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Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample.

Publication ,  Journal Article
Pasquale, LR; Aschard, H; Kang, JH; Bailey, JNC; Lindström, S; Chasman, DI; Christen, WG; Allingham, RR; Ashley-Koch, A; Lee, RK; Moroi, SE ...
Published in: Menopause
February 2017

OBJECTIVE: Several attributes of female reproductive history, including age at natural menopause (ANM), have been related to primary open-angle glaucoma (POAG). We assembled 18 previously reported common genetic variants that predict ANM to determine their association with ANM or POAG. METHODS: Using data from the Nurses' Health Study (7,143 women), we validated the ANM weighted genetic risk score in relation to self-reported ANM. Subsequently, to assess the relation with POAG, we used data from 2,160 female POAG cases and 29,110 controls in the National Eye Institute Glaucoma Human Genetics Collaboration Heritable Overall Operational Database (NEIGHBORHOOD), which consists of 8 datasets with imputed genotypes to 5.6+ million markers. Associations with POAG were assessed in each dataset, and site-specific results were meta-analyzed using the inverse weighted variance method. RESULTS: The genetic risk score was associated with self-reported ANM (P = 2.2 × 10) and predicted 4.8% of the variance in ANM. The ANM genetic risk score was not associated with POAG (Odds Ratio (OR) = 1.002; 95% Confidence Interval (CI): 0.998, 1.007; P = 0.28). No single genetic variant in the panel achieved nominal association with POAG (P ≥0.20). Compared to the middle 80 percent, there was also no association with the lowest 10 percentile or highest 90 percentile of genetic risk score with POAG (OR = 0.75; 95% CI: 0.47, 1.21; P = 0.23 and OR = 1.10; 95% CI: 0.72, 1.69; P = 0.65, respectively). CONCLUSIONS: A genetic risk score predicting 4.8% of ANM variation was not related to POAG; thus, genetic determinants of ANM are unlikely to explain the previously reported association between the two phenotypes.

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Published In

Menopause

DOI

EISSN

1530-0374

Publication Date

February 2017

Volume

24

Issue

2

Start / End Page

150 / 156

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Risk Assessment
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Menopause
  • Humans
  • Glaucoma, Open-Angle
  • Genotype
  • Genetic Variation
 

Citation

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Chicago
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Pasquale, L. R., Aschard, H., Kang, J. H., Bailey, J. N. C., Lindström, S., Chasman, D. I., … Wiggs, J. L. (2017). Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample. Menopause, 24(2), 150–156. https://doi.org/10.1097/GME.0000000000000741
Pasquale, Louis R., Hugues Aschard, Jae H. Kang, Jessica N Cooke Bailey, Sara Lindström, Daniel I. Chasman, William G. Christen, et al. “Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample.Menopause 24, no. 2 (February 2017): 150–56. https://doi.org/10.1097/GME.0000000000000741.
Pasquale LR, Aschard H, Kang JH, Bailey JNC, Lindström S, Chasman DI, et al. Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample. Menopause. 2017 Feb;24(2):150–6.
Pasquale, Louis R., et al. “Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample.Menopause, vol. 24, no. 2, Feb. 2017, pp. 150–56. Pubmed, doi:10.1097/GME.0000000000000741.
Pasquale LR, Aschard H, Kang JH, Bailey JNC, Lindström S, Chasman DI, Christen WG, Allingham RR, Ashley-Koch A, Lee RK, Moroi SE, Brilliant MH, Wollstein G, Schuman JS, Fingert J, Budenz DL, Realini T, Gaasterland T, Gaasterland D, Scott WK, Singh K, Sit AJ, Igo RP, Song YE, Hark L, Ritch R, Rhee DJ, Gulati V, Havens S, Vollrath D, Zack DJ, Medeiros F, Weinreb RN, Pericak-Vance MA, Liu Y, Kraft P, Richards JE, Rosner BA, Hauser MA, Haines JL, Wiggs JL. Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample. Menopause. 2017 Feb;24(2):150–156.

Published In

Menopause

DOI

EISSN

1530-0374

Publication Date

February 2017

Volume

24

Issue

2

Start / End Page

150 / 156

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Risk Assessment
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Menopause
  • Humans
  • Glaucoma, Open-Angle
  • Genotype
  • Genetic Variation