Skip to main content
Journal cover image

Exposure to 1,2-Propanediol Impacts Early Development of Zebrafish (Danio rerio) and Induces Hyperactivity.

Publication ,  Journal Article
Massarsky, A; Abdel, A; Glazer, L; Levin, ED; Di Giulio, RT
Published in: Zebrafish
June 2017

The use of electronic cigarettes (e-cigarettes) is increasing as an alternative to tobacco burning cigarettes; however, their safety remains to be fully determined. The long-term effects of e-cigarettes are unknown, including the effects of maternal e-cigarette use on pre- and postnatal development. Additional research on the safety of e-cigarettes is needed. Especially useful would be information from high- and moderate-throughput economic model systems. This study investigates the effects of 1,2-propanediol, which was identified as the main component of e-cigarette liquid, on early development of zebrafish (an in vivo high-throughput model system that was recently proposed for the study of tobacco cigarette and e-cigarette toxicity). Zebrafish embryos were exposed to 1.25% or 2.5% 1,2-propanediol from 6 to 72 h post-fertilization (hpf). We show that exposure to 1,2-propanediol did not significantly affect mortality. Hatching success was significantly lower in 2.5% 1,2-propanediol-exposed embryos at 48 hpf, but at 72 hpf no significant differences were noted. Moreover, exposure to 1,2-propanediol reduced growth and increased the incidence of string heart, pericardial edema, and yolk sac edema. Most importantly, developmental exposure to 1.25% 1,2-propanediol caused hyperactive swimming behavior in larvae. This study demonstrates that 1,2-propanediol has adverse impacts on early development in zebrafish.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Zebrafish

DOI

EISSN

1557-8542

Publication Date

June 2017

Volume

14

Issue

3

Start / End Page

216 / 222

Location

United States

Related Subject Headings

  • Zebrafish
  • Yolk Sac
  • Teratogens
  • Swimming
  • Propylene Glycol
  • Pharmaceutical Vehicles
  • Larva
  • Hyperkinesis
  • Heart Diseases
  • Embryo, Nonmammalian
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Massarsky, A., Abdel, A., Glazer, L., Levin, E. D., & Di Giulio, R. T. (2017). Exposure to 1,2-Propanediol Impacts Early Development of Zebrafish (Danio rerio) and Induces Hyperactivity. Zebrafish, 14(3), 216–222. https://doi.org/10.1089/zeb.2016.1400
Massarsky, Andrey, Ayham Abdel, Lilah Glazer, Edward D. Levin, and Richard T. Di Giulio. “Exposure to 1,2-Propanediol Impacts Early Development of Zebrafish (Danio rerio) and Induces Hyperactivity.Zebrafish 14, no. 3 (June 2017): 216–22. https://doi.org/10.1089/zeb.2016.1400.
Massarsky A, Abdel A, Glazer L, Levin ED, Di Giulio RT. Exposure to 1,2-Propanediol Impacts Early Development of Zebrafish (Danio rerio) and Induces Hyperactivity. Zebrafish. 2017 Jun;14(3):216–22.
Massarsky, Andrey, et al. “Exposure to 1,2-Propanediol Impacts Early Development of Zebrafish (Danio rerio) and Induces Hyperactivity.Zebrafish, vol. 14, no. 3, June 2017, pp. 216–22. Pubmed, doi:10.1089/zeb.2016.1400.
Massarsky A, Abdel A, Glazer L, Levin ED, Di Giulio RT. Exposure to 1,2-Propanediol Impacts Early Development of Zebrafish (Danio rerio) and Induces Hyperactivity. Zebrafish. 2017 Jun;14(3):216–222.
Journal cover image

Published In

Zebrafish

DOI

EISSN

1557-8542

Publication Date

June 2017

Volume

14

Issue

3

Start / End Page

216 / 222

Location

United States

Related Subject Headings

  • Zebrafish
  • Yolk Sac
  • Teratogens
  • Swimming
  • Propylene Glycol
  • Pharmaceutical Vehicles
  • Larva
  • Hyperkinesis
  • Heart Diseases
  • Embryo, Nonmammalian