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TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.
Publication
, Journal Article
Chen, Y; Moore, CD; Zhang, JY; Hall, RP; MacLeod, AS; Liedtke, W
Published in: J Invest Dermatol
April 2017
Mascarenhas et al. report that TRPV4 expression is upregulated in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosacea model and that TRPV4 loss of function attenuates mast cell degranulation. These findings render TRPV4 a translational-medical target in rosacea. However, signaling mechanisms causing increased expression of TRPV4 await elucidation. Moreover, we ask whether TRPV4-mediated Ca++-influx evokes mast cell degranulation.
Duke Scholars
Published In
J Invest Dermatol
DOI
EISSN
1523-1747
Publication Date
April 2017
Volume
137
Issue
4
Start / End Page
801 / 804
Location
United States
Related Subject Headings
- Up-Regulation
- Translational Research, Biomedical
- TRPV Cation Channels
- Rosacea
- Mice
- Mast Cells
- Humans
- Disease Models, Animal
- Dermatology & Venereal Diseases
- Cells, Cultured
Citation
APA
Chicago
ICMJE
MLA
NLM
Chen, Y., Moore, C. D., Zhang, J. Y., Hall, R. P., MacLeod, A. S., & Liedtke, W. (2017). TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis. J Invest Dermatol, 137(4), 801–804. https://doi.org/10.1016/j.jid.2016.12.013
Chen, Yong, Carlene D. Moore, Jennifer Y. Zhang, Russell P. Hall, Amanda S. MacLeod, and Wolfgang Liedtke. “TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.” J Invest Dermatol 137, no. 4 (April 2017): 801–4. https://doi.org/10.1016/j.jid.2016.12.013.
Chen Y, Moore CD, Zhang JY, Hall RP, MacLeod AS, Liedtke W. TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis. J Invest Dermatol. 2017 Apr;137(4):801–4.
Chen, Yong, et al. “TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.” J Invest Dermatol, vol. 137, no. 4, Apr. 2017, pp. 801–04. Pubmed, doi:10.1016/j.jid.2016.12.013.
Chen Y, Moore CD, Zhang JY, Hall RP, MacLeod AS, Liedtke W. TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis. J Invest Dermatol. 2017 Apr;137(4):801–804.
![Journal cover image](https://secure.syndetics.com/index.aspx?isbn=/lc.gif&issn=1523-1747&client=dukeuniv)
Published In
J Invest Dermatol
DOI
EISSN
1523-1747
Publication Date
April 2017
Volume
137
Issue
4
Start / End Page
801 / 804
Location
United States
Related Subject Headings
- Up-Regulation
- Translational Research, Biomedical
- TRPV Cation Channels
- Rosacea
- Mice
- Mast Cells
- Humans
- Disease Models, Animal
- Dermatology & Venereal Diseases
- Cells, Cultured