The clinical application of monoclonal antibody therapies in renal transplantation.
Publication
, Journal Article
Dhanireddy, KK; Xu, H; Mannon, RB; Hale, DA; Kirk, AD
Published in: Expert Opin Emerg Drugs
May 2004
Monoclonal antibodies have become valuable tools for the precise clinical manipulation of the immune system. These highly specific proteins have proven their usefulness in both the treatment and prevention of organ transplant rejection. Indeed, they are the centrepieces of many evolving regimens designed to reduce or eliminate the need for chronic immunosuppression. This manuscript will review the monoclonal antibodies that have made their way into the clinic either as experimental therapies or approved drugs. It will provide a general overview of this class of agents and their mechanisms of action. Standard therapies and potential new applications will be described.
Duke Scholars
Published In
Expert Opin Emerg Drugs
DOI
EISSN
1744-7623
Publication Date
May 2004
Volume
9
Issue
1
Start / End Page
23 / 37
Location
England
Related Subject Headings
- Transplantation, Homologous
- Terminology as Topic
- T-Lymphocytes, Cytotoxic
- Receptors, Interleukin-2
- Pharmacology & Pharmacy
- Muromonab-CD3
- Mice, Transgenic
- Mice
- Lymphocyte Activation
- Kidney Transplantation
Citation
APA
Chicago
ICMJE
MLA
NLM
Dhanireddy, K. K., Xu, H., Mannon, R. B., Hale, D. A., & Kirk, A. D. (2004). The clinical application of monoclonal antibody therapies in renal transplantation. Expert Opin Emerg Drugs, 9(1), 23–37. https://doi.org/10.1517/eoed.9.1.23.32957
Dhanireddy, Kiran K., He Xu, Roslyn B. Mannon, Douglas A. Hale, and Allan D. Kirk. “The clinical application of monoclonal antibody therapies in renal transplantation.” Expert Opin Emerg Drugs 9, no. 1 (May 2004): 23–37. https://doi.org/10.1517/eoed.9.1.23.32957.
Dhanireddy KK, Xu H, Mannon RB, Hale DA, Kirk AD. The clinical application of monoclonal antibody therapies in renal transplantation. Expert Opin Emerg Drugs. 2004 May;9(1):23–37.
Dhanireddy, Kiran K., et al. “The clinical application of monoclonal antibody therapies in renal transplantation.” Expert Opin Emerg Drugs, vol. 9, no. 1, May 2004, pp. 23–37. Pubmed, doi:10.1517/eoed.9.1.23.32957.
Dhanireddy KK, Xu H, Mannon RB, Hale DA, Kirk AD. The clinical application of monoclonal antibody therapies in renal transplantation. Expert Opin Emerg Drugs. 2004 May;9(1):23–37.
Published In
Expert Opin Emerg Drugs
DOI
EISSN
1744-7623
Publication Date
May 2004
Volume
9
Issue
1
Start / End Page
23 / 37
Location
England
Related Subject Headings
- Transplantation, Homologous
- Terminology as Topic
- T-Lymphocytes, Cytotoxic
- Receptors, Interleukin-2
- Pharmacology & Pharmacy
- Muromonab-CD3
- Mice, Transgenic
- Mice
- Lymphocyte Activation
- Kidney Transplantation