Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination.
Publication
, Journal Article
Zhao, Y; Strope, PK; Kozmin, SG; McCusker, JH; Dietrich, FS; Kokoska, RJ; Petes, TD
Published in: G3 (Bethesda)
September 17, 2014
An important issue in genome evolution is the mechanism by which tandem duplications are generated from single-copy genes. In the yeast Saccharomyces cerevisiae, most strains contain tandemly duplicated copies of CUP1, a gene that encodes a copper-binding metallothionein. By screening 101 natural isolates of S. cerevisiae, we identified five different types of CUP1-containing repeats, as well as strains that only had one copy of CUP1. A comparison of the DNA sequences of these strains indicates that the CUP1 tandem arrays were generated by unequal nonhomologous recombination events from strains that had one CUP1 gene.
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Published In
G3 (Bethesda)
DOI
EISSN
2160-1836
Publication Date
September 17, 2014
Volume
4
Issue
11
Start / End Page
2259 / 2269
Location
England
Related Subject Headings
- Saccharomyces cerevisiae
- Metallothionein
- Homologous Recombination
- Gene Duplication
- Evolution, Molecular
- 4905 Statistics
- 3105 Genetics
- 3101 Biochemistry and cell biology
- 0604 Genetics
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MLA
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Zhao, Y., Strope, P. K., Kozmin, S. G., McCusker, J. H., Dietrich, F. S., Kokoska, R. J., & Petes, T. D. (2014). Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination. G3 (Bethesda), 4(11), 2259–2269. https://doi.org/10.1534/g3.114.012922
Zhao, Ying, Pooja K. Strope, Stanislav G. Kozmin, John H. McCusker, Fred S. Dietrich, Robert J. Kokoska, and Thomas D. Petes. “Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination.” G3 (Bethesda) 4, no. 11 (September 17, 2014): 2259–69. https://doi.org/10.1534/g3.114.012922.
Zhao Y, Strope PK, Kozmin SG, McCusker JH, Dietrich FS, Kokoska RJ, et al. Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination. G3 (Bethesda). 2014 Sep 17;4(11):2259–69.
Zhao, Ying, et al. “Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination.” G3 (Bethesda), vol. 4, no. 11, Sept. 2014, pp. 2259–69. Pubmed, doi:10.1534/g3.114.012922.
Zhao Y, Strope PK, Kozmin SG, McCusker JH, Dietrich FS, Kokoska RJ, Petes TD. Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination. G3 (Bethesda). 2014 Sep 17;4(11):2259–2269.
Published In
G3 (Bethesda)
DOI
EISSN
2160-1836
Publication Date
September 17, 2014
Volume
4
Issue
11
Start / End Page
2259 / 2269
Location
England
Related Subject Headings
- Saccharomyces cerevisiae
- Metallothionein
- Homologous Recombination
- Gene Duplication
- Evolution, Molecular
- 4905 Statistics
- 3105 Genetics
- 3101 Biochemistry and cell biology
- 0604 Genetics