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The role of B cells in solid organ transplantation.

Publication ,  Journal Article
Kwun, J; Bulut, P; Kim, E; Dar, W; Oh, B; Ruhil, R; Iwakoshi, N; Knechtle, SJ
Published in: Semin Immunol
April 2012

The role of antibodies in chronic injury to organ transplants has been suggested for many years, but recently emphasized by new data. We have observed that when immunosuppressive potency decreases either by intentional weaning of maintenance agents or due to homeostatic repopulation after immune cell depletion, the threshold of B cell activation may be lowered. In human transplant recipients the result may be donor-specific antibody, C4d+ injury, and chronic rejection. This scenario has precise parallels in a rhesus monkey renal allograft model in which T cells are depleted with CD3 immunotoxin, or in a CD52-T cell transgenic mouse model using alemtuzumab to deplete T cells. Such animal models may be useful for the testing of therapeutic strategies to prevent DSA. We agree with others who suggest that weaning of immunosuppression may place transplant recipients at risk of chronic antibody-mediated rejection, and that strategies to prevent this scenario are needed if we are to improve long-term graft and patient outcomes in transplantation. We believe that animal models will play a crucial role in defining the pathophysiology of antibody-mediated rejection and in developing effective therapies to prevent graft injury. Two such animal models are described herein.

Duke Scholars

Published In

Semin Immunol

DOI

EISSN

1096-3618

Publication Date

April 2012

Volume

24

Issue

2

Start / End Page

96 / 108

Location

England

Related Subject Headings

  • Transplantation Immunology
  • Rats
  • Organ Transplantation
  • Mice
  • Macaca mulatta
  • Isoantibodies
  • Immunology
  • Humans
  • Graft Rejection
  • Disease Models, Animal
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kwun, J., Bulut, P., Kim, E., Dar, W., Oh, B., Ruhil, R., … Knechtle, S. J. (2012). The role of B cells in solid organ transplantation. Semin Immunol, 24(2), 96–108. https://doi.org/10.1016/j.smim.2011.08.022
Kwun, Jean, Pinar Bulut, Eugenia Kim, Wasim Dar, Byoungchol Oh, Ravi Ruhil, Neal Iwakoshi, and Stuart J. Knechtle. “The role of B cells in solid organ transplantation.Semin Immunol 24, no. 2 (April 2012): 96–108. https://doi.org/10.1016/j.smim.2011.08.022.
Kwun J, Bulut P, Kim E, Dar W, Oh B, Ruhil R, et al. The role of B cells in solid organ transplantation. Semin Immunol. 2012 Apr;24(2):96–108.
Kwun, Jean, et al. “The role of B cells in solid organ transplantation.Semin Immunol, vol. 24, no. 2, Apr. 2012, pp. 96–108. Pubmed, doi:10.1016/j.smim.2011.08.022.
Kwun J, Bulut P, Kim E, Dar W, Oh B, Ruhil R, Iwakoshi N, Knechtle SJ. The role of B cells in solid organ transplantation. Semin Immunol. 2012 Apr;24(2):96–108.
Journal cover image

Published In

Semin Immunol

DOI

EISSN

1096-3618

Publication Date

April 2012

Volume

24

Issue

2

Start / End Page

96 / 108

Location

England

Related Subject Headings

  • Transplantation Immunology
  • Rats
  • Organ Transplantation
  • Mice
  • Macaca mulatta
  • Isoantibodies
  • Immunology
  • Humans
  • Graft Rejection
  • Disease Models, Animal