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A power-law dependence of bacterial invasion on mammalian host receptors.

Publication ,  Journal Article
Lee, TJ; Wong, J; Bae, S; Lee, AJ; Lopatkin, A; Yuan, F; You, L
Published in: PLoS computational biology
April 2015

Pathogenic bacteria such as Listeria and Yersinia gain initial entry by binding to host target cells and stimulating their internalization. Bacterial uptake entails successive, increasingly strong associations between receptors on the surface of bacteria and hosts. Even with genetically identical cells grown in the same environment, there are vast differences in the number of bacteria entering any given cell. To gain insight into this variability, we examined uptake dynamics of Escherichia coli engineered to express the invasin surface receptor from Yersinia, which enables uptake via mammalian host β1-integrins. Surprisingly, we found that the uptake probability of a single bacterium follows a simple power-law dependence on the concentration of integrins. Furthermore, the value of a power-law parameter depends on the particular host-bacterium pair but not on bacterial concentration. This power-law captures the complex, variable processes underlying bacterial invasion while also enabling differentiation of cell lines.

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Published In

PLoS computational biology

DOI

EISSN

1553-7358

ISSN

1553-734X

Publication Date

April 2015

Volume

11

Issue

4

Start / End Page

e1004203

Related Subject Headings

  • Models, Biological
  • Membrane Proteins
  • Humans
  • Host-Pathogen Interactions
  • Hela Cells
  • HeLa Cells
  • Computational Biology
  • Bioinformatics
  • Bacterial Proteins
  • Bacterial Infections
 

Citation

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Lee, T. J., Wong, J., Bae, S., Lee, A. J., Lopatkin, A., Yuan, F., & You, L. (2015). A power-law dependence of bacterial invasion on mammalian host receptors. PLoS Computational Biology, 11(4), e1004203. https://doi.org/10.1371/journal.pcbi.1004203
Lee, Tae J., Jeffrey Wong, Sena Bae, Anna Jisu Lee, Allison Lopatkin, Fan Yuan, and Lingchong You. “A power-law dependence of bacterial invasion on mammalian host receptors.PLoS Computational Biology 11, no. 4 (April 2015): e1004203. https://doi.org/10.1371/journal.pcbi.1004203.
Lee TJ, Wong J, Bae S, Lee AJ, Lopatkin A, Yuan F, et al. A power-law dependence of bacterial invasion on mammalian host receptors. PLoS computational biology. 2015 Apr;11(4):e1004203.
Lee, Tae J., et al. “A power-law dependence of bacterial invasion on mammalian host receptors.PLoS Computational Biology, vol. 11, no. 4, Apr. 2015, p. e1004203. Epmc, doi:10.1371/journal.pcbi.1004203.
Lee TJ, Wong J, Bae S, Lee AJ, Lopatkin A, Yuan F, You L. A power-law dependence of bacterial invasion on mammalian host receptors. PLoS computational biology. 2015 Apr;11(4):e1004203.

Published In

PLoS computational biology

DOI

EISSN

1553-7358

ISSN

1553-734X

Publication Date

April 2015

Volume

11

Issue

4

Start / End Page

e1004203

Related Subject Headings

  • Models, Biological
  • Membrane Proteins
  • Humans
  • Host-Pathogen Interactions
  • Hela Cells
  • HeLa Cells
  • Computational Biology
  • Bioinformatics
  • Bacterial Proteins
  • Bacterial Infections