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25-Hydroxyvitamin D levels and survival in advanced pancreatic cancer: findings from CALGB 80303 (Alliance).

Publication ,  Journal Article
Van Loon, K; Owzar, K; Jiang, C; Kindler, HL; Mulcahy, MF; Niedzwiecki, D; O'Reilly, EM; Fuchs, C; Innocenti, F; Venook, AP ...
Published in: J Natl Cancer Inst
August 2014

BACKGROUND: Data from animal and cell-line models suggest that vitamin D metabolism plays an important role in pancreatic tumor behavior. Although vitamin D deficiency has been implicated in numerous cancers, the vitamin D status of patients with advanced pancreatic cancer and the effect of baseline vitamin D levels on survival are unknown. METHODS: Participants in this correlative study (CALGB 151006) were enrolled in CALGB 80303, which was a randomized trial of patients with advanced pancreatic cancer that demonstrated no difference in overall survival (OS) among patients treated with gemcitabine plus placebo vs gemcitabine plus bevacizumab. We measured baseline serum 25-hydroxyvitamin D (25[OH]D) levels and examined associations between baseline 25(OH)D levels and progression-free survival and OS using the Cox rank score test. All statistical tests were two-sided. RESULTS: Of 256 patients with available serum, the median 25(OH)D level was 21.7ng/mL (range 4 to 77). 44.5% of patients were vitamin D deficient (25[OH]D <20ng/mL), and 32.4% were insufficient (25[OH]D ≥20 and <30ng/mL). 25(OH)D levels were lower in black patients compared with white patients, and patients of other/undisclosed race (10.7 vs 22.4 vs 20.9ng/mL, P < .001). Baseline 25(OH)D levels were not associated with PFS (HR = 1.00, 95% CI = 0.99 to 1.01, P = .60) or OS (HR = 1.00, 95% CI = 0.99 to 1.01, P = .95). CONCLUSION: Vitamin D deficiency was highly prevalent among patients with a new diagnosis of advanced pancreatic cancer. Black patients had statistically significantly lower 25(OH)D levels than white patients. In this cohort of patients with advanced pancreatic cancer receiving gemcitabine-based chemotherapy, baseline 25(OH)D levels were not associated with PFS or OS.

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Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

August 2014

Volume

106

Issue

8

Location

United States

Related Subject Headings

  • White People
  • Vitamin D Deficiency
  • Vitamin D
  • United States
  • Randomized Controlled Trials as Topic
  • Prevalence
  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
 

Citation

APA
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Van Loon, K., Owzar, K., Jiang, C., Kindler, H. L., Mulcahy, M. F., Niedzwiecki, D., … Alliance for Clinical Trials in Oncology, . (2014). 25-Hydroxyvitamin D levels and survival in advanced pancreatic cancer: findings from CALGB 80303 (Alliance). J Natl Cancer Inst, 106(8). https://doi.org/10.1093/jnci/dju185
Van Loon, Katherine, Kouros Owzar, Chen Jiang, Hedy L. Kindler, Mary F. Mulcahy, Donna Niedzwiecki, Eileen M. O’Reilly, et al. “25-Hydroxyvitamin D levels and survival in advanced pancreatic cancer: findings from CALGB 80303 (Alliance).J Natl Cancer Inst 106, no. 8 (August 2014). https://doi.org/10.1093/jnci/dju185.
Van Loon K, Owzar K, Jiang C, Kindler HL, Mulcahy MF, Niedzwiecki D, et al. 25-Hydroxyvitamin D levels and survival in advanced pancreatic cancer: findings from CALGB 80303 (Alliance). J Natl Cancer Inst. 2014 Aug;106(8).
Van Loon, Katherine, et al. “25-Hydroxyvitamin D levels and survival in advanced pancreatic cancer: findings from CALGB 80303 (Alliance).J Natl Cancer Inst, vol. 106, no. 8, Aug. 2014. Pubmed, doi:10.1093/jnci/dju185.
Van Loon K, Owzar K, Jiang C, Kindler HL, Mulcahy MF, Niedzwiecki D, O’Reilly EM, Fuchs C, Innocenti F, Venook AP, Alliance for Clinical Trials in Oncology. 25-Hydroxyvitamin D levels and survival in advanced pancreatic cancer: findings from CALGB 80303 (Alliance). J Natl Cancer Inst. 2014 Aug;106(8).
Journal cover image

Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

August 2014

Volume

106

Issue

8

Location

United States

Related Subject Headings

  • White People
  • Vitamin D Deficiency
  • Vitamin D
  • United States
  • Randomized Controlled Trials as Topic
  • Prevalence
  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male