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The transcriptional landscape of age in human peripheral blood.

Publication ,  Journal Article
Peters, MJ; Joehanes, R; Pilling, LC; Schurmann, C; Conneely, KN; Powell, J; Reinmaa, E; Sutphin, GL; Zhernakova, A; Schramm, K; Wilson, YA ...
Published in: Nat Commun
October 22, 2015
Published version (DOI) Link to item

Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the 'transcriptomic age' of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts.

Duke Scholars

Yongmei Liu
Author Yongmei Liu Medicine, Cardiology
Richard J O'Brien
Author Richard J O'Brien Neurology
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Published In

Nat Commun

DOI

10.1038/ncomms9570

EISSN

2041-1723

Publication Date

October 22, 2015

Volume

6

Start / End Page

8570

Location

England

Related Subject Headings

  • White People
  • Transcriptome
  • Humans
  • Gene Expression Profiling
  • DNA Methylation
  • Biomarkers
  • Aging
 

Citation

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Peters, M. J., Joehanes, R., Pilling, L. C., Schurmann, C., Conneely, K. N., Powell, J., … Johnson, A. D. (2015). The transcriptional landscape of age in human peripheral blood. Nat Commun, 6, 8570. https://doi.org/10.1038/ncomms9570
Peters, Marjolein J., Roby Joehanes, Luke C. Pilling, Claudia Schurmann, Karen N. Conneely, Joseph Powell, Eva Reinmaa, et al. “The transcriptional landscape of age in human peripheral blood.” Nat Commun 6 (October 22, 2015): 8570. https://doi.org/10.1038/ncomms9570.
Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, et al. The transcriptional landscape of age in human peripheral blood. Nat Commun. 2015 Oct 22;6:8570.
Peters, Marjolein J., et al. “The transcriptional landscape of age in human peripheral blood.” Nat Commun, vol. 6, Oct. 2015, p. 8570. Pubmed, doi:10.1038/ncomms9570.
Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, Wilson YA, Kobes S, Tukiainen T, NABEC/UKBEC Consortium, Ramos YF, Göring HHH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A, Levy D, Murabito JM, Munson PJ, Huan T, Hofman A, Uitterlinden AG, Rivadeneira F, van Rooij J, Stolk L, Broer L, Verbiest MMPJ, Jhamai M, Arp P, Metspalu A, Tserel L, Milani L, Samani NJ, Peterson P, Kasela S, Codd V, Peters A, Ward-Caviness CK, Herder C, Waldenberger M, Roden M, Singmann P, Zeilinger S, Illig T, Homuth G, Grabe H-J, Völzke H, Steil L, Kocher T, Murray A, Melzer D, Yaghootkar H, Bandinelli S, Moses EK, Kent JW, Curran JE, Johnson MP, Williams-Blangero S, Westra H-J, McRae AF, Smith JA, Kardia SLR, Hovatta I, Perola M, Ripatti S, Salomaa V, Henders AK, Martin NG, Smith AK, Mehta D, Binder EB, Nylocks KM, Kennedy EM, Klengel T, Ding J, Suchy-Dicey AM, Enquobahrie DA, Brody J, Rotter JI, Chen Y-DI, Houwing-Duistermaat J, Kloppenburg M, Slagboom PE, Helmer Q, den Hollander W, Bean S, Raj T, Bakhshi N, Wang QP, Oyston LJ, Psaty BM, Tracy RP, Montgomery GW, Turner ST, Blangero J, Meulenbelt I, Ressler KJ, Yang J, Franke L, Kettunen J, Visscher PM, Neely GG, Korstanje R, Hanson RL, Prokisch H, Ferrucci L, Esko T, Teumer A, van Meurs JBJ, Johnson AD. The transcriptional landscape of age in human peripheral blood. Nat Commun. 2015 Oct 22;6:8570.

Published In

Nat Commun

DOI

10.1038/ncomms9570

EISSN

2041-1723

Publication Date

October 22, 2015

Volume

6

Start / End Page

8570

Location

England

Related Subject Headings

  • White People
  • Transcriptome
  • Humans
  • Gene Expression Profiling
  • DNA Methylation
  • Biomarkers
  • Aging