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NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition.

Publication ,  Journal Article
Madan, B; Ke, Z; Lei, ZD; Oliver, FA; Oshima, M; Lee, MA; Rozen, S; Virshup, DM
Published in: Oncotarget
March 15, 2016

Activation of Wnt signaling due to Wnt overexpression or mutations of Wnt pathway components is associated with various cancers. Blocking Wnt secretion by inhibiting PORCN enzymatic activity has shown efficacy in a subset of cancers with elevated Wnt signaling. Predicting response to upstream Wnt inhibitors and monitoring response to therapeutics is challenging due to the paucity of well-defined biomarkers. In this study we identify Notum as a potential biomarker for Wnt driven cancers and show that coordinate regulation of NOTUM and AXIN2 expression may be a useful predictor of response to PORCN inhibitors. Most importantly, as NOTUM is a secreted protein and its levels in blood correlate with tumor growth, it has potential as a pharmacodynamic biomarker for PORCN and other Wnt pathway inhibitors.

Duke Scholars

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

March 15, 2016

Volume

7

Issue

11

Start / End Page

12386 / 12392

Location

United States

Related Subject Headings

  • Wnt Signaling Pathway
  • Transfection
  • Pancreatic Neoplasms
  • Mice, Nude
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Membrane Proteins
  • Humans
  • Heterografts
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Madan, B., Ke, Z., Lei, Z. D., Oliver, F. A., Oshima, M., Lee, M. A., … Virshup, D. M. (2016). NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition. Oncotarget, 7(11), 12386–12392. https://doi.org/10.18632/oncotarget.7157
Madan, Babita, Zhiyuan Ke, Zheng Deng Lei, Frois Ashley Oliver, Masanobu Oshima, May Ann Lee, Steve Rozen, and David M. Virshup. “NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition.Oncotarget 7, no. 11 (March 15, 2016): 12386–92. https://doi.org/10.18632/oncotarget.7157.
Madan B, Ke Z, Lei ZD, Oliver FA, Oshima M, Lee MA, et al. NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition. Oncotarget. 2016 Mar 15;7(11):12386–92.
Madan, Babita, et al. “NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition.Oncotarget, vol. 7, no. 11, Mar. 2016, pp. 12386–92. Pubmed, doi:10.18632/oncotarget.7157.
Madan B, Ke Z, Lei ZD, Oliver FA, Oshima M, Lee MA, Rozen S, Virshup DM. NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition. Oncotarget. 2016 Mar 15;7(11):12386–12392.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

March 15, 2016

Volume

7

Issue

11

Start / End Page

12386 / 12392

Location

United States

Related Subject Headings

  • Wnt Signaling Pathway
  • Transfection
  • Pancreatic Neoplasms
  • Mice, Nude
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Membrane Proteins
  • Humans
  • Heterografts