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Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions.

Publication ,  Journal Article
Griffin, NW; Ahern, PP; Cheng, J; Heath, AC; Ilkayeva, O; Newgard, CB; Fontana, L; Gordon, JI
Published in: Cell Host Microbe
January 11, 2017

Ensuring that gut microbiota respond consistently to prescribed dietary interventions, irrespective of prior dietary practices (DPs), is critical for effective nutritional therapy. To address this, we identified DP-associated gut bacterial taxa in individuals either practicing chronic calorie restriction with adequate nutrition (CRON) or without dietary restrictions (AMER). When transplanted into gnotobiotic mice, AMER and CRON microbiota responded predictably to CRON and AMER diets but with variable response strengths. An individual's microbiota is connected to other individuals' communities ("metacommunity") by microbial exchange. Sequentially cohousing AMER-colonized mice with two different groups of CRON-colonized mice simulated metacommunity effects, resulting in enhanced responses to a CRON diet intervention and changes in several metabolic features in AMER animals. This response was driven by an influx of CRON DP-associated taxa. Certain DPs may impair responses to dietary interventions, necessitating the introduction of diet-responsive bacterial lineages present in other individuals and identified using the strategies described.

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Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

January 11, 2017

Volume

21

Issue

1

Start / End Page

84 / 96

Location

United States

Related Subject Headings

  • Mice
  • Male
  • Immunology
  • Humans
  • Germ-Free Life
  • Gastrointestinal Tract
  • Gastrointestinal Microbiome
  • Feeding Behavior
  • Feces
  • Diet
 

Citation

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Griffin, N. W., Ahern, P. P., Cheng, J., Heath, A. C., Ilkayeva, O., Newgard, C. B., … Gordon, J. I. (2017). Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions. Cell Host Microbe, 21(1), 84–96. https://doi.org/10.1016/j.chom.2016.12.006
Griffin, Nicholas W., Philip P. Ahern, Jiye Cheng, Andrew C. Heath, Olga Ilkayeva, Christopher B. Newgard, Luigi Fontana, and Jeffrey I. Gordon. “Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions.Cell Host Microbe 21, no. 1 (January 11, 2017): 84–96. https://doi.org/10.1016/j.chom.2016.12.006.
Griffin NW, Ahern PP, Cheng J, Heath AC, Ilkayeva O, Newgard CB, et al. Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions. Cell Host Microbe. 2017 Jan 11;21(1):84–96.
Griffin, Nicholas W., et al. “Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions.Cell Host Microbe, vol. 21, no. 1, Jan. 2017, pp. 84–96. Pubmed, doi:10.1016/j.chom.2016.12.006.
Griffin NW, Ahern PP, Cheng J, Heath AC, Ilkayeva O, Newgard CB, Fontana L, Gordon JI. Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions. Cell Host Microbe. 2017 Jan 11;21(1):84–96.
Journal cover image

Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

January 11, 2017

Volume

21

Issue

1

Start / End Page

84 / 96

Location

United States

Related Subject Headings

  • Mice
  • Male
  • Immunology
  • Humans
  • Germ-Free Life
  • Gastrointestinal Tract
  • Gastrointestinal Microbiome
  • Feeding Behavior
  • Feces
  • Diet