orthotopic Syngeneic MOC1 and MOC2 Tumor Models

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2024 Cite

Temporary Knockdown of p53 During Focal Limb Irradiation Increases the Development of Sarcomas.

Journal Article Cancer Res Commun · December 5, 2023 UNLABELLED: Approximately half of patients with cancer receive radiotherapy and, as cancer survivorship increases, the low rate of radiation-associated sarcomas is rising. Pharmacologic inhibition of p53 has been proposed as an approach to ameliorate acute ... Full text Link to item Cite

Long-term risk of carotid stenosis and cerebrovascular disease after radiation therapy for head and neck cancer.

Conference Cancer · October 28, 2023 BACKGROUND: Recipients of radiation therapy (RT) for head and neck cancer (HNC) are at significantly increased risk for carotid artery stenosis (CAS) and cerebrovascular disease (CVD). We sought to determine (1) cumulative incidences of CAS and CVD among H ... Full text Link to item Cite

Abstract IA04: Evaluating the therapeutic potential of ATR inhibitor BAY 1895344 and radiation therapy for head and neck squamous cell carcinoma

Conference Clinical Cancer Research · September 15, 2023 AbstractDespite aggressive multimodal treatment with chemoradiation or surgery and adjuvant radiation therapy (RT) +/- chemotherapy, recurrence rates approach 50% for locally advanced human papillomavirus (H ... Full text Cite

Both CD8 and CD4 T cells contribute to immunosurveillance preventing the development of neoantigen-expressing autochthonous sarcomas.

Journal Article bioRxiv · April 6, 2023 The adaptive immune system plays an essential anti-tumor role through immunosurveillance and response to immunotherapies. Characterizing phenotypic features and mechanisms of dysfunction of tumor-specific T cell populations may uncover novel immunotherapeu ... Full text Link to item Cite

Supplementary figure FS4 from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <p>Long-term metastases study of an autochthonous p53/MCA mouse model of STS induced by Cre-LoxP technology using TRP53 fl/fl mice</p> ... Full text Cite

Supplementary figure FS4 from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <p>Long-term metastases study of an autochthonous p53/MCA mouse model of STS induced by Cre-LoxP technology using TRP53 fl/fl mice</p> ... Full text Cite

Supplementary figure FS3 from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <p>Long-term survival of an autochthonous p53/MCA mouse model in immunocompetent 129/SvJae wild-type mice induced by CRISPR/Cas9</p> ... Full text Cite

Supplementary figure FS3 from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <p>Long-term survival of an autochthonous p53/MCA mouse model in immunocompetent 129/SvJae wild-type mice induced by CRISPR/Cas9</p> ... Full text Cite

Data from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <div>Abstract<p>This study aims to investigate whether adding neoadjuvant radiotherapy (RT), anti-programmed cell death protein-1 (PD-1) antibody (anti–PD-1), or RT + anti-PD-1 to surgical resection improves disease-free survival for mi ... Full text Cite

Data from Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma

Other · April 3, 2023 <div>Abstract<p>This study aims to investigate whether adding neoadjuvant radiotherapy (RT), anti-programmed cell death protein-1 (PD-1) antibody (anti–PD-1), or RT + anti-PD-1 to surgical resection improves disease-free survival for mi ... Full text Cite

The Affordable Care Act and suicide incidence among adults with cancer.

Journal Article J Cancer Surviv · April 2023 BACKGROUND: Patients with cancer are at an increased suicide risk, and socioeconomic deprivation may further exacerbate that risk. The Affordable Care Act (ACA) expanded insurance coverage options for low-income individuals and mandated coverage of mental ... Full text Link to item Cite

Insurance Coverage and Forgoing Medical Appointments Because of Cost Among Cancer Survivors After 2016.

Journal Article JCO Oncol Pract · April 2023 PURPOSE: The uninsured rate began rising after 2016, which some have attributed to health policies undermining aspects of the Affordable Care Act. Our primary objectives were to assess the changes in insurance coverage and forgoing medical care because of ... Full text Link to item Cite

Low contralateral neck recurrence risk with ipsilateral neck radiotherapy in N2b tonsillar squamous cell carcinoma.

Journal Article Oral Oncol · April 2023 OBJECTIVES: To characterize factors including nodal burden, pre-treatment imaging, and other patient factors which may influence the role of ipsilateral neck radiotherapy (IRT) in tonsillar squamous cell carcinoma (SCC) with multiple involved ipsilateral n ... Full text Link to item Cite

Animal Models and Their Role in Imaging-Assisted Co-Clinical Trials.

Journal Article Tomography · March 16, 2023 The availability of high-fidelity animal models for oncology research has grown enormously in recent years, enabling preclinical studies relevant to prevention, diagnosis, and treatment of cancer to be undertaken. This has led to increased opportunities to ... Full text Open Access Link to item Cite

Immunogenetic Determinants of Susceptibility to Head and Neck Cancer in the Million Veteran Program Cohort.

