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Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era.

Publication ,  Journal Article
Ludmir, EB; Arya, R; Wu, Y; Palta, M; Willett, CG; Czito, BG
Published in: Ann Surg Oncol
March 2016

BACKGROUND: The role of adjuvant radiation therapy (RT) in the treatment of resected, locally advanced colon cancer is unclear. One randomized controlled trial (Intergroup-0130) addressed this question but failed to meet its accrual goals. Since this trial, few attempts have been made to reassess the role of RT in this clinical setting. METHODS: Sixty-two patients with non-metastatic, American Joint Committee on Cancer 7th edition stage T4 colonic adenocarcinoma were treated at our institution between 2000 and 2013. All underwent curative-intent surgery. Sixteen patients underwent resection only, 33 patients received adjuvant chemotherapy (ChT), and 13 patients received adjuvant chemoradiation therapy (CRT). RESULTS: Patients receiving adjuvant CRT were more likely to have T4b (vs. T4a) disease and were more likely to undergo R1 or R2 resection compared with those receiving adjuvant ChT alone. Despite this, multivariate analysis demonstrated that treatment with adjuvant CRT (vs. adjuvant ChT) enhanced locoregional control and disease-free survival (hazard ratio 0.044 and 0.145, respectively; p < 0.05). CONCLUSIONS: Adjuvant RT for T4 colon cancers may be appropriate in select patients, specifically those with T4b lesions and/or residual disease following resection.

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Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

March 2016

Volume

23

Issue

3

Start / End Page

856 / 862

Location

United States

Related Subject Headings

  • Survival Rate
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female
  • Colonic Neoplasms
 

Citation

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ICMJE
MLA
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Ludmir, E. B., Arya, R., Wu, Y., Palta, M., Willett, C. G., & Czito, B. G. (2016). Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era. Ann Surg Oncol, 23(3), 856–862. https://doi.org/10.1245/s10434-015-4907-3
Ludmir, Ethan B., Ritu Arya, Yuan Wu, Manisha Palta, Christopher G. Willett, and Brian G. Czito. “Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era.Ann Surg Oncol 23, no. 3 (March 2016): 856–62. https://doi.org/10.1245/s10434-015-4907-3.
Ludmir EB, Arya R, Wu Y, Palta M, Willett CG, Czito BG. Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era. Ann Surg Oncol. 2016 Mar;23(3):856–62.
Ludmir, Ethan B., et al. “Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era.Ann Surg Oncol, vol. 23, no. 3, Mar. 2016, pp. 856–62. Pubmed, doi:10.1245/s10434-015-4907-3.
Ludmir EB, Arya R, Wu Y, Palta M, Willett CG, Czito BG. Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era. Ann Surg Oncol. 2016 Mar;23(3):856–862.
Journal cover image

Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

March 2016

Volume

23

Issue

3

Start / End Page

856 / 862

Location

United States

Related Subject Headings

  • Survival Rate
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female
  • Colonic Neoplasms