Scholars@Duke publication: Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample.

Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample.

Publication , Journal Article

Liu, Y; Rimmler, J; Dennis, MF; Ashley-Koch, AE; Hauser, MA; Mid-Atlantic Mental Illness Research Education and Clinical Center Workgroup; Beckham, JC

Published in: J Depress Anxiety

June 1, 2013

Published version (DOI) Link to item

BACKGOUND: Posttraumatic stress sisorder (PTSD) is a complex anxiety disorder that can develop after traumatic event exposure. Genetic factors have been associated with PTSD risk. Recently a variant rs4790904 in the protein kinase C alpha (PRKCA) gene has been shown to be associated with PTSD risk. The objective of this study was to replicate this association in a sample of U.S. Afghanistan/Iraq era veterans. METHODS: The genotypes of rs4790904 were evaluated in all trauma-exposed veterans. The sample of U.S. veterans included 428 Caucasians and 533 African-Americans. The statistical analysis was conducted independently in the Caucasian and African-American subjects to evaluate the association with PTSD symptom clusters of B symptoms (re-experiencing), C symptoms (avoidance and numbing), D symptoms (hyperarousal), and with current PTSD diagnosis. RESULTS: The sample was comprised of 428 Caucasians (186 with current PTSD diagnosis, 242 trauma-exposed controls; median age, 35 years; 15% female) and 533 African-Americans (205 with current PTSD diagnosis, 328 trauma-exposed controls; median age, 41 years; 31% female). We observed a significant correlation between rs4790904 and all three PTSD symptom clusters in the Caucasian population, but no significant association with current PTSD diagnosis. However, these significant associations were with the G allele, rather than the A allele, that was previously reported by de Quervain. A significant association of this variant with current PTSD diagnosis (p=0.046) was detected in the African-American veterans. CONCLUSION: We confirmed the correlation between rs4790904 and all three PTSD symptom clusters in the Caucasian but not the African-American population. A significant association with a current diagnosis of PTSD was found in the African-American veterans.

Duke Scholars

Author Allison Elizabeth Ashley-Koch Medicine, Nephrology

Author Michael Arthur Hauser Medicine, Medical Genetics

Author Jean Crowell Beckham Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...

Published In

J Depress Anxiety

DOI

10.4172/2167-1044.s4-001

ISSN

2167-1044

Publication Date

June 1, 2013

Volume

Issue

Start / End Page

S4001

Location

United States

Related Subject Headings

5203 Clinical and health psychology
3202 Clinical sciences

Citation

APA

Chicago

ICMJE

MLA

NLM

Liu, Y., Rimmler, J., Dennis, M. F., Ashley-Koch, A. E., Hauser, M. A., Mid-Atlantic Mental Illness Research Education and Clinical Center Workgroup, & Beckham, J. C. (2013). Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample. J Depress Anxiety, 2(1), S4001. https://doi.org/10.4172/2167-1044.s4-001

Liu, Yutao, Jacqueline Rimmler, Michelle F. Dennis, Allison E. Ashley-Koch, Michael A. Hauser, Mid-Atlantic Mental Illness Research Education and Clinical Center Workgroup, and Jean C. Beckham. “Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample.” J Depress Anxiety 2, no. 1 (June 1, 2013): S4001. https://doi.org/10.4172/2167-1044.s4-001.

Liu Y, Rimmler J, Dennis MF, Ashley-Koch AE, Hauser MA, Mid-Atlantic Mental Illness Research Education and Clinical Center Workgroup, et al. Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample. J Depress Anxiety. 2013 Jun 1;2(1):S4001.

Liu, Yutao, et al. “Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample.” J Depress Anxiety, vol. 2, no. 1, June 2013, p. S4001. Pubmed, doi:10.4172/2167-1044.s4-001.

Liu Y, Rimmler J, Dennis MF, Ashley-Koch AE, Hauser MA, Mid-Atlantic Mental Illness Research Education and Clinical Center Workgroup, Beckham JC. Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample. J Depress Anxiety. 2013 Jun 1;2(1):S4001.

Published In

J Depress Anxiety

DOI

10.4172/2167-1044.s4-001

ISSN

2167-1044

Publication Date

June 1, 2013

Volume

Issue

Start / End Page

S4001

Location

United States

Related Subject Headings

5203 Clinical and health psychology
3202 Clinical sciences