Journal Article Cancer Res · February 3, 2023 UNLABELLED: Increasing rates of human papillomavirus (HPV)-driven oropharyngeal cancer (OPC) have largely offset declines in tobacco-associated head and neck squamous cell carcinoma (HNSCC) at non-OPC sites. Host immunity is an important modulator of HPV i ... Full text Link to item Cite

Whole-Slide Cytometric Feature Mapping for Distinguishing Tumor Genomic Subtypes in Head and Neck Squamous Cell Carcinoma Whole-Slide Images.

Journal Article Am J Pathol · February 2023 Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease where, in advanced stages, clinical and pathologic stages do not correlate with outcome. Molecular and genomic biomarkers for HNSCC classification have shown promise for prognostic an ... Full text Open Access Link to item Cite

Healthcare provider evaluation of machine learning-directed care: reactions to deployment on a randomised controlled study.

Journal Article BMJ Health Care Inform · February 2023 OBJECTIVES: Clinical artificial intelligence and machine learning (ML) face barriers related to implementation and trust. There have been few prospective opportunities to evaluate these concerns. System for High Intensity EvaLuation During Radiotherapy (NC ... Full text Link to item Cite

Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma.

Journal Article Mol Cancer Ther · January 3, 2023 This study aims to investigate whether adding neoadjuvant radiotherapy (RT), anti-programmed cell death protein-1 (PD-1) antibody (anti-PD-1), or RT + anti-PD-1 to surgical resection improves disease-free survival for mice with soft tissue sarcomas (STS). ... Full text Open Access Link to item Cite

Environmental Toxicity of Driving Distance to External Beam Radiotherapy (EBRT) for Head and Neck Cancer Patients

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2023 Cite

Implementation of machine learning in the clinic: challenges and lessons in prospective deployment from the System for High Intensity EvaLuation During Radiation Therapy (SHIELD-RT) randomized controlled study.

Journal Article BMC Bioinformatics · September 30, 2022 BACKGROUND: Artificial intelligence (AI) and machine learning (ML) have resulted in significant enthusiasm for their promise in healthcare. Despite this, prospective randomized controlled trials and successful clinical implementation remain limited. One cl ... Full text Link to item Cite

Risk and incidence of head and neck cancers in veterans living with HIV and matched HIV-negative veterans.

Journal Article Cancer · September 15, 2022 BACKGROUND: Persons living with HIV/AIDS have a higher incidence of virus-related and tobacco/alcohol-related cancers. This study is the first to estimate the effect of HIV versus HIV-negative veterans on the risk of head and neck squamous cell carcinoma i ... Full text Link to item Cite

Prediction model to estimate overall survival benefit of postoperative radiotherapy for resected major salivary gland cancers.

Journal Article Oral Oncol · September 2022 OBJECTIVES: To develop and validate a prediction model to estimate overall survival (OS) with and without postoperative radiotherapy (PORT) for resected major salivary gland (SG) cancers. MATERIALS AND METHODS: Adults in the National Cancer Database diagno ... Full text Link to item Cite

Automated Nuclear Segmentation in Head and Neck Squamous Cell Carcinoma Pathology Reveals Relationships between Cytometric Features and ESTIMATE Stromal and Immune Scores.

Journal Article Am J Pathol · September 2022 The tumor microenvironment (TME) plays an important role in the progression of head and neck squamous cell carcinoma (HNSCC). Currently, pathologic assessment of TME is nonstandardized and subject to observer bias. Genome-wide transcriptomic approaches to ... Full text Link to item Cite

Comparing Outcomes of Oligometastases Treated with Hypofractionated Image-Guided Radiotherapy (HIGRT) with a Simultaneous Integrated Boost (SIB) Technique versus Metastasis Alone: A Multi-Institutional Analysis.

Journal Article Cancers (Basel) · May 13, 2022 PURPOSE: We previously reported on the clinical outcomes of treating oligometastases with radiation using an elective simultaneous integrated boost technique (SIB), delivering higher doses to known metastases and reduced doses to adjacent bone or nodal bas ... Full text Link to item Cite

Photon Counting CT and Radiomic Analysis Enables Differentiation of Tumors Based on Lymphocyte Burden.

Journal Article Tomography · March 10, 2022 The purpose of this study was to investigate if radiomic analysis based on spectral micro-CT with nanoparticle contrast-enhancement can differentiate tumors based on lymphocyte burden. High mutational load transplant soft tissue sarcomas were initiated in ... Full text Open Access Link to item Cite

An investigation of kV mini-GRID spatially fractionated radiation therapy: dosimetry and preclinical trial.

Journal Article Phys Med Biol · February 18, 2022 Objective. To develop and characterize novel methods of extreme spatially fractionated kV radiation therapy (including mini-GRID therapy) and to evaluate efficacy in the context of a pre-clinical mouse study.Approach. Spatially fractionated GRIDs were prec ... Full text Link to item Cite

Pharmacologic inhibition of ataxia telangiectasia and Rad3-related (ATR) in the treatment of head and neck squamous cell carcinoma.

Journal Article Mol Carcinog · February 2022 Head and neck squamous cell carcinoma (HNSCC) poses significant treatment challenges, with high recurrence rates for locally advanced disease despite aggressive therapy typically involving a combination of surgery, radiation therapy, and/or chemotherapy. H ... Full text Link to item Cite

Preliminary Results of Uveal Melanoma Treated With Iodine-125 Plaques: Analysis of Disease Control and Visual Outcomes With 63 Gy to the Target Volume.

Journal Article Adv Radiat Oncol · 2022 PURPOSE: Our purpose was to review the preliminary outcomes of patients with uveal melanoma treated with iodine-125 plaques using a novel treatment planning approach. METHODS AND MATERIALS: This was a single institution, retrospective review of patients tr ... Full text Link to item Cite

Long-Term Outcomes for Patients With Atypical or Malignant Meningiomas Treated With or Without Radiation Therapy: A 25-Year Retrospective Analysis of a Single-Institution Experience.

Journal Article Adv Radiat Oncol · 2022 PURPOSE: Atypical (World Health Organization [WHO] grade 2) and malignant (WHO grade 3) meningiomas have high rates of local recurrence, and questions remain about the role of adjuvant radiation therapy (RT) for patients with WHO grade 2 disease. These pat ... Full text Link to item Cite

Corrigendum: Brain Metastases from Esophageal Squamous Cell Carcinoma: Clinical Characteristics and Prognosis.

Journal Article Front Oncol · 2022 [This corrects the article DOI: 10.3389/fonc.2021.652509.]. ... Full text Link to item Cite

Post-Radiotherapy PET Image Outcome Prediction by Deep Learning Under Biological Model Guidance: A Feasibility Study of Oropharyngeal Cancer Application.

Journal Article Front Oncol · 2022 PURPOSE: To develop a method of biologically guided deep learning for post-radiation 18FDG-PET image outcome prediction based on pre-radiation images and radiotherapy dose information. METHODS: Based on the classic reaction-diffusion mechanism, a novel bio ... Full text Link to item Cite

Photon Counting Micro-CT for Imaging Cisplatin

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2022 The photon-counting (PC) detector technology promises to enhance the number of CT applications due to the spectral information. Of high interest for the cancer research community is imaging the tumor delivery of Cisplatin (CisPt), a chemotherapeutic agent ... Full text Cite

Spectral micro-CT and nanoradiomic analysis for classification of tumors based on lymphocytic burden in cancer therapy studies

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2022 The purpose of this study was to investigate if radiomic analysis based on spectral micro-CT with nanoparticle contrast-enhancement can differentiate tumors based on tumor-infiltrating lymphocyte (TIL) burden. High mutational load transplant soft tissue sa ... Full text Cite

Co-clinical photon counting CT research for multi-contrast imaging

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2022 Developing novel contrast agents for multi-energy photon-counting (PC)CT will require a clear translation pathway from preclinical validation to clinical applications. To begin this development, we have used a clinical PCCT scanner (Siemens NAEOTOM Alpha) ... Full text Cite

Photon-counting X-ray CT perfusion imaging in animal models of cancer

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2022 Photon-counting detector (PCD) CT promises to improve routine CT imaging applications with higher spatial resolution, lower levels of noise at fixed dose, and improved image contrast while providing spectral information with every scan. We propose and demo ... Full text Cite

Computational Characterization of Lymphocytic Inflammation on Digital Kidney Biopsies

Conference JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY · 2022 Cite

Machine Learning Algorithm Prospectively Predicts Survival for High-Risk Patients Undergoing Radiotherapy: A Survival Analysis of SHIELD-RT.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Mortality prediction is critical to appropriate cancer care planning. This has become a topic of interest, with machine learning (ML) tools demonstrating accurate binary predictions for mortality at specific time points. There ... Full text Cite

A Phase 1-2 Trial of Concurrent Radiation Therapy, Cisplatin and BMX-001 in Locally Advanced Head and Neck Cancer.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Prevention/mitigation of oral mucositis (OM) and xerostomia are challenges to the use of chemoradiation (CRT) for advanced head and neck squamous ca (HNSCC). MnTnBuOE-2-PyP5+(BMX-001) is a lipophilic manganese metall ... Full text Cite

Oligometastases Treated With an Elective Simultaneous Integrated Boost Have Reduced Marginal Recurrence Rates.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Radiation is increasingly used to treat oligometastatic patients (OM). Following metastasis directed radiation therapy, progression in nearby nodal basins or bones is common. We previously reported clinical outcomes of OM treat ... Full text Cite

A Novel Combination of Immunotherapy and Radiation Therapy in a Primary Mouse Model of Soft Tissue Sarcoma With High Mutational Load.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Preclinical studies using transplant tumor models have shown promising results for immunotherapy combined with radiotherapy (RT). However, research using primary tumor models is limited, and results from tumors using transplant ... Full text Cite

Patient Reported Outcomes and Financial Toxicity in Head and Neck Cancer (PaRTNer): Baseline financial toxicity and attitudes toward costs from a pilot study.

Conference Journal of Clinical Oncology · October 1, 2021 56 Background: Cancer patients face considerable financial burden, but few studies have explored associations between radiation therapy (RT) and financial toxicity. This study assessed financial toxicity, patient-reported outcome ... Full text Cite

Detection of Lung Nodules in Micro-CT Imaging Using Deep Learning.

Journal Article Tomography · August 7, 2021 We are developing imaging methods for a co-clinical trial investigating synergy between immunotherapy and radiotherapy. We perform longitudinal micro-computed tomography (micro-CT) of mice to detect lung metastasis after treatment. This work explores deep ... Full text Open Access Link to item Cite

Intrinsic radiomic expression patterns after 20 Gy demonstrate early metabolic response of oropharyngeal cancers.

Journal Article Med Phys · July 2021 PURPOSE: This study investigated the prognostic potential of intra-treatment PET radiomics data in patients undergoing definitive (chemo) radiation therapy for oropharyngeal cancer (OPC) on a prospective clinical trial. We hypothesized that the radiomic ex ... Full text Link to item Cite

Impact of machine learning-directed on-treatment evaluations on cost of acute care visits: Economic analysis of SHIELD-RT.

Conference Journal of Clinical Oncology · May 20, 2021 1509 Background: SHIELD-RT was a randomized controlled quality improvement study (NCT03775265) that implemented electronic health record-based machine learning (ML) to direct supplemental visits for high risk (HR) patients underg ... Full text Cite

Identification of proteins and cellular pathways targeted by 2-nitroimidazole hypoxic cytotoxins.

Journal Article Redox Biol · May 2021 Tumour hypoxia negatively impacts therapy outcomes and continues to be a major unsolved clinical problem. Nitroimidazoles are hypoxia selective compounds that become entrapped in hypoxic cells by forming drug-protein adducts. They are widely used as hypoxi ... Full text Link to item Cite

Ex Vivo MR Histology and Cytometric Feature Mapping Connect Three-dimensional in Vivo MR Images to Two-dimensional Histopathologic Images of Murine Sarcomas.

Journal Article Radiology. Imaging cancer · May 2021 Purpose To establish a platform for quantitative tissue-based interpretation of cytoarchitecture features from tumor MRI measurements. Materials and Methods In a pilot preclinical study, multicontrast in vivo MRI of murine soft-tissue sarcomas in 10 mice, ... Full text Open Access Cite

Chlorhexidine Gluconate Bathing Reduces the Incidence of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Cell Transplantation.

Journal Article Transplant Cell Ther · March 2021 Bloodstream infections (BSIs) occur in 20% to 45% of inpatient autologous and allogeneic hematopoietic cell transplant (HCT) patients. Daily bathing with the antiseptic chlorhexidine gluconate (CHG) has been shown to reduce the incidence of BSIs in critica ... Full text Link to item Cite

Postoperative radiotherapy is associated with improved overall survival for alveolar ridge squamous cell carcinoma with adverse pathologic features.

Journal Article Head Neck · January 2021 BACKGROUND: Alveolar ridge squamous cell carcinoma (ARSCC) is poorly represented in randomized trials. METHODS: Adults in the National Cancer Database diagnosed with ARSCC between 2010 and 2014 who should be considered for postoperative radiotherapy (PORT) ... Full text Link to item Cite

Brain Metastases from Esophageal Squamous Cell Carcinoma: Clinical Characteristics and Prognosis.

Conference Front Oncol · 2021 PURPOSE: Due to the low incidence of intracranial disease among patients with esophageal cancer (EC), optimal management for these patients has not been established. The aim of this real-world study is to describe the clinical characteristics, treatment ap ... Full text Link to item Cite

Towards deep learning detection of lung nodules using micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2021 We are developing imaging methods for the preclinical arm of a co-clinical trial investigating synergy between immunotherapy and radiotherapy. We perform in vivo micro-CT of mouse lungs to detect lung metastasis after treatment. This work explores deep lea ... Full text Cite

Establishing ADC-Based Histogram and Texture Features for Early Treatment-Induced Changes in Head and Neck Squamous Cell Carcinoma.

Journal Article Front Oncol · 2021 The purpose of this study was to assess baseline variability in histogram and texture features derived from apparent diffusion coefficient (ADC) maps from diffusion-weighted MRI (DW-MRI) examinations and to identify early treatment-induced changes to these ... Full text Link to item Cite

Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy.

Journal Article Nat Commun · December 17, 2020 Immunotherapy fails to cure most cancer patients. Preclinical studies indicate that radiotherapy synergizes with immunotherapy, promoting radiation-induced antitumor immunity. Most preclinical immunotherapy studies utilize transplant tumor models, which ov ... Full text Link to item Cite

Early 18F-FDG-PET Response During Radiation Therapy for HPV-Related Oropharyngeal Cancer May Predict Disease Recurrence.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2020 PURPOSE: Early indication of treatment outcome may guide therapeutic de-escalation strategies in patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC). This study investigated the relationships between tumor volume and 18F-fluorodeoxy ... Full text Open Access Link to item Cite

Development and Implementation of an Educational Simulation Workshop in Fiberoptic Laryngoscopy for Radiation Oncology Residents.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2020 PURPOSE: Fiberoptic laryngoscopy (FOL) is a critical tool for the diagnosis, staging, assessment of treatment response, and detection of recurrence for head and neck (H&N) malignancies. No standardized recommendations exist for procedural FOL education in ... Full text Link to item Cite

System for High-Intensity Evaluation During Radiation Therapy (SHIELD-RT): A Prospective Randomized Study of Machine Learning-Directed Clinical Evaluations During Radiation and Chemoradiation.

