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Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies.

Publication ,  Journal Article
Kelsoe, G; Verkoczy, L; Haynes, BF
Published in: Vaccines (Basel)
March 2014

In this brief review, we discuss immune tolerance as a factor that determines the magnitude and quality of serum antibody responses to HIV-1 infection and vaccination in the context of recent work. We propose that many conserved, neutralizing epitopes of HIV-1 are weakly immunogenic because they mimic host antigens. In consequence, B cells that strongly bind these determinants are removed by the physiological process of immune tolerance. This structural mimicry may represent a significant impediment to designing protective HIV-1 vaccines, but we note that several vaccine strategies may be able to mitigate this evolutionary adaptation of HIV and other microbial pathogens.

Duke Scholars

Published In

Vaccines (Basel)

DOI

ISSN

2076-393X

Publication Date

March 2014

Volume

2

Issue

1

Start / End Page

1 / 14

Location

Switzerland

Related Subject Headings

  • 3207 Medical microbiology
  • 3204 Immunology
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kelsoe, G., Verkoczy, L., & Haynes, B. F. (2014). Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies. Vaccines (Basel), 2(1), 1–14. https://doi.org/10.3390/vaccines2010001

Published In

Vaccines (Basel)

DOI

ISSN

2076-393X

Publication Date

March 2014

Volume

2

Issue

1

Start / End Page

1 / 14

Location

Switzerland

Related Subject Headings

  • 3207 Medical microbiology
  • 3204 Immunology
  • 3202 Clinical sciences