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Sex, prescribing practices and guideline recommended, blood pressure, and LDL cholesterol targets at baseline in the BARI 2D trial

Publication ,  Journal Article
Magee, MF; Tamis-Holland, JE; Lu, J; Bittner, VA; Brooks, MM; Lopes, N; Jacobs, AK; Detre, KM; Kelsey, SF; Orchard, TJ; Thomas, SB; Rana, JS ...
Published in: International Journal of Endocrinology
January 1, 2015

Background. Research has shown less aggressive treatment and poorer control of cardiovascular disease (CVD) risk factors in women than men. Methods. We analyzed sex differences in pharmacotherapy strategies and attainment of goals for hemoglobin A1c (HbA1c), blood pressure (BP), and low density lipoprotein cholesterol (LDL-C) in patients with type 2 diabetes and established coronary artery disease enrolled into the BARI 2D trial. Results. Similar numbers of drugs were prescribed in both women and men. Women were less frequent on metformin or sulfonylurea and more likely to take insulin and to be on higher doses of hydroxymethylglutaryl-CoA reductase inhibitors (statins) than men. After adjusting for baseline differences and treatment prescribed, women were less likely to achieve goals for HbA1c (OR = 0.71, 95% CI 0.57, 0.88) and LDL-C (OR = 0.64, 95% CI 0.53, 0.78). More antihypertensives were prescribed to women, and yet BP ≤ 130/80 mmHg did not differ by sex. Conclusions. Women entering the BARI 2D trial were as aggressively treated with drugs as men. Despite equivalent treatment, women less frequently met targets for HbA1c and LDL-C. Our findings suggest that there may be sex differences in response to drug therapies used to treat diabetes, hypertension, and hyperlipidemia.

Duke Scholars

Published In

International Journal of Endocrinology

DOI

EISSN

1687-8345

ISSN

1687-8337

Publication Date

January 1, 2015

Volume

2015

Related Subject Headings

  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

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Chicago
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Magee, M. F., Tamis-Holland, J. E., Lu, J., Bittner, V. A., Brooks, M. M., Lopes, N., … Rico-Verdin, B. (2015). Sex, prescribing practices and guideline recommended, blood pressure, and LDL cholesterol targets at baseline in the BARI 2D trial. International Journal of Endocrinology, 2015. https://doi.org/10.1155/2015/610239
Magee, M. F., J. E. Tamis-Holland, J. Lu, V. A. Bittner, M. M. Brooks, N. Lopes, A. K. Jacobs, et al. “Sex, prescribing practices and guideline recommended, blood pressure, and LDL cholesterol targets at baseline in the BARI 2D trial.” International Journal of Endocrinology 2015 (January 1, 2015). https://doi.org/10.1155/2015/610239.
Magee MF, Tamis-Holland JE, Lu J, Bittner VA, Brooks MM, Lopes N, et al. Sex, prescribing practices and guideline recommended, blood pressure, and LDL cholesterol targets at baseline in the BARI 2D trial. International Journal of Endocrinology. 2015 Jan 1;2015.
Magee, M. F., et al. “Sex, prescribing practices and guideline recommended, blood pressure, and LDL cholesterol targets at baseline in the BARI 2D trial.” International Journal of Endocrinology, vol. 2015, Jan. 2015. Scopus, doi:10.1155/2015/610239.
Magee MF, Tamis-Holland JE, Lu J, Bittner VA, Brooks MM, Lopes N, Jacobs AK, Detre KM, Kelsey SF, Orchard TJ, Thomas SB, Tyrrell KS, Rana JS, Averbach F, MacGregor JM, O’Neal SM, Pitluga K, Sansing V, Tranchine M, Crow SW, Bertolet M, Hardison R, Kip K, Lombardero M, Janiszewski S, Protivnak D, Reiser S, Barton S, Guo P, Kushner Y, Martin JP, Kania C, Kania M, O’Donnell J, Maxwell RA, Frye RL, Goldberg S, Rosenberg Y, Desvigne-Nickens P, Ershow A, Gordon D, Paltoo D, Jones TLZ, Hueb W, Ramires J, Wajchenberg BL, Martinez EE, Oliveira SA, Ribeiro EE, Perin M, Betti R, Schwartz L, Steiner G, Barolet A, Groenewoud Y, Mighton L, Camelon K, O’Rourke R, Blodgett J, Sako E, Nicastro J, Prescott R, Rihal C, Kennedy F, Barsness G, Basu A, Clavell A, Holmes DR, Lerman A, Mullaney C, Reeder G, Rizza R, Schaff H, Smith S, Somers V, Sundt T, Ting H, Wright RS, Helgemoe P, Lesmeister D, Rolbiecki D, Lepe-Montoya L, Escobedo J, Barraza R, Baleón R, Campos A, García P, Lezama C, Miramontes C, Ocampo S, Peñafiel J, Valdespino A, Verdín R, Albarrán H, Ayala F, Chávez E, Murillo H, Buitrón LV, Rico-Verdin B. Sex, prescribing practices and guideline recommended, blood pressure, and LDL cholesterol targets at baseline in the BARI 2D trial. International Journal of Endocrinology. 2015 Jan 1;2015.

Published In

International Journal of Endocrinology

DOI

EISSN

1687-8345

ISSN

1687-8337

Publication Date

January 1, 2015

Volume

2015

Related Subject Headings

  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1114 Paediatrics and Reproductive Medicine