Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies.
Publication
, Journal Article
Kelsoe, G; Verkoczy, L; Haynes, BF
Published in: Vaccines (Basel)
March 2014
In this brief review, we discuss immune tolerance as a factor that determines the magnitude and quality of serum antibody responses to HIV-1 infection and vaccination in the context of recent work. We propose that many conserved, neutralizing epitopes of HIV-1 are weakly immunogenic because they mimic host antigens. In consequence, B cells that strongly bind these determinants are removed by the physiological process of immune tolerance. This structural mimicry may represent a significant impediment to designing protective HIV-1 vaccines, but we note that several vaccine strategies may be able to mitigate this evolutionary adaptation of HIV and other microbial pathogens.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Vaccines (Basel)
DOI
ISSN
2076-393X
Publication Date
March 2014
Volume
2
Issue
1
Start / End Page
1 / 14
Location
Switzerland
Related Subject Headings
- 3207 Medical microbiology
- 3204 Immunology
- 3202 Clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Kelsoe, G., Verkoczy, L., & Haynes, B. F. (2014). Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies. Vaccines (Basel), 2(1), 1–14. https://doi.org/10.3390/vaccines2010001
Kelsoe, Garnett, Laurent Verkoczy, and Barton F. Haynes. “Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies.” Vaccines (Basel) 2, no. 1 (March 2014): 1–14. https://doi.org/10.3390/vaccines2010001.
Kelsoe G, Verkoczy L, Haynes BF. Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies. Vaccines (Basel). 2014 Mar;2(1):1–14.
Kelsoe, Garnett, et al. “Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies.” Vaccines (Basel), vol. 2, no. 1, Mar. 2014, pp. 1–14. Pubmed, doi:10.3390/vaccines2010001.
Kelsoe G, Verkoczy L, Haynes BF. Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies. Vaccines (Basel). 2014 Mar;2(1):1–14.
Published In
Vaccines (Basel)
DOI
ISSN
2076-393X
Publication Date
March 2014
Volume
2
Issue
1
Start / End Page
1 / 14
Location
Switzerland
Related Subject Headings
- 3207 Medical microbiology
- 3204 Immunology
- 3202 Clinical sciences