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Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus.

Publication ,  Journal Article
Brown, MC; Gromeier, M
Published in: Curr Opin Virol
August 2015

An oncolytic virus (OV) based on poliovirus (PV), the highly attenuated polio/rhinovirus recombinant PVSRIPO, may deliver targeted inflammatory cancer cell killing; a principle that is showing promise in clinical trials for recurrent glioblastoma (GBM). The two decisive factors in PVSRIPO anti-tumor efficacy are selective cytotoxicity and its in situ immunogenic imprint. While our work is focused on what constitutes PVSRIPO cancer cytotoxicity, we are also studying how this engenders host immune responses that are vital to tumor regression. We hypothesize that PVSRIPO cytotoxicity and immunogenicity are inextricably linked in essential, complimentary roles that define the anti-neoplastic response. Herein we delineate mechanisms we unraveled to decipher the basis for PVSRIPO cytotoxicity and its immunotherapeutic potential.

Duke Scholars

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Published In

Curr Opin Virol

DOI

EISSN

1879-6265

Publication Date

August 2015

Volume

13

Start / End Page

81 / 85

Location

Netherlands

Related Subject Headings

  • Poliovirus
  • Oncolytic Viruses
  • Oncolytic Virotherapy
  • Humans
  • Glioblastoma
  • Animals
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology
 

Citation

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ICMJE
MLA
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Brown, M. C., & Gromeier, M. (2015). Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus. Curr Opin Virol, 13, 81–85. https://doi.org/10.1016/j.coviro.2015.05.007
Brown, Michael C., and Matthias Gromeier. “Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus.Curr Opin Virol 13 (August 2015): 81–85. https://doi.org/10.1016/j.coviro.2015.05.007.
Brown MC, Gromeier M. Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus. Curr Opin Virol. 2015 Aug;13:81–5.
Brown, Michael C., and Matthias Gromeier. “Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus.Curr Opin Virol, vol. 13, Aug. 2015, pp. 81–85. Pubmed, doi:10.1016/j.coviro.2015.05.007.
Brown MC, Gromeier M. Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus. Curr Opin Virol. 2015 Aug;13:81–85.
Journal cover image

Published In

Curr Opin Virol

DOI

EISSN

1879-6265

Publication Date

August 2015

Volume

13

Start / End Page

81 / 85

Location

Netherlands

Related Subject Headings

  • Poliovirus
  • Oncolytic Viruses
  • Oncolytic Virotherapy
  • Humans
  • Glioblastoma
  • Animals
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology