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Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease.

Publication ,  Journal Article
Shah, SH; Newgard, CB
Published in: Circ Cardiovasc Genet
April 2015

The genetic architecture underlying the heritability of cardiovascular disease is incompletely understood. Metabolomics is an emerging technology platform that has shown early success in identifying biomarkers and mechanisms of common chronic diseases. Integration of metabolomics, genetics, and other omics platforms in a systems biology approach holds potential for elucidating novel genetic markers and mechanisms for cardiovascular disease. We review important studies that have used metabolomic profiling in cardiometabolic diseases, approaches for integrating metabolomics with genetics and other molecular profiling platforms, and key studies showing the potential for such studies in deciphering cardiovascular disease genetics, biomarkers, and mechanisms.

Duke Scholars

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Published In

Circ Cardiovasc Genet

DOI

EISSN

1942-3268

Publication Date

April 2015

Volume

8

Issue

2

Start / End Page

410 / 419

Location

United States

Related Subject Headings

  • Metabolomics
  • Male
  • Humans
  • Genomics
  • Genetic Markers
  • Female
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Biomarkers
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
Chicago
ICMJE
MLA
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Shah, S. H., & Newgard, C. B. (2015). Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease. Circ Cardiovasc Genet, 8(2), 410–419. https://doi.org/10.1161/CIRCGENETICS.114.000223
Shah, Svati H., and Christopher B. Newgard. “Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease.Circ Cardiovasc Genet 8, no. 2 (April 2015): 410–19. https://doi.org/10.1161/CIRCGENETICS.114.000223.
Shah, Svati H., and Christopher B. Newgard. “Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease.Circ Cardiovasc Genet, vol. 8, no. 2, Apr. 2015, pp. 410–19. Pubmed, doi:10.1161/CIRCGENETICS.114.000223.

Published In

Circ Cardiovasc Genet

DOI

EISSN

1942-3268

Publication Date

April 2015

Volume

8

Issue

2

Start / End Page

410 / 419

Location

United States

Related Subject Headings

  • Metabolomics
  • Male
  • Humans
  • Genomics
  • Genetic Markers
  • Female
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Biomarkers
  • 3201 Cardiovascular medicine and haematology