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Immune correlates of vaccine protection against HIV-1 acquisition.

Publication ,  Journal Article
Corey, L; Gilbert, PB; Tomaras, GD; Haynes, BF; Pantaleo, G; Fauci, AS
Published in: Sci Transl Med
October 21, 2015

The partial efficacy reported in the RV144 HIV vaccine trial in 2009 has driven the HIV vaccine field to define correlates of risk associated with HIV-1 acquisition and connect these functionally to preventing HIV infection. Immunological correlates, mainly including CD4(+) T cell responses to the HIV envelope and Fc-mediated antibody effector function, have been connected to reduced acquisition. These immunological correlates place immunological and genetic pressure on the virus. Indeed, antibodies directed at conserved regions of the V1V2 loop and antibodies that mediate antibody-dependent cellular cytotoxicity to HIV envelope in the absence of inhibiting serum immunoglobulin A antibodies correlated with decreased HIV risk. More recently, researchers have expanded their search with nonhuman primate studies using vaccine regimens that differ from that used in RV144; these studies indicate that non-neutralizing antibodies are associated with protection from experimental lentivirus challenge as well. These immunological correlates have provided the basis for the design of a next generation of vaccine regimens to improve upon the qualitative and quantitative degree of magnitude of these immune responses on HIV acquisition.

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Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

October 21, 2015

Volume

7

Issue

310

Start / End Page

310rv7

Location

United States

Related Subject Headings

  • Humans
  • HIV-1
  • HIV Infections
  • CD4-Positive T-Lymphocytes
  • Antibodies, Viral
  • AIDS Vaccines
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Corey, L., Gilbert, P. B., Tomaras, G. D., Haynes, B. F., Pantaleo, G., & Fauci, A. S. (2015). Immune correlates of vaccine protection against HIV-1 acquisition. Sci Transl Med, 7(310), 310rv7. https://doi.org/10.1126/scitranslmed.aac7732
Corey, Lawrence, Peter B. Gilbert, Georgia D. Tomaras, Barton F. Haynes, Giuseppe Pantaleo, and Anthony S. Fauci. “Immune correlates of vaccine protection against HIV-1 acquisition.Sci Transl Med 7, no. 310 (October 21, 2015): 310rv7. https://doi.org/10.1126/scitranslmed.aac7732.
Corey L, Gilbert PB, Tomaras GD, Haynes BF, Pantaleo G, Fauci AS. Immune correlates of vaccine protection against HIV-1 acquisition. Sci Transl Med. 2015 Oct 21;7(310):310rv7.
Corey, Lawrence, et al. “Immune correlates of vaccine protection against HIV-1 acquisition.Sci Transl Med, vol. 7, no. 310, Oct. 2015, p. 310rv7. Pubmed, doi:10.1126/scitranslmed.aac7732.
Corey L, Gilbert PB, Tomaras GD, Haynes BF, Pantaleo G, Fauci AS. Immune correlates of vaccine protection against HIV-1 acquisition. Sci Transl Med. 2015 Oct 21;7(310):310rv7.

Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

October 21, 2015

Volume

7

Issue

310

Start / End Page

310rv7

Location

United States

Related Subject Headings

  • Humans
  • HIV-1
  • HIV Infections
  • CD4-Positive T-Lymphocytes
  • Antibodies, Viral
  • AIDS Vaccines
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences