Scholars@Duke
Zhongwei Qu

Selected Publications

The molecular basis of spinocerebellar ataxia type 48 caused by a de novo mutation in the ubiquitin ligase CHIP.

Journal Article J Biol Chem · May 2022 The spinocerebellar ataxias (SCAs) are a class of incurable diseases characterized by degeneration of the cerebellum that results in movement disorder. Recently, a new heritable form of SCA, spinocerebellar ataxia type 48 (SCA48), was attributed to dominan ... Full text Link to item Cite

Smoothened is a therapeutic target for reducing glutamate toxicity in ischemic stroke.

Journal Article Science translational medicine · September 2021 Extracellular glutamate contributes to brain damage in ischemia. Under physiological conditions, glutamate transporters are responsible for regulating its intracellular/extracellular concentrations in the brain. However, how the extracellular glutamate is ... Full text Cite

STN-ANT plasticity is crucial for the motor control in Parkinson's disease model.

Journal Article Signal transduction and targeted therapy · June 2021 Full text Cite

Robo functions as an attractive cue for glial migration through SYG-1/Neph.

Journal Article Elife · November 19, 2020 As one of the most-studied receptors, Robo plays functions in many biological processes, and its functions highly depend on Slit, the ligand of Robo. Here we uncover a Slit-independent role of Robo in glial migration and show that neurons can release an ex ... Full text Open Access Link to item Cite

Sonic hedgehog induces GLT-1 degradation via PKC delta to suppress its transporter activities.

Journal Article Neuroscience · December 2017 GLT-1 is mainly expressed in astrocytes and has a crucial role in glutamate uptake. Sonic hedgehog (SHH) can inhibit glutamate uptake and its pathway is activated in many brain diseases related with glutamate excitotoxicity. However, whether SHH regulates ... Full text Cite

TRPC6 expression in neurons is differentially regulated by NR2A- and NR2B-containing NMDA receptors.

Journal Article Journal of neurochemistry · November 2017 The expression of transient receptor potential canonical 6 (TRPC6) in central nervous system (CNS) is important for neuronal functions and certain neural disorders. However, the regulatory mechanism of TRPC6 expression in neurons is still obscure. In this ... Full text Cite

Pathological function of transient receptor potential canonical 6 channel in key central nervous system diseases: Its prospects as drug targets

Journal Article Chinese Journal of Pharmacology and Toxicology · November 1, 2017 Transient receptor potential canonical 6 (TRPC6) is a non-selective cation channel, which is involved in various physiological processes, including neuronal axonal growth cone guidance, promotion of dendritic growth and excitatory synaptic formation. Recen ... Full text Cite

RIP3 S-nitrosylation contributes to cerebral ischemic neuronal injury.

Journal Article Brain research · November 2015 Cerebral ischemia-reperfusion is associated with NMDA receptor-mediated calcium influx which activates neuronal nitric oxide synthase (nNOS) and consequently induces NO production. NO S-nitrosylates cellular protein and aggravates neuronal injury. Receptor ... Full text Cite

N-methyl-D-aspartate receptor-dependent denitrosylation of neuronal nitric oxide synthase increase the enzyme activity.

Journal Article PloS one · January 2012 Our laboratory once reported that neuronal nitric oxide synthase (nNOS) S-nitrosylation was decreased in rat hippocampus during cerebral ischemia-reperfusion, but the underlying mechanism was unclear. In this study, we show that nNOS activity is dynamicall ... Full text Cite