Journal Article J Clin Oncol · November 1, 2020 PURPOSE: Patients undergoing outpatient radiotherapy (RT) or chemoradiation (CRT) frequently require acute care (emergency department evaluation or hospitalization). Machine learning (ML) may guide interventions to reduce this risk. There are limited prosp ... Full text Link to item Cite

Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine.

Journal Article Tomography · September 2020 The National Institutes of Health's (National Cancer Institute) precision medicine initiative emphasizes the biological and molecular bases for cancer prevention and treatment. Importantly, it addresses the need for consistency in preclinical and clinical ... Full text Open Access Link to item Cite

Practice Patterns for the Treatment of Uveal Melanoma with Iodine-125 Plaque Brachytherapy: Ocular Oncology Study Consortium Report 5.

Journal Article Ocul Oncol Pathol · May 2020 BACKGROUND: Treatment planning for I-125 plaque therapy for uveal melanoma has advanced significantly since the Collaborative Ocular Melanoma Study trial, with more widely available image-guided planning and improved dosimetry. OBJECTIVE: We evaluated real ... Full text Link to item Cite

Evaluating for disparities in place of death for head and neck cancer patients in the United States utilizing the CDC WONDER database.

Journal Article Oral Oncol · March 2020 OBJECTIVE: Evaluate trends in place of death for patients with head and neck cancers (HNC) in the U.S. from 1999 to 2017 based on the CDC WONDER (Wide-ranging Online Data for Epidemiologic Research) database. MATERIALS/METHODS: Using patient-level data fro ... Full text Link to item Cite

MRI-Based Deep Learning Segmentation and Radiomics of Sarcoma in Mice.

Journal Article Tomography · March 2020 Small-animal imaging is an essential tool that provides noninvasive, longitudinal insight into novel cancer therapies. However, considerable variability in image analysis techniques can lead to inconsistent results. We have developed quantitative imaging f ... Full text Open Access Link to item Cite

Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application

Conference Frontiers in oncology · January 2020 Purpose To develop a deep learning-based AI agent, DDD-PIOP (Dose-Distribution-Driven PET Image Outcome Prediction), for predicting 18FDG-PET image outcomes of oropharyngeal cancer (OPC) in response to intensity-modulated radiation therapy (IMRT). Methods ... Cite

The impact of respiratory gating on improving volume measurement of murine lung tumors in micro-CT imaging.

Journal Article PLoS One · 2020 Small animal imaging has become essential in evaluating new cancer therapies as they are translated from the preclinical to clinical domain. However, preclinical imaging faces unique challenges that emphasize the gap between mouse and man. One example is t ... Full text Open Access Link to item Cite

A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy

Journal Article · 2020 Despite impressive responses in some patients, immunotherapy fails to cure most cancer patients. Preclinical studies indicate that radiotherapy synergizes with immunotherapy, promoting radiation-induced antitumor immunity. Nearly all preclinical immunother ... Full text Cite

MRI-based radiomics of sarcomas in the preclinical arm of a Co-clinical trial

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 Radiomics provide an exciting approach to developing imaging biomarkers in the context of precision medicine. We focus on the preclinical arm of a co-clinical trial investigating synergy of immunotherapy combined with radiation therapy (RT) and surgical re ... Full text Cite

A spectral CT study on iodine augmentation of radiation therapy and its potential for combination with chemotherapy

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 High-Z based nanoparticles (NP) are emerging as promising agents for both cancer radiotherapy (RT) and CT imaging. NPs can be delivered to tumors via the enhanced permeability and retention (EPR) effect and they preferentially accumulate in tumor's perivas ... Full text Cite

Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application.

Journal Article Front Oncol · 2020 PURPOSE: To develop a deep learning-based AI agent, DDD-PIOP (Dose-Distribution-Driven PET Image Outcome Prediction), for predicting 18FDG-PET image outcomes of oropharyngeal cancer (OPC) in response to intensity-modulated radiation therapy (IMRT). METHODS ... Full text Open Access Link to item Cite

Deciphering the Role of MerTK in Sarcomagenesis And Response To Radiation Therapy And Immune Checkpoint Blockade

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2020 Cite

Ipsilateral versus Bilateral Neck Radiation Therapy for Tonsillar Squamous Cell Carcinoma

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2020 Cite

Daily Chlorhexidine Gluconate Bathing Reduces the Rate of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Stem Cell Transplantation

Conference Blood · November 13, 2019 Introduction: While hematopoietic stem cell transplantation (HSCT) has great therapeutic potential, intensive conditioning regimens and variability in time to stem cell engraftment result in a period of pancytopenia and immunosuppression in which p ... Full text Cite

The impact of respiratory gating on improving volume measurement of murine lung tumors in micro-CT imaging

Journal Article · October 29, 2019 ABSTRACTSmall animal imaging has become essential in evaluating new cancer therapies as they are translated from the preclinical to clinical domain. However, preclinical imaging faces unique challenges that emphasize the ga ... Full text Open Access Cite

Targeting cell surface GRP78 enhances pancreatic cancer radiosensitivity through YAP/TAZ protein signaling.

