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Cholesterol and breast cancer pathophysiology.

Publication ,  Journal Article
Nelson, ER; Chang, C-Y; McDonnell, DP
Published in: Trends Endocrinol Metab
December 2014

Cholesterol is a risk factor for breast cancer although the mechanisms by which this occurs are not well understood. One hypothesis is that dyslipidemia results in increased cholesterol content in cell membranes, thus impacting upon membrane fluidity and subsequent signaling. In addition, studies demonstrate that the metabolite, 27-hydroxycholesterol (27HC), can function as an estrogen, increasing the proliferation of estrogen receptor (ER)-positive breast cancer cells. This was unexpected because 27HC and other oxysterols activate the liver X receptors (LXR), resulting in a reduction of intracellular cholesterol. Resolution of this paradox will require dissection of the molecular mechanisms by which ER and LXR converge in breast cancer cells. Regardless, the observation that 27HC influences breast cancer provides a rationale for strategies that target cholesterol metabolism.

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Published In

Trends Endocrinol Metab

DOI

EISSN

1879-3061

Publication Date

December 2014

Volume

25

Issue

12

Start / End Page

649 / 655

Location

United States

Related Subject Headings

  • Receptors, Estrogen
  • Orphan Nuclear Receptors
  • Liver X Receptors
  • Hydroxycholesterols
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Cholesterol
  • Breast Neoplasms
  • 3215 Reproductive medicine
 

Citation

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Nelson, E. R., Chang, C.-Y., & McDonnell, D. P. (2014). Cholesterol and breast cancer pathophysiology. Trends Endocrinol Metab, 25(12), 649–655. https://doi.org/10.1016/j.tem.2014.10.001
Nelson, Erik R., Ching-yi Chang, and Donald P. McDonnell. “Cholesterol and breast cancer pathophysiology.Trends Endocrinol Metab 25, no. 12 (December 2014): 649–55. https://doi.org/10.1016/j.tem.2014.10.001.
Nelson ER, Chang C-Y, McDonnell DP. Cholesterol and breast cancer pathophysiology. Trends Endocrinol Metab. 2014 Dec;25(12):649–55.
Nelson, Erik R., et al. “Cholesterol and breast cancer pathophysiology.Trends Endocrinol Metab, vol. 25, no. 12, Dec. 2014, pp. 649–55. Pubmed, doi:10.1016/j.tem.2014.10.001.
Nelson ER, Chang C-Y, McDonnell DP. Cholesterol and breast cancer pathophysiology. Trends Endocrinol Metab. 2014 Dec;25(12):649–655.
Journal cover image

Published In

Trends Endocrinol Metab

DOI

EISSN

1879-3061

Publication Date

December 2014

Volume

25

Issue

12

Start / End Page

649 / 655

Location

United States

Related Subject Headings

  • Receptors, Estrogen
  • Orphan Nuclear Receptors
  • Liver X Receptors
  • Hydroxycholesterols
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Cholesterol
  • Breast Neoplasms
  • 3215 Reproductive medicine