Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies.
Publication
, Journal Article
Kelsoe, G; Verkoczy, L; Haynes, BF
Published in: Vaccines (Basel)
March 2014
In this brief review, we discuss immune tolerance as a factor that determines the magnitude and quality of serum antibody responses to HIV-1 infection and vaccination in the context of recent work. We propose that many conserved, neutralizing epitopes of HIV-1 are weakly immunogenic because they mimic host antigens. In consequence, B cells that strongly bind these determinants are removed by the physiological process of immune tolerance. This structural mimicry may represent a significant impediment to designing protective HIV-1 vaccines, but we note that several vaccine strategies may be able to mitigate this evolutionary adaptation of HIV and other microbial pathogens.
Duke Scholars
Published In
Vaccines (Basel)
DOI
ISSN
2076-393X
Publication Date
March 2014
Volume
2
Issue
1
Start / End Page
1 / 14
Location
Switzerland
Related Subject Headings
- 3207 Medical microbiology
- 3204 Immunology
- 3202 Clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Kelsoe, G., Verkoczy, L., & Haynes, B. F. (2014). Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies. Vaccines (Basel), 2(1), 1–14. https://doi.org/10.3390/vaccines2010001
Kelsoe, Garnett, Laurent Verkoczy, and Barton F. Haynes. “Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies.” Vaccines (Basel) 2, no. 1 (March 2014): 1–14. https://doi.org/10.3390/vaccines2010001.
Kelsoe G, Verkoczy L, Haynes BF. Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies. Vaccines (Basel). 2014 Mar;2(1):1–14.
Kelsoe, Garnett, et al. “Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies.” Vaccines (Basel), vol. 2, no. 1, Mar. 2014, pp. 1–14. Pubmed, doi:10.3390/vaccines2010001.
Kelsoe G, Verkoczy L, Haynes BF. Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies. Vaccines (Basel). 2014 Mar;2(1):1–14.
Published In
Vaccines (Basel)
DOI
ISSN
2076-393X
Publication Date
March 2014
Volume
2
Issue
1
Start / End Page
1 / 14
Location
Switzerland
Related Subject Headings
- 3207 Medical microbiology
- 3204 Immunology
- 3202 Clinical sciences