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Is Toxoplasma Gondii Infection Related to Brain and Behavior Impairments in Humans? Evidence from a Population-Representative Birth Cohort.

Publication ,  Journal Article
Sugden, K; Moffitt, TE; Pinto, L; Poulton, R; Williams, BS; Caspi, A
Published in: PloS one
January 2016

Toxoplasma gondii (T. gondii) is a protozoan parasite present in around a third of the human population. Infected individuals are commonly asymptomatic, though recent reports have suggested that infection might influence aspects of the host's behavior. In particular, Toxoplasma infection has been linked to schizophrenia, suicide attempt, differences in aspects of personality and poorer neurocognitive performance. However, these studies are often conducted in clinical samples or convenience samples.In a population-representative birth-cohort of individuals tested for presence of antibodies to T. gondii (N = 837) we investigated the association between infection and four facets of human behavior: neuropsychiatric disorder (schizophrenia and major depression), poor impulse control (suicidal behavior and criminality), personality, and neurocognitive performance. Suicide attempt was marginally more frequent among individuals with T. gondii seropositivity (p = .06). Seropositive individuals also performed worse on one out of 14 measures of neuropsychological function.On the whole, there was little evidence that T. gondii was related to increased risk of psychiatric disorder, poor impulse control, personality aberrations or neurocognitive impairment.

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Published In

PloS one

DOI

EISSN

1932-6203

ISSN

1932-6203

Publication Date

January 2016

Volume

11

Issue

2

Start / End Page

e0148435

Related Subject Headings

  • Toxoplasmosis
  • Personality
  • Parturition
  • Male
  • Impulsive Behavior
  • Humans
  • General Science & Technology
  • Female
  • Cohort Studies
  • Cognition
 

Citation

APA
Chicago
ICMJE
MLA
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Sugden, K., Moffitt, T. E., Pinto, L., Poulton, R., Williams, B. S., & Caspi, A. (2016). Is Toxoplasma Gondii Infection Related to Brain and Behavior Impairments in Humans? Evidence from a Population-Representative Birth Cohort. PloS One, 11(2), e0148435. https://doi.org/10.1371/journal.pone.0148435
Sugden, Karen, Terrie E. Moffitt, Lauriane Pinto, Richie Poulton, Benjamin S. Williams, and Avshalom Caspi. “Is Toxoplasma Gondii Infection Related to Brain and Behavior Impairments in Humans? Evidence from a Population-Representative Birth Cohort.PloS One 11, no. 2 (January 2016): e0148435. https://doi.org/10.1371/journal.pone.0148435.
Sugden K, Moffitt TE, Pinto L, Poulton R, Williams BS, Caspi A. Is Toxoplasma Gondii Infection Related to Brain and Behavior Impairments in Humans? Evidence from a Population-Representative Birth Cohort. PloS one. 2016 Jan;11(2):e0148435.
Sugden, Karen, et al. “Is Toxoplasma Gondii Infection Related to Brain and Behavior Impairments in Humans? Evidence from a Population-Representative Birth Cohort.PloS One, vol. 11, no. 2, Jan. 2016, p. e0148435. Epmc, doi:10.1371/journal.pone.0148435.
Sugden K, Moffitt TE, Pinto L, Poulton R, Williams BS, Caspi A. Is Toxoplasma Gondii Infection Related to Brain and Behavior Impairments in Humans? Evidence from a Population-Representative Birth Cohort. PloS one. 2016 Jan;11(2):e0148435.

Published In

PloS one

DOI

EISSN

1932-6203

ISSN

1932-6203

Publication Date

January 2016

Volume

11

Issue

2

Start / End Page

e0148435

Related Subject Headings

  • Toxoplasmosis
  • Personality
  • Parturition
  • Male
  • Impulsive Behavior
  • Humans
  • General Science & Technology
  • Female
  • Cohort Studies
  • Cognition