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Poly(oligo(ethylene glycol) methyl ether methacrylate) Brushes on High-κ Metal Oxide Dielectric Surfaces for Bioelectrical Environments.

Publication ,  Journal Article
Joh, DY; McGuire, F; Abedini-Nassab, R; Andrews, JB; Achar, RK; Zimmers, Z; Mozhdehi, D; Blair, R; Albarghouthi, F; Oles, W; Richter, J ...
Published in: ACS applied materials & interfaces
February 2017

Advances in electronics and life sciences have generated interest in "lab-on-a-chip" systems utilizing complementary metal oxide semiconductor (CMOS) circuitry for low-power, portable, and cost-effective biosensing platforms. Here, we present a simple and reliable approach for coating "high-κ" metal oxide dielectric materials with "non-fouling" (protein- and cell-resistant) poly(oligo(ethylene glycol) methyl ether methacrylate (POEGMA) polymer brushes as biointerfacial coatings to improve their relevance for biosensing applications utilizing advanced electronic components. By using a surface-initiated "grafting from" strategy, POEGMA films were reliably grown on each material, as confirmed by ellipsometric measurements and X-ray photoelectron spectroscopy (XPS) analysis. The electrical behavior of these POEGMA films was also studied to determine the potential impact on surrounding electronic devices, yielding information on relative permittivity and breakdown field for POEGMA in both dry and hydrated states. We show that the incorporation of POEGMA coatings significantly reduced levels of nonspecific protein adsorption compared to uncoated high-κ dielectric oxide surfaces as shown by protein resistance assays. These attributes, combined with the robust dielectric properties of POEGMA brushes on high-κ surfaces open the way to incorporate this protein and cell resistant polymer interface into CMOS devices for biomolecular detection in a complex liquid milieu.

Duke Scholars

Published In

ACS applied materials & interfaces

DOI

EISSN

1944-8252

ISSN

1944-8244

Publication Date

February 2017

Volume

9

Issue

6

Start / End Page

5522 / 5529

Related Subject Headings

  • Nanoscience & Nanotechnology
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
 

Citation

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Joh, D. Y., McGuire, F., Abedini-Nassab, R., Andrews, J. B., Achar, R. K., Zimmers, Z., … Chilkoti, A. (2017). Poly(oligo(ethylene glycol) methyl ether methacrylate) Brushes on High-κ Metal Oxide Dielectric Surfaces for Bioelectrical Environments. ACS Applied Materials & Interfaces, 9(6), 5522–5529. https://doi.org/10.1021/acsami.6b15836
Joh, Daniel Y., Felicia McGuire, Roozbeh Abedini-Nassab, Joseph B. Andrews, Rohan K. Achar, Zackary Zimmers, Darush Mozhdehi, et al. “Poly(oligo(ethylene glycol) methyl ether methacrylate) Brushes on High-κ Metal Oxide Dielectric Surfaces for Bioelectrical Environments.ACS Applied Materials & Interfaces 9, no. 6 (February 2017): 5522–29. https://doi.org/10.1021/acsami.6b15836.
Joh DY, McGuire F, Abedini-Nassab R, Andrews JB, Achar RK, Zimmers Z, et al. Poly(oligo(ethylene glycol) methyl ether methacrylate) Brushes on High-κ Metal Oxide Dielectric Surfaces for Bioelectrical Environments. ACS applied materials & interfaces. 2017 Feb;9(6):5522–9.
Joh, Daniel Y., et al. “Poly(oligo(ethylene glycol) methyl ether methacrylate) Brushes on High-κ Metal Oxide Dielectric Surfaces for Bioelectrical Environments.ACS Applied Materials & Interfaces, vol. 9, no. 6, Feb. 2017, pp. 5522–29. Epmc, doi:10.1021/acsami.6b15836.
Joh DY, McGuire F, Abedini-Nassab R, Andrews JB, Achar RK, Zimmers Z, Mozhdehi D, Blair R, Albarghouthi F, Oles W, Richter J, Fontes CM, Hucknall AM, Yellen BB, Franklin AD, Chilkoti A. Poly(oligo(ethylene glycol) methyl ether methacrylate) Brushes on High-κ Metal Oxide Dielectric Surfaces for Bioelectrical Environments. ACS applied materials & interfaces. 2017 Feb;9(6):5522–5529.
Journal cover image

Published In

ACS applied materials & interfaces

DOI

EISSN

1944-8252

ISSN

1944-8244

Publication Date

February 2017

Volume

9

Issue

6

Start / End Page

5522 / 5529

Related Subject Headings

  • Nanoscience & Nanotechnology
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences