Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals.
Publication
, Journal Article
Naggie, S; Patel, K; Yang, L-Y; Chow, S-C; Johnson, V; Guyton, JR; Muir, AJ; Sulkowski, M; Hicks, C
Published in: Open Forum Infect Dis
April 2015
We evaluated the impact of antiretroviral-induced dyslipidemia on hepatitis C virus (HCV) biogenesis in human immunodeficiency virus (HIV)/HCV coinfected patients. This study used serum samples from antiretroviral-naive HIV/HCV patients initiating their first regimen as part of AIDS Clinical Trials Group study protocols (A5142, A5202). Initiation of antiretrovirals increased most lipoproteins and apolipoproteins. In the multivariable model, changes in apolipoproteins were associated with changes in log10 HCV RNA from baseline to week-24 of therapy. Off-target lipogenic changes need to be considered in the context of liver and other metabolic disease in HIV/HCV patients.
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Published In
Open Forum Infect Dis
DOI
ISSN
2328-8957
Publication Date
April 2015
Volume
2
Issue
2
Start / End Page
ofv066
Location
United States
Related Subject Headings
- 3207 Medical microbiology
- 3202 Clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Naggie, S., Patel, K., Yang, L.-Y., Chow, S.-C., Johnson, V., Guyton, J. R., … Hicks, C. (2015). Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals. Open Forum Infect Dis, 2(2), ofv066. https://doi.org/10.1093/ofid/ofv066
Naggie, Susanna, Keyur Patel, Lan-Yan Yang, Shein-Chung Chow, Victoria Johnson, John R. Guyton, Andrew J. Muir, Mark Sulkowski, and Charles Hicks. “Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals.” Open Forum Infect Dis 2, no. 2 (April 2015): ofv066. https://doi.org/10.1093/ofid/ofv066.
Naggie S, Patel K, Yang L-Y, Chow S-C, Johnson V, Guyton JR, et al. Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals. Open Forum Infect Dis. 2015 Apr;2(2):ofv066.
Naggie, Susanna, et al. “Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals.” Open Forum Infect Dis, vol. 2, no. 2, Apr. 2015, p. ofv066. Pubmed, doi:10.1093/ofid/ofv066.
Naggie S, Patel K, Yang L-Y, Chow S-C, Johnson V, Guyton JR, Muir AJ, Sulkowski M, Hicks C. Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals. Open Forum Infect Dis. 2015 Apr;2(2):ofv066.
Published In
Open Forum Infect Dis
DOI
ISSN
2328-8957
Publication Date
April 2015
Volume
2
Issue
2
Start / End Page
ofv066
Location
United States
Related Subject Headings
- 3207 Medical microbiology
- 3202 Clinical sciences