The clinical application of monoclonal antibody therapies in renal transplantation
Publication
, Journal Article
Dhanireddy, KK; Xu, H; Mannon, RB; Hale, DA; Kirk, AD
Published in: Expert Opinion on Emerging Drugs
2004
Monoclonal antibodies have become valuable tools for the precise clinical manipulation of the immune system. These highly specific proteins have proven their usefulness in both the treatment and prevention of organ transplant rejection. Indeed, they are the centrepieces of many evolving regimens designed to reduce or eliminate the need for chronic immunosuppression. This manuscript will review the monoclonal antibodies that have made their way into the clinic either as experimental therapies or approved drugs. It will provide a general overview of this class of agents and their mechanisms of action. Standard therapies and potential new applications will be described.
Duke Scholars
Published In
Expert Opinion on Emerging Drugs
DOI
Publication Date
2004
Volume
9
Issue
1
Start / End Page
23 / 37
Related Subject Headings
- Transplantation, Homologous
- Terminology as Topic
- T-Lymphocytes, Cytotoxic
- Receptors, Interleukin-2
- Pharmacology & Pharmacy
- Muromonab-CD3
- Mice, Transgenic
- Mice
- Lymphocyte Activation
- Kidney Transplantation
Citation
APA
Chicago
ICMJE
MLA
NLM
Dhanireddy, K. K., Xu, H., Mannon, R. B., Hale, D. A., & Kirk, A. D. (2004). The clinical application of monoclonal antibody therapies in renal transplantation. Expert Opinion on Emerging Drugs, 9(1), 23–37. https://doi.org/10.1517/14728214.9.1.23
Dhanireddy, K. K., H. Xu, R. B. Mannon, D. A. Hale, and A. D. Kirk. “The clinical application of monoclonal antibody therapies in renal transplantation.” Expert Opinion on Emerging Drugs 9, no. 1 (2004): 23–37. https://doi.org/10.1517/14728214.9.1.23.
Dhanireddy KK, Xu H, Mannon RB, Hale DA, Kirk AD. The clinical application of monoclonal antibody therapies in renal transplantation. Expert Opinion on Emerging Drugs. 2004;9(1):23–37.
Dhanireddy, K. K., et al. “The clinical application of monoclonal antibody therapies in renal transplantation.” Expert Opinion on Emerging Drugs, vol. 9, no. 1, 2004, pp. 23–37. Manual, doi:10.1517/14728214.9.1.23.
Dhanireddy KK, Xu H, Mannon RB, Hale DA, Kirk AD. The clinical application of monoclonal antibody therapies in renal transplantation. Expert Opinion on Emerging Drugs. 2004;9(1):23–37.
Published In
Expert Opinion on Emerging Drugs
DOI
Publication Date
2004
Volume
9
Issue
1
Start / End Page
23 / 37
Related Subject Headings
- Transplantation, Homologous
- Terminology as Topic
- T-Lymphocytes, Cytotoxic
- Receptors, Interleukin-2
- Pharmacology & Pharmacy
- Muromonab-CD3
- Mice, Transgenic
- Mice
- Lymphocyte Activation
- Kidney Transplantation