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Necrotizing enterocolitis in infants with ductal-dependent congenital heart disease.

Publication ,  Journal Article
Becker, KC; Hornik, CP; Cotten, CM; Clark, RH; Hill, KD; Smith, PB; Lenfestey, RW
Published in: Am J Perinatol
June 2015

OBJECTIVE: Infants with congenital heart disease (CHD) receiving prostaglandins (PGEs) may be at an increased risk for necrotizing enterocolitis (NEC). Enteral feeding may further increase the risk of NEC in these patients. We evaluated the incidence of NEC and its association with enteral feeding in infants with ductal-dependent CHD. STUDY DESIGN: We examined a cohort of infants with CHD receiving PGE in neonatal intensive care units managed by the Pediatrix Medical Group (Sunrise, FL) between 1997 and 2010. We used logistic regression to evaluate the association between NEC and enteral feeding, as well as other risk factors, including antacid medications, inotropic and ventilator support, and anatomic characteristics, controlling for gestational age. RESULTS: We identified 6,710 infants with ductal-dependent CHD receiving PGE for 17,158 infant days. NEC occurred in 21 of the 6,710 (0.3%) infants, of whom 12/21 (57%) were < 37 weeks gestational age. The incidence of NEC was 1.2/1,000 infant days while on enteral feeds versus 0.4/1,000 infant days while not on enteral feeds (p = 0.27). Enteral feeding was not associated with a statistically significant increased odds of NEC on the day of diagnosis (odds ratio [OR] 2.08; 95% confidence interval [CI] 0.38, 11.7). Risk factors associated with a significant increased odds of NEC included a diagnosis of single-ventricle heart defect (OR 2.82; 95% CI 1.23, 6.49), although the overall risk in this population remained low (8/1,631, 0.5%). CONCLUSION: The incidence of NEC in our cohort of infants with ductal-dependent CHD on PGE therapy was low and did not increase with enteral feeding.

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Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

June 2015

Volume

32

Issue

7

Start / End Page

633 / 638

Location

United States

Related Subject Headings

  • Time Factors
  • Risk Factors
  • Retrospective Studies
  • Prostaglandins
  • Premature Birth
  • Obstetrics & Reproductive Medicine
  • Male
  • Infant, Newborn
  • Incidence
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Becker, K. C., Hornik, C. P., Cotten, C. M., Clark, R. H., Hill, K. D., Smith, P. B., & Lenfestey, R. W. (2015). Necrotizing enterocolitis in infants with ductal-dependent congenital heart disease. Am J Perinatol, 32(7), 633–638. https://doi.org/10.1055/s-0034-1390349
Becker, Kristian C., Christoph P. Hornik, C Michael Cotten, Reese H. Clark, Kevin D. Hill, P Brian Smith, and Robert W. Lenfestey. “Necrotizing enterocolitis in infants with ductal-dependent congenital heart disease.Am J Perinatol 32, no. 7 (June 2015): 633–38. https://doi.org/10.1055/s-0034-1390349.
Becker KC, Hornik CP, Cotten CM, Clark RH, Hill KD, Smith PB, et al. Necrotizing enterocolitis in infants with ductal-dependent congenital heart disease. Am J Perinatol. 2015 Jun;32(7):633–8.
Becker, Kristian C., et al. “Necrotizing enterocolitis in infants with ductal-dependent congenital heart disease.Am J Perinatol, vol. 32, no. 7, June 2015, pp. 633–38. Pubmed, doi:10.1055/s-0034-1390349.
Becker KC, Hornik CP, Cotten CM, Clark RH, Hill KD, Smith PB, Lenfestey RW. Necrotizing enterocolitis in infants with ductal-dependent congenital heart disease. Am J Perinatol. 2015 Jun;32(7):633–638.
Journal cover image

Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

June 2015

Volume

32

Issue

7

Start / End Page

633 / 638

Location

United States

Related Subject Headings

  • Time Factors
  • Risk Factors
  • Retrospective Studies
  • Prostaglandins
  • Premature Birth
  • Obstetrics & Reproductive Medicine
  • Male
  • Infant, Newborn
  • Incidence
  • Humans