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HIV-Host Interactions: Implications for Vaccine Design.

Publication ,  Journal Article
Haynes, BF; Shaw, GM; Korber, B; Kelsoe, G; Sodroski, J; Hahn, BH; Borrow, P; McMichael, AJ
Published in: Cell Host Microbe
March 9, 2016
Published version (DOI) Link to item

Development of an effective AIDS vaccine is a global priority. However, the extreme diversity of HIV type 1 (HIV-1), which is a consequence of its propensity to mutate to escape immune responses, along with host factors that prevent the elicitation of protective immune responses, continue to hinder vaccine development. Breakthroughs in understanding of the biology of the transmitted virus, the structure and nature of its envelope trimer, vaccine-induced CD8 T cell control in primates, and host control of broadly neutralizing antibody elicitation have given rise to new vaccine strategies. Despite this promise, emerging data from preclinical trials reinforce the need for additional insight into virus-host biology in order to facilitate the development of a successful vaccine.

Duke Scholars

Barton Ford Haynes
Author Barton Ford Haynes Medicine, Duke Human Vaccine Institute
Garnett H. Kelsoe
Author Garnett H. Kelsoe Integrative Immunobiology
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Published In

Cell Host Microbe

DOI

10.1016/j.chom.2016.02.002

EISSN

1934-6069

Publication Date

March 9, 2016

Volume

19

Issue

3

Start / End Page

292 / 303

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Primates
  • Immunology
  • Host-Pathogen Interactions
  • HIV-1
  • HIV Antibodies
  • Drug Evaluation, Preclinical
  • Drug Discovery
  • CD8-Positive T-Lymphocytes
  • Antibodies, Neutralizing
 

Citation

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Haynes, B. F., Shaw, G. M., Korber, B., Kelsoe, G., Sodroski, J., Hahn, B. H., … McMichael, A. J. (2016). HIV-Host Interactions: Implications for Vaccine Design. Cell Host Microbe, 19(3), 292–303. https://doi.org/10.1016/j.chom.2016.02.002
Haynes, Barton F., George M. Shaw, Bette Korber, Garnett Kelsoe, Joseph Sodroski, Beatrice H. Hahn, Persephone Borrow, and Andrew J. McMichael. “HIV-Host Interactions: Implications for Vaccine Design.” Cell Host Microbe 19, no. 3 (March 9, 2016): 292–303. https://doi.org/10.1016/j.chom.2016.02.002.
Haynes BF, Shaw GM, Korber B, Kelsoe G, Sodroski J, Hahn BH, et al. HIV-Host Interactions: Implications for Vaccine Design. Cell Host Microbe. 2016 Mar 9;19(3):292–303.
Haynes, Barton F., et al. “HIV-Host Interactions: Implications for Vaccine Design.” Cell Host Microbe, vol. 19, no. 3, Mar. 2016, pp. 292–303. Pubmed, doi:10.1016/j.chom.2016.02.002.
Haynes BF, Shaw GM, Korber B, Kelsoe G, Sodroski J, Hahn BH, Borrow P, McMichael AJ. HIV-Host Interactions: Implications for Vaccine Design. Cell Host Microbe. 2016 Mar 9;19(3):292–303.
Journal cover image

Published In

Cell Host Microbe

DOI

10.1016/j.chom.2016.02.002

EISSN

1934-6069

Publication Date

March 9, 2016

Volume

19

Issue

3

Start / End Page

292 / 303

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Primates
  • Immunology
  • Host-Pathogen Interactions
  • HIV-1
  • HIV Antibodies
  • Drug Evaluation, Preclinical
  • Drug Discovery
  • CD8-Positive T-Lymphocytes
  • Antibodies, Neutralizing