Journal Article J Biol Chem · September 20, 2019 Ionizing radiation (IR) can promote migration and invasion of cancer cells, but the basis for this phenomenon has not been fully elucidated. IR increases expression of glucose-regulated protein 78kDa (GRP78) on the surface of cancer cells (CS-GRP78), and t ... Full text Open Access Link to item Cite

Neutrophils promote tumor resistance to radiation therapy.

Journal Article Proc Natl Acad Sci U S A · September 10, 2019 Nearly two-thirds of cancer patients are treated with radiation therapy (RT), often with the intent to achieve complete and permanent tumor regression (local control). RT is the primary treatment modality used to achieve local control for many malignancies ... Full text Link to item Cite

Retrospective analysis of safety and efficacy of anti-PD-1 therapy and radiation therapy in advanced melanoma: A bi-institutional study.

Journal Article Radiother Oncol · September 2019 BACKGROUND AND PURPOSE: Antibodies against programmed cell death protein 1 (PD-1) are standard treatments for advanced melanoma. Palliative radiation therapy (RT) is commonly administered for this disease. Safety and optimal timing for this combination for ... Full text Link to item Cite

Nomogram to Predict Survival Benefit of Postoperative Radiotherapy for Major Salivary Gland Cancers

Conference International Journal of Radiation Oncology*Biology*Physics · September 2019 Full text Cite

Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma.

Journal Article JCI Insight · July 11, 2019 Cancer development is influenced by hereditary mutations, somatic mutations due to random errors in DNA replication, or external factors. It remains unclear how distinct cell-intrinsic and -extrinsic factors impact oncogenesis within the same tissue type. ... Full text Link to item Cite

Functional imaging of tumor vasculature using iodine and gadolinium-based nanoparticle contrast agents: a comparison of spectral micro-CT using energy integrating and photon counting detectors.

Journal Article Phys Med Biol · March 12, 2019 Advances in computed tomography (CT) hardware have propelled the development of novel CT contrast agents. In particular, the spectral capabilities of x-ray CT can facilitate simultaneous imaging of multiple contrast agents. This approach is particularly us ... Full text Open Access Link to item Cite

USE OF CLINICAL PHOTOGRAPHY IN RADIATION ONCOLOGY

Conference ONCOLOGY NURSING FORUM · March 1, 2019 Link to item Cite

Investigating a chimeric anti-mouse PDGFRα antibody as a radiosensitizer in primary mouse sarcomas.

Journal Article EBioMedicine · February 2019 BACKGROUND: Olaratumab (LY3012207/IMC-3G3/Lartruvo™) is a fully human monoclonal antibody specific for platelet-derived growth factor receptor alpha (PDGFRα). Phase Ib/II trial results of olaratumab plus doxorubicin in adult patients with advanced soft tis ... Full text Link to item Cite

Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trial.

Journal Article PLoS One · 2019 In designing co-clinical cancer studies, preclinical imaging brings unique challenges that emphasize the gap between man and mouse. Our group is developing quantitative imaging methods for the preclinical arm of a co-clinical trial studying immunotherapy a ... Full text Open Access Link to item Cite

Treatment Outcomes in Anaplastic Thyroid Cancer.

Journal Article J Thyroid Res · 2019 BACKGROUND: Anaplastic thyroid cancer (ATC) is rare, accounting for 1-2% of thyroid malignancies. Median survival is only 3-10 months, and the optimal therapeutic approach has not been established. This study aimed to evaluate outcomes in ATC based on trea ... Full text Link to item Cite

To gate or not to gate: An evaluation of respiratory gating techniques to improve volume measurement of murine lung tumors in micro-CT imaging

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2019 Small animal imaging has become essential in evaluating new cancer therapies as they are translated from the preclinical to clinical domain. However, preclinical imaging is faced with unique challenges that emphasize the gap between mouse and man. One exam ... Full text Cite

Multi-modal MRI segmentation of sarcoma tumors using convolutional neural networks

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2019 Small animal imaging is essential in building a bridge from basic science to the clinic by providing the confidence necessary to move new cancer therapies to patients. However, there is considerable variability in preclinical imaging, including tumor volum ... Full text Cite

Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trial

Journal Article · November 5, 2018 Abstract In designing co-clinical cancer studies, preclinical imaging brings unique challenges that emphasize the gap between man and mouse. Our group is developing quantitative imaging methods for the preclinical arm of a co-clinical trial studying immuno ... Full text Cite

Trends in Place of Death for Head and Neck Cancer Patients in the US from 1999 to 2016 Using the CDC WONDER Database

Conference International Journal of Radiation Oncology*Biology*Physics · November 2018 Full text Cite

Adaptive IMRT Planning Improves Pharyngeal Sparing for Oropharyngeal Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2018 Full text Cite

Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma.

