Effects of provision of type 2 diabetes genetic risk feedback on patient perceptions of diabetes control and diet and physical activity self-efficacy.

OBJECTIVE: We examined effects of providing type 2 diabetes genetic risk feedback on controllability perceptions. METHODS: This is a secondary analysis of a randomized controlled trial in which overweight/obese Veterans Affairs patients without diabetes received conventional type 2 diabetes risk counseling that included either (1) personalized diabetes genetic risk feedback (genetic risk arm) or (2) eye disease counseling (comparison arm). Perceived diabetes control, and dietary and physical activity self-efficacy were compared between study arms, and between the comparison arm and each of 3 DNA-based genetic risk levels. RESULTS: Participants (N=531) were predominately male, middle-age, and African American. Immediately post-counseling, perceived diabetes control was higher for the genetic risk arm (risk levels combined) than the comparison arm (p=0.005). In analyses by genetic risk levels, low genetic risk participants reported higher perceived diabetes control than comparison participants (p=0.007). Immediately post-counseling, low genetic risk participants reported higher dietary self-efficacy in situations when mood is negative compared with controls(p=0.01). At 3 months, no differences in constructs were observed. CONCLUSION: Genetic risk feedback for diabetes has temporary effects on perceived controllability among patients with low genetic risk. PRACTICE IMPLICATIONS: Clinicians and other stakeholders should consider the limited effects on behavior change of diabetes genetic risk feedback.

Duke Scholars

Author Rebekah Ryanne Wu Medicine, General Internal Medicine

Author Cynthia Jan Coffman Biostatistics & Bioinformatics, Division of Biostatistics

Author William Samuel Yancy Jr. Medicine, General Internal Medicine