Modulation of immune system inhibitory checkpoints in colorectal cancer
Publication
, Journal Article
Patel, SP; Osada, T; Osada, K; Hurwitz, H; Lyerly, HK; Morse, MA
Published in: Current Colorectal Cancer Reports
December 1, 2013
T cell infiltration of colorectal cancer is associated with improved clinical outcome, underlining the importance of the immune system in cancer control; however, immune checkpoints, including the inhibitory T cell molecules CTLA-4 and PD-1 that temper the native immune response, mitigating autoimmunity, are coopted by tumors to facilitate escape from immune surveillance. Blockade of CTLA-4 and PD-1 and its ligand PD-L1, expressed by many tumors, have shown impressive activity in melanoma, renal cell carcinoma, and lung cancer. Immune checkpoint inhibition has been less well studied in colorectal cancer, but preclinical and clinical investigations are in progress. © Springer Science+Business Media New York 2013.
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Published In
Current Colorectal Cancer Reports
DOI
EISSN
1556-3804
ISSN
1556-3790
Publication Date
December 1, 2013
Volume
9
Issue
4
Start / End Page
391 / 397
Citation
APA
Chicago
ICMJE
MLA
NLM
Patel, S. P., Osada, T., Osada, K., Hurwitz, H., Lyerly, H. K., & Morse, M. A. (2013). Modulation of immune system inhibitory checkpoints in colorectal cancer. Current Colorectal Cancer Reports, 9(4), 391–397. https://doi.org/10.1007/s11888-013-0184-3
Patel, S. P., T. Osada, K. Osada, H. Hurwitz, H. K. Lyerly, and M. A. Morse. “Modulation of immune system inhibitory checkpoints in colorectal cancer.” Current Colorectal Cancer Reports 9, no. 4 (December 1, 2013): 391–97. https://doi.org/10.1007/s11888-013-0184-3.
Patel SP, Osada T, Osada K, Hurwitz H, Lyerly HK, Morse MA. Modulation of immune system inhibitory checkpoints in colorectal cancer. Current Colorectal Cancer Reports. 2013 Dec 1;9(4):391–7.
Patel, S. P., et al. “Modulation of immune system inhibitory checkpoints in colorectal cancer.” Current Colorectal Cancer Reports, vol. 9, no. 4, Dec. 2013, pp. 391–97. Scopus, doi:10.1007/s11888-013-0184-3.
Patel SP, Osada T, Osada K, Hurwitz H, Lyerly HK, Morse MA. Modulation of immune system inhibitory checkpoints in colorectal cancer. Current Colorectal Cancer Reports. 2013 Dec 1;9(4):391–397.
Published In
Current Colorectal Cancer Reports
DOI
EISSN
1556-3804
ISSN
1556-3790
Publication Date
December 1, 2013
Volume
9
Issue
4
Start / End Page
391 / 397