Scholars@Duke publication: Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model--a pilot study.

Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model--a pilot study.

Publication , Journal Article

Bartels, K; Ma, Q; Venkatraman, TN; Campos, CR; Smith, L; Cannon, RE; Podgoreanu, MV; Lascola, CD; Miller, DS; Mathew, JP

Published in: Heart Lung Circ

October 2014

Published version (DOI) Link to item

BACKGROUND: Neurologic injury is common after cardiac surgery and disruption of the blood brain barrier (BBB) has been proposed as a contributing factor. We sought to study BBB characteristics in a rodent model of cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA). METHODS: Adult rats were subjected to CPB/DHCA or to sham surgery. Analysis included Western blotting of relevant BBB proteins in addition to in vivo brain magnetic resonance imaging (MRI) with a clinically used low-molecular contrast agent. RESULTS: While quantitative analysis of BBB proteins revealed similar expression levels, MRI showed evidence of BBB disruption after CPB/DHCA compared to sham surgery. CONCLUSIONS: Combining molecular BBB analysis and MRI technology in a rodent model is a highly translatable approach to study adverse neurologic outcomes following CPB/DHCA.

Duke Scholars

Author Mihai V. Podgoreanu Anesthesiology, Cardiothoracic

Author Christopher David Lascola Radiology, Neuroradiology

Author Joseph P. Mathew Anesthesiology, Cardiothoracic

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Published In

Heart Lung Circ

DOI

10.1016/j.hlc.2014.04.131

EISSN

1444-2892

Publication Date

October 2014

Volume

Issue

Start / End Page

981 / 984

Location

Australia

Related Subject Headings

Rats, Sprague-Dawley
Rats
Pilot Projects
Organometallic Compounds
Occludin
Models, Animal
Male
Magnetic Resonance Imaging
Contrast Media
Claudin-5

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APA

Chicago

ICMJE

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NLM

Bartels, K., Ma, Q., Venkatraman, T. N., Campos, C. R., Smith, L., Cannon, R. E., … Mathew, J. P. (2014). Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model--a pilot study. Heart Lung Circ, 23(10), 981–984. https://doi.org/10.1016/j.hlc.2014.04.131

Bartels, Karsten, Qing Ma, Talaignair N. Venkatraman, Christopher R. Campos, Lindsay Smith, Ronald E. Cannon, Mihai V. Podgoreanu, Christopher D. Lascola, David S. Miller, and Joseph P. Mathew. “Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model--a pilot study.” Heart Lung Circ 23, no. 10 (October 2014): 981–84. https://doi.org/10.1016/j.hlc.2014.04.131.

Bartels K, Ma Q, Venkatraman TN, Campos CR, Smith L, Cannon RE, et al. Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model--a pilot study. Heart Lung Circ. 2014 Oct;23(10):981–4.

Bartels, Karsten, et al. “Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model--a pilot study.” Heart Lung Circ, vol. 23, no. 10, Oct. 2014, pp. 981–84. Pubmed, doi:10.1016/j.hlc.2014.04.131.

Bartels K, Ma Q, Venkatraman TN, Campos CR, Smith L, Cannon RE, Podgoreanu MV, Lascola CD, Miller DS, Mathew JP. Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model--a pilot study. Heart Lung Circ. 2014 Oct;23(10):981–984.

Published In

Heart Lung Circ

DOI

10.1016/j.hlc.2014.04.131

EISSN

1444-2892

Publication Date

October 2014

Volume

Issue

Start / End Page

981 / 984

Location

Australia

Related Subject Headings

Rats, Sprague-Dawley
Rats
Pilot Projects
Organometallic Compounds
Occludin
Models, Animal
Male
Magnetic Resonance Imaging
Contrast Media
Claudin-5