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Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis.

Publication ,  Journal Article
Yang, JD; Abdelmalek, MF; Guy, CD; Gill, RM; Lavine, JE; Yates, K; Klair, J; Terrault, NA; Clark, JM; Unalp-Arida, A; Diehl, AM; Suzuki, A ...
Published in: Clin Gastroenterol Hepatol
January 2017

BACKGROUND & AIMS: Sex and sex hormones can affect responses of patients with nonalcoholic fatty liver disease (NAFLD) to metabolic stress and development of hepatocyte injury and inflammation. METHODS: We collected data from 3 large U.S. studies of patients with NAFLD (between October 2004 and June 2013) to assess the association between histologic severity and sex, menopause status, synthetic hormone use, and menstrual abnormalities in 1112 patients with a histologic diagnosis of NAFLD. We performed logistic or ordinal logistic regression models, adjusting for covariates relevant to an increase of hepatic metabolic stress. RESULTS: Premenopausal women were at an increased risk of lobular inflammation, hepatocyte ballooning, and Mallory-Denk bodies than men and also at an increased risk of lobular inflammation and Mallory-Denk bodies than postmenopausal women (P < .01). Use of oral contraceptives was associated with an increased risk of lobular inflammation and Mallory-Denk bodies in premenopausal women, whereas hormone replacement therapy was associated with an increased risk of lobular inflammation in postmenopausal women (P < .05). CONCLUSIONS: Being a premenopausal woman or a female user of synthetic hormones is associated with increased histologic severity of hepatocyte injury and inflammation among patients with NAFLD at given levels of hepatic metabolic stress.

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Published In

Clin Gastroenterol Hepatol

DOI

EISSN

1542-7714

Publication Date

January 2017

Volume

15

Issue

1

Start / End Page

127 / 131.e2

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Sex Factors
  • Risk Factors
  • Reproduction
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Menopause
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Yang, J. D., Abdelmalek, M. F., Guy, C. D., Gill, R. M., Lavine, J. E., Yates, K., … Nonalcoholic Steatohepatitis Clinical Research Network, . (2017). Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis. Clin Gastroenterol Hepatol, 15(1), 127-131.e2. https://doi.org/10.1016/j.cgh.2016.07.034
Yang, Ju Dong, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Joel E. Lavine, Katherine Yates, Jagpal Klair, et al. “Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis.Clin Gastroenterol Hepatol 15, no. 1 (January 2017): 127-131.e2. https://doi.org/10.1016/j.cgh.2016.07.034.
Yang JD, Abdelmalek MF, Guy CD, Gill RM, Lavine JE, Yates K, et al. Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis. Clin Gastroenterol Hepatol. 2017 Jan;15(1):127-131.e2.
Yang, Ju Dong, et al. “Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis.Clin Gastroenterol Hepatol, vol. 15, no. 1, Jan. 2017, pp. 127-131.e2. Pubmed, doi:10.1016/j.cgh.2016.07.034.
Yang JD, Abdelmalek MF, Guy CD, Gill RM, Lavine JE, Yates K, Klair J, Terrault NA, Clark JM, Unalp-Arida A, Diehl AM, Suzuki A, Nonalcoholic Steatohepatitis Clinical Research Network. Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis. Clin Gastroenterol Hepatol. 2017 Jan;15(1):127-131.e2.
Journal cover image

Published In

Clin Gastroenterol Hepatol

DOI

EISSN

1542-7714

Publication Date

January 2017

Volume

15

Issue

1

Start / End Page

127 / 131.e2

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Sex Factors
  • Risk Factors
  • Reproduction
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Menopause
  • Male
  • Humans