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Host controls of HIV broadly neutralizing antibody development.

Publication ,  Journal Article
Kelsoe, G; Haynes, BF
Published in: Immunol Rev
January 2017

Induction of broadly neutralizing antibodies (bNAbs) is a major goal of HIV vaccine development. BNAbs are made during HIV infection by a subset of individuals but currently cannot be induced in the setting of vaccination. Considerable progress has been made recently in understanding host immunologic controls of bNAb induction and maturation in the setting of HIV infection, and point to key roles for both central and peripheral immunologic tolerance mechanisms in limiting bnAb development. Immune tolerance checkpoint inhibition has been transformative in promotion of anti-tumor CD8 T-cell responses in the treatment of certain malignancies. Here, we review the evidence for host controls of bNAb responses, and discuss strategies for the transient modulation of immune responses with vaccines toward the goal of enhancing germinal center B-cell responses to favor bNAb B-cell lineages and to foster their maturation to full neutralization potency.

Duke Scholars

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Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

January 2017

Volume

275

Issue

1

Start / End Page

79 / 88

Location

England

Related Subject Headings

  • Immunology
  • Immunity, Humoral
  • Immune Tolerance
  • Humans
  • Host-Pathogen Interactions
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Cell Differentiation
  • B-Lymphocytes
 

Citation

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Kelsoe, G., & Haynes, B. F. (2017). Host controls of HIV broadly neutralizing antibody development. Immunol Rev, 275(1), 79–88. https://doi.org/10.1111/imr.12508
Kelsoe, Garnett, and Barton F. Haynes. “Host controls of HIV broadly neutralizing antibody development.Immunol Rev 275, no. 1 (January 2017): 79–88. https://doi.org/10.1111/imr.12508.
Kelsoe G, Haynes BF. Host controls of HIV broadly neutralizing antibody development. Immunol Rev. 2017 Jan;275(1):79–88.
Kelsoe, Garnett, and Barton F. Haynes. “Host controls of HIV broadly neutralizing antibody development.Immunol Rev, vol. 275, no. 1, Jan. 2017, pp. 79–88. Pubmed, doi:10.1111/imr.12508.
Kelsoe G, Haynes BF. Host controls of HIV broadly neutralizing antibody development. Immunol Rev. 2017 Jan;275(1):79–88.
Journal cover image

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

January 2017

Volume

275

Issue

1

Start / End Page

79 / 88

Location

England

Related Subject Headings

  • Immunology
  • Immunity, Humoral
  • Immune Tolerance
  • Humans
  • Host-Pathogen Interactions
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Cell Differentiation
  • B-Lymphocytes