Journal Article Cancer · October 1, 2018 Soft tissue sarcomas (STS) are heterogeneous, mesenchymal malignancies with variable biologic behavior. The primary management for localized STS is surgical resection, which may be combined with neoadjuvant or adjuvant radiation therapy to increase the pro ... Full text Link to item Cite

The risk of carotid stenosis in head and neck cancer patients after radiation therapy.

Journal Article Oral Oncol · May 2018 OBJECTIVES: Head and neck radiotherapy (RT) is a risk factor for cerebrovascular disease. We performed a retrospective cohort study to evaluate carotid artery stenosis (CAS) incidence in head and neck cancer (HNC) patients undergoing RT, characterizing ass ... Full text Link to item Cite

Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma.

Journal Article Mol Cancer Ther · April 2018 Carbon ion therapy (CIT) offers several potential advantages for treating cancers compared with X-ray and proton radiotherapy, including increased biological efficacy and more conformal dosimetry. However, CIT potency has not been characterized in primary ... Full text Link to item Cite

The Risk of Carotid Stenosis in Head and Neck Cancer Patients After Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · April 2018 Full text Cite

Efficacy and Safety of Low-Dose Iodine Plaque Brachytherapy for Juxtapapillary Choroidal Melanoma.

Journal Article Am J Ophthalmol · February 2018 PURPOSE: To evaluate low- vs high-dose plaque brachytherapy for juxtapapillary choroidal melanoma. DESIGN: Retrospective interventional case series. METHODS: Setting: Single institution. STUDY POPULATION: Forty-seven patients with juxtapapillary choroidal ... Full text Link to item Cite

Oral cavity cancer: Diagnosis and treatment

Chapter · January 1, 2018 A comprehensive history, thorough head and neck physical examination, and adequate staging are critical to guide optimal locoregional treatment and evaluate for second primaries in patients with oral cavity cancer. A multidisciplinary approach-including he ... Full text Cite

The Incidence of Carotid Stenosis in Head and Neck Cancer Patients After Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.

Journal Article Nat Commun · July 10, 2017 Genetically engineered mouse models that employ site-specific recombinase technology are important tools for cancer research but can be costly and time-consuming. The CRISPR-Cas9 system has been adapted to generate autochthonous tumours in mice, but how th ... Full text Link to item Cite

Abstract 2810: Using CRISPR/Cas9 to generate primary soft tissue sarcoma in genetically engineered and wild-type mice

Conference Cancer Research · July 1, 2017 AbstractGenetically engineered mouse models (GEMMs) that employ site-specific recombinase (SSR) technology are important tools for pre-clinical studies, but this approach is costly and time-consuming. Here, ... Full text Cite

Neoadjuvant long-course chemoradiation remains strongly favored over short-course radiotherapy by radiation oncologists in the United States.

Journal Article Cancer · April 15, 2017 BACKGROUND: Short-course radiotherapy (SC-RT) and long-course chemoradiotherapy (LC-CRT) are accepted neoadjuvant treatments of rectal cancer. In the current study, the authors surveyed US radiation oncologists to assess practice patterns and attitudes reg ... Full text Link to item Cite

F-18-FDG PET/CT Response at 20 Gy Predicts Treatment Outcome for Head and Neck Squamous Cell Carcinoma (HNSCC)

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · October 1, 2016 Link to item Cite

Toxicity and Survival for Metastatic Melanoma Patients Treated With Anti-PD1 Therapy and Radiation Treatment

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · October 1, 2016 Link to item Cite

SU-F-R-15: Establishing Relevant ADC-Based Texture Analysis Metrics for Quantifying Early Treatment-Induced Changes in Head and Neck Squamous Cell Carcinoma.

Journal Article Med Phys · June 2016 PURPOSE: The purpose of this study is to identify texture analysis metrics from apparent diffusion coefficient (ADC) maps that would provide quantifiable changes with treatment in patients with head and neck squamous cell carcinoma (HNSCC). We discerned wh ... Full text Link to item Cite

Imaging-Guided Core-Needle Breast Biopsy: Impact of Meditation and Music Interventions on Patient Anxiety, Pain, and Fatigue.

Journal Article J Am Coll Radiol · May 2016 PURPOSE: To evaluate the impact of guided meditation and music interventions on patient anxiety, pain, and fatigue during imaging-guided breast biopsy. METHODS: After giving informed consent, 121 women needing percutaneous imaging-guided breast biopsy were ... Full text Link to item Cite

Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era.

Journal Article Cancer J · 2016 Stereotactic body radiation therapy (SBRT) utilizing a small number of high-dose radiation therapy fractions continues to expand in clinical application. Although many approaches have been proposed to radiosensitize tumors with conventional fractionation, ... Full text Link to item Cite

A primer on medical education in the United States through the lens of a current resident physician.

Journal Article J Thorac Dis · October 2015 Physician training and standards for medical licensure differ widely across the globe. The medical education process in the United States (US) typically involves a minimum of 11 years of formal training and multiple standardized examinations between gradua ... Full text Link to item Cite

A primer on medical education in the United States through the lens of a current resident physician.

Journal Article Ann Transl Med · October 2015 Physician training and standards for medical licensure differ widely across the globe. The medical education process in the United States (US) typically involves a minimum of 11 years of formal training and multiple standardized examinations between gradua ... Full text Link to item Cite

Abstract P1-15-10: Low utilization of hypofractionated radiotherapy for the treatment of early-stage breast cancer in the US

Conference Cancer Research · May 1, 2015 AbstractBackground: Large randomized controlled trials have shown that hypofractionated whole breast irradiation (HF-WBI) is not inferior to or more toxic than conventionally fractionated whole breast irradi ... Full text Cite

Preoperative partial breast

Chapter · January 1, 2015 Partial breast irradiation, treatment focused only on the surgical bed plus a variable margin, has evolved as an ultra-convenient alternative to whole breast irradiation for selected patients with early-stage breast cancer. A number of techniques are avail ... Full text Cite

Whole-breast radiation therapy: the long and short of it.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2014 Full text Link to item Cite

TU-F-12A-03: Using 18F-FDG-PET-CT and Deformable Registration During Head-And-Neck Cancer (HNC) Intensity Modulated Radiotherapy (IMRT) to Predict Treatment Response.

Journal Article Med Phys · June 2014 PURPOSE: To evaluate the effect of deformable vs. rigid registration of pre-treatment 18F-FDG-PET-CT to intra-treatment 18F-FDG-PET-CT on different standardized uptake value (SUV) parameters and investigate which parameters correlate best with post-treatme ... Full text Link to item Cite

Clinical aspects of monoclonal B-cell lymphocytosis.

Journal Article Cancer Control · January 2012 BACKGROUND: Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic precursor condition for chronic lymphocytic leukemia (CLL). It is defined by the presence of small clones of aberrant B cells in the peripheral blood, with a total B-cell count below the ... Full text Link to item Cite

Loss of cell surface TFII-I promotes apoptosis in prostate cancer cells stimulated with activated α₂ -macroglobulin.

Journal Article J Cell Biochem · June 2011 Receptor-recognized forms of α₂ -macroglobulin (α₂ M) bind to cell surface-associated GRP78 and initiate pro-proliferative and anti-apoptotic signaling. Ligation of GRP78 with α₂ M also upregulates TFII-I, which binds to the GRP78 promoter and enhances GRP ... Full text Link to item Cite

Cell surface ATP synthase: A potential target for anti-angiogenic therapy

Journal Article · December 1, 2010 Since the presence of F1F0 adenosine triphosphate (ATP) synthase was discovered on the surface of human cells, numerous studies have elucidated new functions for this molecule that classically functions as part of the electron transport chain in mitochondr ... Full text Cite

LMP-420: a novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells.

Journal Article Leukemia · September 2010 B-cell chronic lymphocytic leukemia (CLL) is characterized by slow accumulation of malignant cells, which are supported in the microenvironment by cell-cell interactions and soluble cytokines such as tumor necrosis factor (TNF). We evaluated the effect of ... Full text Link to item Cite

Stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation.

Journal Article Genetics · November 2009 Ovarian follicle formation in Drosophila melanogaster requires stall (stl) gene function, both within and outside the ovary, for follicle individualization, stalk cell intercalation, and oocyte localization. We have identified the stl transcript as CG3622 ... Full text Link to item Cite

The antitumorigenic trifecta.

Journal Article Blood · August 27, 2009 The laboratory of Judah Folkman identified the potent endogenous antiangiogenic protein angiostatin in 1994.(1) In this issue of Blood, Lee and colleagues propose 2 new mechanisms of action for angiostatin that may represent promising targets for new cance ... Full text Link to item Cite

Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis.

Journal Article Mol Cancer Ther · May 2009 Binding of activated α(2)-macroglobulin to GRP78 on the surface of human prostate cancer cells promotes proliferation by activating signaling cascades. Autoantibodies directed against the activated α(2)-macroglobulin binding site in the NH(2)-terminal doma ... Full text Link to item Cite

Targeting cell surface F1F0 ATP synthase in cancer therapy

Journal Article Cancer Biology and Therapy · November 1, 2008 Cite

Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase.

Journal Article Cancer Res · May 15, 2007 The antiangiogenic protein angiostatin inhibits ATP synthase on the endothelial cell surface, blocking cellular proliferation. To examine the specificity of this interaction, we generated monoclonal antibodies (mAb) directed against ATP synthase. mAb direc ... Full text Link to item Cite

Bariatric surgery for severely obese adolescents.

Journal Article J Gastrointest Surg · January 2003 A 1991 National Institutes of Health Consensus Conference concluded that severely obese adults could be eligible for bariatric surgery if they had a body mass index (BMI) > or =35 kg/m(2) with or > or =40 kg/m(2) without obesity comorbidity. It was thought ... Full text Link to item Cite

Training the novice in laparoscopy. More challenge is better.

Journal Article Surg Endosc · December 2002 BACKGROUND: Virtual reality simulation is effective in training the novice to perform basic laparoscopic skills. METHODS: Using the Minimally Invasive Surgery Training--Virtual Reality (MIST-VR) trainer, 27 honors high school students were tested at the ea ... Full text Link to item Cite