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Motor function domains in alternating hemiplegia of childhood.

Publication ,  Journal Article
Masoud, M; Gordon, K; Hall, A; Jasien, J; Lardinois, K; Uchitel, J; Mclean, M; Prange, L; Wuchich, J; Mikati, MA
Published in: Dev Med Child Neurol
August 2017

AIM: To characterize motor function profiles in alternating hemiplegia of childhood, and to investigate interrelationships between these domains and with age. METHOD: We studied a cohort of 23 patients (9 males, 14 females; mean age 9y 4mo, range 4mo-43y) who underwent standardized tests to assess gross motor, upper extremity motor control, motor speech, and dysphagia functions. RESULTS: Gross Motor Function Classification System (GMFCS), Gross Motor Function Measure-88 (GMFM-88), Manual Ability Classification System (MACS), and Revised Melbourne Assessment (MA2) scales manifested predominantly mild impairments; motor speech, moderate to severe; Modified Dysphagia Outcome and Severity Scale (M-DOSS), mild-to moderate deficits. GMFCS correlated with GMFM-88 scores (Pearson's correlation, p=0.002), MACS (p=0.038), and MA2 fluency (p=0.005) and accuracy (p=0.038) scores. GMFCS did not correlate with motor speech (p=0.399), MA2 dexterity (p=0.247), range of motion (p=0.063), or M-DOSS (p=0.856). Motor speech was more severely impaired than the GMFCS (p<0.013). There was no correlation between any of the assessment tools and age (p=0.210-0.798). INTERPRETATION: Our data establish a detailed profile of motor function in alternating hemiplegia of childhood, argue against the presence of worse motor function in older patients, identify tools helpful in evaluating this population, and identify oropharyngeal function as the more severely affected domain, suggesting that brain areas controlling this function are more affected than others.

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Published In

Dev Med Child Neurol

DOI

EISSN

1469-8749

Publication Date

August 2017

Volume

59

Issue

8

Start / End Page

822 / 828

Location

England

Related Subject Headings

  • Young Adult
  • Speech Disorders
  • Severity of Illness Index
  • Pediatrics
  • Movement Disorders
  • Male
  • Infant
  • Humans
  • Hemiplegia
  • Female
 

Citation

APA
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Masoud, M., Gordon, K., Hall, A., Jasien, J., Lardinois, K., Uchitel, J., … Mikati, M. A. (2017). Motor function domains in alternating hemiplegia of childhood. Dev Med Child Neurol, 59(8), 822–828. https://doi.org/10.1111/dmcn.13443
Masoud, Melanie, Kelly Gordon, Amanda Hall, Joan Jasien, Kara Lardinois, Julie Uchitel, Melissa Mclean, Lyndsey Prange, Jeffrey Wuchich, and Mohamad A. Mikati. “Motor function domains in alternating hemiplegia of childhood.Dev Med Child Neurol 59, no. 8 (August 2017): 822–28. https://doi.org/10.1111/dmcn.13443.
Masoud M, Gordon K, Hall A, Jasien J, Lardinois K, Uchitel J, et al. Motor function domains in alternating hemiplegia of childhood. Dev Med Child Neurol. 2017 Aug;59(8):822–8.
Masoud, Melanie, et al. “Motor function domains in alternating hemiplegia of childhood.Dev Med Child Neurol, vol. 59, no. 8, Aug. 2017, pp. 822–28. Pubmed, doi:10.1111/dmcn.13443.
Masoud M, Gordon K, Hall A, Jasien J, Lardinois K, Uchitel J, Mclean M, Prange L, Wuchich J, Mikati MA. Motor function domains in alternating hemiplegia of childhood. Dev Med Child Neurol. 2017 Aug;59(8):822–828.
Journal cover image

Published In

Dev Med Child Neurol

DOI

EISSN

1469-8749

Publication Date

August 2017

Volume

59

Issue

8

Start / End Page

822 / 828

Location

England

Related Subject Headings

  • Young Adult
  • Speech Disorders
  • Severity of Illness Index
  • Pediatrics
  • Movement Disorders
  • Male
  • Infant
  • Humans
  • Hemiplegia
  • Female